The Danish cancer pathway for patients with serious non-specific symptoms and signs of cancer–a cross-sectional study of patient characteristics and ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Mads Lind Ingeman, Morten Bondo Christensen, Flemming Bro, Søren T. Knudsen, Peter Vedsted

ABSTRACT

BACKGROUND: A Danish cancer pathway has been implemented for patients with serious non-specific symptoms and signs of cancer (NSSC-CPP). The initiative is one of several to improve the long diagnostic interval and the poor survival of Danish cancer patients. However, little is known about the patients investigated under this pathway. We aim to describe the characteristics of patients referred from general practice to the NSSC-CPP and to estimate the cancer probability and distribution in this population. METHODS: A cross-sectional study was performed, including all patients referred to the NSSC-CPP at the hospitals in Aarhus or Silkeborg in the Central Denmark Region between March 2012 and March 2013. Data were based on a questionnaire completed by the patient's general practitioner (GP) combined with nationwide registers. Cancer probability was the percentage of new cancers per investigated patient. Associations between patient characteristics and cancer diagnosis were estimated with prevalence rate ratios (PRRs) from a generalised linear model. RESULTS: The mean age of all 1278 included patients was 65.9 years, and 47.5 % were men. In total, 16.2 % of all patients had a cancer diagnosis after six months; the most common types were lung cancer (17.9 %), colorectal cancer (12.6 %), hematopoietic tissue cancer (10.1 %) and pancreatic cancer (9.2 %). All patients in combination had more than 80 different symptoms and 51 different clinical findings at referral. Most symptoms were non-specific and vague; weight loss and fatigue were present in more than half of all cases. The three most common clinical findings were 'affected general condition' (35.8 %), 'GP's gut feeling' (22.5 %) and 'findings from the abdomen' (13.0 %). A strong association was found between GP-estimated cancer risk at referral and probability of cancer. CONCLUSIONS: In total, 16.2 % of the patients referred through the NSSC-CPP had cancer. They constituted a heterogeneous group with many different symptoms and clinical findings. The GP's gut feeling was a common reason for referral which proved to be a strong predictor of cancer. The GP's overall estimation of the patient's risk of cancer at referral was associated with the probability of finding cancer. More... »

PAGES

421

References to SciGraph publications

  • 2013-02. Measures of promptness of cancer diagnosis in primary care: secondary analysis of national audit data on patients with 18 common and rarer cancers in BRITISH JOURNAL OF CANCER
  • 2012-12. Use of general practice, diagnostic investigations and hospital services before and after cancer diagnosis - a population-based nationwide registry study of 127,000 incident adult cancer patients in BMC HEALTH SERVICES RESEARCH
  • 2011-12. Time intervals from first symptom to treatment of cancer: a cohort study of 2,212 newly diagnosed cancer patients in BMC HEALTH SERVICES RESEARCH
  • 2012-03. Enigmatic sex disparities in cancer incidence in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2015-03. A differentiated approach to referrals from general practice to support early cancer diagnosis – the Danish three-legged strategy in BRITISH JOURNAL OF CANCER
  • 2014-12. Primary care referrals of patients with potentially serious diseases to the emergency department or a quick diagnosis unit: a cross-sectional retrospective study in BMC FAMILY PRACTICE
  • 2014-02. Comparison of cancer diagnostic intervals before and after implementation of NICE guidelines: analysis of data from the UK General Practice Research Database in BRITISH JOURNAL OF CANCER
  • 2014-12. Cancer suspicion in general practice, urgent referral and time to diagnosis: a population-based GP survey and registry study in BMC CANCER
  • 2009-12. Delay in diagnosis: the experience in Denmark in BRITISH JOURNAL OF CANCER
  • 2009-12. The CAPER studies: five case-control studies aimed at identifying and quantifying the risk of cancer in symptomatic primary care patients in BRITISH JOURNAL OF CANCER
  • 2012-03. The Aarhus statement: improving design and reporting of studies on early cancer diagnosis in BRITISH JOURNAL OF CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12885-015-1424-5

    DOI

    http://dx.doi.org/10.1186/s12885-015-1424-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039837797

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25990247


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Public Health and Health Services", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cross-Sectional Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Denmark", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Referral and Consultation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Surveys and Questionnaires", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Symptom Assessment", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Aarhus University", 
              "id": "https://www.grid.ac/institutes/grid.7048.b", 
              "name": [
                "Research Unit for General Practice, Aarhus University, Aarhus, Denmark", 
                "Research Centre for Cancer Diagnosis in Primary Care (CaP), Aarhus University, Aarhus, Denmark", 
                "Department of Public Health, Section for General Medical Practice, Aarhus University, Aarhus, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ingeman", 
            "givenName": "Mads Lind", 
            "id": "sg:person.0734641132.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734641132.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Aarhus University", 
              "id": "https://www.grid.ac/institutes/grid.7048.b", 
              "name": [
                "Research Unit for General Practice, Aarhus University, Aarhus, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Christensen", 
            "givenName": "Morten Bondo", 
            "id": "sg:person.01031620207.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031620207.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Aarhus University", 
              "id": "https://www.grid.ac/institutes/grid.7048.b", 
              "name": [
                "Research Unit for General Practice, Aarhus University, Aarhus, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bro", 
            "givenName": "Flemming", 
            "id": "sg:person.01162311550.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162311550.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Aarhus University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.154185.c", 
              "name": [
                "Department of Endocrinology and Internal Medicine (MEA), Aarhus University Hospital, Noerrebrogade, Aarhus, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Knudsen", 
            "givenName": "S\u00f8ren T.", 
            "id": "sg:person.01243477410.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243477410.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Aarhus University", 
              "id": "https://www.grid.ac/institutes/grid.7048.b", 
              "name": [
                "Research Unit for General Practice, Aarhus University, Aarhus, Denmark", 
                "Research Centre for Cancer Diagnosis in Primary Care (CaP), Aarhus University, Aarhus, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vedsted", 
            "givenName": "Peter", 
            "id": "sg:person.01137025352.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137025352.99"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/bjc.2015.44", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000610955", 
              "https://doi.org/10.1038/bjc.2015.44"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.healthpol.2011.11.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002194464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1403494810387965", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002205599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1403494810387965", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002205599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(10)62231-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003353087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(94)90634-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004510159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(94)90634-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004510159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10654-011-9647-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008653899", 
              "https://doi.org/10.1007/s10654-011-9647-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/fampra/cmn028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009128603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2354.2005.00600.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009128902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3399/bjgp11x606591", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009939478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/13814781003653424", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010201156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2012.68", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010902211", 
              "https://doi.org/10.1038/bjc.2012.68"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2013.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013771450", 
              "https://doi.org/10.1038/bjc.2013.1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1472-6963-12-224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013894650", 
              "https://doi.org/10.1186/1472-6963-12-224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(13)70546-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015669631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6605383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017038554", 
              "https://doi.org/10.1038/sj.bjc.6605383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3399/bjgp11x572283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018840374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2013.01.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021438986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3399/bjgp11x606807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022804992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1055-9965.epi-08-1118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023047648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3399/bjgp14x680125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025373015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-14-636", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033292815", 
              "https://doi.org/10.1186/1471-2407-14-636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jclinepi.2011.12.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033393229"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/clep.s62855", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034524724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2296-15-75", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035763418", 
              "https://doi.org/10.1186/1471-2296-15-75"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6605396", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037520129", 
              "https://doi.org/10.1038/sj.bjc.6605396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6605396", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037520129", 
              "https://doi.org/10.1038/sj.bjc.6605396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1472-6963-11-284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037943739", 
              "https://doi.org/10.1186/1472-6963-11-284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3399/bjgp12x654551", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044497140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3122/jabfm.2012.02.110216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045842161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3399/bjgp09x420860", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046521375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3399/bjgp12x658331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047786070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.322.7302.1555", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050392154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2013.791", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053263227", 
              "https://doi.org/10.1038/bjc.2013.791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1403494810393562", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064001857"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1403494810393562", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064001857"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1403494811399958", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064001916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1403494811399958", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064001916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077098699", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078246564", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078830449", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078851732", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083187895", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-12", 
        "datePublishedReg": "2015-12-01", 
        "description": "BACKGROUND: A Danish cancer pathway has been implemented for patients with serious non-specific symptoms and signs of cancer (NSSC-CPP). The initiative is one of several to improve the long diagnostic interval and the poor survival of Danish cancer patients. However, little is known about the patients investigated under this pathway. We aim to describe the characteristics of patients referred from general practice to the NSSC-CPP and to estimate the cancer probability and distribution in this population.\nMETHODS: A cross-sectional study was performed, including all patients referred to the NSSC-CPP at the hospitals in Aarhus or Silkeborg in the Central Denmark Region between March 2012 and March 2013. Data were based on a questionnaire completed by the patient's general practitioner (GP) combined with nationwide registers. Cancer probability was the percentage of new cancers per investigated patient. Associations between patient characteristics and cancer diagnosis were estimated with prevalence rate ratios (PRRs) from a generalised linear model.\nRESULTS: The mean age of all 1278 included patients was 65.9 years, and 47.5 % were men. In total, 16.2 % of all patients had a cancer diagnosis after six months; the most common types were lung cancer (17.9 %), colorectal cancer (12.6 %), hematopoietic tissue cancer (10.1 %) and pancreatic cancer (9.2 %). All patients in combination had more than 80 different symptoms and 51 different clinical findings at referral. Most symptoms were non-specific and vague; weight loss and fatigue were present in more than half of all cases. The three most common clinical findings were 'affected general condition' (35.8 %), 'GP's gut feeling' (22.5 %) and 'findings from the abdomen' (13.0 %). A strong association was found between GP-estimated cancer risk at referral and probability of cancer.\nCONCLUSIONS: In total, 16.2 % of the patients referred through the NSSC-CPP had cancer. They constituted a heterogeneous group with many different symptoms and clinical findings. The GP's gut feeling was a common reason for referral which proved to be a strong predictor of cancer. The GP's overall estimation of the patient's risk of cancer at referral was associated with the probability of finding cancer.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s12885-015-1424-5", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1024632", 
            "issn": [
              "1471-2407"
            ], 
            "name": "BMC Cancer", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "15"
          }
        ], 
        "name": "The Danish cancer pathway for patients with serious non-specific symptoms and signs of cancer\u2013a cross-sectional study of patient characteristics and cancer probability", 
        "pagination": "421", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "bdc4c8e29c86e04cb44195161c8d472c7252d8acf2bd765c512815ec2c70d8b4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25990247"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100967800"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12885-015-1424-5"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1039837797"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12885-015-1424-5", 
          "https://app.dimensions.ai/details/publication/pub.1039837797"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:57", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89807_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2Fs12885-015-1424-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1424-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1424-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1424-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1424-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    284 TRIPLES      21 PREDICATES      83 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12885-015-1424-5 schema:about N415d4fabf959494b8525eaef74c73f16
    2 N52df37846c884215983c872890cb7fb0
    3 N59000d086ff2404aade9275f05c03ffe
    4 N70cd711c88e648a3922a6d2dab3fb3a2
    5 N8790c8ccfbeb476d886e2f0751cb2618
    6 N94bea8469cda4f02b51f826c1a1bb7dd
    7 N955fda55d77643d1964bb747ed51bda6
    8 N9563dae952d8453299ed6eb928ebbfa5
    9 N986d997e118943f58ce61bea488a2994
    10 Na1e958196fac499ba45a62d7f2ca6ff8
    11 Nb215285be37846f9b8f45d360d867ba5
    12 Nce9977487a524dafac4bee1451ba7a77
    13 Nd8e82acd8a094de88e087c563ac8f653
    14 Nfc97a88a01484bff8e42cfd7565fc535
    15 Nfeef065a96d2441cbebdf5a360388c40
    16 anzsrc-for:11
    17 anzsrc-for:1117
    18 schema:author N6a82c30970d942c69be3fa03118bde62
    19 schema:citation sg:pub.10.1007/s10654-011-9647-5
    20 sg:pub.10.1038/bjc.2012.68
    21 sg:pub.10.1038/bjc.2013.1
    22 sg:pub.10.1038/bjc.2013.791
    23 sg:pub.10.1038/bjc.2015.44
    24 sg:pub.10.1038/sj.bjc.6605383
    25 sg:pub.10.1038/sj.bjc.6605396
    26 sg:pub.10.1186/1471-2296-15-75
    27 sg:pub.10.1186/1471-2407-14-636
    28 sg:pub.10.1186/1472-6963-11-284
    29 sg:pub.10.1186/1472-6963-12-224
    30 https://app.dimensions.ai/details/publication/pub.1077098699
    31 https://app.dimensions.ai/details/publication/pub.1078246564
    32 https://app.dimensions.ai/details/publication/pub.1078830449
    33 https://app.dimensions.ai/details/publication/pub.1078851732
    34 https://app.dimensions.ai/details/publication/pub.1083187895
    35 https://doi.org/10.1016/j.ejca.2013.01.025
    36 https://doi.org/10.1016/j.healthpol.2011.11.001
    37 https://doi.org/10.1016/j.jclinepi.2011.12.006
    38 https://doi.org/10.1016/s0140-6736(10)62231-3
    39 https://doi.org/10.1016/s0140-6736(94)90634-3
    40 https://doi.org/10.1016/s1470-2045(13)70546-1
    41 https://doi.org/10.1093/fampra/cmn028
    42 https://doi.org/10.1111/j.1365-2354.2005.00600.x
    43 https://doi.org/10.1136/bmj.322.7302.1555
    44 https://doi.org/10.1158/1055-9965.epi-08-1118
    45 https://doi.org/10.1177/1403494810387965
    46 https://doi.org/10.1177/1403494810393562
    47 https://doi.org/10.1177/1403494811399958
    48 https://doi.org/10.2147/clep.s62855
    49 https://doi.org/10.3109/13814781003653424
    50 https://doi.org/10.3122/jabfm.2012.02.110216
    51 https://doi.org/10.3399/bjgp09x420860
    52 https://doi.org/10.3399/bjgp11x572283
    53 https://doi.org/10.3399/bjgp11x606591
    54 https://doi.org/10.3399/bjgp11x606807
    55 https://doi.org/10.3399/bjgp12x654551
    56 https://doi.org/10.3399/bjgp12x658331
    57 https://doi.org/10.3399/bjgp14x680125
    58 schema:datePublished 2015-12
    59 schema:datePublishedReg 2015-12-01
    60 schema:description BACKGROUND: A Danish cancer pathway has been implemented for patients with serious non-specific symptoms and signs of cancer (NSSC-CPP). The initiative is one of several to improve the long diagnostic interval and the poor survival of Danish cancer patients. However, little is known about the patients investigated under this pathway. We aim to describe the characteristics of patients referred from general practice to the NSSC-CPP and to estimate the cancer probability and distribution in this population. METHODS: A cross-sectional study was performed, including all patients referred to the NSSC-CPP at the hospitals in Aarhus or Silkeborg in the Central Denmark Region between March 2012 and March 2013. Data were based on a questionnaire completed by the patient's general practitioner (GP) combined with nationwide registers. Cancer probability was the percentage of new cancers per investigated patient. Associations between patient characteristics and cancer diagnosis were estimated with prevalence rate ratios (PRRs) from a generalised linear model. RESULTS: The mean age of all 1278 included patients was 65.9 years, and 47.5 % were men. In total, 16.2 % of all patients had a cancer diagnosis after six months; the most common types were lung cancer (17.9 %), colorectal cancer (12.6 %), hematopoietic tissue cancer (10.1 %) and pancreatic cancer (9.2 %). All patients in combination had more than 80 different symptoms and 51 different clinical findings at referral. Most symptoms were non-specific and vague; weight loss and fatigue were present in more than half of all cases. The three most common clinical findings were 'affected general condition' (35.8 %), 'GP's gut feeling' (22.5 %) and 'findings from the abdomen' (13.0 %). A strong association was found between GP-estimated cancer risk at referral and probability of cancer. CONCLUSIONS: In total, 16.2 % of the patients referred through the NSSC-CPP had cancer. They constituted a heterogeneous group with many different symptoms and clinical findings. The GP's gut feeling was a common reason for referral which proved to be a strong predictor of cancer. The GP's overall estimation of the patient's risk of cancer at referral was associated with the probability of finding cancer.
    61 schema:genre research_article
    62 schema:inLanguage en
    63 schema:isAccessibleForFree true
    64 schema:isPartOf Nb8e1d9a052e04ed2817accff9c35da52
    65 Nfd47b14707674fe684450dcc1a32807c
    66 sg:journal.1024632
    67 schema:name The Danish cancer pathway for patients with serious non-specific symptoms and signs of cancer–a cross-sectional study of patient characteristics and cancer probability
    68 schema:pagination 421
    69 schema:productId N20001778a1064b74bc08af9c447d5b8c
    70 N2c86030c1654439087d8a0b5bf073ac9
    71 N7071e51512064d1c9a86d1b3ae3d5af5
    72 N73ff03b004cd4da296241480e583fe11
    73 Nd208131c0bb740cdbcd262e39a4c2b3f
    74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039837797
    75 https://doi.org/10.1186/s12885-015-1424-5
    76 schema:sdDatePublished 2019-04-11T09:57
    77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    78 schema:sdPublisher N5f36675a9d67426ba35fe83fc5611f1f
    79 schema:url http://link.springer.com/10.1186%2Fs12885-015-1424-5
    80 sgo:license sg:explorer/license/
    81 sgo:sdDataset articles
    82 rdf:type schema:ScholarlyArticle
    83 N0940ed28080d48a48788e39bf1996a35 rdf:first sg:person.01137025352.99
    84 rdf:rest rdf:nil
    85 N20001778a1064b74bc08af9c447d5b8c schema:name dimensions_id
    86 schema:value pub.1039837797
    87 rdf:type schema:PropertyValue
    88 N2c86030c1654439087d8a0b5bf073ac9 schema:name readcube_id
    89 schema:value bdc4c8e29c86e04cb44195161c8d472c7252d8acf2bd765c512815ec2c70d8b4
    90 rdf:type schema:PropertyValue
    91 N415d4fabf959494b8525eaef74c73f16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    92 schema:name Male
    93 rdf:type schema:DefinedTerm
    94 N52df37846c884215983c872890cb7fb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    95 schema:name Denmark
    96 rdf:type schema:DefinedTerm
    97 N59000d086ff2404aade9275f05c03ffe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Surveys and Questionnaires
    99 rdf:type schema:DefinedTerm
    100 N5f36675a9d67426ba35fe83fc5611f1f schema:name Springer Nature - SN SciGraph project
    101 rdf:type schema:Organization
    102 N6a82c30970d942c69be3fa03118bde62 rdf:first sg:person.0734641132.55
    103 rdf:rest N78085e65de2f4b8c80e341635b9df81a
    104 N7071e51512064d1c9a86d1b3ae3d5af5 schema:name pubmed_id
    105 schema:value 25990247
    106 rdf:type schema:PropertyValue
    107 N70cd711c88e648a3922a6d2dab3fb3a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Symptom Assessment
    109 rdf:type schema:DefinedTerm
    110 N73ff03b004cd4da296241480e583fe11 schema:name nlm_unique_id
    111 schema:value 100967800
    112 rdf:type schema:PropertyValue
    113 N78085e65de2f4b8c80e341635b9df81a rdf:first sg:person.01031620207.38
    114 rdf:rest Na51259f14a8446e9b4c95406af4d8033
    115 N8790c8ccfbeb476d886e2f0751cb2618 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Middle Aged
    117 rdf:type schema:DefinedTerm
    118 N94bea8469cda4f02b51f826c1a1bb7dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Humans
    120 rdf:type schema:DefinedTerm
    121 N955fda55d77643d1964bb747ed51bda6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Aged, 80 and over
    123 rdf:type schema:DefinedTerm
    124 N9563dae952d8453299ed6eb928ebbfa5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Aged
    126 rdf:type schema:DefinedTerm
    127 N986d997e118943f58ce61bea488a2994 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Young Adult
    129 rdf:type schema:DefinedTerm
    130 Na1e958196fac499ba45a62d7f2ca6ff8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Cross-Sectional Studies
    132 rdf:type schema:DefinedTerm
    133 Na51259f14a8446e9b4c95406af4d8033 rdf:first sg:person.01162311550.95
    134 rdf:rest Na5913abe79df4eafa374711a02ab8e68
    135 Na5913abe79df4eafa374711a02ab8e68 rdf:first sg:person.01243477410.21
    136 rdf:rest N0940ed28080d48a48788e39bf1996a35
    137 Nb215285be37846f9b8f45d360d867ba5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Neoplasms
    139 rdf:type schema:DefinedTerm
    140 Nb8e1d9a052e04ed2817accff9c35da52 schema:issueNumber 1
    141 rdf:type schema:PublicationIssue
    142 Nce9977487a524dafac4bee1451ba7a77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Female
    144 rdf:type schema:DefinedTerm
    145 Nd208131c0bb740cdbcd262e39a4c2b3f schema:name doi
    146 schema:value 10.1186/s12885-015-1424-5
    147 rdf:type schema:PropertyValue
    148 Nd8e82acd8a094de88e087c563ac8f653 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Adult
    150 rdf:type schema:DefinedTerm
    151 Nfc97a88a01484bff8e42cfd7565fc535 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Adolescent
    153 rdf:type schema:DefinedTerm
    154 Nfd47b14707674fe684450dcc1a32807c schema:volumeNumber 15
    155 rdf:type schema:PublicationVolume
    156 Nfeef065a96d2441cbebdf5a360388c40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Referral and Consultation
    158 rdf:type schema:DefinedTerm
    159 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    160 schema:name Medical and Health Sciences
    161 rdf:type schema:DefinedTerm
    162 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
    163 schema:name Public Health and Health Services
    164 rdf:type schema:DefinedTerm
    165 sg:journal.1024632 schema:issn 1471-2407
    166 schema:name BMC Cancer
    167 rdf:type schema:Periodical
    168 sg:person.01031620207.38 schema:affiliation https://www.grid.ac/institutes/grid.7048.b
    169 schema:familyName Christensen
    170 schema:givenName Morten Bondo
    171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031620207.38
    172 rdf:type schema:Person
    173 sg:person.01137025352.99 schema:affiliation https://www.grid.ac/institutes/grid.7048.b
    174 schema:familyName Vedsted
    175 schema:givenName Peter
    176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137025352.99
    177 rdf:type schema:Person
    178 sg:person.01162311550.95 schema:affiliation https://www.grid.ac/institutes/grid.7048.b
    179 schema:familyName Bro
    180 schema:givenName Flemming
    181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162311550.95
    182 rdf:type schema:Person
    183 sg:person.01243477410.21 schema:affiliation https://www.grid.ac/institutes/grid.154185.c
    184 schema:familyName Knudsen
    185 schema:givenName Søren T.
    186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243477410.21
    187 rdf:type schema:Person
    188 sg:person.0734641132.55 schema:affiliation https://www.grid.ac/institutes/grid.7048.b
    189 schema:familyName Ingeman
    190 schema:givenName Mads Lind
    191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734641132.55
    192 rdf:type schema:Person
    193 sg:pub.10.1007/s10654-011-9647-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008653899
    194 https://doi.org/10.1007/s10654-011-9647-5
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/bjc.2012.68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010902211
    197 https://doi.org/10.1038/bjc.2012.68
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/bjc.2013.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013771450
    200 https://doi.org/10.1038/bjc.2013.1
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/bjc.2013.791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053263227
    203 https://doi.org/10.1038/bjc.2013.791
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/bjc.2015.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000610955
    206 https://doi.org/10.1038/bjc.2015.44
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/sj.bjc.6605383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017038554
    209 https://doi.org/10.1038/sj.bjc.6605383
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/sj.bjc.6605396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037520129
    212 https://doi.org/10.1038/sj.bjc.6605396
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1186/1471-2296-15-75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035763418
    215 https://doi.org/10.1186/1471-2296-15-75
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1186/1471-2407-14-636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033292815
    218 https://doi.org/10.1186/1471-2407-14-636
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1186/1472-6963-11-284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037943739
    221 https://doi.org/10.1186/1472-6963-11-284
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1186/1472-6963-12-224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013894650
    224 https://doi.org/10.1186/1472-6963-12-224
    225 rdf:type schema:CreativeWork
    226 https://app.dimensions.ai/details/publication/pub.1077098699 schema:CreativeWork
    227 https://app.dimensions.ai/details/publication/pub.1078246564 schema:CreativeWork
    228 https://app.dimensions.ai/details/publication/pub.1078830449 schema:CreativeWork
    229 https://app.dimensions.ai/details/publication/pub.1078851732 schema:CreativeWork
    230 https://app.dimensions.ai/details/publication/pub.1083187895 schema:CreativeWork
    231 https://doi.org/10.1016/j.ejca.2013.01.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021438986
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1016/j.healthpol.2011.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002194464
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1016/j.jclinepi.2011.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033393229
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1016/s0140-6736(10)62231-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003353087
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1016/s0140-6736(94)90634-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004510159
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1016/s1470-2045(13)70546-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015669631
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1093/fampra/cmn028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009128603
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1111/j.1365-2354.2005.00600.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009128902
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1136/bmj.322.7302.1555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050392154
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1158/1055-9965.epi-08-1118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023047648
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1177/1403494810387965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002205599
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1177/1403494810393562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064001857
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1177/1403494811399958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064001916
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.2147/clep.s62855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034524724
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.3109/13814781003653424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010201156
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.3122/jabfm.2012.02.110216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045842161
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.3399/bjgp09x420860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046521375
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.3399/bjgp11x572283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018840374
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.3399/bjgp11x606591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009939478
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.3399/bjgp11x606807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022804992
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.3399/bjgp12x654551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044497140
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.3399/bjgp12x658331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047786070
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.3399/bjgp14x680125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025373015
    276 rdf:type schema:CreativeWork
    277 https://www.grid.ac/institutes/grid.154185.c schema:alternateName Aarhus University Hospital
    278 schema:name Department of Endocrinology and Internal Medicine (MEA), Aarhus University Hospital, Noerrebrogade, Aarhus, Denmark
    279 rdf:type schema:Organization
    280 https://www.grid.ac/institutes/grid.7048.b schema:alternateName Aarhus University
    281 schema:name Department of Public Health, Section for General Medical Practice, Aarhus University, Aarhus, Denmark
    282 Research Centre for Cancer Diagnosis in Primary Care (CaP), Aarhus University, Aarhus, Denmark
    283 Research Unit for General Practice, Aarhus University, Aarhus, Denmark
    284 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...