DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Lena Nordström, Elin Andersson, Venera Kuci, Elin Gustavsson, Karolina Holm, Markus Ringnér, Per Guldberg, Sara Ek

ABSTRACT

BACKGROUND: The neural transcription factor SOX11 is present at specific stages during embryo development with a very restricted expression in adult tissue, indicating precise regulation of transcription. SOX11 is strongly up-regulated in some malignancies and have a functional role in tumorgenesis. With the aim to explore differences in epigenetic regulation of SOX11 expression in normal versus neoplastic cells, we investigated methylation and histone modifications related to the SOX11 promoter and the possibility to induce re-expression using histone deacetylase (HDAC) or EZH2 inhibitors. METHODS: The epigenetic regulation of SOX11 was investigated in distinct non-malignant cell populations (n = 7) and neoplastic cell-lines (n = 42) of different cellular origins. DNA methylation was assessed using bisulfite sequencing, methylation-specific melting curve analysis, MethyLight and pyrosequencing. The presence of H3K27me3 was assessed using ChIP-qPCR. The HDAC inhibitors Vorinostat and trichostatin A were used to induce SOX11 in cell lines with no endogenous expression. RESULTS: The SOX11 promoter shows a low degree of methylation and strong enrichment of H3K27me3 in non-malignant differentiated cells, independent of cellular origin. Cancers of the B-cell lineage are strongly marked by de novo methylation at the SOX11 promoter in SOX11 non-expressing cells, while solid cancer entities display a more varying degree of SOX11 promoter methylation. The silencing mark H3K27me3 was generally present at the SOX11 promoter in non-expressing cells, and an increased enrichment was observed in cancer cells with a low degree of SOX11 methylation compared to cells with dense methylation. Finally, we demonstrate that the HDAC inhibitors (vorinostat and trichostatin A) induce SOX11 expression in cancer cells with low levels of SOX11 methylation. CONCLUSIONS: We show that SOX11 is strongly marked by repressive histone marks in non-malignant cells. In contrast, SOX11 regulation in neoplastic tissues is more complex involving both DNA methylation and histone modifications. The possibility to re-express SOX11 in non-methylated tissue is of clinical relevance, and was successfully achieved in cell lines with low levels of SOX11 methylation. In breast cancer patients, methylation of the SOX11 promoter was shown to correlate with estrogen receptor status, suggesting that SOX11 may be functionally re-expressed during treatment with HDAC inhibitors in specific patient subgroups. More... »

PAGES

273

References to SciGraph publications

  • 2013-04. Embryonic mammary signature subsets are activated in Brca1-/- and basal-like breast cancers in BREAST CANCER RESEARCH
  • 1998-06. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription in NATURE GENETICS
  • 2010-12. SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies in MOLECULAR CANCER
  • 2007-02. Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer in NATURE GENETICS
  • 2012-12. Expanded clinical and experimental use of SOX11 - using a monoclonal antibody in BMC CANCER
  • 2006-02. The Polycomb group protein EZH2 directly controls DNA methylation in NATURE
  • 2006-02. Evidence for an instructive mechanism of de novo methylation in cancer cells in NATURE GENETICS
  • 2013-12. SOXC transcription factors in mantle cell lymphoma: the role of promoter methylation in SOX11 expression in SCIENTIFIC REPORTS
  • 2013-05. Sox11 expression in astrocytic gliomas: correlation with nestin/c-Met/IDH1-R132H expression phenotypes, p-Stat-3 and survival in BRITISH JOURNAL OF CANCER
  • 2005-04. Azacitidine in NATURE REVIEWS DRUG DISCOVERY
  • 2009-12. DNA microarray profiling of genes differentially regulated by the histone deacetylase inhibitors vorinostat and LBH589 in colon cancer cell lines in BMC MEDICAL GENOMICS
  • 2013-12. Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer - overexpression of HDAC2 and HDAC3 is associated with clinicopathological indicators of disease progression in BMC CANCER
  • 2007-08. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells in NATURE
  • 2012-09. An integrated encyclopedia of DNA elements in the human genome in NATURE
  • 2013-12. Promoter methylation status of the tumor suppressor gene SOX11 is associated with cell growth and invasion in nasopharyngeal carcinoma in CANCER CELL INTERNATIONAL
  • 2011-09. Roles of the Polycomb group proteins in stem cells and cancer in CELL DEATH & DISEASE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12885-015-1208-y

    DOI

    http://dx.doi.org/10.1186/s12885-015-1208-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040514002

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25880212


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Methylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epigenesis, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histone Code", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hydroxamic Acids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Palatine Tonsil", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Promoter Regions, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "SOXC Transcription Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vorinostat", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Lund University", 
              "id": "https://www.grid.ac/institutes/grid.4514.4", 
              "name": [
                "Department of Immunotechnology, CREATE Health, Lund University, Lund, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nordstr\u00f6m", 
            "givenName": "Lena", 
            "id": "sg:person.0754343526.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754343526.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Danish Cancer Society", 
              "id": "https://www.grid.ac/institutes/grid.417390.8", 
              "name": [
                "Danish Cancer Society Research Center, Copenhagen, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Andersson", 
            "givenName": "Elin", 
            "id": "sg:person.0763164265.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763164265.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lund University", 
              "id": "https://www.grid.ac/institutes/grid.4514.4", 
              "name": [
                "Department of Immunotechnology, CREATE Health, Lund University, Lund, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kuci", 
            "givenName": "Venera", 
            "id": "sg:person.0610010212.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610010212.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lund University", 
              "id": "https://www.grid.ac/institutes/grid.4514.4", 
              "name": [
                "Department of Immunotechnology, CREATE Health, Lund University, Lund, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gustavsson", 
            "givenName": "Elin", 
            "id": "sg:person.01143512621.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143512621.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Oncology and Pathology, Clinical Sciences, Lund University, Sk\u00e5ne University Hospital, Lund, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Holm", 
            "givenName": "Karolina", 
            "id": "sg:person.0670064051.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670064051.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Oncology and Pathology, Clinical Sciences, Lund University, Sk\u00e5ne University Hospital, Lund, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ringn\u00e9r", 
            "givenName": "Markus", 
            "id": "sg:person.015577666144.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015577666144.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Danish Cancer Society", 
              "id": "https://www.grid.ac/institutes/grid.417390.8", 
              "name": [
                "Danish Cancer Society Research Center, Copenhagen, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guldberg", 
            "givenName": "Per", 
            "id": "sg:person.0760021664.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760021664.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lund University", 
              "id": "https://www.grid.ac/institutes/grid.4514.4", 
              "name": [
                "Department of Immunotechnology, CREATE Health, Lund University, Lund, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ek", 
            "givenName": "Sara", 
            "id": "sg:person.01045473454.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045473454.83"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1006/meth.2001.1268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000748523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/meth.2001.1268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000748523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-0877", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002051562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-4598-9-187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003416547", 
              "https://doi.org/10.1186/1476-4598-9-187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-13-215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004045936", 
              "https://doi.org/10.1186/1471-2407-13-215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.21.6150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004525479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2008.08.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005007531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1950", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005618296", 
              "https://doi.org/10.1038/ng1950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1950", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005618296", 
              "https://doi.org/10.1038/ng1950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/epi.11.105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005689442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1698", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007512283", 
              "https://doi.org/10.1038/nrd1698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1698", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007512283", 
              "https://doi.org/10.1038/nrd1698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bjh.12854", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009627477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1541-7786.mcr-07-0330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011502375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-3419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011862359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.21792", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012150990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.21792", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012150990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013027025", 
              "https://doi.org/10.1038/nature04431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013027025", 
              "https://doi.org/10.1038/nature04431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013027025", 
              "https://doi.org/10.1038/nature04431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gki987", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013244220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2010-04-280149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013705795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2013.04.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014488439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0021382", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015026928"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep01400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016989896", 
              "https://doi.org/10.1038/srep01400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017063597", 
              "https://doi.org/10.1038/ng1719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017063597", 
              "https://doi.org/10.1038/ng1719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biocel.2009.07.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017520546"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2011.84", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017623706", 
              "https://doi.org/10.1038/cddis.2011.84"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/theoncologist.12-10-1247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017951984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3324/haematol.2009.008474", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018247239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dvdy.21218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019474966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkn162", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020291405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr3403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021491665", 
              "https://doi.org/10.1186/bcr3403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bcp.2006.12.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022667216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2008.07329.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023657046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1755-8794-2-67", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025134642", 
              "https://doi.org/10.1186/1755-8794-2-67"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2009.01.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026560812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/561", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027172656", 
              "https://doi.org/10.1038/561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/561", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027172656", 
              "https://doi.org/10.1038/561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01304-10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027416479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bti652", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028027978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bti652", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028027978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029065430", 
              "https://doi.org/10.1038/nature11247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.02.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030427346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1055-9965.epi-11-0067", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032514442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejcb.2012.11.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033061418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-12-1615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033203705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2867-13-109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033907466", 
              "https://doi.org/10.1186/1475-2867-13-109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036216819", 
              "https://doi.org/10.1038/nature06008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2011-12-400580", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038009599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2013.176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039214457", 
              "https://doi.org/10.1038/bjc.2013.176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01516-07", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040012711"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2014.06.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041563418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkn083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042802828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1215/15228517-2008-032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044393210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biocel.2007.05.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047687864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-12-269", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048088434", 
              "https://doi.org/10.1186/1471-2407-12-269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.06.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048271589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dvdy.23962", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048416091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2007-06-093401", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051018508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo.32.4.821", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071516815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/or.13.1.139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071529450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074840865", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075238675", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082926793", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-12", 
        "datePublishedReg": "2015-12-01", 
        "description": "BACKGROUND: The neural transcription factor SOX11 is present at specific stages during embryo development with a very restricted expression in adult tissue, indicating precise regulation of transcription. SOX11 is strongly up-regulated in some malignancies and have a functional role in tumorgenesis. With the aim to explore differences in epigenetic regulation of SOX11 expression in normal versus neoplastic cells, we investigated methylation and histone modifications related to the SOX11 promoter and the possibility to induce re-expression using histone deacetylase (HDAC) or EZH2 inhibitors.\nMETHODS: The epigenetic regulation of SOX11 was investigated in distinct non-malignant cell populations (n = 7) and neoplastic cell-lines (n = 42) of different cellular origins. DNA methylation was assessed using bisulfite sequencing, methylation-specific melting curve analysis, MethyLight and pyrosequencing. The presence of H3K27me3 was assessed using ChIP-qPCR. The HDAC inhibitors Vorinostat and trichostatin A were used to induce SOX11 in cell lines with no endogenous expression.\nRESULTS: The SOX11 promoter shows a low degree of methylation and strong enrichment of H3K27me3 in non-malignant differentiated cells, independent of cellular origin. Cancers of the B-cell lineage are strongly marked by de novo methylation at the SOX11 promoter in SOX11 non-expressing cells, while solid cancer entities display a more varying degree of SOX11 promoter methylation. The silencing mark H3K27me3 was generally present at the SOX11 promoter in non-expressing cells, and an increased enrichment was observed in cancer cells with a low degree of SOX11 methylation compared to cells with dense methylation. Finally, we demonstrate that the HDAC inhibitors (vorinostat and trichostatin A) induce SOX11 expression in cancer cells with low levels of SOX11 methylation.\nCONCLUSIONS: We show that SOX11 is strongly marked by repressive histone marks in non-malignant cells. In contrast, SOX11 regulation in neoplastic tissues is more complex involving both DNA methylation and histone modifications. The possibility to re-express SOX11 in non-methylated tissue is of clinical relevance, and was successfully achieved in cell lines with low levels of SOX11 methylation. In breast cancer patients, methylation of the SOX11 promoter was shown to correlate with estrogen receptor status, suggesting that SOX11 may be functionally re-expressed during treatment with HDAC inhibitors in specific patient subgroups.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s12885-015-1208-y", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1024632", 
            "issn": [
              "1471-2407"
            ], 
            "name": "BMC Cancer", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "15"
          }
        ], 
        "name": "DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells", 
        "pagination": "273", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "c0fe0a114a2c0150016da1419981eb73b60233ba876bd07d5f8e9d2419e45cef"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25880212"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100967800"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12885-015-1208-y"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1040514002"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12885-015-1208-y", 
          "https://app.dimensions.ai/details/publication/pub.1040514002"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:54", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89798_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2Fs12885-015-1208-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1208-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1208-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1208-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1208-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    356 TRIPLES      21 PREDICATES      98 URIs      33 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12885-015-1208-y schema:about N06c74dfeb4d44930bcc753f183dcb4b0
    2 N15e782424af7448e909517a9d9a85849
    3 N2c9e5e8d45034699885e21dfa582654d
    4 N55cb7317f9aa41579e7ba4f86e44f6fa
    5 N62c02d4aef5d43829b6b499fcff8d71b
    6 N7565dfcecd434089871726fdce1bb451
    7 N792b1d68c05d409f997e0a1ba729279a
    8 Na1e7b90510824d44acfb1a9f4f2d0da1
    9 Naf086effb4084c28b15bb496fb7509db
    10 Nb88d78bfbdfc4898b5c9d101aa3d51ce
    11 Nd1f1833a5ebb43e59166ed61852e0dac
    12 Ned1b418e4767435d839260fa8d2ecd82
    13 anzsrc-for:11
    14 anzsrc-for:1112
    15 schema:author N01fa7c96eb6445bca9587ffc57c4828a
    16 schema:citation sg:pub.10.1038/561
    17 sg:pub.10.1038/bjc.2013.176
    18 sg:pub.10.1038/cddis.2011.84
    19 sg:pub.10.1038/nature04431
    20 sg:pub.10.1038/nature06008
    21 sg:pub.10.1038/nature11247
    22 sg:pub.10.1038/ng1719
    23 sg:pub.10.1038/ng1950
    24 sg:pub.10.1038/nrd1698
    25 sg:pub.10.1038/srep01400
    26 sg:pub.10.1186/1471-2407-12-269
    27 sg:pub.10.1186/1471-2407-13-215
    28 sg:pub.10.1186/1475-2867-13-109
    29 sg:pub.10.1186/1476-4598-9-187
    30 sg:pub.10.1186/1755-8794-2-67
    31 sg:pub.10.1186/bcr3403
    32 https://app.dimensions.ai/details/publication/pub.1074840865
    33 https://app.dimensions.ai/details/publication/pub.1075238675
    34 https://app.dimensions.ai/details/publication/pub.1082926793
    35 https://doi.org/10.1002/cncr.21792
    36 https://doi.org/10.1002/dvdy.21218
    37 https://doi.org/10.1002/dvdy.23962
    38 https://doi.org/10.1006/meth.2001.1268
    39 https://doi.org/10.1016/j.bcp.2006.12.032
    40 https://doi.org/10.1016/j.biocel.2007.05.019
    41 https://doi.org/10.1016/j.biocel.2009.07.018
    42 https://doi.org/10.1016/j.canlet.2008.08.016
    43 https://doi.org/10.1016/j.ccr.2013.04.020
    44 https://doi.org/10.1016/j.cell.2006.02.041
    45 https://doi.org/10.1016/j.cell.2012.06.013
    46 https://doi.org/10.1016/j.ejca.2009.01.028
    47 https://doi.org/10.1016/j.ejcb.2012.11.001
    48 https://doi.org/10.1016/j.molcel.2014.06.005
    49 https://doi.org/10.1093/bioinformatics/bti652
    50 https://doi.org/10.1093/nar/gki987
    51 https://doi.org/10.1093/nar/gkn083
    52 https://doi.org/10.1093/nar/gkn162
    53 https://doi.org/10.1111/bjh.12854
    54 https://doi.org/10.1111/j.1365-2141.2008.07329.x
    55 https://doi.org/10.1128/mcb.01304-10
    56 https://doi.org/10.1128/mcb.01516-07
    57 https://doi.org/10.1158/0008-5472.can-09-3419
    58 https://doi.org/10.1158/0008-5472.can-12-1615
    59 https://doi.org/10.1158/1055-9965.epi-11-0067
    60 https://doi.org/10.1158/1078-0432.ccr-13-0877
    61 https://doi.org/10.1158/1541-7786.mcr-07-0330
    62 https://doi.org/10.1182/blood-2007-06-093401
    63 https://doi.org/10.1182/blood-2010-04-280149
    64 https://doi.org/10.1182/blood-2011-12-400580
    65 https://doi.org/10.1200/jco.2008.21.6150
    66 https://doi.org/10.1215/15228517-2008-032
    67 https://doi.org/10.1371/journal.pone.0021382
    68 https://doi.org/10.1634/theoncologist.12-10-1247
    69 https://doi.org/10.2217/epi.11.105
    70 https://doi.org/10.3324/haematol.2009.008474
    71 https://doi.org/10.3892/ijo.32.4.821
    72 https://doi.org/10.3892/or.13.1.139
    73 schema:datePublished 2015-12
    74 schema:datePublishedReg 2015-12-01
    75 schema:description BACKGROUND: The neural transcription factor SOX11 is present at specific stages during embryo development with a very restricted expression in adult tissue, indicating precise regulation of transcription. SOX11 is strongly up-regulated in some malignancies and have a functional role in tumorgenesis. With the aim to explore differences in epigenetic regulation of SOX11 expression in normal versus neoplastic cells, we investigated methylation and histone modifications related to the SOX11 promoter and the possibility to induce re-expression using histone deacetylase (HDAC) or EZH2 inhibitors. METHODS: The epigenetic regulation of SOX11 was investigated in distinct non-malignant cell populations (n = 7) and neoplastic cell-lines (n = 42) of different cellular origins. DNA methylation was assessed using bisulfite sequencing, methylation-specific melting curve analysis, MethyLight and pyrosequencing. The presence of H3K27me3 was assessed using ChIP-qPCR. The HDAC inhibitors Vorinostat and trichostatin A were used to induce SOX11 in cell lines with no endogenous expression. RESULTS: The SOX11 promoter shows a low degree of methylation and strong enrichment of H3K27me3 in non-malignant differentiated cells, independent of cellular origin. Cancers of the B-cell lineage are strongly marked by de novo methylation at the SOX11 promoter in SOX11 non-expressing cells, while solid cancer entities display a more varying degree of SOX11 promoter methylation. The silencing mark H3K27me3 was generally present at the SOX11 promoter in non-expressing cells, and an increased enrichment was observed in cancer cells with a low degree of SOX11 methylation compared to cells with dense methylation. Finally, we demonstrate that the HDAC inhibitors (vorinostat and trichostatin A) induce SOX11 expression in cancer cells with low levels of SOX11 methylation. CONCLUSIONS: We show that SOX11 is strongly marked by repressive histone marks in non-malignant cells. In contrast, SOX11 regulation in neoplastic tissues is more complex involving both DNA methylation and histone modifications. The possibility to re-express SOX11 in non-methylated tissue is of clinical relevance, and was successfully achieved in cell lines with low levels of SOX11 methylation. In breast cancer patients, methylation of the SOX11 promoter was shown to correlate with estrogen receptor status, suggesting that SOX11 may be functionally re-expressed during treatment with HDAC inhibitors in specific patient subgroups.
    76 schema:genre research_article
    77 schema:inLanguage en
    78 schema:isAccessibleForFree true
    79 schema:isPartOf N054a7600def1401688242a56107b08f1
    80 Nbb6e0c768d49472592f975e2370f9e94
    81 sg:journal.1024632
    82 schema:name DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells
    83 schema:pagination 273
    84 schema:productId N67c3d7bac64247f380baeeec00071271
    85 N7afa6020481b42ed9f74d0aa8c0e18a3
    86 Nac4f45a551f944108fbbc570c751f4b5
    87 Nc5bdd520127a42a987b053996953db4b
    88 Nf962e89f8667465796d85399ecfbc39e
    89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040514002
    90 https://doi.org/10.1186/s12885-015-1208-y
    91 schema:sdDatePublished 2019-04-11T09:54
    92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    93 schema:sdPublisher Nc2524ebd8f5e42c4956e4cb22465d514
    94 schema:url http://link.springer.com/10.1186%2Fs12885-015-1208-y
    95 sgo:license sg:explorer/license/
    96 sgo:sdDataset articles
    97 rdf:type schema:ScholarlyArticle
    98 N01fa7c96eb6445bca9587ffc57c4828a rdf:first sg:person.0754343526.57
    99 rdf:rest N892b5626496e430285dd14651daedada
    100 N054a7600def1401688242a56107b08f1 schema:issueNumber 1
    101 rdf:type schema:PublicationIssue
    102 N06c74dfeb4d44930bcc753f183dcb4b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Palatine Tonsil
    104 rdf:type schema:DefinedTerm
    105 N15e782424af7448e909517a9d9a85849 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Histone Code
    107 rdf:type schema:DefinedTerm
    108 N2c9e5e8d45034699885e21dfa582654d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name DNA Methylation
    110 rdf:type schema:DefinedTerm
    111 N30ac545ad28646cbba6609c9c041689e rdf:first sg:person.01045473454.83
    112 rdf:rest rdf:nil
    113 N55cb7317f9aa41579e7ba4f86e44f6fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Epigenesis, Genetic
    115 rdf:type schema:DefinedTerm
    116 N61a7750938f44277b7c4a1fb18ab88af schema:name Department of Oncology and Pathology, Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden
    117 rdf:type schema:Organization
    118 N62c02d4aef5d43829b6b499fcff8d71b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Cell Line, Tumor
    120 rdf:type schema:DefinedTerm
    121 N67c3d7bac64247f380baeeec00071271 schema:name pubmed_id
    122 schema:value 25880212
    123 rdf:type schema:PropertyValue
    124 N6c32ddd58f79427ea24eba98c43f4aa2 rdf:first sg:person.01143512621.63
    125 rdf:rest Nd342f5b11b254311b4b0ec29e82f5fb1
    126 N7565dfcecd434089871726fdce1bb451 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Promoter Regions, Genetic
    128 rdf:type schema:DefinedTerm
    129 N792b1d68c05d409f997e0a1ba729279a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Gene Expression Regulation, Neoplastic
    131 rdf:type schema:DefinedTerm
    132 N7afa6020481b42ed9f74d0aa8c0e18a3 schema:name readcube_id
    133 schema:value c0fe0a114a2c0150016da1419981eb73b60233ba876bd07d5f8e9d2419e45cef
    134 rdf:type schema:PropertyValue
    135 N892b5626496e430285dd14651daedada rdf:first sg:person.0763164265.42
    136 rdf:rest Nbe39fe2ace6c466ab26e770ee408c883
    137 N89db42725b4c407ea11d48caf59d77e5 schema:name Department of Oncology and Pathology, Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden
    138 rdf:type schema:Organization
    139 Na1e7b90510824d44acfb1a9f4f2d0da1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Humans
    141 rdf:type schema:DefinedTerm
    142 Nac4f45a551f944108fbbc570c751f4b5 schema:name doi
    143 schema:value 10.1186/s12885-015-1208-y
    144 rdf:type schema:PropertyValue
    145 Naf086effb4084c28b15bb496fb7509db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name SOXC Transcription Factors
    147 rdf:type schema:DefinedTerm
    148 Nb88d78bfbdfc4898b5c9d101aa3d51ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Neoplasms
    150 rdf:type schema:DefinedTerm
    151 Nbb6e0c768d49472592f975e2370f9e94 schema:volumeNumber 15
    152 rdf:type schema:PublicationVolume
    153 Nbe39fe2ace6c466ab26e770ee408c883 rdf:first sg:person.0610010212.09
    154 rdf:rest N6c32ddd58f79427ea24eba98c43f4aa2
    155 Nc023493174ac4c438adc46201aa37ead rdf:first sg:person.015577666144.14
    156 rdf:rest Nc795aee351b04b4ab24b9dac3bea5aba
    157 Nc2524ebd8f5e42c4956e4cb22465d514 schema:name Springer Nature - SN SciGraph project
    158 rdf:type schema:Organization
    159 Nc5bdd520127a42a987b053996953db4b schema:name nlm_unique_id
    160 schema:value 100967800
    161 rdf:type schema:PropertyValue
    162 Nc795aee351b04b4ab24b9dac3bea5aba rdf:first sg:person.0760021664.46
    163 rdf:rest N30ac545ad28646cbba6609c9c041689e
    164 Nd1f1833a5ebb43e59166ed61852e0dac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Hydroxamic Acids
    166 rdf:type schema:DefinedTerm
    167 Nd342f5b11b254311b4b0ec29e82f5fb1 rdf:first sg:person.0670064051.14
    168 rdf:rest Nc023493174ac4c438adc46201aa37ead
    169 Ned1b418e4767435d839260fa8d2ecd82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Vorinostat
    171 rdf:type schema:DefinedTerm
    172 Nf962e89f8667465796d85399ecfbc39e schema:name dimensions_id
    173 schema:value pub.1040514002
    174 rdf:type schema:PropertyValue
    175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    176 schema:name Medical and Health Sciences
    177 rdf:type schema:DefinedTerm
    178 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    179 schema:name Oncology and Carcinogenesis
    180 rdf:type schema:DefinedTerm
    181 sg:journal.1024632 schema:issn 1471-2407
    182 schema:name BMC Cancer
    183 rdf:type schema:Periodical
    184 sg:person.01045473454.83 schema:affiliation https://www.grid.ac/institutes/grid.4514.4
    185 schema:familyName Ek
    186 schema:givenName Sara
    187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045473454.83
    188 rdf:type schema:Person
    189 sg:person.01143512621.63 schema:affiliation https://www.grid.ac/institutes/grid.4514.4
    190 schema:familyName Gustavsson
    191 schema:givenName Elin
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143512621.63
    193 rdf:type schema:Person
    194 sg:person.015577666144.14 schema:affiliation N89db42725b4c407ea11d48caf59d77e5
    195 schema:familyName Ringnér
    196 schema:givenName Markus
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015577666144.14
    198 rdf:type schema:Person
    199 sg:person.0610010212.09 schema:affiliation https://www.grid.ac/institutes/grid.4514.4
    200 schema:familyName Kuci
    201 schema:givenName Venera
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610010212.09
    203 rdf:type schema:Person
    204 sg:person.0670064051.14 schema:affiliation N61a7750938f44277b7c4a1fb18ab88af
    205 schema:familyName Holm
    206 schema:givenName Karolina
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670064051.14
    208 rdf:type schema:Person
    209 sg:person.0754343526.57 schema:affiliation https://www.grid.ac/institutes/grid.4514.4
    210 schema:familyName Nordström
    211 schema:givenName Lena
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754343526.57
    213 rdf:type schema:Person
    214 sg:person.0760021664.46 schema:affiliation https://www.grid.ac/institutes/grid.417390.8
    215 schema:familyName Guldberg
    216 schema:givenName Per
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760021664.46
    218 rdf:type schema:Person
    219 sg:person.0763164265.42 schema:affiliation https://www.grid.ac/institutes/grid.417390.8
    220 schema:familyName Andersson
    221 schema:givenName Elin
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763164265.42
    223 rdf:type schema:Person
    224 sg:pub.10.1038/561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027172656
    225 https://doi.org/10.1038/561
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/bjc.2013.176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039214457
    228 https://doi.org/10.1038/bjc.2013.176
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/cddis.2011.84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017623706
    231 https://doi.org/10.1038/cddis.2011.84
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/nature04431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013027025
    234 https://doi.org/10.1038/nature04431
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/nature06008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036216819
    237 https://doi.org/10.1038/nature06008
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/nature11247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029065430
    240 https://doi.org/10.1038/nature11247
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/ng1719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017063597
    243 https://doi.org/10.1038/ng1719
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/ng1950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005618296
    246 https://doi.org/10.1038/ng1950
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/nrd1698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007512283
    249 https://doi.org/10.1038/nrd1698
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/srep01400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016989896
    252 https://doi.org/10.1038/srep01400
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1186/1471-2407-12-269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048088434
    255 https://doi.org/10.1186/1471-2407-12-269
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1186/1471-2407-13-215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004045936
    258 https://doi.org/10.1186/1471-2407-13-215
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1186/1475-2867-13-109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033907466
    261 https://doi.org/10.1186/1475-2867-13-109
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1186/1476-4598-9-187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003416547
    264 https://doi.org/10.1186/1476-4598-9-187
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1186/1755-8794-2-67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025134642
    267 https://doi.org/10.1186/1755-8794-2-67
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1186/bcr3403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021491665
    270 https://doi.org/10.1186/bcr3403
    271 rdf:type schema:CreativeWork
    272 https://app.dimensions.ai/details/publication/pub.1074840865 schema:CreativeWork
    273 https://app.dimensions.ai/details/publication/pub.1075238675 schema:CreativeWork
    274 https://app.dimensions.ai/details/publication/pub.1082926793 schema:CreativeWork
    275 https://doi.org/10.1002/cncr.21792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012150990
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1002/dvdy.21218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019474966
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1002/dvdy.23962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048416091
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1006/meth.2001.1268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000748523
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.bcp.2006.12.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022667216
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.biocel.2007.05.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047687864
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.biocel.2009.07.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017520546
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/j.canlet.2008.08.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005007531
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/j.ccr.2013.04.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014488439
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/j.cell.2006.02.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030427346
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/j.cell.2012.06.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048271589
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.ejca.2009.01.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026560812
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/j.ejcb.2012.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033061418
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/j.molcel.2014.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041563418
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1093/bioinformatics/bti652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028027978
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1093/nar/gki987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013244220
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1093/nar/gkn083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042802828
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1093/nar/gkn162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020291405
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1111/bjh.12854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009627477
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1111/j.1365-2141.2008.07329.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023657046
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1128/mcb.01304-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027416479
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1128/mcb.01516-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040012711
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1158/0008-5472.can-09-3419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011862359
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1158/0008-5472.can-12-1615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033203705
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1158/1055-9965.epi-11-0067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032514442
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1158/1078-0432.ccr-13-0877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002051562
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1158/1541-7786.mcr-07-0330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011502375
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1182/blood-2007-06-093401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051018508
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1182/blood-2010-04-280149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013705795
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1182/blood-2011-12-400580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038009599
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1200/jco.2008.21.6150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004525479
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1215/15228517-2008-032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044393210
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1371/journal.pone.0021382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015026928
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1634/theoncologist.12-10-1247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017951984
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.2217/epi.11.105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005689442
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.3324/haematol.2009.008474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018247239
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.3892/ijo.32.4.821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071516815
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.3892/or.13.1.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071529450
    350 rdf:type schema:CreativeWork
    351 https://www.grid.ac/institutes/grid.417390.8 schema:alternateName Danish Cancer Society
    352 schema:name Danish Cancer Society Research Center, Copenhagen, Denmark
    353 rdf:type schema:Organization
    354 https://www.grid.ac/institutes/grid.4514.4 schema:alternateName Lund University
    355 schema:name Department of Immunotechnology, CREATE Health, Lund University, Lund, Sweden
    356 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...