Association of angiogenic factors with prognosis in esophageal cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Lena Dreikhausen, Susanne Blank, Leila Sisic, Ulrike Heger, Wilko Weichert, Dirk Jäger, Thomas Bruckner, Natalia Giese, Lars Grenacher, Christine Falk, Katja Ott, Thomas Schmidt

ABSTRACT

BACKGROUND: Despite multimodal therapy esophageal cancer often presents with poor prognosis. To improve outcome, tumor angiogenesis and anti-angiogenic therapeutic agents have recently gained importance. However, patient subgroups who benefit from anti-angiogenic therapy are not yet defined. In this retrospective exploratory study we investigated 9 angiogenic factors in patients' serum and tissue samples with regard to their association with clinicopathological parameters, prognosis and response in patients with locally advanced preoperatively treated esophageal cancer. METHODS: From 2007 to 2012 preoperative serum and corresponding tumor tissue (n = 54), only serum (n = 20) or only tumor tissue (n = 4) were collected from esophageal squamous cell carcinoma (SCC) (n = 34) and adenocarcinoma of the esophagogastric junction (AEG) (n = 44) staged cT3/4NanyM0/x after preoperative chemo(radio)therapy. Angiogenic cytokine levels in both tissue and serum were measured by multiplex immunoassay. RESULTS: Median survival in all patients was 28.49 months. No significant difference was found in survival between SCC and AEG (p = 0.90). 26 patients were histopathological responders. Histopathological response was associated with prognosis (p = 0.05). Angiogenic factors were associated with the following clinicopathological factors: tumor tissue expression of Angiopoietin-2 and Follistatin was higher in SCC compared to AEG (p = 0.022 and p = 0.001). High HGF and Follistatin expression in the tumor tissue was associated with poor prognosis in all patients (p = 0.037 and p = 0.036). No association with prognosis was found in the patients' serum. Neither patients' serum nor tumor tissue showed an association between angiogenic factors and response to neoadjuvant therapy. CONCLUSION: Two angiogenic factors (HGF and Follistatin) in posttherapeutic tumor tissue are associated with prognosis in esophageal cancer patients. Biological differences of AEG and SCC with respect to angiogenesis were evident by the different expression of 2 angiogenic factors. Results are promising and should be pursued prospectively, optimally sequentially pre- and posttherapeutically. More... »

PAGES

121

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12885-015-1120-5

DOI

http://dx.doi.org/10.1186/s12885-015-1120-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037362303

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25885021


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Squamous Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Esophageal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Esophageal Squamous Cell Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follistatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatocyte Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dreikhausen", 
        "givenName": "Lena", 
        "id": "sg:person.01014701376.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014701376.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blank", 
        "givenName": "Susanne", 
        "id": "sg:person.0677475742.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677475742.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sisic", 
        "givenName": "Leila", 
        "id": "sg:person.0767241442.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767241442.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heger", 
        "givenName": "Ulrike", 
        "id": "sg:person.01131755560.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131755560.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of Pathology, University of Heidelberg, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weichert", 
        "givenName": "Wilko", 
        "id": "sg:person.0657434205.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657434205.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "National Center of Tumor Diseases, University of Heidelberg, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "J\u00e4ger", 
        "givenName": "Dirk", 
        "id": "sg:person.0726633256.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726633256.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Institute of Medical Biometry, University of Heidelberg, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bruckner", 
        "givenName": "Thomas", 
        "id": "sg:person.0703170701.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703170701.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giese", 
        "givenName": "Natalia", 
        "id": "sg:person.0656103275.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656103275.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grenacher", 
        "givenName": "Lars", 
        "id": "sg:person.0731631641.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731631641.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Institute for Transplant Immunology, Hannover Medical School, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Falk", 
        "givenName": "Christine", 
        "id": "sg:person.0777737146.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777737146.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ott", 
        "givenName": "Katja", 
        "id": "sg:person.01214055342.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214055342.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmidt", 
        "givenName": "Thomas", 
        "id": "sg:person.0605741476.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605741476.97"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1200/jco.2006.10.4760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002794441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/147323001204000306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003420405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/147323001204000306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003420405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-013-0296-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004408645", 
          "https://doi.org/10.1007/s10120-013-0296-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semradonc.2006.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005238661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-006-0373-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005580994", 
          "https://doi.org/10.1007/s00268-006-0373-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-006-0373-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005580994", 
          "https://doi.org/10.1007/s00268-006-0373-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/003655202753416939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008546053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2010-0387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009751150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2013.51.2186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009817811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-12-26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011156460", 
          "https://doi.org/10.1186/1476-4598-12-26"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-2553", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012580522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa032691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014051315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejso.2004.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016923623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-011-1743-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017685245", 
          "https://doi.org/10.1245/s10434-011-1743-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3835(95)03967-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018045831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ol.2013.1409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020938870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ol.2013.1409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020938870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.02.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023540354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1112088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024545289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.25146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024599389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.25146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024599389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra035010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025473194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2013/302862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025736751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semcancer.2009.05.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028162543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20010801)92:3<663::aid-cncr1368>3.0.co;2-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030550640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-12-0020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033366719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00423-012-1034-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034359745", 
          "https://doi.org/10.1007/s00423-012-1034-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cyto.2010.05.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035648010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036162157", 
          "https://doi.org/10.1038/nrm1261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036162157", 
          "https://doi.org/10.1038/nrm1261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djm135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036694202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6604251", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036865649", 
          "https://doi.org/10.1038/sj.bjc.6604251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jss.2014.11.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040222778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80108-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042440169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-2952(00)00529-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042568382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdn403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042723309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1947601909356574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047976371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1947601909356574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047976371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(11)70142-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049054354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10585-010-9344-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049891884", 
          "https://doi.org/10.1007/s10585-010-9344-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)60643-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050256847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa055531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050751169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0748-7983(04)00149-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054660532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v11.i14.2188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071362947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.17.3.557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071530329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078335934", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "BACKGROUND: Despite multimodal therapy esophageal cancer often presents with poor prognosis. To improve outcome, tumor angiogenesis and anti-angiogenic therapeutic agents have recently gained importance. However, patient subgroups who benefit from anti-angiogenic therapy are not yet defined. In this retrospective exploratory study we investigated 9 angiogenic factors in patients' serum and tissue samples with regard to their association with clinicopathological parameters, prognosis and response in patients with locally advanced preoperatively treated esophageal cancer.\nMETHODS: From 2007 to 2012 preoperative serum and corresponding tumor tissue (n\u2009=\u200954), only serum (n\u2009=\u200920) or only tumor tissue (n\u2009=\u20094) were collected from esophageal squamous cell carcinoma (SCC) (n\u2009=\u200934) and adenocarcinoma of the esophagogastric junction (AEG) (n\u2009=\u200944) staged cT3/4NanyM0/x after preoperative chemo(radio)therapy. Angiogenic cytokine levels in both tissue and serum were measured by multiplex immunoassay.\nRESULTS: Median survival in all patients was 28.49 months. No significant difference was found in survival between SCC and AEG (p\u2009=\u20090.90). 26 patients were histopathological responders. Histopathological response was associated with prognosis (p\u2009=\u20090.05). Angiogenic factors were associated with the following clinicopathological factors: tumor tissue expression of Angiopoietin-2 and Follistatin was higher in SCC compared to AEG (p\u2009=\u20090.022 and p\u2009=\u20090.001). High HGF and Follistatin expression in the tumor tissue was associated with poor prognosis in all patients (p\u2009=\u20090.037 and p\u2009=\u20090.036). No association with prognosis was found in the patients' serum. Neither patients' serum nor tumor tissue showed an association between angiogenic factors and response to neoadjuvant therapy.\nCONCLUSION: Two angiogenic factors (HGF and Follistatin) in posttherapeutic tumor tissue are associated with prognosis in esophageal cancer patients. Biological differences of AEG and SCC with respect to angiogenesis were evident by the different expression of 2 angiogenic factors. Results are promising and should be pursued prospectively, optimally sequentially pre- and posttherapeutically.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12885-015-1120-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "name": "Association of angiogenic factors with prognosis in esophageal cancer", 
    "pagination": "121", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b1fa92bb8d6617af91855e2c2754508a456c5abe5876f27709ac23d45fc06c37"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25885021"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967800"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12885-015-1120-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1037362303"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12885-015-1120-5", 
      "https://app.dimensions.ai/details/publication/pub.1037362303"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89801_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs12885-015-1120-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1120-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1120-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1120-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1120-5'


 

This table displays all metadata directly associated to this object as RDF triples.

349 TRIPLES      21 PREDICATES      86 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12885-015-1120-5 schema:about N12fe878537ae4b89835c99134d479039
2 N1d42130a5967437aae40fb434dcca9d5
3 N38fa2883e06c4408ba962e45fc70951e
4 N39097c45ff5d49fe8c19bc005157c0ee
5 N533211ee1773457da5779f8a366db694
6 N60e782aff63e4b01b35a7fbca922556c
7 N6e059bb55f274e9c9fcec6040e15cf6a
8 N77fe8351e43b433c8e6a5c6f663ad7bb
9 N9c428043d5df4b3e9e66729265cf2201
10 Na0865307508843f0a7f57ae0dd9ea9b7
11 Na8ba970b9bc84a5895e5320ad9123062
12 Nb061e1a4b62649eaa4b2d65dc02217e2
13 Nbd4ea3f9800a4cad8111659766ce2c75
14 Ncc4eaf8e243d4014bacc17ce71cc239f
15 Ncda0aec0d1cb42ee9a34a35f4d8f2dd8
16 Nfb6dfc0489d14899aa67ec5683ecdd31
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author N2a85faa85b4f4c96aeba8124b91261ac
20 schema:citation sg:pub.10.1007/s00268-006-0373-1
21 sg:pub.10.1007/s00423-012-1034-5
22 sg:pub.10.1007/s10120-013-0296-0
23 sg:pub.10.1007/s10585-010-9344-x
24 sg:pub.10.1038/nrm1261
25 sg:pub.10.1038/sj.bjc.6604251
26 sg:pub.10.1186/1476-4598-12-26
27 sg:pub.10.1245/s10434-011-1743-y
28 https://app.dimensions.ai/details/publication/pub.1078335934
29 https://doi.org/10.1002/1097-0142(20010801)92:3<663::aid-cncr1368>3.0.co;2-l
30 https://doi.org/10.1002/cncr.25146
31 https://doi.org/10.1016/0304-3835(95)03967-2
32 https://doi.org/10.1016/j.cell.2011.02.013
33 https://doi.org/10.1016/j.cyto.2010.05.006
34 https://doi.org/10.1016/j.ejso.2004.06.008
35 https://doi.org/10.1016/j.jss.2014.11.028
36 https://doi.org/10.1016/j.semcancer.2009.05.003
37 https://doi.org/10.1016/j.semradonc.2006.09.007
38 https://doi.org/10.1016/s0006-2952(00)00529-3
39 https://doi.org/10.1016/s0092-8674(00)80108-7
40 https://doi.org/10.1016/s0140-6736(12)60643-6
41 https://doi.org/10.1016/s0748-7983(04)00149-0
42 https://doi.org/10.1016/s1470-2045(11)70142-5
43 https://doi.org/10.1056/nejmoa032691
44 https://doi.org/10.1056/nejmoa055531
45 https://doi.org/10.1056/nejmoa1112088
46 https://doi.org/10.1056/nejmra035010
47 https://doi.org/10.1080/003655202753416939
48 https://doi.org/10.1093/annonc/mdn403
49 https://doi.org/10.1093/jnci/djm135
50 https://doi.org/10.1155/2013/302862
51 https://doi.org/10.1158/1055-9965.epi-12-0020
52 https://doi.org/10.1158/1078-0432.ccr-04-2553
53 https://doi.org/10.1177/147323001204000306
54 https://doi.org/10.1177/1947601909356574
55 https://doi.org/10.1200/jco.2006.10.4760
56 https://doi.org/10.1200/jco.2013.51.2186
57 https://doi.org/10.1634/theoncologist.2010-0387
58 https://doi.org/10.3748/wjg.v11.i14.2188
59 https://doi.org/10.3892/ol.2013.1409
60 https://doi.org/10.3892/or.17.3.557
61 schema:datePublished 2015-12
62 schema:datePublishedReg 2015-12-01
63 schema:description BACKGROUND: Despite multimodal therapy esophageal cancer often presents with poor prognosis. To improve outcome, tumor angiogenesis and anti-angiogenic therapeutic agents have recently gained importance. However, patient subgroups who benefit from anti-angiogenic therapy are not yet defined. In this retrospective exploratory study we investigated 9 angiogenic factors in patients' serum and tissue samples with regard to their association with clinicopathological parameters, prognosis and response in patients with locally advanced preoperatively treated esophageal cancer. METHODS: From 2007 to 2012 preoperative serum and corresponding tumor tissue (n = 54), only serum (n = 20) or only tumor tissue (n = 4) were collected from esophageal squamous cell carcinoma (SCC) (n = 34) and adenocarcinoma of the esophagogastric junction (AEG) (n = 44) staged cT3/4NanyM0/x after preoperative chemo(radio)therapy. Angiogenic cytokine levels in both tissue and serum were measured by multiplex immunoassay. RESULTS: Median survival in all patients was 28.49 months. No significant difference was found in survival between SCC and AEG (p = 0.90). 26 patients were histopathological responders. Histopathological response was associated with prognosis (p = 0.05). Angiogenic factors were associated with the following clinicopathological factors: tumor tissue expression of Angiopoietin-2 and Follistatin was higher in SCC compared to AEG (p = 0.022 and p = 0.001). High HGF and Follistatin expression in the tumor tissue was associated with poor prognosis in all patients (p = 0.037 and p = 0.036). No association with prognosis was found in the patients' serum. Neither patients' serum nor tumor tissue showed an association between angiogenic factors and response to neoadjuvant therapy. CONCLUSION: Two angiogenic factors (HGF and Follistatin) in posttherapeutic tumor tissue are associated with prognosis in esophageal cancer patients. Biological differences of AEG and SCC with respect to angiogenesis were evident by the different expression of 2 angiogenic factors. Results are promising and should be pursued prospectively, optimally sequentially pre- and posttherapeutically.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree true
67 schema:isPartOf N8f6cdfddf07e49b4b6cf6445940f1c51
68 Nf249c2d7daaa4f64ad8d747b4d42698c
69 sg:journal.1024632
70 schema:name Association of angiogenic factors with prognosis in esophageal cancer
71 schema:pagination 121
72 schema:productId N3e9efbac4cb3499e8816f478010c2028
73 N98404da79d8f4eb8b6710e99c84519fc
74 Na1a331215134482592c491dfdd35157d
75 Nc7a400360b3b4b7d8f13653a898e777c
76 Ncff6155f5b0b45ec9acdd4d8f5a32659
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037362303
78 https://doi.org/10.1186/s12885-015-1120-5
79 schema:sdDatePublished 2019-04-11T09:55
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N9374e5d27b6345489f3e5d2fd436002d
82 schema:url http://link.springer.com/10.1186%2Fs12885-015-1120-5
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N12f134aae2204785b5c221bb92348a9b rdf:first sg:person.0726633256.58
87 rdf:rest N2f117a0d9038432b8c49b95acc844dba
88 N12fe878537ae4b89835c99134d479039 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Carcinoma, Squamous Cell
90 rdf:type schema:DefinedTerm
91 N1d42130a5967437aae40fb434dcca9d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Esophageal Neoplasms
93 rdf:type schema:DefinedTerm
94 N2a85faa85b4f4c96aeba8124b91261ac rdf:first sg:person.01014701376.91
95 rdf:rest N63c04c172bb1417f94b18f35eeb376f8
96 N2f117a0d9038432b8c49b95acc844dba rdf:first sg:person.0703170701.53
97 rdf:rest Na094aa385dc644d0854a20539c07821e
98 N38fa2883e06c4408ba962e45fc70951e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Aged, 80 and over
100 rdf:type schema:DefinedTerm
101 N39097c45ff5d49fe8c19bc005157c0ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Prognosis
103 rdf:type schema:DefinedTerm
104 N3e9efbac4cb3499e8816f478010c2028 schema:name nlm_unique_id
105 schema:value 100967800
106 rdf:type schema:PropertyValue
107 N533211ee1773457da5779f8a366db694 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Follistatin
109 rdf:type schema:DefinedTerm
110 N60e782aff63e4b01b35a7fbca922556c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Hepatocyte Growth Factor
112 rdf:type schema:DefinedTerm
113 N614ac882dfb44aefbf1880a5e3e65f3a rdf:first sg:person.01214055342.00
114 rdf:rest N8336cffcd98d4bd09c03ba5e66c7c349
115 N63c04c172bb1417f94b18f35eeb376f8 rdf:first sg:person.0677475742.17
116 rdf:rest Nf804fc784f37442fbb378277b2b839db
117 N6e059bb55f274e9c9fcec6040e15cf6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Esophageal Squamous Cell Carcinoma
119 rdf:type schema:DefinedTerm
120 N77fe8351e43b433c8e6a5c6f663ad7bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Follow-Up Studies
122 rdf:type schema:DefinedTerm
123 N8336cffcd98d4bd09c03ba5e66c7c349 rdf:first sg:person.0605741476.97
124 rdf:rest rdf:nil
125 N870bb52c312b4275a3241d251a2073e0 rdf:first sg:person.01131755560.86
126 rdf:rest N8b6135cdfa9c4f5a8c02e684f914c71b
127 N8b6135cdfa9c4f5a8c02e684f914c71b rdf:first sg:person.0657434205.21
128 rdf:rest N12f134aae2204785b5c221bb92348a9b
129 N8f6cdfddf07e49b4b6cf6445940f1c51 schema:issueNumber 1
130 rdf:type schema:PublicationIssue
131 N9374e5d27b6345489f3e5d2fd436002d schema:name Springer Nature - SN SciGraph project
132 rdf:type schema:Organization
133 N98404da79d8f4eb8b6710e99c84519fc schema:name doi
134 schema:value 10.1186/s12885-015-1120-5
135 rdf:type schema:PropertyValue
136 N9c428043d5df4b3e9e66729265cf2201 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Biomarkers, Tumor
138 rdf:type schema:DefinedTerm
139 Na0865307508843f0a7f57ae0dd9ea9b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Adult
141 rdf:type schema:DefinedTerm
142 Na094aa385dc644d0854a20539c07821e rdf:first sg:person.0656103275.63
143 rdf:rest Nc979bcc855974fd0ab3f16a543b0c140
144 Na125fa4707804dc7933839ab23fc18a7 rdf:first sg:person.0777737146.57
145 rdf:rest N614ac882dfb44aefbf1880a5e3e65f3a
146 Na1a331215134482592c491dfdd35157d schema:name pubmed_id
147 schema:value 25885021
148 rdf:type schema:PropertyValue
149 Na8ba970b9bc84a5895e5320ad9123062 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Middle Aged
151 rdf:type schema:DefinedTerm
152 Nb061e1a4b62649eaa4b2d65dc02217e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Adenocarcinoma
154 rdf:type schema:DefinedTerm
155 Nb4eb23f1335b4262bed921892cb42ecb schema:name National Center of Tumor Diseases, University of Heidelberg, 69120, Heidelberg, Germany
156 rdf:type schema:Organization
157 Nbd4ea3f9800a4cad8111659766ce2c75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Humans
159 rdf:type schema:DefinedTerm
160 Nc7a400360b3b4b7d8f13653a898e777c schema:name readcube_id
161 schema:value b1fa92bb8d6617af91855e2c2754508a456c5abe5876f27709ac23d45fc06c37
162 rdf:type schema:PropertyValue
163 Nc979bcc855974fd0ab3f16a543b0c140 rdf:first sg:person.0731631641.53
164 rdf:rest Na125fa4707804dc7933839ab23fc18a7
165 Ncc4eaf8e243d4014bacc17ce71cc239f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Female
167 rdf:type schema:DefinedTerm
168 Ncda0aec0d1cb42ee9a34a35f4d8f2dd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Aged
170 rdf:type schema:DefinedTerm
171 Ncff6155f5b0b45ec9acdd4d8f5a32659 schema:name dimensions_id
172 schema:value pub.1037362303
173 rdf:type schema:PropertyValue
174 Nf249c2d7daaa4f64ad8d747b4d42698c schema:volumeNumber 15
175 rdf:type schema:PublicationVolume
176 Nf804fc784f37442fbb378277b2b839db rdf:first sg:person.0767241442.45
177 rdf:rest N870bb52c312b4275a3241d251a2073e0
178 Nfb6dfc0489d14899aa67ec5683ecdd31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Male
180 rdf:type schema:DefinedTerm
181 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
182 schema:name Medical and Health Sciences
183 rdf:type schema:DefinedTerm
184 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
185 schema:name Oncology and Carcinogenesis
186 rdf:type schema:DefinedTerm
187 sg:journal.1024632 schema:issn 1471-2407
188 schema:name BMC Cancer
189 rdf:type schema:Periodical
190 sg:person.01014701376.91 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
191 schema:familyName Dreikhausen
192 schema:givenName Lena
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014701376.91
194 rdf:type schema:Person
195 sg:person.01131755560.86 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
196 schema:familyName Heger
197 schema:givenName Ulrike
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131755560.86
199 rdf:type schema:Person
200 sg:person.01214055342.00 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
201 schema:familyName Ott
202 schema:givenName Katja
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214055342.00
204 rdf:type schema:Person
205 sg:person.0605741476.97 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
206 schema:familyName Schmidt
207 schema:givenName Thomas
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605741476.97
209 rdf:type schema:Person
210 sg:person.0656103275.63 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
211 schema:familyName Giese
212 schema:givenName Natalia
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656103275.63
214 rdf:type schema:Person
215 sg:person.0657434205.21 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
216 schema:familyName Weichert
217 schema:givenName Wilko
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657434205.21
219 rdf:type schema:Person
220 sg:person.0677475742.17 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
221 schema:familyName Blank
222 schema:givenName Susanne
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677475742.17
224 rdf:type schema:Person
225 sg:person.0703170701.53 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
226 schema:familyName Bruckner
227 schema:givenName Thomas
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703170701.53
229 rdf:type schema:Person
230 sg:person.0726633256.58 schema:affiliation Nb4eb23f1335b4262bed921892cb42ecb
231 schema:familyName Jäger
232 schema:givenName Dirk
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726633256.58
234 rdf:type schema:Person
235 sg:person.0731631641.53 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
236 schema:familyName Grenacher
237 schema:givenName Lars
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731631641.53
239 rdf:type schema:Person
240 sg:person.0767241442.45 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
241 schema:familyName Sisic
242 schema:givenName Leila
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767241442.45
244 rdf:type schema:Person
245 sg:person.0777737146.57 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
246 schema:familyName Falk
247 schema:givenName Christine
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777737146.57
249 rdf:type schema:Person
250 sg:pub.10.1007/s00268-006-0373-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005580994
251 https://doi.org/10.1007/s00268-006-0373-1
252 rdf:type schema:CreativeWork
253 sg:pub.10.1007/s00423-012-1034-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034359745
254 https://doi.org/10.1007/s00423-012-1034-5
255 rdf:type schema:CreativeWork
256 sg:pub.10.1007/s10120-013-0296-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004408645
257 https://doi.org/10.1007/s10120-013-0296-0
258 rdf:type schema:CreativeWork
259 sg:pub.10.1007/s10585-010-9344-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049891884
260 https://doi.org/10.1007/s10585-010-9344-x
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/nrm1261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036162157
263 https://doi.org/10.1038/nrm1261
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/sj.bjc.6604251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036865649
266 https://doi.org/10.1038/sj.bjc.6604251
267 rdf:type schema:CreativeWork
268 sg:pub.10.1186/1476-4598-12-26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011156460
269 https://doi.org/10.1186/1476-4598-12-26
270 rdf:type schema:CreativeWork
271 sg:pub.10.1245/s10434-011-1743-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1017685245
272 https://doi.org/10.1245/s10434-011-1743-y
273 rdf:type schema:CreativeWork
274 https://app.dimensions.ai/details/publication/pub.1078335934 schema:CreativeWork
275 https://doi.org/10.1002/1097-0142(20010801)92:3<663::aid-cncr1368>3.0.co;2-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1030550640
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1002/cncr.25146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024599389
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/0304-3835(95)03967-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018045831
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.cell.2011.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023540354
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.cyto.2010.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035648010
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.ejso.2004.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016923623
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.jss.2014.11.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040222778
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.semcancer.2009.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028162543
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.semradonc.2006.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005238661
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/s0006-2952(00)00529-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042568382
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/s0092-8674(00)80108-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042440169
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/s0140-6736(12)60643-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050256847
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/s0748-7983(04)00149-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054660532
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/s1470-2045(11)70142-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049054354
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1056/nejmoa032691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014051315
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1056/nejmoa055531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050751169
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1056/nejmoa1112088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024545289
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1056/nejmra035010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025473194
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1080/003655202753416939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008546053
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1093/annonc/mdn403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042723309
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1093/jnci/djm135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036694202
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1155/2013/302862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025736751
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1158/1055-9965.epi-12-0020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033366719
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1158/1078-0432.ccr-04-2553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012580522
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1177/147323001204000306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003420405
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1177/1947601909356574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047976371
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1200/jco.2006.10.4760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002794441
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1200/jco.2013.51.2186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009817811
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1634/theoncologist.2010-0387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009751150
332 rdf:type schema:CreativeWork
333 https://doi.org/10.3748/wjg.v11.i14.2188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071362947
334 rdf:type schema:CreativeWork
335 https://doi.org/10.3892/ol.2013.1409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020938870
336 rdf:type schema:CreativeWork
337 https://doi.org/10.3892/or.17.3.557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071530329
338 rdf:type schema:CreativeWork
339 https://www.grid.ac/institutes/grid.10423.34 schema:alternateName Hannover Medical School
340 schema:name Institute for Transplant Immunology, Hannover Medical School, Hannover, Germany
341 rdf:type schema:Organization
342 https://www.grid.ac/institutes/grid.5253.1 schema:alternateName University Hospital Heidelberg
343 schema:name Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany
344 rdf:type schema:Organization
345 https://www.grid.ac/institutes/grid.7700.0 schema:alternateName Heidelberg University
346 schema:name Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
347 Department of Pathology, University of Heidelberg, 69120, Heidelberg, Germany
348 Institute of Medical Biometry, University of Heidelberg, Heidelberg, Germany
349 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...