S100A4-neutralizing antibody suppresses spontaneous tumor progression, pre-metastatic niche formation and alters T-cell polarization balance View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Birgitte Grum-Schwensen, Jörg Klingelhöfer, Mette Beck, Charlotte Menné Bonefeld, Petra Hamerlik, Per Guldberg, Mariam Grigorian, Eugene Lukanidin, Noona Ambartsumian

ABSTRACT

BACKGROUND: The tumor microenvironment plays a determinative role in stimulating tumor progression and metastasis. Notably, tumor-stroma signals affect the pattern of infiltrated immune cells and the profile of tumor-released cytokines. Among the known molecules that are engaged in stimulating the metastatic spread of tumor cells is the S100A4 protein. S100A4 is known as an inducer of inflammatory processes and has been shown to attract T-cells to the primary tumor and to the pre-metastatic niche. The present study aims to examine the immunomodulatory role of S100A4 in vivo and in vitro and assess the mode of action of 6B12, a S100A4 neutralizing antibody. METHODS: The therapeutic effect of the 6B12 antibody was evaluated in two different mouse models. First, in a model of spontaneous breast cancer we assessed the dynamics of tumor growth and metastasis. Second, in a model of metastatic niche formation we determined the expression of metastatic niche markers. The levels of cytokine expression were assessed using antibody as well as PCR arrays and the results confirmed by qRT-PCR and ELISA. T-cell phenotyping and in vitro differentiation analyses were performed by flow cytometry. RESULTS: We show that the S100A4 protein alters the expression of transcription factor and signal transduction pathway genes involved in the T-cell lineage differentiation. T-cells challenged with S100A4 demonstrated reduced proportion of Th1-polarized cells shifting the Th1/Th2 balance towards the Th2 pro-tumorigenic phenotype. The 6B12 antibody restored the Th1/Th2 balance. Furthermore, we provide evidence that the 6B12 antibody deploys its anti-metastatic effect, by suppressing the attraction of T-cells to the site of primary tumor and pre-metastatic niche. This was associated with delayed primary tumor growth, decreased vessel density and inhibition of metastases. CONCLUSION: The S100A4 blocking antibody (6B12) reduces tumor growth and metastasis in a model of spontaneous breast cancer. The 6B12 antibody treatment inhibits T cell accumulation at the primary and pre-metastatic tumor sites. The 6B12 antibody acts as an immunomodulatory agent and thus supports the view that the 6B12 antibody is a promising therapeutic candidate to fight cancer. More... »

PAGES

44

References to SciGraph publications

  • 2012-01. The metastasis-promoting S100A4 protein confers neuroprotection in brain injury in NATURE COMMUNICATIONS
  • 2009-04. Microenvironmental regulation of metastasis in NATURE REVIEWS CANCER
  • 2012-12. The metastatic niche and stromal progression in CANCER AND METASTASIS REVIEWS
  • 2015-01. A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4 in ONCOGENE
  • 2013-10. CSF-1R inhibition alters macrophage polarization and blocks glioma progression in NATURE MEDICINE
  • 2013-11. Microenvironmental regulation of tumor progression and metastasis in NATURE MEDICINE
  • 2008-07. Cancer-related inflammation in NATURE
  • 2005-12. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche in NATURE
  • 2004-07. Extracellular S100A4(mts1) stimulates invasive growth of mouse endothelial cells and modulates MMP-13 matrix metalloproteinase activity in ONCOGENE
  • 2001-08. The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor in ONCOGENE
  • 2012-02. Effect of VIP on the balance between cytokines and master regulators of activated helper T cells in IMMUNOLOGY AND CELL BIOLOGY
  • 2004-04. Cancer predisposition in mice deficient for the metastasis-associated Mts1(S100A4) gene in ONCOGENE
  • 2010-12. Signal transduction mechanisms involved in S100A4-induced activation of the transcription factor NF-κB in BMC CANCER
  • 2012-06. S100A4 calcium-binding protein is key player in tumor progression and metastasis: preclinical and clinical evidence in CANCER AND METASTASIS REVIEWS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12885-015-1034-2

    DOI

    http://dx.doi.org/10.1186/s12885-015-1034-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1050803639

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25884510


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