Ontology type: schema:ScholarlyArticle Open Access: True
2015-12
AUTHORSHector H Li-Chang, Katayoon Kasaian, Ying Ng, Amy Lum, Esther Kong, Howard Lim, Steven JM Jones, David G Huntsman, David F Schaeffer, Stephen Yip
ABSTRACTBACKGROUND: Adenocarcinomas of both the gastroesophageal junction and stomach are molecularly complex, but differ with respect to epidemiology, etiology and survival. There are few data directly comparing the frequencies of single nucleotide mutations in cancer-related genes between the two sites. Sequencing of targeted gene panels may be useful in uncovering multiple genomic aberrations using a single test. METHODS: DNA from 92 gastroesophageal junction and 75 gastric adenocarcinoma resection specimens was extracted from formalin-fixed paraffin-embedded tissue. Targeted deep sequencing of 46 cancer-related genes was performed through emulsion PCR followed by semiconductor-based sequencing. Gastroesophageal junction and gastric carcinomas were contrasted with respect to mutational profiles, immunohistochemistry and in situ hybridization, as well as corresponding clinicopathologic data. RESULTS: Gastroesophageal junction carcinomas were associated with younger age, more frequent intestinal-type histology, more frequent p53 overexpression, and worse disease-free survival on multivariable analysis. Among all cases, 145 mutations were detected in 31 genes. TP53 mutations were the most common abnormality detected, and were more common in gastroesophageal junction carcinomas (42% vs. 27%, p = 0.036). Mutations in the Wnt pathway components APC and CTNNB1 were more common among gastric carcinomas (16% vs. 3%, p = 0.006), and gastric carcinomas were more likely to have ≥3 driver mutations detected (11% vs. 2%, p = 0.044). Twenty percent of cases had potentially actionable mutations identified. R132H and R132C missense mutations in the IDH1 gene were observed, and are the first reported mutations of their kind in gastric carcinoma. CONCLUSIONS: Panel sequencing of routine pathology material can yield mutational information on several driver genes, including some for which targeted therapies are available. Differing rates of mutations and clinicopathologic differences support a distinction between adenocarcinomas that arise in the gastroesophageal junction and those that arise in the stomach proper. More... »
PAGES32
http://scigraph.springernature.com/pub.10.1186/s12885-015-1021-7
DOIhttp://dx.doi.org/10.1186/s12885-015-1021-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1017246576
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25656989
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adenocarcinoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Esophageal Diseases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Esophagogastric Junction",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "High-Throughput Nucleotide Sequencing",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mutation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Grading",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Staging",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prognosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Stomach Neoplasms",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"University of British Columbia, Vancouver, Canada",
"Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine, Vancouver General Hospital, 855 12 Ave W, V5Z 1\u00a0M9, Vancouver, BC, Canada",
"Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver, Canada"
],
"type": "Organization"
},
"familyName": "Li-Chang",
"givenName": "Hector H",
"id": "sg:person.01267300000.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267300000.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"University of British Columbia, Vancouver, Canada",
"Canada\u2019s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, Canada"
],
"type": "Organization"
},
"familyName": "Kasaian",
"givenName": "Katayoon",
"id": "sg:person.01271403320.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271403320.05"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"Centre for Translational and Applied Genomics, British Columbia Cancer Agency, Vancouver, Canada"
],
"type": "Organization"
},
"familyName": "Ng",
"givenName": "Ying",
"id": "sg:person.01241165445.21",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241165445.21"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"Centre for Translational and Applied Genomics, British Columbia Cancer Agency, Vancouver, Canada"
],
"type": "Organization"
},
"familyName": "Lum",
"givenName": "Amy",
"id": "sg:person.01316034776.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316034776.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"Centre for Translational and Applied Genomics, British Columbia Cancer Agency, Vancouver, Canada"
],
"type": "Organization"
},
"familyName": "Kong",
"givenName": "Esther",
"id": "sg:person.01243022306.64",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243022306.64"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"University of British Columbia, Vancouver, Canada",
"Department of Medical Oncology, British Columbia Cancer Agency, Vancouver, Canada"
],
"type": "Organization"
},
"familyName": "Lim",
"givenName": "Howard",
"id": "sg:person.01022072546.74",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022072546.74"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"Canada\u2019s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, Canada"
],
"type": "Organization"
},
"familyName": "Jones",
"givenName": "Steven JM",
"id": "sg:person.011076371162.80",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011076371162.80"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"University of British Columbia, Vancouver, Canada",
"Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine, Vancouver General Hospital, 855 12 Ave W, V5Z 1\u00a0M9, Vancouver, BC, Canada",
"Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver, Canada",
"Centre for Translational and Applied Genomics, British Columbia Cancer Agency, Vancouver, Canada"
],
"type": "Organization"
},
"familyName": "Huntsman",
"givenName": "David G",
"id": "sg:person.015140454124.62",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015140454124.62"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vancouver General Hospital",
"id": "https://www.grid.ac/institutes/grid.412541.7",
"name": [
"University of British Columbia, Vancouver, Canada",
"Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine, Vancouver General Hospital, 855 12 Ave W, V5Z 1\u00a0M9, Vancouver, BC, Canada"
],
"type": "Organization"
},
"familyName": "Schaeffer",
"givenName": "David F",
"id": "sg:person.01002345662.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002345662.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"University of British Columbia, Vancouver, Canada",
"Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine, Vancouver General Hospital, 855 12 Ave W, V5Z 1\u00a0M9, Vancouver, BC, Canada",
"Centre for Translational and Applied Genomics, British Columbia Cancer Agency, Vancouver, Canada"
],
"type": "Organization"
},
"familyName": "Yip",
"givenName": "Stephen",
"id": "sg:person.0745471507.67",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745471507.67"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1158/1535-7163.mct-11-0450",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000031481"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0405220101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000546271"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/modpathol.2013.122",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000906290",
"https://doi.org/10.1038/modpathol.2013.122"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/gut.2006.114504",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002458205"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-10-2203",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002780517"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1940-6207.capr-08-0109",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003249007"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1479-5876-9-119",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003297095",
"https://doi.org/10.1186/1479-5876-9-119"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.semradonc.2012.09.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003505784"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2013-03-491571",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003975252"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrd3847",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004232546",
"https://doi.org/10.1038/nrd3847"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrclinonc.2013.170",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005291210",
"https://doi.org/10.1038/nrclinonc.2013.170"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/modpathol.2010.183",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006584492",
"https://doi.org/10.1038/modpathol.2010.183"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-12-1726",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007576422"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.2591",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008213220",
"https://doi.org/10.1038/ng.2591"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10120-013-0315-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008321190",
"https://doi.org/10.1007/s10120-013-0315-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-200002000-00005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008374656"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-200002000-00005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008374656"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-62703-727-3_24",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008523059",
"https://doi.org/10.1007/978-1-62703-727-3_24"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3322/caac.20107",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009055747"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature11252",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010619765",
"https://doi.org/10.1038/nature11252"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-12-3950",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011285970"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jmoldx.2012.09.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011539230"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/annonc/mds244",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011737848"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-07-4839",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012121457"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2006.06.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013718525"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/gut.2008.168641",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015245863"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.humpath.2010.06.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015352347"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jmoldx.2013.06.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015693520"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08617",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016136939",
"https://doi.org/10.1038/nature08617"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08617",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016136939",
"https://doi.org/10.1038/nature08617"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-62703-107-3_17",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017157205",
"https://doi.org/10.1007/978-1-62703-107-3_17"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/28.1.27",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017305614"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0063826",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018867184"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3389/fonc.2013.00086",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018877156"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-12-1800",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020457638"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.20212",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021477746"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/gut.2007.137364",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022437982"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35106009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023694803",
"https://doi.org/10.1038/35106009"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35106009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023694803",
"https://doi.org/10.1038/35106009"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pmed.0020017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023971579"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(12)70489-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024631546"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1207759109",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025114219"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1479-5876-9-33",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025950271",
"https://doi.org/10.1186/1479-5876-9-33"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.semdp.2006.04.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031908832"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jmoldx.2012.11.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033447367"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0080478",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035043749"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0080478",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035043749"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2013-2292",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035347371"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1535-7163.mct-13-0049-t",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035634897"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1235122",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035954369"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0054014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036379729"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2403630",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041325796",
"https://doi.org/10.1038/sj.leu.2403630"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2403630",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041325796",
"https://doi.org/10.1038/sj.leu.2403630"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/mp.52.5.263",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042031731"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/mp.52.5.263",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042031731"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/gut.46.1.9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042965578"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/gut.2009.186825",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043090209"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6603583",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043374361",
"https://doi.org/10.1038/sj.bjc.6603583"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6603583",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043374361",
"https://doi.org/10.1038/sj.bjc.6603583"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jmoldx.2013.05.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043903587"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(10)61121-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044182432"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1515/cclm-2013-0883",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047214828"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2353/jmoldx.2010.080131",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047567812"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2403838",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049352910",
"https://doi.org/10.1038/sj.leu.2403838"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2403838",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049352910",
"https://doi.org/10.1038/sj.leu.2403838"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1535-7163.mct-10-1044",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049488979"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/2159-8290.cd-12-0028",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052739264"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2012-2672",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064293768"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3748/wjg.v19.i36.6098",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071369728"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3748/wjg.v19.i36.6098",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071369728"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078832672",
"type": "CreativeWork"
}
],
"datePublished": "2015-12",
"datePublishedReg": "2015-12-01",
"description": "BACKGROUND: Adenocarcinomas of both the gastroesophageal junction and stomach are molecularly complex, but differ with respect to epidemiology, etiology and survival. There are few data directly comparing the frequencies of single nucleotide mutations in cancer-related genes between the two sites. Sequencing of targeted gene panels may be useful in uncovering multiple genomic aberrations using a single test.\nMETHODS: DNA from 92 gastroesophageal junction and 75 gastric adenocarcinoma resection specimens was extracted from formalin-fixed paraffin-embedded tissue. Targeted deep sequencing of 46 cancer-related genes was performed through emulsion PCR followed by semiconductor-based sequencing. Gastroesophageal junction and gastric carcinomas were contrasted with respect to mutational profiles, immunohistochemistry and in situ hybridization, as well as corresponding clinicopathologic data.\nRESULTS: Gastroesophageal junction carcinomas were associated with younger age, more frequent intestinal-type histology, more frequent p53 overexpression, and worse disease-free survival on multivariable analysis. Among all cases, 145 mutations were detected in 31 genes. TP53 mutations were the most common abnormality detected, and were more common in gastroesophageal junction carcinomas (42% vs. 27%, p\u2009=\u20090.036). Mutations in the Wnt pathway components APC and CTNNB1 were more common among gastric carcinomas (16% vs. 3%, p\u2009=\u20090.006), and gastric carcinomas were more likely to have \u22653 driver mutations detected (11% vs. 2%, p\u2009=\u20090.044). Twenty percent of cases had potentially actionable mutations identified. R132H and R132C missense mutations in the IDH1 gene were observed, and are the first reported mutations of their kind in gastric carcinoma.\nCONCLUSIONS: Panel sequencing of routine pathology material can yield mutational information on several driver genes, including some for which targeted therapies are available. Differing rates of mutations and clinicopathologic differences support a distinction between adenocarcinomas that arise in the gastroesophageal junction and those that arise in the stomach proper.",
"genre": "research_article",
"id": "sg:pub.10.1186/s12885-015-1021-7",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1024632",
"issn": [
"1471-2407"
],
"name": "BMC Cancer",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "15"
}
],
"name": "Retrospective review using targeted deep sequencing reveals mutational differences between gastroesophageal junction and gastric carcinomas",
"pagination": "32",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"522b9b6a1afb934baedb9e7bb5430823e127b3e3c193316b4bdaae722db0aa0a"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"25656989"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"100967800"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s12885-015-1021-7"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1017246576"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s12885-015-1021-7",
"https://app.dimensions.ai/details/publication/pub.1017246576"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T09:57",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89807_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1186%2Fs12885-015-1021-7"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1021-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1021-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1021-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1021-7'
This table displays all metadata directly associated to this object as RDF triples.
409 TRIPLES
21 PREDICATES
108 URIs
38 LITERALS
26 BLANK NODES