Prognostic factors and treatment outcomes in patients with Small Bowel Adenocarcinoma (SBA): The Royal Marsden Hospital (RMH) experience View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-01-21

AUTHORS

Khurum Khan, Clare Peckitt, Francesco Sclafani, David Watkins, Sheela Rao, Naureen Starling, Vikram Jain, Sachin Trivedi, Susannah Stanway, David Cunningham, Ian Chau

ABSTRACT

BackgroundSBA is a rare tumour which carries a poor prognosis. Very few data on prognostic factors and treatment outcomes are available. We conducted a retrospective analysis of patients treated for SBA at our institution.MethodsClinico-pathological characteristics, treatments and outcomes of all the SBA patients treated consecutively from 1996 to 2011 were retrospectively collected. The prognostic value of baseline factors was assessed using the Cox regression model. The Kaplan-Meier method was used to estimate the survival outcomes.ResultsEighty-four patients with SBA were treated during the study period. Of these, 48 presented with early stage SBA, while 36 had unresectable disease. All early stage SBA patients (58.3% males; median age, 59 years) underwent resection (R0 in 44/48) and 27 (56%) received adjuvant chemotherapy. Median relapse-free survival and overall survival (OS) were 31.1 months (95% CI: 8.0-54.3) and 42.9 (95% CI: 0–94.9), respectively. In univariate analyses, poor histological differentiation (p = 0.025) and lymphovascular invasion (p = 0.003) were prognostic for OS. In the group of patients with relapsed, unresectable or metastatic disease (n = 59), systemic chemotherapy was administered in 46 cases (78%). The response rate to first line chemotherapy was 50%. Median progression-free survival and OS were 8.8 (95% CI: 5.5-12.3) and 12.8 months (95% CI: 8.4-17.2), respectively. In univariate analyses, low albumin (p = 0.041) and high platelet count (p = 0.007) were prognostic for OS.ConclusionProspective clinical trials are needed to inform the management of SBA patients. Prognostic factors evaluated in our series may be useful for patient stratification and treatment selection in future studies. More... »

PAGES

15

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12885-015-1014-6

DOI

http://dx.doi.org/10.1186/s12885-015-1014-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050565223

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25603878


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestine, Small", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK", 
          "id": "http://www.grid.ac/institutes/grid.5072.0", 
          "name": [
            "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khan", 
        "givenName": "Khurum", 
        "id": "sg:person.01124306174.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124306174.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK", 
          "id": "http://www.grid.ac/institutes/grid.5072.0", 
          "name": [
            "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peckitt", 
        "givenName": "Clare", 
        "id": "sg:person.01332410360.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332410360.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK", 
          "id": "http://www.grid.ac/institutes/grid.5072.0", 
          "name": [
            "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sclafani", 
        "givenName": "Francesco", 
        "id": "sg:person.0653217174.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653217174.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK", 
          "id": "http://www.grid.ac/institutes/grid.5072.0", 
          "name": [
            "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watkins", 
        "givenName": "David", 
        "id": "sg:person.0723551231.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723551231.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK", 
          "id": "http://www.grid.ac/institutes/grid.5072.0", 
          "name": [
            "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rao", 
        "givenName": "Sheela", 
        "id": "sg:person.01321127272.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321127272.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK", 
          "id": "http://www.grid.ac/institutes/grid.5072.0", 
          "name": [
            "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Starling", 
        "givenName": "Naureen", 
        "id": "sg:person.01136565472.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136565472.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK", 
          "id": "http://www.grid.ac/institutes/grid.5072.0", 
          "name": [
            "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jain", 
        "givenName": "Vikram", 
        "id": "sg:person.0764143473.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764143473.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK", 
          "id": "http://www.grid.ac/institutes/grid.5072.0", 
          "name": [
            "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trivedi", 
        "givenName": "Sachin", 
        "id": "sg:person.0777741541.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777741541.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK", 
          "id": "http://www.grid.ac/institutes/grid.5072.0", 
          "name": [
            "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stanway", 
        "givenName": "Susannah", 
        "id": "sg:person.01266604502.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266604502.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK", 
          "id": "http://www.grid.ac/institutes/grid.5072.0", 
          "name": [
            "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cunningham", 
        "givenName": "David", 
        "id": "sg:person.01320161130.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320161130.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK", 
          "id": "http://www.grid.ac/institutes/grid.5072.0", 
          "name": [
            "Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chau", 
        "givenName": "Ian", 
        "id": "sg:person.01035560774.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035560774.45"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10120-013-0328-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000268376", 
          "https://doi.org/10.1007/s10120-013-0328-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2013.132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053599458", 
          "https://doi.org/10.1038/nrclinonc.2013.132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2013.677", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013589069", 
          "https://doi.org/10.1038/bjc.2013.677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015493174", 
          "https://doi.org/10.1038/bjc.1998.523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-005-7898-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053678039", 
          "https://doi.org/10.1007/s00268-005-7898-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-007-9428-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010789175", 
          "https://doi.org/10.1245/s10434-007-9428-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-010-1109-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048689631", 
          "https://doi.org/10.1245/s10434-010-1109-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-01-21", 
    "datePublishedReg": "2015-01-21", 
    "description": "BackgroundSBA is a rare tumour which carries a poor prognosis. Very few data on prognostic factors and treatment outcomes are available. We conducted a retrospective analysis of patients treated for SBA at our institution.MethodsClinico-pathological characteristics, treatments and outcomes of all the SBA patients treated consecutively from 1996 to 2011 were retrospectively collected. The prognostic value of baseline factors was assessed using the Cox regression model. The Kaplan-Meier method was used to estimate the survival outcomes.ResultsEighty-four patients with SBA were treated during the study period. Of these, 48 presented with early stage SBA, while 36 had unresectable disease. All early stage SBA patients (58.3% males; median age, 59\u00a0years) underwent resection (R0 in 44/48) and 27 (56%) received adjuvant chemotherapy. Median relapse-free survival and overall survival (OS) were 31.1\u00a0months (95% CI: 8.0-54.3) and 42.9 (95% CI: 0\u201394.9), respectively. In univariate analyses, poor histological differentiation (p\u2009=\u20090.025) and lymphovascular invasion (p\u2009=\u20090.003) were prognostic for OS. In the group of patients with relapsed, unresectable or metastatic disease (n\u2009=\u200959), systemic chemotherapy was administered in 46 cases (78%). The response rate to first line chemotherapy was 50%. Median progression-free survival and OS were 8.8 (95% CI: 5.5-12.3) and 12.8\u00a0months (95% CI: 8.4-17.2), respectively. In univariate analyses, low albumin (p\u2009=\u20090.041) and high platelet count (p\u2009=\u20090.007) were prognostic for OS.ConclusionProspective clinical trials are needed to inform the management of SBA patients. Prognostic factors evaluated in our series may be useful for patient stratification and treatment selection in future studies.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12885-015-1014-6", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024632", 
        "issn": [
          "1471-2407"
        ], 
        "name": "BMC Cancer", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "keywords": [
      "small bowel adenocarcinoma", 
      "overall survival", 
      "prognostic factors", 
      "SBA patients", 
      "univariate analysis", 
      "treatment outcomes", 
      "early-stage small bowel adenocarcinoma", 
      "median progression-free survival", 
      "Royal Marsden Hospital experience", 
      "median relapse-free survival", 
      "ResultsEighty-four patients", 
      "first-line chemotherapy", 
      "progression-free survival", 
      "Kaplan-Meier method", 
      "relapse-free survival", 
      "poor histological differentiation", 
      "group of patients", 
      "Cox regression model", 
      "higher platelet counts", 
      "unresectable disease", 
      "adjuvant chemotherapy", 
      "line chemotherapy", 
      "systemic chemotherapy", 
      "bowel adenocarcinoma", 
      "lymphovascular invasion", 
      "metastatic disease", 
      "baseline factors", 
      "low albumin", 
      "poor prognosis", 
      "prognostic value", 
      "survival outcomes", 
      "platelet count", 
      "rare tumor", 
      "hospital experience", 
      "clinical trials", 
      "retrospective analysis", 
      "histological differentiation", 
      "treatment selection", 
      "patients", 
      "patient stratification", 
      "response rate", 
      "chemotherapy", 
      "study period", 
      "outcomes", 
      "survival", 
      "disease", 
      "months", 
      "regression models", 
      "future studies", 
      "resection", 
      "adenocarcinoma", 
      "prognosis", 
      "factors", 
      "tumors", 
      "trials", 
      "treatment", 
      "invasion", 
      "count", 
      "albumin", 
      "group", 
      "stratification", 
      "differentiation", 
      "management", 
      "period", 
      "cases", 
      "analysis", 
      "study", 
      "rate", 
      "experience", 
      "data", 
      "institutions", 
      "series", 
      "characteristics", 
      "values", 
      "selection", 
      "method", 
      "model"
    ], 
    "name": "Prognostic factors and treatment outcomes in patients with Small Bowel Adenocarcinoma (SBA): The Royal Marsden Hospital (RMH) experience", 
    "pagination": "15", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1050565223"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12885-015-1014-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25603878"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12885-015-1014-6", 
      "https://app.dimensions.ai/details/publication/pub.1050565223"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:41", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_677.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12885-015-1014-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1014-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1014-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1014-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12885-015-1014-6'


 

This table displays all metadata directly associated to this object as RDF triples.

287 TRIPLES      21 PREDICATES      122 URIs      107 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12885-015-1014-6 schema:about N418b7d8c40bc4bf087f95309ea0b57e6
2 N5ad9bbcd086e4360a1da3c05641f0516
3 N5c7a99a12649475e8989a438af3844d8
4 N71a695592ca7449892deec4e6576db91
5 N77fa29509576415bbb89347d036b531a
6 N8b43d1283e33428d8ea9aad809028be7
7 N8d87d51970fb47bdbd5fb903b618f520
8 Na7d4dff0806c4ef38faf8b0d483e63b6
9 Nd72a7c638db146b9abd62ff8d7ac357a
10 Nda44501ca41643d69333b10671f8dc23
11 Ne52b0e1162834f43be1403cbb43ee2a9
12 Ne7f4b235a29848bf9921370acc18fdb3
13 Nfc6cd0cced78485dbe33072c12ecba4c
14 anzsrc-for:11
15 anzsrc-for:1112
16 schema:author Necaf1298c81f48b187d420256ebce17b
17 schema:citation sg:pub.10.1007/s00268-005-7898-6
18 sg:pub.10.1007/s10120-013-0328-9
19 sg:pub.10.1038/bjc.1998.523
20 sg:pub.10.1038/bjc.2013.677
21 sg:pub.10.1038/nrclinonc.2013.132
22 sg:pub.10.1245/s10434-007-9428-2
23 sg:pub.10.1245/s10434-010-1109-x
24 schema:datePublished 2015-01-21
25 schema:datePublishedReg 2015-01-21
26 schema:description BackgroundSBA is a rare tumour which carries a poor prognosis. Very few data on prognostic factors and treatment outcomes are available. We conducted a retrospective analysis of patients treated for SBA at our institution.MethodsClinico-pathological characteristics, treatments and outcomes of all the SBA patients treated consecutively from 1996 to 2011 were retrospectively collected. The prognostic value of baseline factors was assessed using the Cox regression model. The Kaplan-Meier method was used to estimate the survival outcomes.ResultsEighty-four patients with SBA were treated during the study period. Of these, 48 presented with early stage SBA, while 36 had unresectable disease. All early stage SBA patients (58.3% males; median age, 59 years) underwent resection (R0 in 44/48) and 27 (56%) received adjuvant chemotherapy. Median relapse-free survival and overall survival (OS) were 31.1 months (95% CI: 8.0-54.3) and 42.9 (95% CI: 0–94.9), respectively. In univariate analyses, poor histological differentiation (p = 0.025) and lymphovascular invasion (p = 0.003) were prognostic for OS. In the group of patients with relapsed, unresectable or metastatic disease (n = 59), systemic chemotherapy was administered in 46 cases (78%). The response rate to first line chemotherapy was 50%. Median progression-free survival and OS were 8.8 (95% CI: 5.5-12.3) and 12.8 months (95% CI: 8.4-17.2), respectively. In univariate analyses, low albumin (p = 0.041) and high platelet count (p = 0.007) were prognostic for OS.ConclusionProspective clinical trials are needed to inform the management of SBA patients. Prognostic factors evaluated in our series may be useful for patient stratification and treatment selection in future studies.
27 schema:genre article
28 schema:isAccessibleForFree true
29 schema:isPartOf N8f2237ce59b048a4a95cb0f838e8f5ef
30 Nd5193e929f9547158bd7db933983f9f3
31 sg:journal.1024632
32 schema:keywords Cox regression model
33 Kaplan-Meier method
34 ResultsEighty-four patients
35 Royal Marsden Hospital experience
36 SBA patients
37 adenocarcinoma
38 adjuvant chemotherapy
39 albumin
40 analysis
41 baseline factors
42 bowel adenocarcinoma
43 cases
44 characteristics
45 chemotherapy
46 clinical trials
47 count
48 data
49 differentiation
50 disease
51 early-stage small bowel adenocarcinoma
52 experience
53 factors
54 first-line chemotherapy
55 future studies
56 group
57 group of patients
58 higher platelet counts
59 histological differentiation
60 hospital experience
61 institutions
62 invasion
63 line chemotherapy
64 low albumin
65 lymphovascular invasion
66 management
67 median progression-free survival
68 median relapse-free survival
69 metastatic disease
70 method
71 model
72 months
73 outcomes
74 overall survival
75 patient stratification
76 patients
77 period
78 platelet count
79 poor histological differentiation
80 poor prognosis
81 prognosis
82 prognostic factors
83 prognostic value
84 progression-free survival
85 rare tumor
86 rate
87 regression models
88 relapse-free survival
89 resection
90 response rate
91 retrospective analysis
92 selection
93 series
94 small bowel adenocarcinoma
95 stratification
96 study
97 study period
98 survival
99 survival outcomes
100 systemic chemotherapy
101 treatment
102 treatment outcomes
103 treatment selection
104 trials
105 tumors
106 univariate analysis
107 unresectable disease
108 values
109 schema:name Prognostic factors and treatment outcomes in patients with Small Bowel Adenocarcinoma (SBA): The Royal Marsden Hospital (RMH) experience
110 schema:pagination 15
111 schema:productId N359aae204e87484b89b294b0c8324457
112 N86d70803717e42839197b372471b4bab
113 Na295fdea608b4c5f81d46cf1b2a288e5
114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050565223
115 https://doi.org/10.1186/s12885-015-1014-6
116 schema:sdDatePublished 2022-10-01T06:41
117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
118 schema:sdPublisher N235a3911d4ec4b07bb2e1760988c1b7b
119 schema:url https://doi.org/10.1186/s12885-015-1014-6
120 sgo:license sg:explorer/license/
121 sgo:sdDataset articles
122 rdf:type schema:ScholarlyArticle
123 N12a6b6d865994fbb96e03572006fd2d2 rdf:first sg:person.0653217174.51
124 rdf:rest N2fb32eed48f949cfa2769f156b29f7b3
125 N175f9364728e46ad8b9aab5e9932b961 rdf:first sg:person.0764143473.94
126 rdf:rest N819164cf3ee54a68ac8e669b96e371c7
127 N235a3911d4ec4b07bb2e1760988c1b7b schema:name Springer Nature - SN SciGraph project
128 rdf:type schema:Organization
129 N2fb32eed48f949cfa2769f156b29f7b3 rdf:first sg:person.0723551231.39
130 rdf:rest Na9a481a2c2e0428991d5e729f901c54f
131 N359aae204e87484b89b294b0c8324457 schema:name doi
132 schema:value 10.1186/s12885-015-1014-6
133 rdf:type schema:PropertyValue
134 N40567187129f414da8da1673f105be9f rdf:first sg:person.01136565472.17
135 rdf:rest N175f9364728e46ad8b9aab5e9932b961
136 N418b7d8c40bc4bf087f95309ea0b57e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Treatment Outcome
138 rdf:type schema:DefinedTerm
139 N5ad9bbcd086e4360a1da3c05641f0516 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Prognosis
141 rdf:type schema:DefinedTerm
142 N5c7a99a12649475e8989a438af3844d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Middle Aged
144 rdf:type schema:DefinedTerm
145 N6f39736799f045ee82b7eb874204c62a rdf:first sg:person.01035560774.45
146 rdf:rest rdf:nil
147 N71a695592ca7449892deec4e6576db91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Female
149 rdf:type schema:DefinedTerm
150 N77fa29509576415bbb89347d036b531a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Aged
152 rdf:type schema:DefinedTerm
153 N79376ae1bbdc4c218670669376e5ba7b rdf:first sg:person.01320161130.16
154 rdf:rest N6f39736799f045ee82b7eb874204c62a
155 N819164cf3ee54a68ac8e669b96e371c7 rdf:first sg:person.0777741541.71
156 rdf:rest Nc88874c85ff547dc8ef2f4e56fd01979
157 N86d70803717e42839197b372471b4bab schema:name pubmed_id
158 schema:value 25603878
159 rdf:type schema:PropertyValue
160 N8b43d1283e33428d8ea9aad809028be7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Aged, 80 and over
162 rdf:type schema:DefinedTerm
163 N8d87d51970fb47bdbd5fb903b618f520 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Adult
165 rdf:type schema:DefinedTerm
166 N8f2237ce59b048a4a95cb0f838e8f5ef schema:volumeNumber 15
167 rdf:type schema:PublicationVolume
168 Na295fdea608b4c5f81d46cf1b2a288e5 schema:name dimensions_id
169 schema:value pub.1050565223
170 rdf:type schema:PropertyValue
171 Na7d4dff0806c4ef38faf8b0d483e63b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Disease-Free Survival
173 rdf:type schema:DefinedTerm
174 Na9a481a2c2e0428991d5e729f901c54f rdf:first sg:person.01321127272.55
175 rdf:rest N40567187129f414da8da1673f105be9f
176 Nbec63e54cb9a48bcba833fb8bb4bde1d rdf:first sg:person.01332410360.78
177 rdf:rest N12a6b6d865994fbb96e03572006fd2d2
178 Nc88874c85ff547dc8ef2f4e56fd01979 rdf:first sg:person.01266604502.96
179 rdf:rest N79376ae1bbdc4c218670669376e5ba7b
180 Nd5193e929f9547158bd7db933983f9f3 schema:issueNumber 1
181 rdf:type schema:PublicationIssue
182 Nd72a7c638db146b9abd62ff8d7ac357a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Male
184 rdf:type schema:DefinedTerm
185 Nda44501ca41643d69333b10671f8dc23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Neoplasm Recurrence, Local
187 rdf:type schema:DefinedTerm
188 Ne52b0e1162834f43be1403cbb43ee2a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Adenocarcinoma
190 rdf:type schema:DefinedTerm
191 Ne7f4b235a29848bf9921370acc18fdb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Intestine, Small
193 rdf:type schema:DefinedTerm
194 Necaf1298c81f48b187d420256ebce17b rdf:first sg:person.01124306174.74
195 rdf:rest Nbec63e54cb9a48bcba833fb8bb4bde1d
196 Nfc6cd0cced78485dbe33072c12ecba4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Humans
198 rdf:type schema:DefinedTerm
199 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
200 schema:name Medical and Health Sciences
201 rdf:type schema:DefinedTerm
202 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
203 schema:name Oncology and Carcinogenesis
204 rdf:type schema:DefinedTerm
205 sg:journal.1024632 schema:issn 1471-2407
206 schema:name BMC Cancer
207 schema:publisher Springer Nature
208 rdf:type schema:Periodical
209 sg:person.01035560774.45 schema:affiliation grid-institutes:grid.5072.0
210 schema:familyName Chau
211 schema:givenName Ian
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035560774.45
213 rdf:type schema:Person
214 sg:person.01124306174.74 schema:affiliation grid-institutes:grid.5072.0
215 schema:familyName Khan
216 schema:givenName Khurum
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124306174.74
218 rdf:type schema:Person
219 sg:person.01136565472.17 schema:affiliation grid-institutes:grid.5072.0
220 schema:familyName Starling
221 schema:givenName Naureen
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136565472.17
223 rdf:type schema:Person
224 sg:person.01266604502.96 schema:affiliation grid-institutes:grid.5072.0
225 schema:familyName Stanway
226 schema:givenName Susannah
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266604502.96
228 rdf:type schema:Person
229 sg:person.01320161130.16 schema:affiliation grid-institutes:grid.5072.0
230 schema:familyName Cunningham
231 schema:givenName David
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320161130.16
233 rdf:type schema:Person
234 sg:person.01321127272.55 schema:affiliation grid-institutes:grid.5072.0
235 schema:familyName Rao
236 schema:givenName Sheela
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321127272.55
238 rdf:type schema:Person
239 sg:person.01332410360.78 schema:affiliation grid-institutes:grid.5072.0
240 schema:familyName Peckitt
241 schema:givenName Clare
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332410360.78
243 rdf:type schema:Person
244 sg:person.0653217174.51 schema:affiliation grid-institutes:grid.5072.0
245 schema:familyName Sclafani
246 schema:givenName Francesco
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653217174.51
248 rdf:type schema:Person
249 sg:person.0723551231.39 schema:affiliation grid-institutes:grid.5072.0
250 schema:familyName Watkins
251 schema:givenName David
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723551231.39
253 rdf:type schema:Person
254 sg:person.0764143473.94 schema:affiliation grid-institutes:grid.5072.0
255 schema:familyName Jain
256 schema:givenName Vikram
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764143473.94
258 rdf:type schema:Person
259 sg:person.0777741541.71 schema:affiliation grid-institutes:grid.5072.0
260 schema:familyName Trivedi
261 schema:givenName Sachin
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777741541.71
263 rdf:type schema:Person
264 sg:pub.10.1007/s00268-005-7898-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053678039
265 https://doi.org/10.1007/s00268-005-7898-6
266 rdf:type schema:CreativeWork
267 sg:pub.10.1007/s10120-013-0328-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000268376
268 https://doi.org/10.1007/s10120-013-0328-9
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/bjc.1998.523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015493174
271 https://doi.org/10.1038/bjc.1998.523
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/bjc.2013.677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013589069
274 https://doi.org/10.1038/bjc.2013.677
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/nrclinonc.2013.132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053599458
277 https://doi.org/10.1038/nrclinonc.2013.132
278 rdf:type schema:CreativeWork
279 sg:pub.10.1245/s10434-007-9428-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010789175
280 https://doi.org/10.1245/s10434-007-9428-2
281 rdf:type schema:CreativeWork
282 sg:pub.10.1245/s10434-010-1109-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048689631
283 https://doi.org/10.1245/s10434-010-1109-x
284 rdf:type schema:CreativeWork
285 grid-institutes:grid.5072.0 schema:alternateName Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK
286 schema:name Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK
287 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...