No association between early antiretroviral therapy during pregnancy and plasma levels of angiogenic factors: a cohort study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12-09

AUTHORS

Ameyo Djeha, Sylvie Girard, Helen Trottier, Fatima Kakkar, Hugo Soudeyns, Marc Boucher, Normand Lapointe, Isabelle Boucoiran

ABSTRACT

BackgroundEarly antiretroviral therapy (ART) during pregnancy has dramatically reduced the risk of perinatal HIV transmission. However, studies have shown an association between premature delivery and the use of ART during pregnancy (particularly protease inhibitor (PI)-based therapies), which could be explained by placental dysfunction. The objective of this study was to evaluate the association of ART (class, duration of exposure and time of initiation) with placental function by using angiogenic factors placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) as biomarkers.MethodsClinical and biological data from 159 pregnant women living with HIV were analyzed. Levels of each biomarker were measured in the first and second trimester of pregnancy. After logarithmic transformation, we compared these using generalized estimating equations according to (a) the type of ART; (b) the duration of exposure to ART; and (c) the time of initiation of ART.ResultsAfter adjusting for variables such as ethnicity, maternal age, gestational age, body mass index, parity, smoking status, and sex of the fetus, we found no significant association between the class of ART (PI-based or not) and serum concentrations of PlGF or sFlt-1. Furthermore, no significant association was found between biomarker levels and the duration of ART exposure or the timing of ART initiation (pre- or post-conception).ConclusionsThis study suggests that first and second trimester angiogenic factor levels are not significantly associated with ART, regardless of the duration or type (with or without PI). These observations seem reassuring when considering the use of ART during early pregnancy. More... »

PAGES

482

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12884-019-2600-4

DOI

http://dx.doi.org/10.1186/s12884-019-2600-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1123243339

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31815612


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