Assessing the sensitivity of placental growth factor and soluble fms-like tyrosine kinase 1 at 36 weeks’ gestation to predict small-for-gestational-age ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Teresa M. MacDonald, Chuong Tran, Tu’uhevaha J. Kaitu’u-Lino, Shaun P. Brennecke, Richard J. Hiscock, Lisa Hui, Kirsten M. Dane, Anna L. Middleton, Ping Cannon, Susan P. Walker, Stephen Tong

ABSTRACT

BACKGROUND: Fetal growth restriction is a disorder of placental dysfunction with three to four-fold increased risk of stillbirth. Fetal growth restriction has pathophysiological features in common with preeclampsia. We hypothesised that angiogenesis-related factors in maternal plasma, known to predict preeclampsia, may also detect fetal growth restriction at 36 weeks' gestation. We therefore set out to determine the diagnostic performance of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), and the sFlt-1:PlGF ratio, measured at 36 weeks' gestation, in identifying women who subsequently give birth to small-for-gestational-age (SGA; birthweight <10th centile) infants. We also aimed to validate the predictive performance of the analytes for late-onset preeclampsia in a large independent, prospective cohort. METHODS: A nested 1:2 case-control study was performed including 102 cases of SGA infants and a matched group of 207 controls; and 39 cases of preeclampsia. We determined the diagnostic performance of each angiogenesis-related factor, and of their ratio, to detect SGA infants or preeclampsia, for a predetermined 10% false positive rate. RESULTS: Median plasma levels of PlGF at 36 weeks' gestation were significantly lower in women who subsequently had SGA newborns (178.5 pg/ml) compared to normal birthweight controls (326.7 pg/ml, p < 0.0001). sFlt-1 was also higher among SGA cases, but this was not significant after women with concurrent preeclampsia were excluded. The sensitivity of PlGF to predict SGA infants was 28.8% for a 10% false positive rate. The sFlt-1:PlGF ratio demonstrated better sensitivity for preeclampsia than either analyte alone, detecting 69.2% of cases for a 10% false positive rate. CONCLUSIONS: Plasma PlGF at 36 weeks' gestation is significantly lower in women who subsequently deliver a SGA infant. While the sensitivity and specificity of PlGF currently limit clinical translation, our findings support a blood-based biomarker approach to detect late-onset fetal growth restriction. Thirty-six week sFlt-1:PlGF ratio predicts 69.2% of preeclampsia cases, and could be a useful screening test to triage antenatal surveillance. More... »

PAGES

354

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12884-018-1992-x

DOI

http://dx.doi.org/10.1186/s12884-018-1992-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106473653

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30170567


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Mercy Perinatal, Mercy Hospital for Women, Melbourne, VIC, Australia", 
            "Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, Australia", 
            "Translational Obstetrics Group, University of Melbourne, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "MacDonald", 
        "givenName": "Teresa M.", 
        "id": "sg:person.01006203245.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006203245.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416107.5", 
          "name": [
            "Department of Laboratory Services, Royal Children\u2019s Hospital, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tran", 
        "givenName": "Chuong", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, Australia", 
            "Translational Obstetrics Group, University of Melbourne, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaitu\u2019u-Lino", 
        "givenName": "Tu\u2019uhevaha J.", 
        "id": "sg:person.010661646727.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010661646727.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Women's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416259.d", 
          "name": [
            "Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, Australia", 
            "Department of Maternal-Fetal Medicine, Royal Women\u2019s Hospital, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brennecke", 
        "givenName": "Shaun P.", 
        "id": "sg:person.01313042233.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313042233.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hiscock", 
        "givenName": "Richard J.", 
        "id": "sg:person.0641761076.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641761076.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Mercy Perinatal, Mercy Hospital for Women, Melbourne, VIC, Australia", 
            "Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, Australia", 
            "Translational Obstetrics Group, University of Melbourne, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hui", 
        "givenName": "Lisa", 
        "id": "sg:person.0744452031.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744452031.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mercy Hospital for Women", 
          "id": "https://www.grid.ac/institutes/grid.415379.d", 
          "name": [
            "Mercy Perinatal, Mercy Hospital for Women, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dane", 
        "givenName": "Kirsten M.", 
        "id": "sg:person.011322466441.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011322466441.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Mercy Perinatal, Mercy Hospital for Women, Melbourne, VIC, Australia", 
            "Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Middleton", 
        "givenName": "Anna L.", 
        "id": "sg:person.014463316137.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014463316137.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, Australia", 
            "Translational Obstetrics Group, University of Melbourne, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cannon", 
        "givenName": "Ping", 
        "id": "sg:person.01165375165.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165375165.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Mercy Perinatal, Mercy Hospital for Women, Melbourne, VIC, Australia", 
            "Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, Australia", 
            "Translational Obstetrics Group, University of Melbourne, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walker", 
        "givenName": "Susan P.", 
        "id": "sg:person.011223274152.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011223274152.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Mercy Perinatal, Mercy Hospital for Women, Melbourne, VIC, Australia", 
            "Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, Australia", 
            "Translational Obstetrics Group, University of Melbourne, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tong", 
        "givenName": "Stephen", 
        "id": "sg:person.01062512710.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062512710.58"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmoa1414838", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003676622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/jpm-2013-0074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005479049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(15)00131-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006259325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1479-828x.2007.00742.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006940026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2016.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009444493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2016.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009444493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(10)62306-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010215547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/01443615.2011.567343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011057822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/uog.14862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011485742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.f6564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011841321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/jpm-2016-0178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011877952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2393-13-110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012581037", 
          "https://doi.org/10.1186/1471-2393-13-110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajog.2016.06.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013594640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/uog.15884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014640807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00404-016-4024-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015162672", 
          "https://doi.org/10.1007/s00404-016-4024-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20060161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016604869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20060161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016604869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/uog.17393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016635563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jech-2012-202141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016689945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/uog.5184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017982324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/uog.3930", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020916305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.25789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024679004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aog.0000000000000367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024925693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aog.0000000000000367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024925693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2288-12-166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026108652", 
          "https://doi.org/10.1186/1471-2288-12-166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajog.2006.01.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029555088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00097.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030584495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.aog.0000265804.09161.0d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033726786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.aog.0000265804.09161.0d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033726786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.semperi.2009.02.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036796598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.f108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038887725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/01443615.2013.834304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040355100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/14767050701830480", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040852896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.b2255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043580098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000440650", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043742789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajog.2011.07.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044267477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2014.03.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046137925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gyobfe.2015.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048480906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(10)62233-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048592080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/uog.15879", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050869444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajog.2009.04.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052381523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/14767058.2010.516285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052509596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077591483", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.116.08620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083687651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.116.08620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083687651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2352-4642(18)30129-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104908297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2352-4642(18)30129-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104908297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2352-4642(18)30129-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104908297"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Fetal growth restriction is a disorder of placental dysfunction with three to four-fold increased risk of stillbirth. Fetal growth restriction has pathophysiological features in common with preeclampsia. We hypothesised that angiogenesis-related factors in maternal plasma, known to predict preeclampsia, may also detect fetal growth restriction at 36\u00a0weeks' gestation. We therefore set out to determine the diagnostic performance of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), and the sFlt-1:PlGF ratio, measured at 36\u00a0weeks' gestation, in identifying women who subsequently give birth to small-for-gestational-age (SGA; birthweight <10th centile) infants. We also aimed to validate the predictive performance of the analytes for late-onset preeclampsia in a large independent, prospective cohort.\nMETHODS: A nested 1:2 case-control study was performed including 102 cases of SGA infants and a matched group of 207 controls; and 39 cases of preeclampsia. We determined the diagnostic performance of each angiogenesis-related factor, and of their ratio, to detect SGA infants or preeclampsia, for a predetermined 10% false positive rate.\nRESULTS: Median plasma levels of PlGF at 36\u00a0weeks' gestation were significantly lower in women who subsequently had SGA newborns (178.5\u00a0pg/ml) compared to normal birthweight controls (326.7\u00a0pg/ml, p\u2009<\u20090.0001). sFlt-1 was also higher among SGA cases, but this was not significant after women with concurrent preeclampsia were excluded. The sensitivity of PlGF to predict SGA infants was 28.8% for a 10% false positive rate. The sFlt-1:PlGF ratio demonstrated better sensitivity for preeclampsia than either analyte alone, detecting 69.2% of cases for a 10% false positive rate.\nCONCLUSIONS: Plasma PlGF at 36\u00a0weeks' gestation is significantly lower in women who subsequently deliver a SGA infant. While the sensitivity and specificity of PlGF currently limit clinical translation, our findings support a blood-based biomarker approach to detect late-onset fetal growth restriction. Thirty-six\u00a0week sFlt-1:PlGF ratio predicts 69.2% of preeclampsia cases, and could be a useful screening test to triage antenatal surveillance.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12884-018-1992-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6728439", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6721329", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024631", 
        "issn": [
          "1471-2393"
        ], 
        "name": "BMC Pregnancy and Childbirth", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Assessing the sensitivity of placental growth factor and soluble fms-like tyrosine kinase 1 at 36 weeks\u2019 gestation to predict small-for-gestational-age infants or late-onset preeclampsia: a prospective nested case-control study", 
    "pagination": "354", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fd54c5b9ebfb2d0d097c57c750c6d072a0b670559172f527b85d3a3f5dfde21b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30170567"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967799"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12884-018-1992-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1106473653"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12884-018-1992-x", 
      "https://app.dimensions.ai/details/publication/pub.1106473653"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000572.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12884-018-1992-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12884-018-1992-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12884-018-1992-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12884-018-1992-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12884-018-1992-x'


 

This table displays all metadata directly associated to this object as RDF triples.

278 TRIPLES      21 PREDICATES      70 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12884-018-1992-x schema:about anzsrc-for:11
2 anzsrc-for:1114
3 schema:author N83d5de2955074146bab7e6ed30dca730
4 schema:citation sg:pub.10.1007/s00404-016-4024-y
5 sg:pub.10.1186/1471-2288-12-166
6 sg:pub.10.1186/1471-2393-13-110
7 https://app.dimensions.ai/details/publication/pub.1077591483
8 https://doi.org/10.1002/jcb.25789
9 https://doi.org/10.1002/uog.14862
10 https://doi.org/10.1002/uog.15879
11 https://doi.org/10.1002/uog.15884
12 https://doi.org/10.1002/uog.17393
13 https://doi.org/10.1002/uog.3930
14 https://doi.org/10.1002/uog.5184
15 https://doi.org/10.1016/j.ajog.2006.01.014
16 https://doi.org/10.1016/j.ajog.2009.04.034
17 https://doi.org/10.1016/j.ajog.2011.07.037
18 https://doi.org/10.1016/j.ajog.2016.06.043
19 https://doi.org/10.1016/j.gyobfe.2015.11.005
20 https://doi.org/10.1016/j.placenta.2014.03.021
21 https://doi.org/10.1016/j.placenta.2016.03.010
22 https://doi.org/10.1016/s0140-6736(10)62233-7
23 https://doi.org/10.1016/s0140-6736(10)62306-9
24 https://doi.org/10.1016/s0140-6736(15)00131-2
25 https://doi.org/10.1016/s2352-4642(18)30129-9
26 https://doi.org/10.1042/cs20060161
27 https://doi.org/10.1053/j.semperi.2009.02.010
28 https://doi.org/10.1056/nejmoa1414838
29 https://doi.org/10.1080/14767050701830480
30 https://doi.org/10.1097/01.aog.0000265804.09161.0d
31 https://doi.org/10.1097/aog.0000000000000367
32 https://doi.org/10.1111/j.1479-828x.2007.00742.x
33 https://doi.org/10.1136/bmj.b2255
34 https://doi.org/10.1136/bmj.f108
35 https://doi.org/10.1136/bmj.f6564
36 https://doi.org/10.1136/jech-2012-202141
37 https://doi.org/10.1152/ajpregu.00097.2007
38 https://doi.org/10.1159/000440650
39 https://doi.org/10.1161/hypertensionaha.116.08620
40 https://doi.org/10.1515/jpm-2013-0074
41 https://doi.org/10.1515/jpm-2016-0178
42 https://doi.org/10.3109/01443615.2011.567343
43 https://doi.org/10.3109/01443615.2013.834304
44 https://doi.org/10.3109/14767058.2010.516285
45 schema:datePublished 2018-12
46 schema:datePublishedReg 2018-12-01
47 schema:description BACKGROUND: Fetal growth restriction is a disorder of placental dysfunction with three to four-fold increased risk of stillbirth. Fetal growth restriction has pathophysiological features in common with preeclampsia. We hypothesised that angiogenesis-related factors in maternal plasma, known to predict preeclampsia, may also detect fetal growth restriction at 36 weeks' gestation. We therefore set out to determine the diagnostic performance of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), and the sFlt-1:PlGF ratio, measured at 36 weeks' gestation, in identifying women who subsequently give birth to small-for-gestational-age (SGA; birthweight <10th centile) infants. We also aimed to validate the predictive performance of the analytes for late-onset preeclampsia in a large independent, prospective cohort. METHODS: A nested 1:2 case-control study was performed including 102 cases of SGA infants and a matched group of 207 controls; and 39 cases of preeclampsia. We determined the diagnostic performance of each angiogenesis-related factor, and of their ratio, to detect SGA infants or preeclampsia, for a predetermined 10% false positive rate. RESULTS: Median plasma levels of PlGF at 36 weeks' gestation were significantly lower in women who subsequently had SGA newborns (178.5 pg/ml) compared to normal birthweight controls (326.7 pg/ml, p < 0.0001). sFlt-1 was also higher among SGA cases, but this was not significant after women with concurrent preeclampsia were excluded. The sensitivity of PlGF to predict SGA infants was 28.8% for a 10% false positive rate. The sFlt-1:PlGF ratio demonstrated better sensitivity for preeclampsia than either analyte alone, detecting 69.2% of cases for a 10% false positive rate. CONCLUSIONS: Plasma PlGF at 36 weeks' gestation is significantly lower in women who subsequently deliver a SGA infant. While the sensitivity and specificity of PlGF currently limit clinical translation, our findings support a blood-based biomarker approach to detect late-onset fetal growth restriction. Thirty-six week sFlt-1:PlGF ratio predicts 69.2% of preeclampsia cases, and could be a useful screening test to triage antenatal surveillance.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree true
51 schema:isPartOf N2d7e35a330804abb87326b3b21dd2ef7
52 N48be96ea475a4c64a124349599bbc037
53 sg:journal.1024631
54 schema:name Assessing the sensitivity of placental growth factor and soluble fms-like tyrosine kinase 1 at 36 weeks’ gestation to predict small-for-gestational-age infants or late-onset preeclampsia: a prospective nested case-control study
55 schema:pagination 354
56 schema:productId N3f87a9cbb3d940489b41ba8c6551c953
57 N57d8b32425e94cad8b169390239d96cb
58 N5e7c0e1de94d42568fc9babd4d7eac88
59 N902d32b8b4864793964e0b2870f6a288
60 Nb87c4761e5954d6da202c68242366ea3
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106473653
62 https://doi.org/10.1186/s12884-018-1992-x
63 schema:sdDatePublished 2019-04-10T20:55
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher N4a3587ad06674f8fbeeea37ed4ff463b
66 schema:url https://link.springer.com/10.1186%2Fs12884-018-1992-x
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N2d7e35a330804abb87326b3b21dd2ef7 schema:volumeNumber 18
71 rdf:type schema:PublicationVolume
72 N3320c72162a94e95a4ee548ead2a26ad rdf:first sg:person.01165375165.15
73 rdf:rest N5c6ab6708e5c4f2e9a0db3f04b1ca8ae
74 N3f87a9cbb3d940489b41ba8c6551c953 schema:name doi
75 schema:value 10.1186/s12884-018-1992-x
76 rdf:type schema:PropertyValue
77 N48be96ea475a4c64a124349599bbc037 schema:issueNumber 1
78 rdf:type schema:PublicationIssue
79 N4a3587ad06674f8fbeeea37ed4ff463b schema:name Springer Nature - SN SciGraph project
80 rdf:type schema:Organization
81 N57d8b32425e94cad8b169390239d96cb schema:name dimensions_id
82 schema:value pub.1106473653
83 rdf:type schema:PropertyValue
84 N5c6ab6708e5c4f2e9a0db3f04b1ca8ae rdf:first sg:person.011223274152.85
85 rdf:rest Nd790e0626347461a84b531d981596fd5
86 N5e7c0e1de94d42568fc9babd4d7eac88 schema:name nlm_unique_id
87 schema:value 100967799
88 rdf:type schema:PropertyValue
89 N611062d08d5345cdb18e051d06ca0a9b rdf:first sg:person.010661646727.91
90 rdf:rest N9a056e3b1974470594cf08f783e83608
91 N642cab38bd184784864fece64de8cd9b rdf:first sg:person.0641761076.39
92 rdf:rest N9b51511efa134ccd9c420f98a8b4dcf5
93 N83d5de2955074146bab7e6ed30dca730 rdf:first sg:person.01006203245.68
94 rdf:rest Nca806f2b4ab3468b8ae169c201be9e15
95 N868f7075fde94cdb8fa7ebdfcdeee5ec schema:affiliation https://www.grid.ac/institutes/grid.416107.5
96 schema:familyName Tran
97 schema:givenName Chuong
98 rdf:type schema:Person
99 N902d32b8b4864793964e0b2870f6a288 schema:name pubmed_id
100 schema:value 30170567
101 rdf:type schema:PropertyValue
102 N9a056e3b1974470594cf08f783e83608 rdf:first sg:person.01313042233.96
103 rdf:rest N642cab38bd184784864fece64de8cd9b
104 N9b51511efa134ccd9c420f98a8b4dcf5 rdf:first sg:person.0744452031.14
105 rdf:rest Ncdfa792581d14917a8d9f3e562fa98fd
106 Na8f933f0203346bb8ecf7b31d441621a rdf:first sg:person.014463316137.77
107 rdf:rest N3320c72162a94e95a4ee548ead2a26ad
108 Nb87c4761e5954d6da202c68242366ea3 schema:name readcube_id
109 schema:value fd54c5b9ebfb2d0d097c57c750c6d072a0b670559172f527b85d3a3f5dfde21b
110 rdf:type schema:PropertyValue
111 Nca806f2b4ab3468b8ae169c201be9e15 rdf:first N868f7075fde94cdb8fa7ebdfcdeee5ec
112 rdf:rest N611062d08d5345cdb18e051d06ca0a9b
113 Ncdfa792581d14917a8d9f3e562fa98fd rdf:first sg:person.011322466441.99
114 rdf:rest Na8f933f0203346bb8ecf7b31d441621a
115 Nd790e0626347461a84b531d981596fd5 rdf:first sg:person.01062512710.58
116 rdf:rest rdf:nil
117 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
118 schema:name Medical and Health Sciences
119 rdf:type schema:DefinedTerm
120 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
121 schema:name Paediatrics and Reproductive Medicine
122 rdf:type schema:DefinedTerm
123 sg:grant.6721329 http://pending.schema.org/fundedItem sg:pub.10.1186/s12884-018-1992-x
124 rdf:type schema:MonetaryGrant
125 sg:grant.6728439 http://pending.schema.org/fundedItem sg:pub.10.1186/s12884-018-1992-x
126 rdf:type schema:MonetaryGrant
127 sg:journal.1024631 schema:issn 1471-2393
128 schema:name BMC Pregnancy and Childbirth
129 rdf:type schema:Periodical
130 sg:person.01006203245.68 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
131 schema:familyName MacDonald
132 schema:givenName Teresa M.
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006203245.68
134 rdf:type schema:Person
135 sg:person.01062512710.58 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
136 schema:familyName Tong
137 schema:givenName Stephen
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062512710.58
139 rdf:type schema:Person
140 sg:person.010661646727.91 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
141 schema:familyName Kaitu’u-Lino
142 schema:givenName Tu’uhevaha J.
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010661646727.91
144 rdf:type schema:Person
145 sg:person.011223274152.85 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
146 schema:familyName Walker
147 schema:givenName Susan P.
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011223274152.85
149 rdf:type schema:Person
150 sg:person.011322466441.99 schema:affiliation https://www.grid.ac/institutes/grid.415379.d
151 schema:familyName Dane
152 schema:givenName Kirsten M.
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011322466441.99
154 rdf:type schema:Person
155 sg:person.01165375165.15 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
156 schema:familyName Cannon
157 schema:givenName Ping
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165375165.15
159 rdf:type schema:Person
160 sg:person.01313042233.96 schema:affiliation https://www.grid.ac/institutes/grid.416259.d
161 schema:familyName Brennecke
162 schema:givenName Shaun P.
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313042233.96
164 rdf:type schema:Person
165 sg:person.014463316137.77 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
166 schema:familyName Middleton
167 schema:givenName Anna L.
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014463316137.77
169 rdf:type schema:Person
170 sg:person.0641761076.39 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
171 schema:familyName Hiscock
172 schema:givenName Richard J.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641761076.39
174 rdf:type schema:Person
175 sg:person.0744452031.14 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
176 schema:familyName Hui
177 schema:givenName Lisa
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744452031.14
179 rdf:type schema:Person
180 sg:pub.10.1007/s00404-016-4024-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1015162672
181 https://doi.org/10.1007/s00404-016-4024-y
182 rdf:type schema:CreativeWork
183 sg:pub.10.1186/1471-2288-12-166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026108652
184 https://doi.org/10.1186/1471-2288-12-166
185 rdf:type schema:CreativeWork
186 sg:pub.10.1186/1471-2393-13-110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012581037
187 https://doi.org/10.1186/1471-2393-13-110
188 rdf:type schema:CreativeWork
189 https://app.dimensions.ai/details/publication/pub.1077591483 schema:CreativeWork
190 https://doi.org/10.1002/jcb.25789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024679004
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1002/uog.14862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011485742
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1002/uog.15879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050869444
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1002/uog.15884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014640807
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1002/uog.17393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016635563
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1002/uog.3930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020916305
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1002/uog.5184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017982324
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.ajog.2006.01.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029555088
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.ajog.2009.04.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052381523
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.ajog.2011.07.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044267477
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.ajog.2016.06.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013594640
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.gyobfe.2015.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048480906
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.placenta.2014.03.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046137925
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.placenta.2016.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009444493
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/s0140-6736(10)62233-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048592080
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/s0140-6736(10)62306-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010215547
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/s0140-6736(15)00131-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006259325
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/s2352-4642(18)30129-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104908297
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1042/cs20060161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016604869
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1053/j.semperi.2009.02.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036796598
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1056/nejmoa1414838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003676622
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1080/14767050701830480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040852896
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1097/01.aog.0000265804.09161.0d schema:sameAs https://app.dimensions.ai/details/publication/pub.1033726786
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1097/aog.0000000000000367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024925693
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1111/j.1479-828x.2007.00742.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006940026
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1136/bmj.b2255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043580098
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1136/bmj.f108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038887725
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1136/bmj.f6564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011841321
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1136/jech-2012-202141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016689945
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1152/ajpregu.00097.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030584495
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1159/000440650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043742789
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1161/hypertensionaha.116.08620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083687651
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1515/jpm-2013-0074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005479049
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1515/jpm-2016-0178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011877952
257 rdf:type schema:CreativeWork
258 https://doi.org/10.3109/01443615.2011.567343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011057822
259 rdf:type schema:CreativeWork
260 https://doi.org/10.3109/01443615.2013.834304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040355100
261 rdf:type schema:CreativeWork
262 https://doi.org/10.3109/14767058.2010.516285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052509596
263 rdf:type schema:CreativeWork
264 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
265 schema:name Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, Australia
266 Mercy Perinatal, Mercy Hospital for Women, Melbourne, VIC, Australia
267 Translational Obstetrics Group, University of Melbourne, Melbourne, VIC, Australia
268 rdf:type schema:Organization
269 https://www.grid.ac/institutes/grid.415379.d schema:alternateName Mercy Hospital for Women
270 schema:name Mercy Perinatal, Mercy Hospital for Women, Melbourne, VIC, Australia
271 rdf:type schema:Organization
272 https://www.grid.ac/institutes/grid.416107.5 schema:alternateName Royal Children's Hospital
273 schema:name Department of Laboratory Services, Royal Children’s Hospital, Melbourne, VIC, Australia
274 rdf:type schema:Organization
275 https://www.grid.ac/institutes/grid.416259.d schema:alternateName Royal Women's Hospital
276 schema:name Department of Maternal-Fetal Medicine, Royal Women’s Hospital, Melbourne, VIC, Australia
277 Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, Australia
278 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...