STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): an international consortium of randomised placebo-controlled trials View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12-28

AUTHORS

A. Pels, L. C. Kenny, Z. Alfirevic, P. N. Baker, Peter von Dadelszen, C. Gluud, C. T. Kariya, B. W. Mol, A. T. Papageorghiou, A. G. van Wassenaer-Leemhuis, W. Ganzevoort, K. M. Groom, the international STRIDER Consortium

ABSTRACT

BackgroundSevere, early-onset fetal growth restriction due to placental insufficiency is associated with a high risk of perinatal mortality and morbidity with long-lasting sequelae. Placental insufficiency is the result of abnormal formation and function of the placenta with inadequate remodelling of the maternal spiral arteries. There is currently no effective therapy available. Some evidence suggests sildenafil citrate may improve uteroplacental blood flow, fetal growth, and meaningful infant outcomes. The objective of the Sildenafil TheRapy In Dismal prognosis Early onset fetal growth Restriction (STRIDER) collaboration is to evaluate the effectiveness of sildenafil versus placebo in achieving healthy perinatal survival through the conduct of randomised clinical trials and systematic review including individual patient data meta-analysis.MethodsFive national/bi-national multicentre randomised placebo-controlled trials have been launched. Women with a singleton pregnancy between 18 and 30 weeks with severe fetal growth restriction of likely placental origin, and where the likelihood of perinatal death/severe morbidity is estimated to be significant are included. Participants will receive either sildenafil 25 mg or matching placebo tablets orally three times daily from recruitment to 32 weeks gestation.DiscussionThe STRIDER trials were conceived and designed through international collaboration. Although the individual trials have different primary outcomes for reasons of sample size and feasibility, all trials will collect a standard set of outcomes including survival without severe neonatal morbidity at time of hospital discharge. This is a summary of all the STRIDER trial protocols and provides an example of a prospectively planned international clinical research collaboration. All five individual trials will contribute to a pre-planned systematic review of the topic including individual patient data meta-analysis.Trial registrationsNew Zealand and Australia: ACTRN12612000584831. Registered 30/05/2012.Canada: NCT02442492. Registered 05/05/2015.Ireland: CT 900/572/1. Registered 15/07/2015.The Netherlands: NCT02277132. Registered 29/09/2014.United Kingdom: ISRCTN39133303. Registered 31/07/2014. More... »

PAGES

440

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12884-017-1594-z

DOI

http://dx.doi.org/10.1186/s12884-017-1594-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100091870

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29282009


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Australia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Canada", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clinical Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fetal Growth Retardation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gestational Age", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "International Cooperation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ireland", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Netherlands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "New Zealand", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sildenafil Citrate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "United Kingdom", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vasodilator Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Academisch Medisch Centrum, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.5650.6", 
          "name": [
            "Academisch Medisch Centrum, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pels", 
        "givenName": "A.", 
        "id": "sg:person.01056041276.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056041276.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College Cork, Cork, Ireland", 
          "id": "http://www.grid.ac/institutes/grid.7872.a", 
          "name": [
            "University College Cork, Cork, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kenny", 
        "givenName": "L. C.", 
        "id": "sg:person.0702354555.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702354555.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Liverpool, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "University of Liverpool, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alfirevic", 
        "givenName": "Z.", 
        "id": "sg:person.01042617755.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042617755.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "College of Life Sciences, University of Leicester, Leicester, UK", 
          "id": "http://www.grid.ac/institutes/grid.9918.9", 
          "name": [
            "College of Life Sciences, University of Leicester, Leicester, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baker", 
        "givenName": "P. N.", 
        "id": "sg:person.01111505377.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111505377.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Women\u2019s and Children\u2019s Health, School of Life Course Sciences, King\u2019s College London, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Department of Women\u2019s and Children\u2019s Health, School of Life Course Sciences, King\u2019s College London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "von Dadelszen", 
        "givenName": "Peter", 
        "id": "sg:person.0707426565.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707426565.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark", 
          "id": "http://www.grid.ac/institutes/grid.475435.4", 
          "name": [
            "Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gluud", 
        "givenName": "C.", 
        "id": "sg:person.01320367256.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320367256.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Women\u2019s and Children\u2019s Health, School of Life Course Sciences, King\u2019s College London, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Department of Women\u2019s and Children\u2019s Health, School of Life Course Sciences, King\u2019s College London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kariya", 
        "givenName": "C. T.", 
        "id": "sg:person.0631322522.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631322522.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Robinson Research Institute, School of Paediatrics and Reproductive Health, University of Adelaide, 5000, Adelaide, SA, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1010.0", 
          "name": [
            "The Robinson Research Institute, School of Paediatrics and Reproductive Health, University of Adelaide, 5000, Adelaide, SA, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mol", 
        "givenName": "B. W.", 
        "id": "sg:person.016116520377.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016116520377.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford, Oxford, UK", 
          "id": "http://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "University of Oxford, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Papageorghiou", 
        "givenName": "A. T.", 
        "id": "sg:person.01145573564.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145573564.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academisch Medisch Centrum, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.5650.6", 
          "name": [
            "Academisch Medisch Centrum, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Wassenaer-Leemhuis", 
        "givenName": "A. G.", 
        "id": "sg:person.0631503406.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631503406.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academisch Medisch Centrum, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.5650.6", 
          "name": [
            "Academisch Medisch Centrum, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ganzevoort", 
        "givenName": "W.", 
        "id": "sg:person.014174620120.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014174620120.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Auckland, Auckland, New Zealand", 
          "id": "http://www.grid.ac/institutes/grid.9654.e", 
          "name": [
            "University of Auckland, Auckland, New Zealand"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Groom", 
        "givenName": "K. M.", 
        "id": "sg:person.0725574322.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725574322.56"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "the international STRIDER Consortium", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/2046-4053-3-23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004779506", 
          "https://doi.org/10.1186/2046-4053-3-23"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.4076/1752-1947-3-7255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010379149", 
          "https://doi.org/10.4076/1752-1947-3-7255"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12-28", 
    "datePublishedReg": "2017-12-28", 
    "description": "BackgroundSevere, early-onset fetal growth restriction due to placental insufficiency is associated with a high risk of perinatal mortality and morbidity with long-lasting sequelae. Placental insufficiency is the result of abnormal formation and function of the placenta with inadequate remodelling of the maternal spiral arteries. There is currently no effective therapy available. Some evidence suggests sildenafil citrate may improve uteroplacental blood flow, fetal growth, and meaningful infant outcomes. The objective of the Sildenafil TheRapy In Dismal prognosis Early onset fetal growth Restriction (STRIDER) collaboration is to evaluate the effectiveness of sildenafil versus placebo in achieving healthy perinatal survival through the conduct of randomised clinical trials and systematic review including individual patient data meta-analysis.MethodsFive national/bi-national multicentre randomised placebo-controlled trials have been launched. Women with a singleton pregnancy between 18 and 30\u00a0weeks with severe fetal growth restriction of likely placental origin, and where the likelihood of perinatal death/severe morbidity is estimated to be significant are included. Participants will receive either sildenafil 25\u00a0mg or matching placebo tablets orally three times daily from recruitment to 32\u00a0weeks gestation.DiscussionThe STRIDER trials were conceived and designed through international collaboration. Although the individual trials have different primary outcomes for reasons of sample size and feasibility, all trials will collect a standard set of outcomes including survival without severe neonatal morbidity at time of hospital discharge. This is a summary of all the STRIDER trial protocols and provides an example of a prospectively planned international clinical research collaboration. All five individual trials will contribute to a pre-planned systematic review of the topic including individual patient data meta-analysis.Trial registrationsNew Zealand and Australia: ACTRN12612000584831. Registered 30/05/2012.Canada: NCT02442492. Registered 05/05/2015.Ireland: CT 900/572/1. Registered 15/07/2015.The Netherlands: NCT02277132. Registered 29/09/2014.United Kingdom: ISRCTN39133303. Registered 31/07/2014.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12884-017-1594-z", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.9712258", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024631", 
        "issn": [
          "1471-2393"
        ], 
        "name": "BMC Pregnancy and Childbirth", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "keywords": [
      "placebo-controlled trial", 
      "fetal growth restriction", 
      "individual patient data", 
      "placental insufficiency", 
      "growth restriction", 
      "early-onset fetal growth restriction", 
      "systematic review", 
      "severe fetal growth restriction", 
      "patient data", 
      "severe neonatal morbidity", 
      "uteroplacental blood flow", 
      "individual trials", 
      "maternal spiral arteries", 
      "different primary outcomes", 
      "Clinical Research Collaboration", 
      "inadequate remodelling", 
      "sildenafil therapy", 
      "neonatal morbidity", 
      "singleton pregnancies", 
      "hospital discharge", 
      "perinatal mortality", 
      "severe morbidity", 
      "weeks' gestation", 
      "primary outcome", 
      "spiral arteries", 
      "infant outcomes", 
      "placebo tablets", 
      "fetal growth", 
      "perinatal survival", 
      "effective therapy", 
      "clinical trials", 
      "placental origin", 
      "high risk", 
      "blood flow", 
      "morbidity", 
      "trials", 
      "abnormal formation", 
      "therapy", 
      "insufficiency", 
      "outcomes", 
      "survival", 
      "sample size", 
      "BackgroundSevere", 
      "multicentre", 
      "placebo", 
      "sequelae", 
      "pregnancy", 
      "artery", 
      "review", 
      "gestation", 
      "International Consortium", 
      "mortality", 
      "placenta", 
      "weeks", 
      "women", 
      "remodelling", 
      "risk", 
      "participants", 
      "international collaboration", 
      "restriction", 
      "recruitment", 
      "evidence", 
      "tablets", 
      "citrate", 
      "data", 
      "discharge", 
      "likelihood", 
      "summary", 
      "time", 
      "research collaboration", 
      "collaboration", 
      "standard set", 
      "Netherlands", 
      "objective", 
      "function", 
      "feasibility", 
      "consortium", 
      "reasons", 
      "effectiveness", 
      "origin", 
      "Kingdom", 
      "results", 
      "growth", 
      "Australia", 
      "conduct", 
      "Zealand", 
      "size", 
      "formation", 
      "topic", 
      "flow", 
      "set", 
      "example", 
      "striders"
    ], 
    "name": "STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): an international consortium of randomised placebo-controlled trials", 
    "pagination": "440", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100091870"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12884-017-1594-z"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29282009"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12884-017-1594-z", 
      "https://app.dimensions.ai/details/publication/pub.1100091870"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_723.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12884-017-1594-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12884-017-1594-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12884-017-1594-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12884-017-1594-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12884-017-1594-z'


 

This table displays all metadata directly associated to this object as RDF triples.

348 TRIPLES      21 PREDICATES      140 URIs      130 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12884-017-1594-z schema:about N010a2f9e59334338bc94df83693a2c70
2 N1197fc12d3fd4082bdf3a90bbf6fdb92
3 N1456ec6d15f04775ab277b6a84b3379f
4 N31a4ebe055484d90aa42628cd9110346
5 N5835105b9ad74e00a991afa89dd237a4
6 N6370595e57954c1bb94403061a103493
7 N687e98aa8cae4d2d808cc57e02f866e8
8 N6b2e2ef8be214562b3addba87f108a5a
9 N8c4168f1ed4b4b3aa6ecf5180d87b051
10 N8d94b7488bc44786b5ae7a5699889cae
11 N8db4a64680304dfb87a58ada7d08a933
12 N995bb1a3478e427b9011589fad7a9af8
13 Nb1b8798f2b184512ae6decc0611a98e5
14 Nb8921e17389a47a6881eb18671bcc3a4
15 Ncb06847bf2054bc4bf0d253c2c577f26
16 Ncf0e6bc4e3eb4f19ae51fb794f0830d2
17 Ndb3feec4926849a4826501d83d3cbf74
18 Ndd3c65e91e984c779fbd01fd4a5096e3
19 Ne6249c308e9644579762fc5abbfbc113
20 Nf5f16012443f46d89225dbe012f3e816
21 anzsrc-for:11
22 anzsrc-for:1114
23 schema:author N698b7b1ee6a94a058703c7568bf4c812
24 schema:citation sg:pub.10.1186/2046-4053-3-23
25 sg:pub.10.4076/1752-1947-3-7255
26 schema:datePublished 2017-12-28
27 schema:datePublishedReg 2017-12-28
28 schema:description BackgroundSevere, early-onset fetal growth restriction due to placental insufficiency is associated with a high risk of perinatal mortality and morbidity with long-lasting sequelae. Placental insufficiency is the result of abnormal formation and function of the placenta with inadequate remodelling of the maternal spiral arteries. There is currently no effective therapy available. Some evidence suggests sildenafil citrate may improve uteroplacental blood flow, fetal growth, and meaningful infant outcomes. The objective of the Sildenafil TheRapy In Dismal prognosis Early onset fetal growth Restriction (STRIDER) collaboration is to evaluate the effectiveness of sildenafil versus placebo in achieving healthy perinatal survival through the conduct of randomised clinical trials and systematic review including individual patient data meta-analysis.MethodsFive national/bi-national multicentre randomised placebo-controlled trials have been launched. Women with a singleton pregnancy between 18 and 30 weeks with severe fetal growth restriction of likely placental origin, and where the likelihood of perinatal death/severe morbidity is estimated to be significant are included. Participants will receive either sildenafil 25 mg or matching placebo tablets orally three times daily from recruitment to 32 weeks gestation.DiscussionThe STRIDER trials were conceived and designed through international collaboration. Although the individual trials have different primary outcomes for reasons of sample size and feasibility, all trials will collect a standard set of outcomes including survival without severe neonatal morbidity at time of hospital discharge. This is a summary of all the STRIDER trial protocols and provides an example of a prospectively planned international clinical research collaboration. All five individual trials will contribute to a pre-planned systematic review of the topic including individual patient data meta-analysis.Trial registrationsNew Zealand and Australia: ACTRN12612000584831. Registered 30/05/2012.Canada: NCT02442492. Registered 05/05/2015.Ireland: CT 900/572/1. Registered 15/07/2015.The Netherlands: NCT02277132. Registered 29/09/2014.United Kingdom: ISRCTN39133303. Registered 31/07/2014.
29 schema:genre article
30 schema:isAccessibleForFree true
31 schema:isPartOf N3b867b9f2bae4c60bd10595a3c46645a
32 N97ee802f6a8842db849ade5da56fd493
33 sg:journal.1024631
34 schema:keywords Australia
35 BackgroundSevere
36 Clinical Research Collaboration
37 International Consortium
38 Kingdom
39 Netherlands
40 Zealand
41 abnormal formation
42 artery
43 blood flow
44 citrate
45 clinical trials
46 collaboration
47 conduct
48 consortium
49 data
50 different primary outcomes
51 discharge
52 early-onset fetal growth restriction
53 effective therapy
54 effectiveness
55 evidence
56 example
57 feasibility
58 fetal growth
59 fetal growth restriction
60 flow
61 formation
62 function
63 gestation
64 growth
65 growth restriction
66 high risk
67 hospital discharge
68 inadequate remodelling
69 individual patient data
70 individual trials
71 infant outcomes
72 insufficiency
73 international collaboration
74 likelihood
75 maternal spiral arteries
76 morbidity
77 mortality
78 multicentre
79 neonatal morbidity
80 objective
81 origin
82 outcomes
83 participants
84 patient data
85 perinatal mortality
86 perinatal survival
87 placebo
88 placebo tablets
89 placebo-controlled trial
90 placenta
91 placental insufficiency
92 placental origin
93 pregnancy
94 primary outcome
95 reasons
96 recruitment
97 remodelling
98 research collaboration
99 restriction
100 results
101 review
102 risk
103 sample size
104 sequelae
105 set
106 severe fetal growth restriction
107 severe morbidity
108 severe neonatal morbidity
109 sildenafil therapy
110 singleton pregnancies
111 size
112 spiral arteries
113 standard set
114 striders
115 summary
116 survival
117 systematic review
118 tablets
119 therapy
120 time
121 topic
122 trials
123 uteroplacental blood flow
124 weeks
125 weeks' gestation
126 women
127 schema:name STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): an international consortium of randomised placebo-controlled trials
128 schema:pagination 440
129 schema:productId N0d357df4f17a4693bb646fefc59b024c
130 N41296a8030f847fcac92a9613abcb3d0
131 N5510b740b35f4134a22e5340e5f1d1cc
132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100091870
133 https://doi.org/10.1186/s12884-017-1594-z
134 schema:sdDatePublished 2022-12-01T06:35
135 schema:sdLicense https://scigraph.springernature.com/explorer/license/
136 schema:sdPublisher N8ffc573237f64e3cbb2b5d64eeecc036
137 schema:url https://doi.org/10.1186/s12884-017-1594-z
138 sgo:license sg:explorer/license/
139 sgo:sdDataset articles
140 rdf:type schema:ScholarlyArticle
141 N010a2f9e59334338bc94df83693a2c70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Sildenafil Citrate
143 rdf:type schema:DefinedTerm
144 N0b3cdfef707c483e9aa44d6db2aea171 schema:familyName the international STRIDER Consortium
145 rdf:type schema:Person
146 N0d357df4f17a4693bb646fefc59b024c schema:name doi
147 schema:value 10.1186/s12884-017-1594-z
148 rdf:type schema:PropertyValue
149 N1197fc12d3fd4082bdf3a90bbf6fdb92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Canada
151 rdf:type schema:DefinedTerm
152 N1456ec6d15f04775ab277b6a84b3379f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Prognosis
154 rdf:type schema:DefinedTerm
155 N1479af8e4e994c999198ecd9ed7cefdf rdf:first sg:person.0631503406.18
156 rdf:rest Nebed27f055ae435a90a8b154d4226a67
157 N29cc36fca82d433eb584f26b6b07f784 rdf:first sg:person.0631322522.19
158 rdf:rest Naaf1964cef7847f698029f25add86982
159 N2c127b07cbfa4dabadd223ef55bc138f rdf:first sg:person.01042617755.32
160 rdf:rest Ncf7af3e33ad847d5b0d93f6af271acee
161 N31a4ebe055484d90aa42628cd9110346 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Clinical Protocols
163 rdf:type schema:DefinedTerm
164 N3b867b9f2bae4c60bd10595a3c46645a schema:volumeNumber 17
165 rdf:type schema:PublicationVolume
166 N41296a8030f847fcac92a9613abcb3d0 schema:name dimensions_id
167 schema:value pub.1100091870
168 rdf:type schema:PropertyValue
169 N45ff860e9b1645cdb2e8bf5a374502d0 rdf:first sg:person.0702354555.62
170 rdf:rest N2c127b07cbfa4dabadd223ef55bc138f
171 N52ed4adfa6724ff3af93d43f86effcec rdf:first sg:person.0707426565.93
172 rdf:rest Na726da820a144481886aaea4f5b42d77
173 N5510b740b35f4134a22e5340e5f1d1cc schema:name pubmed_id
174 schema:value 29282009
175 rdf:type schema:PropertyValue
176 N5835105b9ad74e00a991afa89dd237a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Fetal Growth Retardation
178 rdf:type schema:DefinedTerm
179 N6022d46128da4455b982a1f566c6bbff rdf:first N0b3cdfef707c483e9aa44d6db2aea171
180 rdf:rest rdf:nil
181 N6370595e57954c1bb94403061a103493 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Adult
183 rdf:type schema:DefinedTerm
184 N687e98aa8cae4d2d808cc57e02f866e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Vasodilator Agents
186 rdf:type schema:DefinedTerm
187 N698b7b1ee6a94a058703c7568bf4c812 rdf:first sg:person.01056041276.56
188 rdf:rest N45ff860e9b1645cdb2e8bf5a374502d0
189 N6b2e2ef8be214562b3addba87f108a5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Treatment Outcome
191 rdf:type schema:DefinedTerm
192 N8c4168f1ed4b4b3aa6ecf5180d87b051 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Female
194 rdf:type schema:DefinedTerm
195 N8d94b7488bc44786b5ae7a5699889cae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Pregnancy Outcome
197 rdf:type schema:DefinedTerm
198 N8db4a64680304dfb87a58ada7d08a933 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Ireland
200 rdf:type schema:DefinedTerm
201 N8ffc573237f64e3cbb2b5d64eeecc036 schema:name Springer Nature - SN SciGraph project
202 rdf:type schema:Organization
203 N97ee802f6a8842db849ade5da56fd493 schema:issueNumber 1
204 rdf:type schema:PublicationIssue
205 N995bb1a3478e427b9011589fad7a9af8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Humans
207 rdf:type schema:DefinedTerm
208 Na207efcc8f1a46a9bb0be4f427883de5 rdf:first sg:person.01145573564.53
209 rdf:rest N1479af8e4e994c999198ecd9ed7cefdf
210 Na61c11dce2f44d75ac2d60e24a852ad9 rdf:first sg:person.0725574322.56
211 rdf:rest N6022d46128da4455b982a1f566c6bbff
212 Na726da820a144481886aaea4f5b42d77 rdf:first sg:person.01320367256.32
213 rdf:rest N29cc36fca82d433eb584f26b6b07f784
214 Naaf1964cef7847f698029f25add86982 rdf:first sg:person.016116520377.99
215 rdf:rest Na207efcc8f1a46a9bb0be4f427883de5
216 Nb1b8798f2b184512ae6decc0611a98e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name International Cooperation
218 rdf:type schema:DefinedTerm
219 Nb8921e17389a47a6881eb18671bcc3a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Netherlands
221 rdf:type schema:DefinedTerm
222 Ncb06847bf2054bc4bf0d253c2c577f26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name United Kingdom
224 rdf:type schema:DefinedTerm
225 Ncf0e6bc4e3eb4f19ae51fb794f0830d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
226 schema:name Gestational Age
227 rdf:type schema:DefinedTerm
228 Ncf7af3e33ad847d5b0d93f6af271acee rdf:first sg:person.01111505377.31
229 rdf:rest N52ed4adfa6724ff3af93d43f86effcec
230 Ndb3feec4926849a4826501d83d3cbf74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
231 schema:name Young Adult
232 rdf:type schema:DefinedTerm
233 Ndd3c65e91e984c779fbd01fd4a5096e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
234 schema:name Pregnancy
235 rdf:type schema:DefinedTerm
236 Ne6249c308e9644579762fc5abbfbc113 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
237 schema:name New Zealand
238 rdf:type schema:DefinedTerm
239 Nebed27f055ae435a90a8b154d4226a67 rdf:first sg:person.014174620120.59
240 rdf:rest Na61c11dce2f44d75ac2d60e24a852ad9
241 Nf5f16012443f46d89225dbe012f3e816 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
242 schema:name Australia
243 rdf:type schema:DefinedTerm
244 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
245 schema:name Medical and Health Sciences
246 rdf:type schema:DefinedTerm
247 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
248 schema:name Paediatrics and Reproductive Medicine
249 rdf:type schema:DefinedTerm
250 sg:grant.9712258 http://pending.schema.org/fundedItem sg:pub.10.1186/s12884-017-1594-z
251 rdf:type schema:MonetaryGrant
252 sg:journal.1024631 schema:issn 1471-2393
253 schema:name BMC Pregnancy and Childbirth
254 schema:publisher Springer Nature
255 rdf:type schema:Periodical
256 sg:person.01042617755.32 schema:affiliation grid-institutes:grid.10025.36
257 schema:familyName Alfirevic
258 schema:givenName Z.
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042617755.32
260 rdf:type schema:Person
261 sg:person.01056041276.56 schema:affiliation grid-institutes:grid.5650.6
262 schema:familyName Pels
263 schema:givenName A.
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056041276.56
265 rdf:type schema:Person
266 sg:person.01111505377.31 schema:affiliation grid-institutes:grid.9918.9
267 schema:familyName Baker
268 schema:givenName P. N.
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111505377.31
270 rdf:type schema:Person
271 sg:person.01145573564.53 schema:affiliation grid-institutes:grid.4991.5
272 schema:familyName Papageorghiou
273 schema:givenName A. T.
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145573564.53
275 rdf:type schema:Person
276 sg:person.01320367256.32 schema:affiliation grid-institutes:grid.475435.4
277 schema:familyName Gluud
278 schema:givenName C.
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320367256.32
280 rdf:type schema:Person
281 sg:person.014174620120.59 schema:affiliation grid-institutes:grid.5650.6
282 schema:familyName Ganzevoort
283 schema:givenName W.
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014174620120.59
285 rdf:type schema:Person
286 sg:person.016116520377.99 schema:affiliation grid-institutes:grid.1010.0
287 schema:familyName Mol
288 schema:givenName B. W.
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016116520377.99
290 rdf:type schema:Person
291 sg:person.0631322522.19 schema:affiliation grid-institutes:grid.13097.3c
292 schema:familyName Kariya
293 schema:givenName C. T.
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631322522.19
295 rdf:type schema:Person
296 sg:person.0631503406.18 schema:affiliation grid-institutes:grid.5650.6
297 schema:familyName van Wassenaer-Leemhuis
298 schema:givenName A. G.
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631503406.18
300 rdf:type schema:Person
301 sg:person.0702354555.62 schema:affiliation grid-institutes:grid.7872.a
302 schema:familyName Kenny
303 schema:givenName L. C.
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702354555.62
305 rdf:type schema:Person
306 sg:person.0707426565.93 schema:affiliation grid-institutes:grid.13097.3c
307 schema:familyName von Dadelszen
308 schema:givenName Peter
309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707426565.93
310 rdf:type schema:Person
311 sg:person.0725574322.56 schema:affiliation grid-institutes:grid.9654.e
312 schema:familyName Groom
313 schema:givenName K. M.
314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725574322.56
315 rdf:type schema:Person
316 sg:pub.10.1186/2046-4053-3-23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004779506
317 https://doi.org/10.1186/2046-4053-3-23
318 rdf:type schema:CreativeWork
319 sg:pub.10.4076/1752-1947-3-7255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010379149
320 https://doi.org/10.4076/1752-1947-3-7255
321 rdf:type schema:CreativeWork
322 grid-institutes:grid.10025.36 schema:alternateName University of Liverpool, Liverpool, UK
323 schema:name University of Liverpool, Liverpool, UK
324 rdf:type schema:Organization
325 grid-institutes:grid.1010.0 schema:alternateName The Robinson Research Institute, School of Paediatrics and Reproductive Health, University of Adelaide, 5000, Adelaide, SA, Australia
326 schema:name The Robinson Research Institute, School of Paediatrics and Reproductive Health, University of Adelaide, 5000, Adelaide, SA, Australia
327 rdf:type schema:Organization
328 grid-institutes:grid.13097.3c schema:alternateName Department of Women’s and Children’s Health, School of Life Course Sciences, King’s College London, London, UK
329 schema:name Department of Women’s and Children’s Health, School of Life Course Sciences, King’s College London, London, UK
330 rdf:type schema:Organization
331 grid-institutes:grid.475435.4 schema:alternateName Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
332 schema:name Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
333 rdf:type schema:Organization
334 grid-institutes:grid.4991.5 schema:alternateName University of Oxford, Oxford, UK
335 schema:name University of Oxford, Oxford, UK
336 rdf:type schema:Organization
337 grid-institutes:grid.5650.6 schema:alternateName Academisch Medisch Centrum, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands
338 schema:name Academisch Medisch Centrum, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands
339 rdf:type schema:Organization
340 grid-institutes:grid.7872.a schema:alternateName University College Cork, Cork, Ireland
341 schema:name University College Cork, Cork, Ireland
342 rdf:type schema:Organization
343 grid-institutes:grid.9654.e schema:alternateName University of Auckland, Auckland, New Zealand
344 schema:name University of Auckland, Auckland, New Zealand
345 rdf:type schema:Organization
346 grid-institutes:grid.9918.9 schema:alternateName College of Life Sciences, University of Leicester, Leicester, UK
347 schema:name College of Life Sciences, University of Leicester, Leicester, UK
348 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...