High serum levels of tissue inhibitor of matrix metalloproteinase-1 during the first week of a malignant middle cerebral artery infarction ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-07-18

AUTHORS

Leonardo Lorente, María M. Martín, Luis Ramos, Mónica Argueso, Juan J. Cáceres, Jordi Solé-Violán, Alejandro Jiménez, Juan M. Borreguero-León, Agustín F. González-Rivero, Josune Orbe, José A. Rodríguez, José A. Páramo

ABSTRACT

BackgroundHigher circulating levels of tissue inhibitor of matrix metalloproteinases (TIMP)-1 early after ischemic stroke have been associated with lower survival. The objectives of this study were to determine serum TIMP-1 levels during the first week of a severe cerebral infarction in surviving and non-surviving patients, and whether those levels during the first week could be used as a mortality biomarker for these patients.MethodsWe included patients with severe malignant middle cerebral artery infarction (MMCAI) defined as computer tomography showing ischaemic changes in more than 50% of the middle cerebral artery territory and Glasgow Coma Scale (GCS) ≤ 8. We measured serum levels of matrix metalloproteinases (MMP)-9 and TIMP-1. End-point study was 30-day mortality.ResultsWe found higher TIMP-1 concentrations at days 1 (p < 0.001), 4 (p = 0.001), and 8 (p = 0.03) of MMCAI in non- urviving (n = 34) than in surviving (n = 34) patients. We found lower serum MMP-9 concentrations at day 1 (p = 0.03) of MMCAI and no significant differences at days 4 and 8. ROC curve analysis of TIMP-1 concentrations performed at days 1, 4, and 8 of MMCAI showed an area under curve to predict 30-day mortality of 81% (p < 0.001), 80% (p < 0.001) and 72% (p = 0.07) respectively.ConclusionsThe new findings of our study were that non-surviving MMCAI patients showed higher serum TIMP-1 levels during the first week of MMCAI that surviving patients, and those levels during the first week of MMCAI could be used as mortality biomarkers. More... »

PAGES

167

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12883-019-1401-8

DOI

http://dx.doi.org/10.1186/s12883-019-1401-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1118095046

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31319804


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29 schema:description BackgroundHigher circulating levels of tissue inhibitor of matrix metalloproteinases (TIMP)-1 early after ischemic stroke have been associated with lower survival. The objectives of this study were to determine serum TIMP-1 levels during the first week of a severe cerebral infarction in surviving and non-surviving patients, and whether those levels during the first week could be used as a mortality biomarker for these patients.MethodsWe included patients with severe malignant middle cerebral artery infarction (MMCAI) defined as computer tomography showing ischaemic changes in more than 50% of the middle cerebral artery territory and Glasgow Coma Scale (GCS) ≤ 8. We measured serum levels of matrix metalloproteinases (MMP)-9 and TIMP-1. End-point study was 30-day mortality.ResultsWe found higher TIMP-1 concentrations at days 1 (p < 0.001), 4 (p = 0.001), and 8 (p = 0.03) of MMCAI in non- urviving (n = 34) than in surviving (n = 34) patients. We found lower serum MMP-9 concentrations at day 1 (p = 0.03) of MMCAI and no significant differences at days 4 and 8. ROC curve analysis of TIMP-1 concentrations performed at days 1, 4, and 8 of MMCAI showed an area under curve to predict 30-day mortality of 81% (p < 0.001), 80% (p < 0.001) and 72% (p = 0.07) respectively.ConclusionsThe new findings of our study were that non-surviving MMCAI patients showed higher serum TIMP-1 levels during the first week of MMCAI that surviving patients, and those levels during the first week of MMCAI could be used as mortality biomarkers.
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35 schema:keywords Coma Scale
36 Glasgow Coma Scale
37 MMP-9 concentrations
38 MethodsWe
39 ROC curve analysis
40 ResultsWe
41 TIMP-1
42 TIMP-1 concentrations
43 TIMP-1 levels
44 analysis
45 area
46 artery infarction
47 artery territory
48 biomarkers
49 cerebral artery infarction
50 cerebral infarction
51 changes
52 computer tomography
53 concentration
54 curve analysis
55 curves
56 day 1
57 day 4
58 differences
59 end-point study
60 findings
61 first week
62 higher serum TIMP-1 levels
63 higher serum levels
64 infarction
65 inhibitors
66 ischemic changes
67 ischemic stroke
68 levels
69 lower survival
70 malignant middle cerebral artery infarction
71 matrix metalloproteinase-1
72 matrix metalloproteinases
73 metalloproteinase-1
74 metalloproteinases
75 middle cerebral artery infarction
76 middle cerebral artery territory
77 mortality
78 mortality biomarkers
79 new findings
80 non-surviving patients
81 objective
82 patients
83 scale
84 serum MMP-9 concentration
85 serum TIMP-1 levels
86 serum levels
87 severe cerebral infarction
88 severe malignant middle cerebral artery infarction
89 significant differences
90 stroke
91 study
92 survival
93 territory
94 tissue inhibitor
95 tomography
96 weeks
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