Cilostazol improves endothelial function in acute cerebral ischemia patients: a double-blind placebo controlled trial with flow-mediated dilation technique View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Seong-Joon Lee, Jin Soo Lee, Mun Hee Choi, Sung Eun Lee, Dong Hoon Shin, Ji Man Hong

ABSTRACT

BACKGROUND: In order to evaluate the impact of cilostazol on endothelial function, we compared the changes of flow-mediated dilation (FMD) between aspirin and cilostazol groups in patients with acute cerebral ischemia. METHODS: Patients presenting with acute cerebral ischemic events were randomly assigned into aspirin (n = 40) or cilostazol (n = 40) group in a double-blinded manner. FMD was measured at baseline (T0) and 90 days (T1). We measured L-arginine at baseline (a precursor of biologically active nitric oxides). Serious and non-serious adverse events were described. RESULTS: Despite no difference in the baseline FMD values (p = 0.363), there was a significant increase of FMD values in cilostazol group (7.9 ± 2.4 to 8.9 ± 2.3%, p = 0.001) and not in aspirin group (8.5 ± 2.6 to 9.3 ± 2.8%, p = 0.108). In the multiple regression analysis performed in cilostazol group, serum L-arginine levels were inversely correlated with FMD at T1 (ß = -0.050, SE: 0.012, p < 0.001) with age, total cholesterol levels, and C-reactive protein as confounders. While T0 FMD values in both aspirin and cilostazol groups did not show any correlation with serum L-arginine levels, the correlation is restored in the cilostazol group at T1 (r = 0.467, p = 0.007), while such is not shown in the aspirin group. There was no difference of serious adverse events between the two groups (p = 0.235). Adverse events were more common in the cilostazol group (35/40 vs. 25/40, p = 0.010), due to frequent headaches (14/40 vs. 3/30, p = 0.003) which was well tolerated. CONCLUSION: Cilostazol improved endothelial function in acute cerebral ischemia patients. It also restored an inverse correlation between 3-month FMD and baseline L-arginine levels. TRIAL REGISTRATION: NCT03116269 , 04/12/2017, retrospectively registered. More... »

PAGES

169

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12883-017-0950-y

DOI

http://dx.doi.org/10.1186/s12883-017-0950-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091371041

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28851320


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arginine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aspirin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Ischemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "C-Reactive Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dilatation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Double-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelium, Vascular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tetrazoles", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Ajou University", 
          "id": "https://www.grid.ac/institutes/grid.251916.8", 
          "name": [
            "Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Seong-Joon", 
        "id": "sg:person.0624430642.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624430642.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ajou University", 
          "id": "https://www.grid.ac/institutes/grid.251916.8", 
          "name": [
            "Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jin Soo", 
        "id": "sg:person.01312361012.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312361012.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ajou University", 
          "id": "https://www.grid.ac/institutes/grid.251916.8", 
          "name": [
            "Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Mun Hee", 
        "id": "sg:person.016575447637.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016575447637.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ajou University", 
          "id": "https://www.grid.ac/institutes/grid.251916.8", 
          "name": [
            "Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Sung Eun", 
        "id": "sg:person.07636174157.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07636174157.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gachon University Gil Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411652.5", 
          "name": [
            "Department of Neurology, Gachon University Gil Hospital, Incheon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shin", 
        "givenName": "Dong Hoon", 
        "id": "sg:person.07657670040.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07657670040.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ajou University", 
          "id": "https://www.grid.ac/institutes/grid.251916.8", 
          "name": [
            "Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea", 
            "Department of Neurology, Ajou University School of Medicine, 164, World cup-ro, Yeongtong-gu, 16499, Suwon-si, Gyeonggi-do, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hong", 
        "givenName": "Ji Man", 
        "id": "sg:person.01265626405.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265626405.46"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0021-9150(98)00170-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000061122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000117403.64398.53", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000188595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.37.2.444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002624083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2005.04.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004102061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2005.04.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004102061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pharmthera.2007.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006624547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcu.21972", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008334745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjcard.2003.08.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009264348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.109.892414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010862404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2006.01.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011250022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2013.00111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015988907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000327036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016463772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2003.08.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017304511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0024-3205(01)01258-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017425991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.106.652859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017457392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(92)93147-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018847241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(92)93147-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018847241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9149(00)01001-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019702542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/str.0b013e318284056a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020032012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/str.0b013e318284056a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020032012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-2999(96)00551-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022347291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/362801a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024417120", 
          "https://doi.org/10.1038/362801a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/clc.4960250610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028192303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.98.18.1842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030114723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00380-012-0282-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033533308", 
          "https://doi.org/10.1007/s00380-012-0282-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-8227(00)00235-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034240338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000138400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035138520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci114688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037655139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000157667.06542.b7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038035957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000157667.06542.b7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038035957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5551/jat.10.93", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038460781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(01)07217-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038554710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005344-199212000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047393043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005344-199212000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047393043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000129501.88485.1f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047983395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4250/jcu.2011.19.1.21", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049168500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2008.01.103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049646147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(08)70094-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050662276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5551/jat.32912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052765797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1191/1358863x03vm474oa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064157834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1191/1358863x03vm474oa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064157834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/137.6.1650s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077420336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079476120", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: In order to evaluate the impact of cilostazol on endothelial function, we compared the changes of flow-mediated dilation (FMD) between aspirin and cilostazol groups in patients with acute cerebral ischemia.\nMETHODS: Patients presenting with acute cerebral ischemic events were randomly assigned into aspirin (n\u00a0=\u00a040) or cilostazol (n\u00a0=\u00a040) group in a double-blinded manner. FMD was measured at baseline (T0) and 90\u00a0days (T1). We measured L-arginine at baseline (a precursor of biologically active nitric oxides). Serious and non-serious adverse events were described.\nRESULTS: Despite no difference in the baseline FMD values (p\u00a0=\u00a00.363), there was a significant increase of FMD values in cilostazol group (7.9\u00a0\u00b1\u00a02.4 to 8.9\u00a0\u00b1\u00a02.3%, p\u00a0=\u00a00.001) and not in aspirin group (8.5\u00a0\u00b1\u00a02.6 to 9.3\u00a0\u00b1\u00a02.8%, p\u00a0=\u00a00.108). In the multiple regression analysis performed in cilostazol group, serum L-arginine levels were inversely correlated with FMD at T1 (\u00df\u00a0=\u00a0-0.050, SE: 0.012, p\u00a0<\u00a00.001) with age, total cholesterol levels, and C-reactive protein as confounders. While T0 FMD values in both aspirin and cilostazol groups did not show any correlation with serum L-arginine levels, the correlation is restored in the cilostazol group at T1 (r\u00a0=\u00a00.467, p\u00a0=\u00a00.007), while such is not shown in the aspirin group. There was no difference of serious adverse events between the two groups (p\u00a0=\u00a00.235). Adverse events were more common in the cilostazol group (35/40 vs. 25/40, p\u00a0=\u00a00.010), due to frequent headaches (14/40 vs. 3/30, p\u00a0=\u00a00.003) which was well tolerated.\nCONCLUSION: Cilostazol improved endothelial function in acute cerebral ischemia patients. It also restored an inverse correlation between 3-month FMD and baseline L-arginine levels.\nTRIAL REGISTRATION: NCT03116269 , 04/12/2017, retrospectively registered.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12883-017-0950-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024950", 
        "issn": [
          "1471-2377"
        ], 
        "name": "BMC Neurology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Cilostazol improves endothelial function in acute cerebral ischemia patients: a double-blind placebo controlled trial with flow-mediated dilation technique", 
    "pagination": "169", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "700cda1acc8d339032aefbb0a8781f097c7be6e7e54b6c15298228e63994ccaf"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28851320"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12883-017-0950-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1091371041"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12883-017-0950-y", 
      "https://app.dimensions.ai/details/publication/pub.1091371041"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000484.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186/s12883-017-0950-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12883-017-0950-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12883-017-0950-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12883-017-0950-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12883-017-0950-y'


 

This table displays all metadata directly associated to this object as RDF triples.

279 TRIPLES      21 PREDICATES      81 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12883-017-0950-y schema:about N1c22808a9e004360869a3b137090f2a8
2 N1cddcf05e0824326887e1b474ae9c230
3 N36cff6223cde499dbbf01b4f63e87ba5
4 N3aee8852b16b4074ba16c5db702c7b49
5 N3aef955ebf614adea1613f7af4bc7f26
6 N3b3742f82b7441d78445edadbe2741e9
7 N47f4bbbca07246149941cf0ec04e5e38
8 N56c7ad93a9404182b35076990247976c
9 N643f8890368c4f2588ce950799ad6d4f
10 N90a5478a91f54be19af0066a26e1b32d
11 Na0b73c83064143b88b0fc747aa051f18
12 Na6bea89c491e463aa5dcfe3f8b0680e1
13 Nbcd35aaca6304051a6f9a694a1f21398
14 Ne3a3c6ab10d24f0c878d7d59322a56d7
15 Nec1c15131a8e4197aff1d249a89738ad
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author N6bad5e36bab1445f9ebb1d431455698f
19 schema:citation sg:pub.10.1007/s00380-012-0282-1
20 sg:pub.10.1038/362801a0
21 https://app.dimensions.ai/details/publication/pub.1079476120
22 https://doi.org/10.1002/clc.4960250610
23 https://doi.org/10.1002/jcu.21972
24 https://doi.org/10.1016/0140-6736(92)93147-f
25 https://doi.org/10.1016/j.amjcard.2003.08.013
26 https://doi.org/10.1016/j.atherosclerosis.2003.08.017
27 https://doi.org/10.1016/j.atherosclerosis.2006.01.022
28 https://doi.org/10.1016/j.brainres.2008.01.103
29 https://doi.org/10.1016/j.jacc.2005.04.040
30 https://doi.org/10.1016/j.pharmthera.2007.03.002
31 https://doi.org/10.1016/s0002-9149(00)01001-8
32 https://doi.org/10.1016/s0014-2999(96)00551-1
33 https://doi.org/10.1016/s0021-9150(98)00170-1
34 https://doi.org/10.1016/s0024-3205(01)01258-9
35 https://doi.org/10.1016/s0140-6736(01)07217-8
36 https://doi.org/10.1016/s0168-8227(00)00235-7
37 https://doi.org/10.1016/s1474-4422(08)70094-2
38 https://doi.org/10.1093/jn/137.6.1650s
39 https://doi.org/10.1097/00005344-199212000-00009
40 https://doi.org/10.1159/000138400
41 https://doi.org/10.1159/000327036
42 https://doi.org/10.1161/01.cir.0000117403.64398.53
43 https://doi.org/10.1161/01.cir.0000129501.88485.1f
44 https://doi.org/10.1161/01.cir.98.18.1842
45 https://doi.org/10.1161/01.hyp.37.2.444
46 https://doi.org/10.1161/01.str.0000157667.06542.b7
47 https://doi.org/10.1161/circulationaha.106.652859
48 https://doi.org/10.1161/circulationaha.109.892414
49 https://doi.org/10.1161/str.0b013e318284056a
50 https://doi.org/10.1172/jci114688
51 https://doi.org/10.1191/1358863x03vm474oa
52 https://doi.org/10.3389/fimmu.2013.00111
53 https://doi.org/10.4250/jcu.2011.19.1.21
54 https://doi.org/10.5551/jat.10.93
55 https://doi.org/10.5551/jat.32912
56 schema:datePublished 2017-12
57 schema:datePublishedReg 2017-12-01
58 schema:description BACKGROUND: In order to evaluate the impact of cilostazol on endothelial function, we compared the changes of flow-mediated dilation (FMD) between aspirin and cilostazol groups in patients with acute cerebral ischemia. METHODS: Patients presenting with acute cerebral ischemic events were randomly assigned into aspirin (n = 40) or cilostazol (n = 40) group in a double-blinded manner. FMD was measured at baseline (T0) and 90 days (T1). We measured L-arginine at baseline (a precursor of biologically active nitric oxides). Serious and non-serious adverse events were described. RESULTS: Despite no difference in the baseline FMD values (p = 0.363), there was a significant increase of FMD values in cilostazol group (7.9 ± 2.4 to 8.9 ± 2.3%, p = 0.001) and not in aspirin group (8.5 ± 2.6 to 9.3 ± 2.8%, p = 0.108). In the multiple regression analysis performed in cilostazol group, serum L-arginine levels were inversely correlated with FMD at T1 (ß = -0.050, SE: 0.012, p < 0.001) with age, total cholesterol levels, and C-reactive protein as confounders. While T0 FMD values in both aspirin and cilostazol groups did not show any correlation with serum L-arginine levels, the correlation is restored in the cilostazol group at T1 (r = 0.467, p = 0.007), while such is not shown in the aspirin group. There was no difference of serious adverse events between the two groups (p = 0.235). Adverse events were more common in the cilostazol group (35/40 vs. 25/40, p = 0.010), due to frequent headaches (14/40 vs. 3/30, p = 0.003) which was well tolerated. CONCLUSION: Cilostazol improved endothelial function in acute cerebral ischemia patients. It also restored an inverse correlation between 3-month FMD and baseline L-arginine levels. TRIAL REGISTRATION: NCT03116269 , 04/12/2017, retrospectively registered.
59 schema:genre research_article
60 schema:inLanguage en
61 schema:isAccessibleForFree true
62 schema:isPartOf Nb6ae9824b1584f3cb24daafe6cd05ec4
63 Nb9884e2f1dfe4f95a7b1b68386963c74
64 sg:journal.1024950
65 schema:name Cilostazol improves endothelial function in acute cerebral ischemia patients: a double-blind placebo controlled trial with flow-mediated dilation technique
66 schema:pagination 169
67 schema:productId N08f63559c8cd4c07a2ef51b5ef8b3674
68 N45b2f4046fdb4b14af6e200edbb999a4
69 N5d21702e26424b68b0349de780295807
70 N84b7882da9e7454ebdaaafcb7ca9fb46
71 N8ac47d595ad745bb99f957bb4a496ca1
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091371041
73 https://doi.org/10.1186/s12883-017-0950-y
74 schema:sdDatePublished 2019-04-10T23:18
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher N527f049e901147778616b32106f71a51
77 schema:url http://link.springer.com/10.1186/s12883-017-0950-y
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N08f63559c8cd4c07a2ef51b5ef8b3674 schema:name pubmed_id
82 schema:value 28851320
83 rdf:type schema:PropertyValue
84 N1c22808a9e004360869a3b137090f2a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Arginine
86 rdf:type schema:DefinedTerm
87 N1cddcf05e0824326887e1b474ae9c230 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Adult
89 rdf:type schema:DefinedTerm
90 N1ff722d7c22a413faf3b7d5ea51c5f16 rdf:first sg:person.01265626405.46
91 rdf:rest rdf:nil
92 N36cff6223cde499dbbf01b4f63e87ba5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Dilatation
94 rdf:type schema:DefinedTerm
95 N3aee8852b16b4074ba16c5db702c7b49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Tetrazoles
97 rdf:type schema:DefinedTerm
98 N3aef955ebf614adea1613f7af4bc7f26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Brain Ischemia
100 rdf:type schema:DefinedTerm
101 N3b3742f82b7441d78445edadbe2741e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Humans
103 rdf:type schema:DefinedTerm
104 N45b2f4046fdb4b14af6e200edbb999a4 schema:name doi
105 schema:value 10.1186/s12883-017-0950-y
106 rdf:type schema:PropertyValue
107 N47f4bbbca07246149941cf0ec04e5e38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Female
109 rdf:type schema:DefinedTerm
110 N4a534164620b4683921f9d5a77d868a9 rdf:first sg:person.016575447637.50
111 rdf:rest N6eead8b4c0f7458d9a5bd40354a8c727
112 N502b70d9b31e488a839259513f83afe9 rdf:first sg:person.07657670040.86
113 rdf:rest N1ff722d7c22a413faf3b7d5ea51c5f16
114 N527f049e901147778616b32106f71a51 schema:name Springer Nature - SN SciGraph project
115 rdf:type schema:Organization
116 N56c7ad93a9404182b35076990247976c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Middle Aged
118 rdf:type schema:DefinedTerm
119 N5d21702e26424b68b0349de780295807 schema:name dimensions_id
120 schema:value pub.1091371041
121 rdf:type schema:PropertyValue
122 N643f8890368c4f2588ce950799ad6d4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name C-Reactive Protein
124 rdf:type schema:DefinedTerm
125 N6bad5e36bab1445f9ebb1d431455698f rdf:first sg:person.0624430642.56
126 rdf:rest Nc76234ae1a8a4fcfbb00d26dc85ce1fa
127 N6eead8b4c0f7458d9a5bd40354a8c727 rdf:first sg:person.07636174157.22
128 rdf:rest N502b70d9b31e488a839259513f83afe9
129 N84b7882da9e7454ebdaaafcb7ca9fb46 schema:name readcube_id
130 schema:value 700cda1acc8d339032aefbb0a8781f097c7be6e7e54b6c15298228e63994ccaf
131 rdf:type schema:PropertyValue
132 N8ac47d595ad745bb99f957bb4a496ca1 schema:name nlm_unique_id
133 schema:value 100968555
134 rdf:type schema:PropertyValue
135 N90a5478a91f54be19af0066a26e1b32d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Aged
137 rdf:type schema:DefinedTerm
138 Na0b73c83064143b88b0fc747aa051f18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Male
140 rdf:type schema:DefinedTerm
141 Na6bea89c491e463aa5dcfe3f8b0680e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Double-Blind Method
143 rdf:type schema:DefinedTerm
144 Nb6ae9824b1584f3cb24daafe6cd05ec4 schema:issueNumber 1
145 rdf:type schema:PublicationIssue
146 Nb9884e2f1dfe4f95a7b1b68386963c74 schema:volumeNumber 17
147 rdf:type schema:PublicationVolume
148 Nbcd35aaca6304051a6f9a694a1f21398 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Prospective Studies
150 rdf:type schema:DefinedTerm
151 Nc76234ae1a8a4fcfbb00d26dc85ce1fa rdf:first sg:person.01312361012.35
152 rdf:rest N4a534164620b4683921f9d5a77d868a9
153 Ne3a3c6ab10d24f0c878d7d59322a56d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Endothelium, Vascular
155 rdf:type schema:DefinedTerm
156 Nec1c15131a8e4197aff1d249a89738ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Aspirin
158 rdf:type schema:DefinedTerm
159 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
160 schema:name Medical and Health Sciences
161 rdf:type schema:DefinedTerm
162 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
163 schema:name Clinical Sciences
164 rdf:type schema:DefinedTerm
165 sg:journal.1024950 schema:issn 1471-2377
166 schema:name BMC Neurology
167 rdf:type schema:Periodical
168 sg:person.01265626405.46 schema:affiliation https://www.grid.ac/institutes/grid.251916.8
169 schema:familyName Hong
170 schema:givenName Ji Man
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265626405.46
172 rdf:type schema:Person
173 sg:person.01312361012.35 schema:affiliation https://www.grid.ac/institutes/grid.251916.8
174 schema:familyName Lee
175 schema:givenName Jin Soo
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312361012.35
177 rdf:type schema:Person
178 sg:person.016575447637.50 schema:affiliation https://www.grid.ac/institutes/grid.251916.8
179 schema:familyName Choi
180 schema:givenName Mun Hee
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016575447637.50
182 rdf:type schema:Person
183 sg:person.0624430642.56 schema:affiliation https://www.grid.ac/institutes/grid.251916.8
184 schema:familyName Lee
185 schema:givenName Seong-Joon
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624430642.56
187 rdf:type schema:Person
188 sg:person.07636174157.22 schema:affiliation https://www.grid.ac/institutes/grid.251916.8
189 schema:familyName Lee
190 schema:givenName Sung Eun
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07636174157.22
192 rdf:type schema:Person
193 sg:person.07657670040.86 schema:affiliation https://www.grid.ac/institutes/grid.411652.5
194 schema:familyName Shin
195 schema:givenName Dong Hoon
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07657670040.86
197 rdf:type schema:Person
198 sg:pub.10.1007/s00380-012-0282-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033533308
199 https://doi.org/10.1007/s00380-012-0282-1
200 rdf:type schema:CreativeWork
201 sg:pub.10.1038/362801a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024417120
202 https://doi.org/10.1038/362801a0
203 rdf:type schema:CreativeWork
204 https://app.dimensions.ai/details/publication/pub.1079476120 schema:CreativeWork
205 https://doi.org/10.1002/clc.4960250610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028192303
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1002/jcu.21972 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008334745
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/0140-6736(92)93147-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1018847241
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.amjcard.2003.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009264348
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.atherosclerosis.2003.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017304511
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.atherosclerosis.2006.01.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011250022
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.brainres.2008.01.103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049646147
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.jacc.2005.04.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004102061
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.pharmthera.2007.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006624547
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/s0002-9149(00)01001-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019702542
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/s0014-2999(96)00551-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022347291
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0021-9150(98)00170-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000061122
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0024-3205(01)01258-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017425991
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s0140-6736(01)07217-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038554710
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/s0168-8227(00)00235-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034240338
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/s1474-4422(08)70094-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050662276
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1093/jn/137.6.1650s schema:sameAs https://app.dimensions.ai/details/publication/pub.1077420336
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1097/00005344-199212000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047393043
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1159/000138400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035138520
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1159/000327036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016463772
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1161/01.cir.0000117403.64398.53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000188595
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1161/01.cir.0000129501.88485.1f schema:sameAs https://app.dimensions.ai/details/publication/pub.1047983395
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1161/01.cir.98.18.1842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030114723
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1161/01.hyp.37.2.444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002624083
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1161/01.str.0000157667.06542.b7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038035957
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1161/circulationaha.106.652859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017457392
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1161/circulationaha.109.892414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010862404
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1161/str.0b013e318284056a schema:sameAs https://app.dimensions.ai/details/publication/pub.1020032012
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1172/jci114688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037655139
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1191/1358863x03vm474oa schema:sameAs https://app.dimensions.ai/details/publication/pub.1064157834
264 rdf:type schema:CreativeWork
265 https://doi.org/10.3389/fimmu.2013.00111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015988907
266 rdf:type schema:CreativeWork
267 https://doi.org/10.4250/jcu.2011.19.1.21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049168500
268 rdf:type schema:CreativeWork
269 https://doi.org/10.5551/jat.10.93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038460781
270 rdf:type schema:CreativeWork
271 https://doi.org/10.5551/jat.32912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052765797
272 rdf:type schema:CreativeWork
273 https://www.grid.ac/institutes/grid.251916.8 schema:alternateName Ajou University
274 schema:name Department of Neurology, Ajou University School of Medicine, 164, World cup-ro, Yeongtong-gu, 16499, Suwon-si, Gyeonggi-do, South Korea
275 Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea
276 rdf:type schema:Organization
277 https://www.grid.ac/institutes/grid.411652.5 schema:alternateName Gachon University Gil Hospital
278 schema:name Department of Neurology, Gachon University Gil Hospital, Incheon, Republic of Korea
279 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...