Ontology type: schema:ScholarlyArticle Open Access: True
2017-12
AUTHORSSeong-Joon Lee, Jin Soo Lee, Mun Hee Choi, Sung Eun Lee, Dong Hoon Shin, Ji Man Hong
ABSTRACTBACKGROUND: In order to evaluate the impact of cilostazol on endothelial function, we compared the changes of flow-mediated dilation (FMD) between aspirin and cilostazol groups in patients with acute cerebral ischemia. METHODS: Patients presenting with acute cerebral ischemic events were randomly assigned into aspirin (n = 40) or cilostazol (n = 40) group in a double-blinded manner. FMD was measured at baseline (T0) and 90 days (T1). We measured L-arginine at baseline (a precursor of biologically active nitric oxides). Serious and non-serious adverse events were described. RESULTS: Despite no difference in the baseline FMD values (p = 0.363), there was a significant increase of FMD values in cilostazol group (7.9 ± 2.4 to 8.9 ± 2.3%, p = 0.001) and not in aspirin group (8.5 ± 2.6 to 9.3 ± 2.8%, p = 0.108). In the multiple regression analysis performed in cilostazol group, serum L-arginine levels were inversely correlated with FMD at T1 (ß = -0.050, SE: 0.012, p < 0.001) with age, total cholesterol levels, and C-reactive protein as confounders. While T0 FMD values in both aspirin and cilostazol groups did not show any correlation with serum L-arginine levels, the correlation is restored in the cilostazol group at T1 (r = 0.467, p = 0.007), while such is not shown in the aspirin group. There was no difference of serious adverse events between the two groups (p = 0.235). Adverse events were more common in the cilostazol group (35/40 vs. 25/40, p = 0.010), due to frequent headaches (14/40 vs. 3/30, p = 0.003) which was well tolerated. CONCLUSION: Cilostazol improved endothelial function in acute cerebral ischemia patients. It also restored an inverse correlation between 3-month FMD and baseline L-arginine levels. TRIAL REGISTRATION: NCT03116269 , 04/12/2017, retrospectively registered. More... »
PAGES169
http://scigraph.springernature.com/pub.10.1186/s12883-017-0950-y
DOIhttp://dx.doi.org/10.1186/s12883-017-0950-y
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1091371041
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/28851320
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Arginine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aspirin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Brain Ischemia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "C-Reactive Protein",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dilatation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Double-Blind Method",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Endothelium, Vascular",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tetrazoles",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Ajou University",
"id": "https://www.grid.ac/institutes/grid.251916.8",
"name": [
"Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Seong-Joon",
"id": "sg:person.0624430642.56",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624430642.56"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ajou University",
"id": "https://www.grid.ac/institutes/grid.251916.8",
"name": [
"Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Jin Soo",
"id": "sg:person.01312361012.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312361012.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ajou University",
"id": "https://www.grid.ac/institutes/grid.251916.8",
"name": [
"Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea"
],
"type": "Organization"
},
"familyName": "Choi",
"givenName": "Mun Hee",
"id": "sg:person.016575447637.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016575447637.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ajou University",
"id": "https://www.grid.ac/institutes/grid.251916.8",
"name": [
"Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Sung Eun",
"id": "sg:person.07636174157.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07636174157.22"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Gachon University Gil Hospital",
"id": "https://www.grid.ac/institutes/grid.411652.5",
"name": [
"Department of Neurology, Gachon University Gil Hospital, Incheon, Republic of Korea"
],
"type": "Organization"
},
"familyName": "Shin",
"givenName": "Dong Hoon",
"id": "sg:person.07657670040.86",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07657670040.86"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ajou University",
"id": "https://www.grid.ac/institutes/grid.251916.8",
"name": [
"Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea",
"Department of Neurology, Ajou University School of Medicine, 164, World cup-ro, Yeongtong-gu, 16499, Suwon-si, Gyeonggi-do, South Korea"
],
"type": "Organization"
},
"familyName": "Hong",
"givenName": "Ji Man",
"id": "sg:person.01265626405.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265626405.46"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/s0021-9150(98)00170-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000061122"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.cir.0000117403.64398.53",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000188595"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.hyp.37.2.444",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002624083"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jacc.2005.04.040",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004102061"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jacc.2005.04.040",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004102061"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.pharmthera.2007.03.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006624547"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jcu.21972",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008334745"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.amjcard.2003.08.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009264348"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circulationaha.109.892414",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010862404"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.atherosclerosis.2006.01.022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011250022"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3389/fimmu.2013.00111",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015988907"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000327036",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016463772"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.atherosclerosis.2003.08.017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017304511"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0024-3205(01)01258-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017425991"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circulationaha.106.652859",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017457392"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0140-6736(92)93147-f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018847241"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0140-6736(92)93147-f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018847241"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0002-9149(00)01001-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019702542"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/str.0b013e318284056a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020032012"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/str.0b013e318284056a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020032012"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0014-2999(96)00551-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022347291"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/362801a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024417120",
"https://doi.org/10.1038/362801a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/clc.4960250610",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028192303"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.cir.98.18.1842",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030114723"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00380-012-0282-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033533308",
"https://doi.org/10.1007/s00380-012-0282-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0168-8227(00)00235-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034240338"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000138400",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035138520"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci114688",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037655139"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.str.0000157667.06542.b7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038035957"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.str.0000157667.06542.b7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038035957"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.5551/jat.10.93",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038460781"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(01)07217-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038554710"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00005344-199212000-00009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047393043"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00005344-199212000-00009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047393043"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.cir.0000129501.88485.1f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047983395"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4250/jcu.2011.19.1.21",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049168500"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.brainres.2008.01.103",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049646147"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1474-4422(08)70094-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050662276"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.5551/jat.32912",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052765797"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1191/1358863x03vm474oa",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064157834"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1191/1358863x03vm474oa",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064157834"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jn/137.6.1650s",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077420336"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079476120",
"type": "CreativeWork"
}
],
"datePublished": "2017-12",
"datePublishedReg": "2017-12-01",
"description": "BACKGROUND: In order to evaluate the impact of cilostazol on endothelial function, we compared the changes of flow-mediated dilation (FMD) between aspirin and cilostazol groups in patients with acute cerebral ischemia.\nMETHODS: Patients presenting with acute cerebral ischemic events were randomly assigned into aspirin (n\u00a0=\u00a040) or cilostazol (n\u00a0=\u00a040) group in a double-blinded manner. FMD was measured at baseline (T0) and 90\u00a0days (T1). We measured L-arginine at baseline (a precursor of biologically active nitric oxides). Serious and non-serious adverse events were described.\nRESULTS: Despite no difference in the baseline FMD values (p\u00a0=\u00a00.363), there was a significant increase of FMD values in cilostazol group (7.9\u00a0\u00b1\u00a02.4 to 8.9\u00a0\u00b1\u00a02.3%, p\u00a0=\u00a00.001) and not in aspirin group (8.5\u00a0\u00b1\u00a02.6 to 9.3\u00a0\u00b1\u00a02.8%, p\u00a0=\u00a00.108). In the multiple regression analysis performed in cilostazol group, serum L-arginine levels were inversely correlated with FMD at T1 (\u00df\u00a0=\u00a0-0.050, SE: 0.012, p\u00a0<\u00a00.001) with age, total cholesterol levels, and C-reactive protein as confounders. While T0 FMD values in both aspirin and cilostazol groups did not show any correlation with serum L-arginine levels, the correlation is restored in the cilostazol group at T1 (r\u00a0=\u00a00.467, p\u00a0=\u00a00.007), while such is not shown in the aspirin group. There was no difference of serious adverse events between the two groups (p\u00a0=\u00a00.235). Adverse events were more common in the cilostazol group (35/40 vs. 25/40, p\u00a0=\u00a00.010), due to frequent headaches (14/40 vs. 3/30, p\u00a0=\u00a00.003) which was well tolerated.\nCONCLUSION: Cilostazol improved endothelial function in acute cerebral ischemia patients. It also restored an inverse correlation between 3-month FMD and baseline L-arginine levels.\nTRIAL REGISTRATION: NCT03116269 , 04/12/2017, retrospectively registered.",
"genre": "research_article",
"id": "sg:pub.10.1186/s12883-017-0950-y",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1024950",
"issn": [
"1471-2377"
],
"name": "BMC Neurology",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "17"
}
],
"name": "Cilostazol improves endothelial function in acute cerebral ischemia patients: a double-blind placebo controlled trial with flow-mediated dilation technique",
"pagination": "169",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"700cda1acc8d339032aefbb0a8781f097c7be6e7e54b6c15298228e63994ccaf"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"28851320"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"100968555"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s12883-017-0950-y"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1091371041"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s12883-017-0950-y",
"https://app.dimensions.ai/details/publication/pub.1091371041"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T23:18",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000484.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1186/s12883-017-0950-y"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12883-017-0950-y'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12883-017-0950-y'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12883-017-0950-y'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12883-017-0950-y'
This table displays all metadata directly associated to this object as RDF triples.
279 TRIPLES
21 PREDICATES
81 URIs
36 LITERALS
24 BLANK NODES