Association between total-Tau and brain atrophy one year after first-ever stroke View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Hege Ihle-Hansen, Guri Hagberg, Brynjar Fure, Bente Thommessen, Morten W. Fagerland, Anne R. Øksengård, Knut Engedal, Per Selnes

ABSTRACT

BACKGROUND: Although the most serious consequence of neuronal ischemia is acute neuronal death, mounting evidence suggests similarities between stroke and neurodegenerative disease. Brain atrophy visualized on structural MRI and pathological cerebrospinal fluid (CSF) concentrations of microtubule-associated protein tau (T-tau) and phosphorylated microtubule-associated protein tau indicate neurofibrillary degeneration. We aimed to explore the association between CSF T-tau and brain atrophy 1 year post-stroke. METHODS: We included 210 patients with first-ever ischemic stroke or transitory ischemic attack without pre-existing cognitive impairment. After 12 months, subjects underwent MRI, and CSF biomarkers were assessed. Using SIENAX (part of FSL), ventricular CSF volume and total brain volume were estimated and normalized for subject head size. The association between T-tau as explanatory variable and ventricular and total brain volume as outcome variables were studied using linear regression. RESULTS: One hundred eighty-two patients completed the follow-up. Forty-four had a lumbar puncture. Of these, 31 had their MRI with identical scan parameters. Mean age was 70.2 years (SD 11.7). Ventricular volume on MRI was significantly associated with age, but not with gender. In the multiple regression model, there was a significant association between T-tau and both ventricular (beta 0.44, 95% CI 376.3, 394.9, p = 0.021) and global brain volume (beta -0.50, 95% CI -565.9, -78.3, p = 0.011). There was no significant association between CSF T-tau 1 year post-stroke and baseline volumes. CONCLUSION: T-tau measured 1 year post-stroke is associated with measures of brain atrophy. The findings indicate that acute stroke may enhance or trigger tau-linked neurodegeneration with loss of neurons. TRIAL REGISTRATION: Clinicaltrials.gov NCT00506818 , July 23, 2007. Inclusion from February 2007, randomization and intervention from May 2007 and trial registration in July 2007. More... »

PAGES

107

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12883-017-0890-6

DOI

http://dx.doi.org/10.1186/s12883-017-0890-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085864378

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28583116


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Atrophy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multivariate Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurodegenerative Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurofibrillary Tangles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stroke", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "tau Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "B\u00e6rum sykehus", 
          "id": "https://www.grid.ac/institutes/grid.414168.e", 
          "name": [
            "Department of Internal medicine, Vestre Viken Hospital Trust, Baerum Hospital, Norway, 3004, Drammen, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ihle-Hansen", 
        "givenName": "Hege", 
        "id": "sg:person.01170676514.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170676514.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "B\u00e6rum sykehus", 
          "id": "https://www.grid.ac/institutes/grid.414168.e", 
          "name": [
            "Department of Internal medicine, Vestre Viken Hospital Trust, Baerum Hospital, Norway, 3004, Drammen, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hagberg", 
        "givenName": "Guri", 
        "id": "sg:person.0774525423.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774525423.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nasjonalt Kunnskapssenter for Helsetjenesten", 
          "id": "https://www.grid.ac/institutes/grid.425407.0", 
          "name": [
            "Norwegian Knowledge Centre for the Health Services, Oslo, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fure", 
        "givenName": "Brynjar", 
        "id": "sg:person.01304053435.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304053435.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Akershus University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411279.8", 
          "name": [
            "Department of Neurology, Akershus University Hospital, L\u00f8renskog, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thommessen", 
        "givenName": "Bente", 
        "id": "sg:person.0671034635.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671034635.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oslo University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.55325.34", 
          "name": [
            "Unit of Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fagerland", 
        "givenName": "Morten W.", 
        "id": "sg:person.0737150035.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737150035.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "B\u00e6rum sykehus", 
          "id": "https://www.grid.ac/institutes/grid.414168.e", 
          "name": [
            "Department of Internal medicine, Vestre Viken Hospital Trust, Baerum Hospital, Norway, 3004, Drammen, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "\u00d8kseng\u00e5rd", 
        "givenName": "Anne R.", 
        "id": "sg:person.0627634214.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627634214.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oslo University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.55325.34", 
          "name": [
            "Norwegian Centre for Dementia Research, Oslo University Hospital, Oslo, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Engedal", 
        "givenName": "Knut", 
        "id": "sg:person.0676726215.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676726215.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Akershus University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411279.8", 
          "name": [
            "Department of Neurology, Akershus University Hospital, L\u00f8renskog, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Selnes", 
        "givenName": "Per", 
        "id": "sg:person.01012146526.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012146526.82"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00308809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000355620", 
          "https://doi.org/10.1007/bf00308809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0033722", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001689682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2000.tb06399.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003000536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2000.tb06399.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003000536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2010.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004493689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.114.004285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006169364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.114.004285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006169364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(12)70291-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006207765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(89)90383-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010289600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(89)90383-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010289600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2012.09.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011013699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2015.110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013230372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2015.110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013230372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrneurol.2010.4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016181353", 
          "https://doi.org/10.1038/nrneurol.2010.4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrneurol.2010.4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016181353", 
          "https://doi.org/10.1038/nrneurol.2010.4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-010-0718-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016558559", 
          "https://doi.org/10.1007/s00401-010-0718-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-010-0718-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016558559", 
          "https://doi.org/10.1007/s00401-010-0718-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0606298103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016571909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02815073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016772530", 
          "https://doi.org/10.1007/bf02815073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02815073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016772530", 
          "https://doi.org/10.1007/bf02815073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1361-8415(01)00036-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017700837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2010.09.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022395260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/exnr.1998.6899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022439708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa022066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024495201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2004.07.051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024629846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-8454-7-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025897250", 
          "https://doi.org/10.1186/1743-8454-7-10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/nimg.2002.1132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026019363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1747-4949.2012.00928.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026325508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1747-4949.2012.00928.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026325508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1747-4949.2012.00928.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026325508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.24.1.35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026601739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hbm.22782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027070733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-3956(75)90026-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027523106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(91)93206-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028339004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2013.18", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030649611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2013.18", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030649611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1996.66010286.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031668014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1747-4949.2012.00837.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032119383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1747-4949.2012.00837.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032119383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1076/jcen.20.3.310.823", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033829489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.30.8.1538", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035512861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/00004647-200003000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038425380", 
          "https://doi.org/10.1097/00004647-200003000-00013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-200003000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038425380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-200003000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038425380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2012.10.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040008529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-200105000-00022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040737197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-200105000-00022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040737197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hbm.10062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041224324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/nimg.2002.1040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041876068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/nimg.2002.1040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041876068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.1989.00520420080026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049090678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(09)70236-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053235341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0033291700005742", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053750510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/42.906424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061171006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e318221acee", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064356261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e318221acee", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064356261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e318221acee", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064356261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.27.6.595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064362138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.55.11.1626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064378774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2466/pms.1958.8.3.271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070783411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2466/pms.1958.8.3.271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070783411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-2000-23-402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075117826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-2012-120802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078600843"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: Although the most serious consequence of neuronal ischemia is acute neuronal death, mounting evidence suggests similarities between stroke and neurodegenerative disease. Brain atrophy visualized on structural MRI and pathological cerebrospinal fluid (CSF) concentrations of microtubule-associated protein tau (T-tau) and phosphorylated microtubule-associated protein tau indicate neurofibrillary degeneration. We aimed to explore the association between CSF T-tau and brain atrophy 1\u00a0year post-stroke.\nMETHODS: We included 210 patients with first-ever ischemic stroke or transitory ischemic attack without pre-existing cognitive impairment. After 12\u00a0months, subjects underwent MRI, and CSF biomarkers were assessed. Using SIENAX (part of FSL), ventricular CSF volume and total brain volume were estimated and normalized for subject head size. The association between T-tau as explanatory variable and ventricular and total brain volume as outcome variables were studied using linear regression.\nRESULTS: One hundred eighty-two patients completed the follow-up. Forty-four had a lumbar puncture. Of these, 31 had their MRI with identical scan parameters. Mean age was 70.2\u00a0years (SD 11.7). Ventricular volume on MRI was significantly associated with age, but not with gender. In the multiple regression model, there was a significant association between T-tau and both ventricular (beta 0.44, 95% CI 376.3, 394.9, p\u00a0=\u00a00.021) and global brain volume (beta -0.50, 95% CI -565.9, -78.3, p\u00a0=\u00a00.011). There was no significant association between CSF T-tau 1\u00a0year post-stroke and baseline volumes.\nCONCLUSION: T-tau measured 1\u00a0year post-stroke is associated with measures of brain atrophy. The findings indicate that acute stroke may enhance or trigger tau-linked neurodegeneration with loss of neurons.\nTRIAL REGISTRATION: Clinicaltrials.gov NCT00506818 , July 23, 2007. Inclusion from February 2007, randomization and intervention from May 2007 and trial registration in July 2007.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12883-017-0890-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024950", 
        "issn": [
          "1471-2377"
        ], 
        "name": "BMC Neurology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Association between total-Tau and brain atrophy one year after first-ever stroke", 
    "pagination": "107", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a58416ee6663f26ebceb91d6e7367cc24a372f765ff0d80dacdb2cebee5da2f4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28583116"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12883-017-0890-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1085864378"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12883-017-0890-6", 
      "https://app.dimensions.ai/details/publication/pub.1085864378"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54310_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12883-017-0890-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12883-017-0890-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12883-017-0890-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12883-017-0890-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12883-017-0890-6'


 

This table displays all metadata directly associated to this object as RDF triples.

335 TRIPLES      21 PREDICATES      91 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12883-017-0890-6 schema:about N15116dda25df47368cb970bddf61e0e7
2 N35d291520d5d44d4a3f2732441f7bcf5
3 N37d7a65d1b224fbfb42a7849f62d5b38
4 N45f84d18c9964b4796bc0cf144ef9955
5 N5565c22dde2c4605846579286c892f6d
6 N5b3b8e8f06684d71a3d83632eb65d463
7 N8aa87b0d5ed6484ca36c514b8c92e3bd
8 N8e39c2a84d19493b878d2588de46c2ad
9 N96636018c2744c669b4c7613b0384254
10 Nb2092cec975c40cca429ae306d2eb9cd
11 Nb9e9482d771c49b2b347079370ceac15
12 Nba96d16f2862445997344dcbaf1022c7
13 Nbd8a11c974804eaa94192a177c566d73
14 Nc5608d0e8a984ce8a40c49da71697e0b
15 Ncc35e2de87ee49a493b40a2e788def59
16 Ne8c222e626d643c4959623fa75b89eeb
17 anzsrc-for:11
18 anzsrc-for:1109
19 schema:author Nefc4825086af4c488a8427fa029403a8
20 schema:citation sg:pub.10.1007/bf00308809
21 sg:pub.10.1007/bf02815073
22 sg:pub.10.1007/s00401-010-0718-6
23 sg:pub.10.1038/nrneurol.2010.4
24 sg:pub.10.1097/00004647-200003000-00013
25 sg:pub.10.1186/1743-8454-7-10
26 https://doi.org/10.1001/archneur.1989.00520420080026
27 https://doi.org/10.1002/hbm.10062
28 https://doi.org/10.1002/hbm.22782
29 https://doi.org/10.1006/exnr.1998.6899
30 https://doi.org/10.1006/nimg.2002.1040
31 https://doi.org/10.1006/nimg.2002.1132
32 https://doi.org/10.1016/0022-3956(75)90026-6
33 https://doi.org/10.1016/0140-6736(91)93206-o
34 https://doi.org/10.1016/0306-4522(89)90383-7
35 https://doi.org/10.1016/j.ejphar.2012.10.032
36 https://doi.org/10.1016/j.neurobiolaging.2012.09.011
37 https://doi.org/10.1016/j.neuroimage.2004.07.051
38 https://doi.org/10.1016/j.neuron.2010.07.002
39 https://doi.org/10.1016/j.neuron.2010.09.043
40 https://doi.org/10.1016/s1361-8415(01)00036-6
41 https://doi.org/10.1016/s1474-4422(09)70236-4
42 https://doi.org/10.1016/s1474-4422(12)70291-0
43 https://doi.org/10.1017/s0033291700005742
44 https://doi.org/10.1038/jcbfm.2013.18
45 https://doi.org/10.1038/jcbfm.2015.110
46 https://doi.org/10.1046/j.1471-4159.1996.66010286.x
47 https://doi.org/10.1056/nejmoa022066
48 https://doi.org/10.1073/pnas.0606298103
49 https://doi.org/10.1076/jcen.20.3.310.823
50 https://doi.org/10.1097/00004647-200003000-00013
51 https://doi.org/10.1097/00004728-200105000-00022
52 https://doi.org/10.1109/42.906424
53 https://doi.org/10.1111/j.1747-4949.2012.00837.x
54 https://doi.org/10.1111/j.1747-4949.2012.00928.x
55 https://doi.org/10.1111/j.1749-6632.2000.tb06399.x
56 https://doi.org/10.1161/01.str.24.1.35
57 https://doi.org/10.1161/01.str.30.8.1538
58 https://doi.org/10.1161/strokeaha.114.004285
59 https://doi.org/10.1212/wnl.0b013e318221acee
60 https://doi.org/10.1212/wnl.27.6.595
61 https://doi.org/10.1212/wnl.55.11.1626
62 https://doi.org/10.1371/journal.pone.0033722
63 https://doi.org/10.2466/pms.1958.8.3.271
64 https://doi.org/10.3233/jad-2000-23-402
65 https://doi.org/10.3233/jad-2012-120802
66 schema:datePublished 2017-12
67 schema:datePublishedReg 2017-12-01
68 schema:description BACKGROUND: Although the most serious consequence of neuronal ischemia is acute neuronal death, mounting evidence suggests similarities between stroke and neurodegenerative disease. Brain atrophy visualized on structural MRI and pathological cerebrospinal fluid (CSF) concentrations of microtubule-associated protein tau (T-tau) and phosphorylated microtubule-associated protein tau indicate neurofibrillary degeneration. We aimed to explore the association between CSF T-tau and brain atrophy 1 year post-stroke. METHODS: We included 210 patients with first-ever ischemic stroke or transitory ischemic attack without pre-existing cognitive impairment. After 12 months, subjects underwent MRI, and CSF biomarkers were assessed. Using SIENAX (part of FSL), ventricular CSF volume and total brain volume were estimated and normalized for subject head size. The association between T-tau as explanatory variable and ventricular and total brain volume as outcome variables were studied using linear regression. RESULTS: One hundred eighty-two patients completed the follow-up. Forty-four had a lumbar puncture. Of these, 31 had their MRI with identical scan parameters. Mean age was 70.2 years (SD 11.7). Ventricular volume on MRI was significantly associated with age, but not with gender. In the multiple regression model, there was a significant association between T-tau and both ventricular (beta 0.44, 95% CI 376.3, 394.9, p = 0.021) and global brain volume (beta -0.50, 95% CI -565.9, -78.3, p = 0.011). There was no significant association between CSF T-tau 1 year post-stroke and baseline volumes. CONCLUSION: T-tau measured 1 year post-stroke is associated with measures of brain atrophy. The findings indicate that acute stroke may enhance or trigger tau-linked neurodegeneration with loss of neurons. TRIAL REGISTRATION: Clinicaltrials.gov NCT00506818 , July 23, 2007. Inclusion from February 2007, randomization and intervention from May 2007 and trial registration in July 2007.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree true
72 schema:isPartOf N5694a917e9034552b8a71fe6e5e10e96
73 Nb093f2f81b214f9eaacadcf4a7d4618d
74 sg:journal.1024950
75 schema:name Association between total-Tau and brain atrophy one year after first-ever stroke
76 schema:pagination 107
77 schema:productId N0bf54452d3bc489da540bcc4818e0a8d
78 N414bb6ee555b4eff86106ab27327f5d7
79 Naf05c9816d874d3f860d9895e91b498b
80 Nfd57749cade7457488fed01eb629d556
81 Nfffc45e15bf245fc90543b1a4fde2235
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085864378
83 https://doi.org/10.1186/s12883-017-0890-6
84 schema:sdDatePublished 2019-04-11T10:17
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher Na9ec00f002c3477f91e5f21f9cc803b6
87 schema:url https://link.springer.com/10.1186%2Fs12883-017-0890-6
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N0bf54452d3bc489da540bcc4818e0a8d schema:name nlm_unique_id
92 schema:value 100968555
93 rdf:type schema:PropertyValue
94 N15116dda25df47368cb970bddf61e0e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Middle Aged
96 rdf:type schema:DefinedTerm
97 N35d291520d5d44d4a3f2732441f7bcf5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Neurodegenerative Diseases
99 rdf:type schema:DefinedTerm
100 N37d7a65d1b224fbfb42a7849f62d5b38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Humans
102 rdf:type schema:DefinedTerm
103 N414bb6ee555b4eff86106ab27327f5d7 schema:name doi
104 schema:value 10.1186/s12883-017-0890-6
105 rdf:type schema:PropertyValue
106 N45f84d18c9964b4796bc0cf144ef9955 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Multivariate Analysis
108 rdf:type schema:DefinedTerm
109 N53ea34e79f7d430f90996e20f6b39e61 rdf:first sg:person.0627634214.17
110 rdf:rest Ne0e14a59b3d549ed9d4d2754100d2cf1
111 N5565c22dde2c4605846579286c892f6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Aged
113 rdf:type schema:DefinedTerm
114 N5694a917e9034552b8a71fe6e5e10e96 schema:issueNumber 1
115 rdf:type schema:PublicationIssue
116 N5b3b8e8f06684d71a3d83632eb65d463 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Male
118 rdf:type schema:DefinedTerm
119 N8aa87b0d5ed6484ca36c514b8c92e3bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name tau Proteins
121 rdf:type schema:DefinedTerm
122 N8e39c2a84d19493b878d2588de46c2ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Stroke
124 rdf:type schema:DefinedTerm
125 N96636018c2744c669b4c7613b0384254 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Magnetic Resonance Imaging
127 rdf:type schema:DefinedTerm
128 Na676a7e5eaf64c28a613708696ea8754 rdf:first sg:person.01012146526.82
129 rdf:rest rdf:nil
130 Na9ec00f002c3477f91e5f21f9cc803b6 schema:name Springer Nature - SN SciGraph project
131 rdf:type schema:Organization
132 Naa1029059de74fb391decd83a16b9127 rdf:first sg:person.01304053435.02
133 rdf:rest Nfffb99ccfd3048cda1bf7535e1a886c3
134 Naf05c9816d874d3f860d9895e91b498b schema:name pubmed_id
135 schema:value 28583116
136 rdf:type schema:PropertyValue
137 Nb093f2f81b214f9eaacadcf4a7d4618d schema:volumeNumber 17
138 rdf:type schema:PublicationVolume
139 Nb2092cec975c40cca429ae306d2eb9cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Follow-Up Studies
141 rdf:type schema:DefinedTerm
142 Nb9e9482d771c49b2b347079370ceac15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Neurofibrillary Tangles
144 rdf:type schema:DefinedTerm
145 Nba96d16f2862445997344dcbaf1022c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Atrophy
147 rdf:type schema:DefinedTerm
148 Nbd8a11c974804eaa94192a177c566d73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Biomarkers
150 rdf:type schema:DefinedTerm
151 Nc5608d0e8a984ce8a40c49da71697e0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Aged, 80 and over
153 rdf:type schema:DefinedTerm
154 Nc942c3fd25944e76b46f4f6b777cd25f rdf:first sg:person.0774525423.77
155 rdf:rest Naa1029059de74fb391decd83a16b9127
156 Ncc35e2de87ee49a493b40a2e788def59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Female
158 rdf:type schema:DefinedTerm
159 Nd81e19e137f5457494f1d5edd979c404 rdf:first sg:person.0737150035.41
160 rdf:rest N53ea34e79f7d430f90996e20f6b39e61
161 Ne0e14a59b3d549ed9d4d2754100d2cf1 rdf:first sg:person.0676726215.31
162 rdf:rest Na676a7e5eaf64c28a613708696ea8754
163 Ne8c222e626d643c4959623fa75b89eeb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Brain
165 rdf:type schema:DefinedTerm
166 Nefc4825086af4c488a8427fa029403a8 rdf:first sg:person.01170676514.57
167 rdf:rest Nc942c3fd25944e76b46f4f6b777cd25f
168 Nfd57749cade7457488fed01eb629d556 schema:name readcube_id
169 schema:value a58416ee6663f26ebceb91d6e7367cc24a372f765ff0d80dacdb2cebee5da2f4
170 rdf:type schema:PropertyValue
171 Nfffb99ccfd3048cda1bf7535e1a886c3 rdf:first sg:person.0671034635.09
172 rdf:rest Nd81e19e137f5457494f1d5edd979c404
173 Nfffc45e15bf245fc90543b1a4fde2235 schema:name dimensions_id
174 schema:value pub.1085864378
175 rdf:type schema:PropertyValue
176 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
177 schema:name Medical and Health Sciences
178 rdf:type schema:DefinedTerm
179 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
180 schema:name Neurosciences
181 rdf:type schema:DefinedTerm
182 sg:journal.1024950 schema:issn 1471-2377
183 schema:name BMC Neurology
184 rdf:type schema:Periodical
185 sg:person.01012146526.82 schema:affiliation https://www.grid.ac/institutes/grid.411279.8
186 schema:familyName Selnes
187 schema:givenName Per
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012146526.82
189 rdf:type schema:Person
190 sg:person.01170676514.57 schema:affiliation https://www.grid.ac/institutes/grid.414168.e
191 schema:familyName Ihle-Hansen
192 schema:givenName Hege
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170676514.57
194 rdf:type schema:Person
195 sg:person.01304053435.02 schema:affiliation https://www.grid.ac/institutes/grid.425407.0
196 schema:familyName Fure
197 schema:givenName Brynjar
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304053435.02
199 rdf:type schema:Person
200 sg:person.0627634214.17 schema:affiliation https://www.grid.ac/institutes/grid.414168.e
201 schema:familyName Øksengård
202 schema:givenName Anne R.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627634214.17
204 rdf:type schema:Person
205 sg:person.0671034635.09 schema:affiliation https://www.grid.ac/institutes/grid.411279.8
206 schema:familyName Thommessen
207 schema:givenName Bente
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671034635.09
209 rdf:type schema:Person
210 sg:person.0676726215.31 schema:affiliation https://www.grid.ac/institutes/grid.55325.34
211 schema:familyName Engedal
212 schema:givenName Knut
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676726215.31
214 rdf:type schema:Person
215 sg:person.0737150035.41 schema:affiliation https://www.grid.ac/institutes/grid.55325.34
216 schema:familyName Fagerland
217 schema:givenName Morten W.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737150035.41
219 rdf:type schema:Person
220 sg:person.0774525423.77 schema:affiliation https://www.grid.ac/institutes/grid.414168.e
221 schema:familyName Hagberg
222 schema:givenName Guri
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774525423.77
224 rdf:type schema:Person
225 sg:pub.10.1007/bf00308809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000355620
226 https://doi.org/10.1007/bf00308809
227 rdf:type schema:CreativeWork
228 sg:pub.10.1007/bf02815073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016772530
229 https://doi.org/10.1007/bf02815073
230 rdf:type schema:CreativeWork
231 sg:pub.10.1007/s00401-010-0718-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016558559
232 https://doi.org/10.1007/s00401-010-0718-6
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nrneurol.2010.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016181353
235 https://doi.org/10.1038/nrneurol.2010.4
236 rdf:type schema:CreativeWork
237 sg:pub.10.1097/00004647-200003000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038425380
238 https://doi.org/10.1097/00004647-200003000-00013
239 rdf:type schema:CreativeWork
240 sg:pub.10.1186/1743-8454-7-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025897250
241 https://doi.org/10.1186/1743-8454-7-10
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1001/archneur.1989.00520420080026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049090678
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1002/hbm.10062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041224324
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1002/hbm.22782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027070733
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1006/exnr.1998.6899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022439708
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1006/nimg.2002.1040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041876068
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1006/nimg.2002.1132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026019363
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/0022-3956(75)90026-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027523106
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/0140-6736(91)93206-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1028339004
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/0306-4522(89)90383-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010289600
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.ejphar.2012.10.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040008529
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.neurobiolaging.2012.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011013699
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.neuroimage.2004.07.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024629846
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.neuron.2010.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004493689
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.neuron.2010.09.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022395260
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/s1361-8415(01)00036-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017700837
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s1474-4422(09)70236-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053235341
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s1474-4422(12)70291-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006207765
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1017/s0033291700005742 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053750510
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1038/jcbfm.2013.18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030649611
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1038/jcbfm.2015.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013230372
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1046/j.1471-4159.1996.66010286.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031668014
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1056/nejmoa022066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024495201
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1073/pnas.0606298103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016571909
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1076/jcen.20.3.310.823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033829489
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1097/00004647-200003000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038425380
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1097/00004728-200105000-00022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040737197
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1109/42.906424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061171006
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1111/j.1747-4949.2012.00837.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032119383
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1111/j.1747-4949.2012.00928.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026325508
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1111/j.1749-6632.2000.tb06399.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003000536
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1161/01.str.24.1.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026601739
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1161/01.str.30.8.1538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035512861
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1161/strokeaha.114.004285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006169364
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1212/wnl.0b013e318221acee schema:sameAs https://app.dimensions.ai/details/publication/pub.1064356261
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1212/wnl.27.6.595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064362138
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1212/wnl.55.11.1626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064378774
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1371/journal.pone.0033722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001689682
316 rdf:type schema:CreativeWork
317 https://doi.org/10.2466/pms.1958.8.3.271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070783411
318 rdf:type schema:CreativeWork
319 https://doi.org/10.3233/jad-2000-23-402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075117826
320 rdf:type schema:CreativeWork
321 https://doi.org/10.3233/jad-2012-120802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078600843
322 rdf:type schema:CreativeWork
323 https://www.grid.ac/institutes/grid.411279.8 schema:alternateName Akershus University Hospital
324 schema:name Department of Neurology, Akershus University Hospital, Lørenskog, Norway
325 rdf:type schema:Organization
326 https://www.grid.ac/institutes/grid.414168.e schema:alternateName Bærum sykehus
327 schema:name Department of Internal medicine, Vestre Viken Hospital Trust, Baerum Hospital, Norway, 3004, Drammen, Norway
328 rdf:type schema:Organization
329 https://www.grid.ac/institutes/grid.425407.0 schema:alternateName Nasjonalt Kunnskapssenter for Helsetjenesten
330 schema:name Norwegian Knowledge Centre for the Health Services, Oslo, Norway
331 rdf:type schema:Organization
332 https://www.grid.ac/institutes/grid.55325.34 schema:alternateName Oslo University Hospital
333 schema:name Norwegian Centre for Dementia Research, Oslo University Hospital, Oslo, Norway
334 Unit of Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway
335 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...