Serum tissue inhibitor of matrix metalloproteinase-1 levels are associated with mortality in patients with malignant middle cerebral artery infarction View Full Text


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Article Info

DATE

2015-07-11

AUTHORS

Leonardo Lorente, María M. Martín, Luis Ramos, Juan J. Cáceres, Jordi Solé-Violán, Mónica Argueso, Alejandro Jiménez, Juan M. Borreguero-León, Josune Orbe, José A. Rodríguez, José A. Páramo

ABSTRACT

BackgroundIn the last years, circulating matrix metalloproteinases (MMP)-9 levels have been associated with functional outcome in ischemic stroke patients. However the prognostic value of circulating levels of tissue inhibitor of matrix metalloproteinases (TIMP)-1 and MMP-10 in functional outcome of ischemic stroke patients has been scarcely studied. In addition, to our knowledge, serum MMP-9, MMP-10 and TIMP-1 levels in patients with malignant middle cerebral artery infarction (MMCAI) for mortality prediction have not been studied, and these were the objectives of this study.MethodsThis was a multicenter, observational and prospective study carried out in six Spanish Intensive Care Units. We included patients with severe MMCAI defined as Glasgow Coma Scale (GCS) lower than 9. We measured circulating levels of MMP-9, MMP-10, TIMP-1, in 50 patients with severe MMCAI at diagnosis and in 50 healthy subjects. Endpoint was 30-day mortality.ResultsPatients with severe MMCAI showed higher serum levels of MMP-9 (p = 0.001), MMP-10 (p < 0.001), and TIMP-1 (p = 0.02) than healthy subjects. Non-surviving MMCAI patients (n = 26) compared to survivor ones (n = 24) showed higher circulating levels of TIMP-1 (p < 0.001), MMP-10 (p = 0.02) and PAI-1(p = 0.02), and lower MMP-9 levels (p = 0.04). Multiple binomial logistic regression analysis showed that serum TIMP-1 levels > 239 ng/mL are associated with 30-day mortality (OR = 5.82; 95 % CI = 1.37-24.73; P = 0.02) controlling for GCS and age. The area under the curve for TIMP-1 as predictor of 30-day mortality was 0.81 (95 % CI = 0.67-0.91; P < 0.001). We found an association between circulating levels of TIMP-1 and MMP-10 (rho = 0.45; P = 0.001), plasminogen activator inhibitor (PAI)-1 (rho = 0.53; P < 0.001), and tumor necrosis factor (TNF)-alpha (rho = 0.70; P < 0.001).ConclusionsThe most relevant and new findings of our study, were that serum TIMP-1 levels in MMCAI patients were associated with mortality, and could be used as a prognostic biomarker of mortality in MMCAI patients. More... »

PAGES

111

References to SciGraph publications

  • 2002-03. Matrix metalloproteinases: a tail of a frog that became a prince in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2006-07-17. Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke in BMC NEUROSCIENCE
  • 2008-08-11. Delayed administration of a matrix metalloproteinase inhibitor limits progressive brain injury after hypoxia-ischemia in the neonatal rat in JOURNAL OF NEUROINFLAMMATION
  • 2009-10-02. Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis in CRITICAL CARE
  • 2001-09. Matrix Metalloproteinase and Cytokine Profiles in Monocytes over the Course of Stroke in JOURNAL OF CLINICAL IMMUNOLOGY
  • 2013-05-25. The 372 T/C genetic polymorphism of TIMP-1 is associated with serum levels of TIMP-1 and survival in patients with severe sepsis in CRITICAL CARE
  • 2011-12-16. Doxycycline-Mediated Protective Effect Against Focal Cerebral Ischemia–Reperfusion Injury Through the Modulation of Tight Junctions and PKCδ Signaling in Rats in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2009-04-24. Impact of plasma tissue inhibitor of metalloproteinase-1 on long-term survival in patients with gastric cancer in GASTRIC CANCER
  • 2012-11-17. Association of dimethylarginines and mediators of inflammation after acute ischemic stroke in JOURNAL OF NEUROINFLAMMATION
  • 2007-08-10. Different roles of matrix metalloproteinases-2 and -9 after human ischaemic stroke in NEUROLOGICAL SCIENCES
  • Journal

    TITLE

    BMC Neurology

    ISSUE

    1

    VOLUME

    15

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12883-015-0364-7

    DOI

    http://dx.doi.org/10.1186/s12883-015-0364-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020574109

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26162891


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        "description": "BackgroundIn the last years, circulating matrix metalloproteinases (MMP)-9 levels have been associated with functional outcome in ischemic stroke patients. However the prognostic value of circulating levels of tissue inhibitor of matrix metalloproteinases (TIMP)-1 and MMP-10 in functional outcome of ischemic stroke patients has been scarcely studied. In addition, to our knowledge, serum MMP-9, MMP-10 and TIMP-1 levels in patients with malignant middle cerebral artery infarction (MMCAI) for mortality prediction have not been studied, and these were the objectives of this study.MethodsThis was a multicenter, observational and prospective study carried out in six Spanish Intensive Care Units. We included patients with severe MMCAI defined as Glasgow Coma Scale (GCS) lower than 9. We measured circulating levels of MMP-9, MMP-10, TIMP-1, in 50 patients with severe MMCAI at diagnosis and in 50 healthy subjects. Endpoint was 30-day mortality.ResultsPatients with severe MMCAI showed higher serum levels of MMP-9 (p\u2009=\u20090.001), MMP-10 (p\u2009<\u20090.001), and TIMP-1 (p\u2009=\u20090.02) than healthy subjects. Non-surviving MMCAI patients (n\u2009=\u200926) compared to survivor ones (n\u2009=\u200924) showed higher circulating levels of TIMP-1 (p\u2009<\u20090.001), MMP-10 (p\u2009=\u20090.02) and PAI-1(p\u2009=\u20090.02), and lower MMP-9 levels (p\u2009=\u20090.04). Multiple binomial logistic regression analysis showed that serum TIMP-1 levels\u2009>\u2009239\u00a0ng/mL are associated with 30-day mortality (OR\u2009=\u20095.82; 95\u00a0% CI\u2009=\u20091.37-24.73; P\u2009=\u20090.02) controlling for GCS and age. The area under the curve for TIMP-1 as predictor of 30-day mortality was 0.81 (95\u00a0% CI\u2009=\u20090.67-0.91; P\u2009<\u20090.001). We found an association between circulating levels of TIMP-1 and MMP-10 (rho\u2009=\u20090.45; P\u2009=\u20090.001), plasminogen activator inhibitor (PAI)-1 (rho\u2009=\u20090.53; P\u2009<\u20090.001), and tumor necrosis factor (TNF)-alpha (rho\u2009=\u20090.70; P\u2009<\u20090.001).ConclusionsThe most relevant and new findings of our study, were that serum TIMP-1 levels in MMCAI patients were associated with mortality, and could be used as a prognostic biomarker of mortality in MMCAI patients.", 
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