The clinical and pathological characteristics of IgA nephropathy patients in Tibet View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-07-27

AUTHORS

Fenglei Si, Jiarong Mei, Yong A, Chen Tang, Yuxuan Yao, Lijun Liu

ABSTRACT

BackgroundThere are few studies on immunoglobulin A nephropathy (IgAN) at high altitude. This study aimed to analyze the clinical and pathological characteristics of IgAN between Tibet and Beijing, which provided a basis for improving diagnosis and treatment in Tibet.MethodThe clinical and pathological data of 80 patients from the People’s Hospital of Tibet Autonomous Region (Tibetan group) and 991 patients from Peking University First Hospital (Beijing group) with IgAN proven by renal biopsy were compared retrospectively between January 2016 and July 2020. The kidney biopsy tissue was sent to the Department of Nephrology, Peking University First Hospital for pathological evaluation.ResultsThe proteinuria (2.9 [2.0, 4.9] vs. 1.1 [0.5, 2.4] g/day, P < 0.001) in the Tibetan group was significantly higher than that in the Beijing group. The serum albumin (30.4 ± 7.7 vs. 38.2 ± 5.5 g/L, P < 0.001) was significantly lower in the Tibetan group. The eGFR (77.7 ± 37.8 vs. 62.1 ± 33.6 ml/min/1.73 m2, P = 0.001) was higher in the Tibetan group. The percentage of patients with nephrotic syndrome in the Tibetan group was significantly higher than that in the Beijing group (33.8% vs. 4.7%, P < 0.001).ConclusionThere are differences in the clinical and pathological characteristics of IgAN between plateau and plain regions. More... »

PAGES

269

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URI

http://scigraph.springernature.com/pub.10.1186/s12882-022-02895-4

DOI

http://dx.doi.org/10.1186/s12882-022-02895-4

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https://app.dimensions.ai/details/publication/pub.1149784306

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35896958


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