RNA-Seq identifies condition-specific biological signatures of ischemia-reperfusion injury in the human kidney View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-09-25

AUTHORS

Meeyoung Park, Chae Hwa Kwon, Hong Koo Ha, Miyeun Han, Sang Heon Song

ABSTRACT

BackgroundAcute kidney injury (AKI) is defined as a sudden event of kidney failure or kidney damage within a short period. Ischemia-reperfusion injury (IRI) is a critical factor associated with severe AKI and end-stage kidney disease (ESKD). However, the biological mechanisms underlying ischemia and reperfusion are incompletely understood, owing to the complexity of these pathophysiological processes. We aimed to investigate the key biological pathways individually affected by ischemia and reperfusion at the transcriptome level.ResultsWe analyzed the steady-state gene expression pattern of human kidney tissues from normal (pre-ischemia), ischemia, and reperfusion conditions using RNA-sequencing. Conventional differential expression and self-organizing map (SOM) clustering analyses followed by pathway analysis were performed. Differential expression analysis revealed the metabolic pathways dysregulated in ischemia. Cellular assembly, development and migration, and immune response-related pathways were dysregulated in reperfusion. SOM clustering analysis highlighted the ischemia-mediated significant dysregulation in metabolism, apoptosis, and fibrosis-related pathways, while cell growth, migration, and immune response-related pathways were highly dysregulated by reperfusion after ischemia. The expression of pro-apoptotic genes and death receptors was downregulated during ischemia, indicating the existence of a protective mechanism against ischemic injury. Reperfusion induced alterations in the expression of the genes associated with immune response such as inflammasome and antigen representing genes. Further, the genes related to cell growth and migration, such as AKT, KRAS, and those related to Rho signaling, were downregulated, suggestive of injury responses during reperfusion. Semaphorin 4D and plexin B1 levels were also downregulated.ConclusionsWe show that specific biological pathways were distinctively involved in ischemia and reperfusion during IRI, indicating that condition-specific therapeutic strategies may be imperative to prevent severe kidney damage after IRI in the clinical setting. More... »

PAGES

398

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12882-020-02025-y

DOI

http://dx.doi.org/10.1186/s12882-020-02025-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1131192565

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32977749


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acute Kidney Injury", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA-Seq", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reperfusion Injury", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.412588.2", 
          "name": [
            "Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Meeyoung", 
        "id": "sg:person.013112032141.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013112032141.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.412588.2", 
          "name": [
            "Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwon", 
        "givenName": "Chae Hwa", 
        "id": "sg:person.0724001121.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724001121.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.412588.2", 
          "name": [
            "Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ha", 
        "givenName": "Hong Koo", 
        "id": "sg:person.0712676025.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712676025.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Urology, Pusan National University Hospital, Busan, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.412588.2", 
          "name": [
            "Department of Urology, Pusan National University Hospital, Busan, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Miyeun", 
        "id": "sg:person.01144036024.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144036024.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.412588.2", 
          "name": [
            "Department of Internal Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "Sang Heon", 
        "id": "sg:person.01032567265.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032567265.78"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00068-007-7152-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047983489", 
          "https://doi.org/10.1007/s00068-007-7152-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-014-0550-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015222646", 
          "https://doi.org/10.1186/s13059-014-0550-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-018-26804-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104306715", 
          "https://doi.org/10.1038/s41598-018-26804-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41419-019-1556-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1113300649", 
          "https://doi.org/10.1038/s41419-019-1556-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrneph.2011.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036564609", 
          "https://doi.org/10.1038/nrneph.2011.13"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.4197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084129290", 
          "https://doi.org/10.1038/nmeth.4197"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-09-25", 
    "datePublishedReg": "2020-09-25", 
    "description": "BackgroundAcute kidney injury (AKI) is defined as a sudden event of kidney failure or kidney damage within a short period. Ischemia-reperfusion injury (IRI) is a critical factor associated with severe AKI and end-stage kidney disease (ESKD). However, the biological mechanisms underlying ischemia and reperfusion are incompletely understood, owing to the complexity of these pathophysiological processes. We aimed to investigate the key biological pathways individually affected by ischemia and reperfusion at the transcriptome level.ResultsWe analyzed the steady-state gene expression pattern of human kidney tissues from normal (pre-ischemia), ischemia, and reperfusion conditions using RNA-sequencing. Conventional differential expression and self-organizing map (SOM) clustering analyses followed by pathway analysis were performed. Differential expression analysis revealed the metabolic pathways dysregulated in ischemia. Cellular assembly, development and migration, and immune response-related pathways were dysregulated in reperfusion. SOM clustering analysis highlighted the ischemia-mediated significant dysregulation in metabolism, apoptosis, and fibrosis-related pathways, while cell growth, migration, and immune response-related pathways were highly dysregulated by reperfusion after ischemia. The expression of pro-apoptotic genes and death receptors was downregulated during ischemia, indicating the existence of a protective mechanism against ischemic injury. Reperfusion induced alterations in the expression of the genes associated with immune response such as inflammasome and antigen representing genes. Further, the genes related to cell growth and migration, such as AKT, KRAS, and those related to Rho signaling, were downregulated, suggestive of injury responses during reperfusion. Semaphorin 4D and plexin B1 levels were also downregulated.ConclusionsWe show that specific biological pathways were distinctively involved in ischemia and reperfusion during IRI, indicating that condition-specific therapeutic strategies may be imperative to prevent severe kidney damage after IRI in the clinical setting.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12882-020-02025-y", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024626", 
        "issn": [
          "1471-2369"
        ], 
        "name": "BMC Nephrology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "Suppl 1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "keywords": [
      "ischemia-reperfusion injury", 
      "end-stage kidney disease", 
      "immune response-related pathways", 
      "kidney damage", 
      "BackgroundAcute kidney injury", 
      "fibrosis-related pathways", 
      "severe kidney damage", 
      "human kidney tissue", 
      "severe AKI", 
      "kidney injury", 
      "reperfusion conditions", 
      "ischemic injury", 
      "kidney failure", 
      "kidney disease", 
      "cell growth", 
      "immune response", 
      "reperfusion", 
      "ischemia", 
      "therapeutic strategies", 
      "kidney tissue", 
      "injury response", 
      "pathophysiological processes", 
      "clinical setting", 
      "injury", 
      "pro-apoptotic genes", 
      "key biological pathways", 
      "Semaphorin 4D", 
      "human kidney", 
      "significant dysregulation", 
      "protective mechanism", 
      "biological pathways", 
      "induced alterations", 
      "specific biological pathways", 
      "death receptors", 
      "biological mechanisms", 
      "pathway analysis", 
      "RNA sequencing", 
      "B1 levels", 
      "differential expression", 
      "pathway", 
      "biological signatures", 
      "gene expression patterns", 
      "expression patterns", 
      "expression", 
      "metabolic pathways", 
      "Rho signaling", 
      "AKI", 
      "inflammasome", 
      "KRAS", 
      "kidney", 
      "disease", 
      "differential expression analysis", 
      "genes", 
      "expression analysis", 
      "damage", 
      "transcriptome level", 
      "ResultsWe", 
      "receptors", 
      "response", 
      "dysregulation", 
      "Akt", 
      "levels", 
      "short period", 
      "apoptosis", 
      "tissue", 
      "cellular assembly", 
      "alterations", 
      "metabolism", 
      "ConclusionsWe", 
      "migration", 
      "signaling", 
      "failure", 
      "mechanism", 
      "setting", 
      "period", 
      "factors", 
      "analysis", 
      "critical factor", 
      "events", 
      "sudden events", 
      "growth", 
      "patterns", 
      "development", 
      "strategies", 
      "conditions", 
      "signatures", 
      "process", 
      "existence", 
      "complexity", 
      "maps", 
      "self-organizing map", 
      "assembly"
    ], 
    "name": "RNA-Seq identifies condition-specific biological signatures of ischemia-reperfusion injury in the human kidney", 
    "pagination": "398", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1131192565"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12882-020-02025-y"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "32977749"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12882-020-02025-y", 
      "https://app.dimensions.ai/details/publication/pub.1131192565"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T22:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_843.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12882-020-02025-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12882-020-02025-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12882-020-02025-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12882-020-02025-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12882-020-02025-y'


 

This table displays all metadata directly associated to this object as RDF triples.

245 TRIPLES      22 PREDICATES      133 URIs      119 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12882-020-02025-y schema:about N4795c16cd99b41ca9d332809cace5768
2 N5789a06da8ce4fdcad5580de58feedcb
3 N831c406d8a58457285cc77b443465b63
4 N8d517cd6b26e4e84beb5a2d19c940ec5
5 N95900d42aa894eacbf980d5d47736799
6 N99d5ca2cd3c44389af1996573c345028
7 Nb32f4b2caa774594a2a6c941f7246d5b
8 Nb7ab6b1f0fe941e8b3d3d391b02b0a55
9 Nc58af7e646cc4022a6ac756c8377d3b5
10 anzsrc-for:11
11 anzsrc-for:1103
12 schema:author N14f2771a77d7419ba8b8b3528c97efe3
13 schema:citation sg:pub.10.1007/s00068-007-7152-z
14 sg:pub.10.1038/nmeth.4197
15 sg:pub.10.1038/nrneph.2011.13
16 sg:pub.10.1038/s41419-019-1556-7
17 sg:pub.10.1038/s41598-018-26804-8
18 sg:pub.10.1186/s13059-014-0550-8
19 schema:datePublished 2020-09-25
20 schema:datePublishedReg 2020-09-25
21 schema:description BackgroundAcute kidney injury (AKI) is defined as a sudden event of kidney failure or kidney damage within a short period. Ischemia-reperfusion injury (IRI) is a critical factor associated with severe AKI and end-stage kidney disease (ESKD). However, the biological mechanisms underlying ischemia and reperfusion are incompletely understood, owing to the complexity of these pathophysiological processes. We aimed to investigate the key biological pathways individually affected by ischemia and reperfusion at the transcriptome level.ResultsWe analyzed the steady-state gene expression pattern of human kidney tissues from normal (pre-ischemia), ischemia, and reperfusion conditions using RNA-sequencing. Conventional differential expression and self-organizing map (SOM) clustering analyses followed by pathway analysis were performed. Differential expression analysis revealed the metabolic pathways dysregulated in ischemia. Cellular assembly, development and migration, and immune response-related pathways were dysregulated in reperfusion. SOM clustering analysis highlighted the ischemia-mediated significant dysregulation in metabolism, apoptosis, and fibrosis-related pathways, while cell growth, migration, and immune response-related pathways were highly dysregulated by reperfusion after ischemia. The expression of pro-apoptotic genes and death receptors was downregulated during ischemia, indicating the existence of a protective mechanism against ischemic injury. Reperfusion induced alterations in the expression of the genes associated with immune response such as inflammasome and antigen representing genes. Further, the genes related to cell growth and migration, such as AKT, KRAS, and those related to Rho signaling, were downregulated, suggestive of injury responses during reperfusion. Semaphorin 4D and plexin B1 levels were also downregulated.ConclusionsWe show that specific biological pathways were distinctively involved in ischemia and reperfusion during IRI, indicating that condition-specific therapeutic strategies may be imperative to prevent severe kidney damage after IRI in the clinical setting.
22 schema:genre article
23 schema:inLanguage en
24 schema:isAccessibleForFree true
25 schema:isPartOf N683e335d0e5046b8b8bcd8fad64fd07a
26 N84df7be78b1846c280cee8e1cc764211
27 sg:journal.1024626
28 schema:keywords AKI
29 Akt
30 B1 levels
31 BackgroundAcute kidney injury
32 ConclusionsWe
33 KRAS
34 RNA sequencing
35 ResultsWe
36 Rho signaling
37 Semaphorin 4D
38 alterations
39 analysis
40 apoptosis
41 assembly
42 biological mechanisms
43 biological pathways
44 biological signatures
45 cell growth
46 cellular assembly
47 clinical setting
48 complexity
49 conditions
50 critical factor
51 damage
52 death receptors
53 development
54 differential expression
55 differential expression analysis
56 disease
57 dysregulation
58 end-stage kidney disease
59 events
60 existence
61 expression
62 expression analysis
63 expression patterns
64 factors
65 failure
66 fibrosis-related pathways
67 gene expression patterns
68 genes
69 growth
70 human kidney
71 human kidney tissue
72 immune response
73 immune response-related pathways
74 induced alterations
75 inflammasome
76 injury
77 injury response
78 ischemia
79 ischemia-reperfusion injury
80 ischemic injury
81 key biological pathways
82 kidney
83 kidney damage
84 kidney disease
85 kidney failure
86 kidney injury
87 kidney tissue
88 levels
89 maps
90 mechanism
91 metabolic pathways
92 metabolism
93 migration
94 pathophysiological processes
95 pathway
96 pathway analysis
97 patterns
98 period
99 pro-apoptotic genes
100 process
101 protective mechanism
102 receptors
103 reperfusion
104 reperfusion conditions
105 response
106 self-organizing map
107 setting
108 severe AKI
109 severe kidney damage
110 short period
111 signaling
112 signatures
113 significant dysregulation
114 specific biological pathways
115 strategies
116 sudden events
117 therapeutic strategies
118 tissue
119 transcriptome level
120 schema:name RNA-Seq identifies condition-specific biological signatures of ischemia-reperfusion injury in the human kidney
121 schema:pagination 398
122 schema:productId N189c7c84638e4366a0bec143abad2a61
123 N47b767ef48f24856a765dd34a9fe0330
124 N66cd904c89f844ddbbe683abfcf4727f
125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1131192565
126 https://doi.org/10.1186/s12882-020-02025-y
127 schema:sdDatePublished 2022-06-01T22:20
128 schema:sdLicense https://scigraph.springernature.com/explorer/license/
129 schema:sdPublisher Nb582c635f3e44431ac589ce337e5e7f7
130 schema:url https://doi.org/10.1186/s12882-020-02025-y
131 sgo:license sg:explorer/license/
132 sgo:sdDataset articles
133 rdf:type schema:ScholarlyArticle
134 N14f2771a77d7419ba8b8b3528c97efe3 rdf:first sg:person.013112032141.39
135 rdf:rest N4aa13790997d486da333f4b2443f20c4
136 N189c7c84638e4366a0bec143abad2a61 schema:name pubmed_id
137 schema:value 32977749
138 rdf:type schema:PropertyValue
139 N1d3d2db35ab846af98782a2593353fac rdf:first sg:person.01144036024.89
140 rdf:rest Nae25f908ef4340d08e33211c334f7ae1
141 N4795c16cd99b41ca9d332809cace5768 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Signal Transduction
143 rdf:type schema:DefinedTerm
144 N47b767ef48f24856a765dd34a9fe0330 schema:name doi
145 schema:value 10.1186/s12882-020-02025-y
146 rdf:type schema:PropertyValue
147 N4aa13790997d486da333f4b2443f20c4 rdf:first sg:person.0724001121.26
148 rdf:rest N6db92989256c45ed87e1036d6d8efcb8
149 N5789a06da8ce4fdcad5580de58feedcb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Reperfusion Injury
151 rdf:type schema:DefinedTerm
152 N66cd904c89f844ddbbe683abfcf4727f schema:name dimensions_id
153 schema:value pub.1131192565
154 rdf:type schema:PropertyValue
155 N683e335d0e5046b8b8bcd8fad64fd07a schema:issueNumber Suppl 1
156 rdf:type schema:PublicationIssue
157 N6db92989256c45ed87e1036d6d8efcb8 rdf:first sg:person.0712676025.34
158 rdf:rest N1d3d2db35ab846af98782a2593353fac
159 N831c406d8a58457285cc77b443465b63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Male
161 rdf:type schema:DefinedTerm
162 N84df7be78b1846c280cee8e1cc764211 schema:volumeNumber 21
163 rdf:type schema:PublicationVolume
164 N8d517cd6b26e4e84beb5a2d19c940ec5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Kidney
166 rdf:type schema:DefinedTerm
167 N95900d42aa894eacbf980d5d47736799 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Humans
169 rdf:type schema:DefinedTerm
170 N99d5ca2cd3c44389af1996573c345028 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Acute Kidney Injury
172 rdf:type schema:DefinedTerm
173 Nae25f908ef4340d08e33211c334f7ae1 rdf:first sg:person.01032567265.78
174 rdf:rest rdf:nil
175 Nb32f4b2caa774594a2a6c941f7246d5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Gene Expression
177 rdf:type schema:DefinedTerm
178 Nb582c635f3e44431ac589ce337e5e7f7 schema:name Springer Nature - SN SciGraph project
179 rdf:type schema:Organization
180 Nb7ab6b1f0fe941e8b3d3d391b02b0a55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Gene Expression Profiling
182 rdf:type schema:DefinedTerm
183 Nc58af7e646cc4022a6ac756c8377d3b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name RNA-Seq
185 rdf:type schema:DefinedTerm
186 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
187 schema:name Medical and Health Sciences
188 rdf:type schema:DefinedTerm
189 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
190 schema:name Clinical Sciences
191 rdf:type schema:DefinedTerm
192 sg:journal.1024626 schema:issn 1471-2369
193 schema:name BMC Nephrology
194 schema:publisher Springer Nature
195 rdf:type schema:Periodical
196 sg:person.01032567265.78 schema:affiliation grid-institutes:grid.412588.2
197 schema:familyName Song
198 schema:givenName Sang Heon
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032567265.78
200 rdf:type schema:Person
201 sg:person.01144036024.89 schema:affiliation grid-institutes:grid.412588.2
202 schema:familyName Han
203 schema:givenName Miyeun
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144036024.89
205 rdf:type schema:Person
206 sg:person.013112032141.39 schema:affiliation grid-institutes:grid.412588.2
207 schema:familyName Park
208 schema:givenName Meeyoung
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013112032141.39
210 rdf:type schema:Person
211 sg:person.0712676025.34 schema:affiliation grid-institutes:grid.412588.2
212 schema:familyName Ha
213 schema:givenName Hong Koo
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712676025.34
215 rdf:type schema:Person
216 sg:person.0724001121.26 schema:affiliation grid-institutes:grid.412588.2
217 schema:familyName Kwon
218 schema:givenName Chae Hwa
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724001121.26
220 rdf:type schema:Person
221 sg:pub.10.1007/s00068-007-7152-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1047983489
222 https://doi.org/10.1007/s00068-007-7152-z
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/nmeth.4197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129290
225 https://doi.org/10.1038/nmeth.4197
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/nrneph.2011.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036564609
228 https://doi.org/10.1038/nrneph.2011.13
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/s41419-019-1556-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113300649
231 https://doi.org/10.1038/s41419-019-1556-7
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/s41598-018-26804-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104306715
234 https://doi.org/10.1038/s41598-018-26804-8
235 rdf:type schema:CreativeWork
236 sg:pub.10.1186/s13059-014-0550-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015222646
237 https://doi.org/10.1186/s13059-014-0550-8
238 rdf:type schema:CreativeWork
239 grid-institutes:grid.412588.2 schema:alternateName Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea
240 Department of Internal Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea
241 Department of Urology, Pusan National University Hospital, Busan, South Korea
242 schema:name Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea
243 Department of Internal Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea
244 Department of Urology, Pusan National University Hospital, Busan, South Korea
245 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...