LOng-term follow-up after liVE kidney donation (LOVE) study: a longitudinal comparison study protocol View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Shiromani Janki, Karel W. J. Klop, Hendrikus J. A. N. Kimenai, Jacqueline van de Wetering, Willem Weimar, Emma K. Massey, Abbas Dehghan, Dimitris Rizopoulos, Henry Völzke, Albert Hofman, Jan N. M. Ijzermans

ABSTRACT

BACKGROUND: The benefits of live donor kidney transplantation must be balanced against the potential harm to the donor. Well-designed prospective studies are needed to study the long-term consequences of kidney donation. METHODS: The "LOng-term follow-up after liVE kidney donation" (LOVE) study is a single center longitudinal cohort study on long-term consequences after living kidney donation. We will study individuals who have donated a kidney from 1981 through 2010 in the Erasmus University Medical Center in Rotterdam, The Netherlands. In this time period, 1092 individuals donated a kidney and contact information is available for all individuals. Each participating donor will be matched (1:4) to non-donors derived from the population-based cohort studies of the Rotterdam Study and the Study of Health in Pomerania. Matching will be based on baseline age, gender, BMI, ethnicity, kidney function, blood pressure, pre-existing co-morbidity, smoking, the use of alcohol and highest education degree. Follow-up data is collected on kidney function, kidney-related comorbidity, mortality, quality of life and psychological outcomes in all participants. DISCUSSION: This study will provide evidence on the long-term consequences of live kidney donation for the donor compared to matched non-donors and evaluate the current donor eligibility criteria. TRIAL REGISTRATION: Dutch Trial Register NTR3795 . More... »

PAGES

14

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12882-016-0227-5

DOI

http://dx.doi.org/10.1186/s12882-016-0227-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044909223

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26830198


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