18F-FDG-PET/CT in relapsed multiple myeloma: Are prognostic thresholds different from first-line therapy? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-04-04

AUTHORS

Romans Zukovs, Christina Antke, Eduards Mamlins, Lino Morris Sawicki, Annemarie Mohring, David Lopez y Niedenhoff, Amelie Boquoi, Mustafa Kondakci, Gerald Antoch, Hans-Wilhelm Müller, Roland Fenk, Rainer Haas

ABSTRACT

PurposeWhile 18F-FDG PET/CT yields valuable prognostic information for patients in first-line therapy of multiple myeloma (MM), its prognostic relevance in relapse is not established. Available studies of relapsed MM describe prognostic thresholds for frequently used PET/CT parameters that are significantly higher than those identified in the first-line setting. The purpose of this study was to evaluate the prognostic role of PET/CT in relapsed MM, based on parameters used in the first-line setting.MethodsOur retrospective study included 36 patients with MM who had received autologous or allogeneic stem cell transplantation, suffered at least one relapse, and underwent FDG-PET/CT at relapse. Number of focal bone lesions (FL), maximal standardised uptake value (SUVmax), and presence of PET-positive extramedullary lesions (EMD) were analysed.ResultsFor the number of FLs, the prognostic value was demonstrated with a cut-off of > 3 (median OS 3.8 months vs. not reached, p = 0.003). Median OS of patients with SUVmax ≤ 4 was not reached, while it was 3.9 months in patients with SUVmax > 4 (p = 0.014). Presence of EMD was a significant prognostic parameter too, with median OS of 3.6 months versus not reached (p = 0.004). The above-mentioned parameters showed prognostic significance for PFS as well. Combination of higher ISS stage and PET/CT parameters identified patients with particularly short OS (3.7 months vs. not reached, p < 0.001) and PFS (3.6 vs. 11.7 months p < 0.001).ConclusionThe PET/CT parameters SUVmax > 4, nFL > 3, and presence of EMD identify patients with poor prognosis not only in the first-line setting but also in relapsed MM. More... »

PAGES

63

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12880-022-00788-4

DOI

http://dx.doi.org/10.1186/s12880-022-00788-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1146867372

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35379187


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