Quantification of porcine myocardial perfusion with modified dual bolus MRI – a prospective study with a PET reference View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-07-26

AUTHORS

Minna Husso, Mikko J. Nissi, Antti Kuivanen, Paavo Halonen, Miikka Tarkia, Jarmo Teuho, Virva Saunavaara, Pauli Vainio, Petri Sipola, Hannu Manninen, Seppo Ylä-Herttuala, Juhani Knuuti, Juha Töyräs

ABSTRACT

BackgroundThe reliable quantification of myocardial blood flow (MBF) with MRI, necessitates the correction of errors in arterial input function (AIF) caused by the T1 saturation effect. The aim of this study was to compare MBF determined by a traditional dual bolus method against a modified dual bolus approach and to evaluate both methods against PET in a porcine model of myocardial ischemia.MethodsLocal myocardial ischemia was induced in five pigs, which were subsequently examined with contrast enhanced MRI (gadoteric acid) and PET (O-15 water). In the determination of MBF, the initial high concentration AIF was corrected using the ratio of low and high contrast AIF areas, normalized according to the corresponding heart rates. MBF was determined from the MRI, during stress and at rest, using the dual bolus and the modified dual bolus methods in 24 segments of the myocardium (total of 240 segments, five pigs in stress and rest). Due to image artifacts and technical problems 53% of the segments had to be rejected from further analyses. These two estimates were later compared against respective rest and stress PET-based MBF measurements.ResultsValues of MBF were determined for 112/240 regions. Correlations for MBF between the modified dual bolus method and PET was rs = 0.84, and between the traditional dual bolus method and PET rs = 0.79. The intraclass correlation was very good (ICC = 0.85) between the modified dual bolus method and PET, but poor between the traditional dual bolus method and PET (ICC = 0.07).ConclusionsThe modified dual bolus method showed a better agreement with PET than the traditional dual bolus method. The modified dual bolus method was found to be more reliable than the traditional dual bolus method, especially when there was variation in the heart rate. However, the difference between the MBF values estimated with either of the two MRI-based dual-bolus methods and those estimated with the gold-standard PET method were statistically significant. More... »

PAGES

58

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12880-019-0359-8

DOI

http://dx.doi.org/10.1186/s12880-019-0359-8

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https://app.dimensions.ai/details/publication/pub.1119864639

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31349798


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25 schema:description BackgroundThe reliable quantification of myocardial blood flow (MBF) with MRI, necessitates the correction of errors in arterial input function (AIF) caused by the T1 saturation effect. The aim of this study was to compare MBF determined by a traditional dual bolus method against a modified dual bolus approach and to evaluate both methods against PET in a porcine model of myocardial ischemia.MethodsLocal myocardial ischemia was induced in five pigs, which were subsequently examined with contrast enhanced MRI (gadoteric acid) and PET (O-15 water). In the determination of MBF, the initial high concentration AIF was corrected using the ratio of low and high contrast AIF areas, normalized according to the corresponding heart rates. MBF was determined from the MRI, during stress and at rest, using the dual bolus and the modified dual bolus methods in 24 segments of the myocardium (total of 240 segments, five pigs in stress and rest). Due to image artifacts and technical problems 53% of the segments had to be rejected from further analyses. These two estimates were later compared against respective rest and stress PET-based MBF measurements.ResultsValues of MBF were determined for 112/240 regions. Correlations for MBF between the modified dual bolus method and PET was rs = 0.84, and between the traditional dual bolus method and PET rs = 0.79. The intraclass correlation was very good (ICC = 0.85) between the modified dual bolus method and PET, but poor between the traditional dual bolus method and PET (ICC = 0.07).ConclusionsThe modified dual bolus method showed a better agreement with PET than the traditional dual bolus method. The modified dual bolus method was found to be more reliable than the traditional dual bolus method, especially when there was variation in the heart rate. However, the difference between the MBF values estimated with either of the two MRI-based dual-bolus methods and those estimated with the gold-standard PET method were statistically significant.
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33 Further analysis
34 MBF measurements
35 MBF values
36 MRI
37 PET
38 PET method
39 RS
40 ResultsValues
41 T1 saturation effects
42 agreement
43 aim
44 analysis
45 approach
46 area
47 arterial input function
48 artifacts
49 blood flow
50 bolus
51 bolus method
52 contrast
53 correction
54 correction of errors
55 correlation
56 corresponding heart rate
57 determination
58 determination of MBF
59 differences
60 dual bolus
61 dual-bolus approach
62 dual-bolus method
63 effect
64 error
65 estimates
66 flow
67 function
68 good agreement
69 heart rate
70 input function
71 intraclass correlation
72 ischemia
73 measurements
74 method
75 model
76 myocardial blood flow
77 myocardial ischemia
78 myocardial perfusion
79 myocardium
80 perfusion
81 pigs
82 porcine model
83 prospective study
84 quantification
85 rate
86 ratio
87 reference
88 region
89 reliable quantification
90 rest
91 saturation effects
92 segments
93 stress
94 stress PET
95 study
96 values
97 variation
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