Evaluation of a standardised protocol to measure the disease burden of respiratory syncytial virus infection in young children in primary ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-07-26

AUTHORS

J. J. G. T. van Summeren, C. Rizzo, M. Hooiveld, J. C. Korevaar, J. M. T. Hendriksen, M. L. A. Dückers, D. Loconsole, M. Chironna, M. Bangert, C. Demont, A. Meijer, S. Caini, E. Pandolfi, J. Paget

ABSTRACT

BACKGROUND: A better understanding of the burden of respiratory syncytial virus (RSV) infections in primary care is needed for policymakers to make informed decisions regarding new preventive measures and treatments. The aim of this study was to develop and evaluate a protocol for the standardised measurement of the disease burden of RSV infection in primary care in children aged < 5 years. METHODS: The standardised protocol was evaluated in Italy and the Netherlands during the 2019/20 winter. Children aged < 5 years who consulted their primary care physician, met the WHO acute respiratory infections (ARI) case definition, and had a laboratory confirmed positive test for RSV (RT-PCR) were included. RSV symptoms were collected at the time of swabbing. Health care use, duration of symptoms and socio-economic impact was measured 14 days after swabbing. Health related Quality of life (HRQoL) was measured using the parent-proxy report of the PedsQL™4.0 generic core scales (2-4 years) and PedsQL™4.0 infant scales (0-2 years) 30 days after swabbing. The standardised protocol was evaluated in terms of the feasibility of patient recruitment, data collection procedures and whether parents understood the questions. RESULTS: Children were recruited via a network of paediatricians in Italy and a sentinel influenza surveillance network of general practitioners in the Netherlands. In Italy and the Netherlands, 293 and 152 children were swabbed respectively, 119 and 32 tested RSV positive; for 119 and 12 children the Day-14 questionnaire was completed and for 116 and 11 the Day-30 questionnaire. In Italy, 33% of the children had persistent symptoms after 14 days and in the Netherlands this figure was 67%. Parents had no problems completing questions concerning health care use, duration of symptoms and socio-economic impact, however, they had some difficulties scoring the HRQoL of their young children. CONCLUSION: RSV symptoms are common after 14 days, and therefore, measuring disease burden outcomes like health care use, duration of symptoms, and socio-economic impact is also recommended at Day-30. The standardised protocol is suitable to measure the clinical and socio-economic disease burden of RSV in young children in primary care. More... »

PAGES

705

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12879-021-06397-w

DOI

http://dx.doi.org/10.1186/s12879-021-06397-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1139923379

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34311699


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22 schema:description BACKGROUND: A better understanding of the burden of respiratory syncytial virus (RSV) infections in primary care is needed for policymakers to make informed decisions regarding new preventive measures and treatments. The aim of this study was to develop and evaluate a protocol for the standardised measurement of the disease burden of RSV infection in primary care in children aged < 5 years. METHODS: The standardised protocol was evaluated in Italy and the Netherlands during the 2019/20 winter. Children aged < 5 years who consulted their primary care physician, met the WHO acute respiratory infections (ARI) case definition, and had a laboratory confirmed positive test for RSV (RT-PCR) were included. RSV symptoms were collected at the time of swabbing. Health care use, duration of symptoms and socio-economic impact was measured 14 days after swabbing. Health related Quality of life (HRQoL) was measured using the parent-proxy report of the PedsQL™4.0 generic core scales (2-4 years) and PedsQL™4.0 infant scales (0-2 years) 30 days after swabbing. The standardised protocol was evaluated in terms of the feasibility of patient recruitment, data collection procedures and whether parents understood the questions. RESULTS: Children were recruited via a network of paediatricians in Italy and a sentinel influenza surveillance network of general practitioners in the Netherlands. In Italy and the Netherlands, 293 and 152 children were swabbed respectively, 119 and 32 tested RSV positive; for 119 and 12 children the Day-14 questionnaire was completed and for 116 and 11 the Day-30 questionnaire. In Italy, 33% of the children had persistent symptoms after 14 days and in the Netherlands this figure was 67%. Parents had no problems completing questions concerning health care use, duration of symptoms and socio-economic impact, however, they had some difficulties scoring the HRQoL of their young children. CONCLUSION: RSV symptoms are common after 14 days, and therefore, measuring disease burden outcomes like health care use, duration of symptoms, and socio-economic impact is also recommended at Day-30. The standardised protocol is suitable to measure the clinical and socio-economic disease burden of RSV in young children in primary care.
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29 schema:keywords Core Scales
30 Day-14 questionnaire
31 Day-30 questionnaire
32 Generic Core Scales
33 HRQoL
34 Influenza Surveillance Network
35 Italy
36 Netherlands
37 PedsQL
38 RSV
39 RSV infection
40 RSV symptoms
41 Scale-30
42 WHO acute respiratory infections (ARI) case definition
43 acute respiratory infections (ARI) case definition
44 aim
45 better understanding
46 burden
47 burden outcomes
48 care
49 care physicians
50 care use
51 case definition
52 children
53 collection procedures
54 data collection procedures
55 day 30
56 days
57 decisions
58 definition
59 difficulties
60 disease burden
61 disease burden outcomes
62 duration
63 duration of symptoms
64 evaluation
65 feasibility
66 figures
67 general practitioners
68 health
69 health care use
70 impact
71 infant scales (0-2 years) 30
72 infection
73 infections (ARI) case definition
74 informed decisions
75 laboratory
76 life
77 measurements
78 measures
79 network
80 network of pediatricians
81 new preventive measures
82 outcomes
83 parent proxy report
84 parents
85 patient recruitment
86 pediatricians
87 persistent symptoms
88 physicians
89 policymakers
90 positive test
91 practitioners
92 preventive measures
93 primary care
94 primary care physicians
95 problem
96 procedure
97 protocol
98 quality
99 quality of life
100 questionnaire
101 questions
102 recruitment
103 report
104 respiratory infections (ARI) case definition
105 respiratory syncytial virus infection
106 scale
107 sentinel influenza surveillance network
108 socio-economic disease burden
109 socio-economic impacts
110 standardised measurements
111 standardised protocol
112 study
113 surveillance network
114 swabbing
115 symptoms
116 syncytial virus infection
117 terms
118 test
119 time
120 time of swabbing
121 treatment
122 understanding
123 use
124 virus infection
125 winter
126 years
127 young children
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