Toll-like receptor 2 downregulation and cytokine dysregulation predict mortality in patients with Staphylococcus aureus bacteremia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-11-30

AUTHORS

Nak-Hyun Kim, Ji Yeon Sung, Yoon Jung Choi, Su-Jin Choi, Soyeon Ahn, Eunjeong Ji, Moonsuk Kim, Chung Jong Kim, Kyoung-Ho Song, Pyoeng Gyun Choe, Wan Beom Park, Eu Suk Kim, Kyoung Un Park, Nam-Joong Kim, Myoung-don Oh, Hong Bin Kim

ABSTRACT

BACKGROUND: Staphylococcus aureus bacteremia (SAB) presents heterogeneously, owing to the differences in underlying host conditions and immune responses. Although Toll-like receptor 2 (TLR2) is important in recognizing S. aureus, its function during S. aureus infection remains controversial. We aimed to examine the association of TLR2 expression and associated cytokine responses with clinical SAB outcomes. METHODS: Patients from a prospective SAB cohort at two tertiary-care medical centers were enrolled. Blood was sampled at several timepoints (≤5 d, 6-9 d, 10-13 d, 14-19 d, and ≥ 20 d) after SAB onset. TLR2 mRNA levels were determined via real-time PCR and serum tumor necrosis factor [TNF]-α, interleukin [IL]-6, and IL-10 levels were analyzed with multiplex-high-sensitivity electrochemiluminescent ELISA. RESULTS: TLR2 levels varied among 59 SAB patients. On days 2-5, TLR2 levels were significantly higher in SAB survivors than in healthy controls (p = 0.040) and slightly but not significantly higher than non-survivors (p = 0.120), and SAB patients dying within 7 d had lower TLR2 levels than survivors (P = 0.077) although statistically insignificant. IL-6 and IL-10 levels were significantly higher in non-survivors than in survivors on days 2-5 post-bacteremia (P = 0.010 and P = 0.021, respectively), and those dying within 7 d of SAB (n = 3) displayed significantly higher IL-10/TNF-α ratios than the survivors did (P = 0.007). CONCLUSION: TLR2 downregulation and IL-6 and IL-10 concentrations suggestive of immune dysregulation during early bacteremia may be associated with mortality from SAB. TLR2 expression levels and associated cytokine reactions during early-phase SAB may be potential prognostic factors in SAB, although larger studies are warranted. More... »

PAGES

901

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12879-020-05641-z

DOI

http://dx.doi.org/10.1186/s12879-020-05641-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1132949066

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33256638


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacteremia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Real-Time Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Staphylococcal Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Staphylococcus aureus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survivors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tertiary Care Centers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Toll-Like Receptor 2", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 173 Gumi-ro, Bundang-gu, Seongnam, 463-707 Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 173 Gumi-ro, Bundang-gu, Seongnam, 463-707 Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Nak-Hyun", 
        "id": "sg:person.0616675767.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616675767.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Present Address: Roche Korea, Seoul, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.497724.b", 
          "name": [
            "Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea", 
            "Present Address: Roche Korea, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sung", 
        "givenName": "Ji Yeon", 
        "id": "sg:person.01235652043.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235652043.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 173 Gumi-ro, Bundang-gu, Seongnam, 463-707 Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 173 Gumi-ro, Bundang-gu, Seongnam, 463-707 Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Yoon Jung", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Su-Jin", 
        "id": "sg:person.0635245473.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635245473.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahn", 
        "givenName": "Soyeon", 
        "id": "sg:person.0612662613.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612662613.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ji", 
        "givenName": "Eunjeong", 
        "id": "sg:person.016541652125.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016541652125.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 173 Gumi-ro, Bundang-gu, Seongnam, 463-707 Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 173 Gumi-ro, Bundang-gu, Seongnam, 463-707 Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Moonsuk", 
        "id": "sg:person.0665725307.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665725307.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Present Address: Department of Internal Medicine, Ewha Womans University, Seoul Hospital, Seoul, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.255649.9", 
          "name": [
            "Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 173 Gumi-ro, Bundang-gu, Seongnam, 463-707 Republic of Korea", 
            "Present Address: Department of Internal Medicine, Ewha Womans University, Seoul Hospital, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Chung Jong", 
        "id": "sg:person.0655170332.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655170332.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 173 Gumi-ro, Bundang-gu, Seongnam, 463-707 Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 173 Gumi-ro, Bundang-gu, Seongnam, 463-707 Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "Kyoung-Ho", 
        "id": "sg:person.01310554357.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310554357.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choe", 
        "givenName": "Pyoeng Gyun", 
        "id": "sg:person.01210522174.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210522174.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Wan Beom", 
        "id": "sg:person.01324716211.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324716211.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 173 Gumi-ro, Bundang-gu, Seongnam, 463-707 Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 173 Gumi-ro, Bundang-gu, Seongnam, 463-707 Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Eu Suk", 
        "id": "sg:person.0647315516.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647315516.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Kyoung Un", 
        "id": "sg:person.016150674734.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016150674734.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Nam-Joong", 
        "id": "sg:person.01002153707.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002153707.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oh", 
        "givenName": "Myoung-don", 
        "id": "sg:person.0753553026.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753553026.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 173 Gumi-ro, Bundang-gu, Seongnam, 463-707 Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 173 Gumi-ro, Bundang-gu, Seongnam, 463-707 Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bin Kim", 
        "givenName": "Hong", 
        "id": "sg:person.014062430341.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014062430341.86"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/s12879-014-0580-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028229302", 
          "https://doi.org/10.1186/s12879-014-0580-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2008.73", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005355981", 
          "https://doi.org/10.1038/nprot.2008.73"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2334-13-581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027387041", 
          "https://doi.org/10.1186/1471-2334-13-581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023753307", 
          "https://doi.org/10.1038/nri1391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-012-0926-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030283936", 
          "https://doi.org/10.1007/s00109-012-0926-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms12304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026509644", 
          "https://doi.org/10.1038/ncomms12304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01709751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052044737", 
          "https://doi.org/10.1007/bf01709751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1746-1596-4-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038474274", 
          "https://doi.org/10.1186/1746-1596-4-12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048773380", 
          "https://doi.org/10.1038/nature03253"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-11-30", 
    "datePublishedReg": "2020-11-30", 
    "description": "BACKGROUND: Staphylococcus aureus bacteremia (SAB) presents heterogeneously, owing to the differences in underlying host conditions and immune responses. Although Toll-like receptor 2 (TLR2) is important in recognizing S. aureus, its function during S. aureus infection remains controversial. We aimed to examine the association of TLR2 expression and associated cytokine responses with clinical SAB outcomes.\nMETHODS: Patients from a prospective SAB cohort at two tertiary-care medical centers were enrolled. Blood was sampled at several timepoints (\u22645 d, 6-9 d, 10-13 d, 14-19 d, and\u2009\u2265\u200920 d) after SAB onset. TLR2 mRNA levels were determined via real-time PCR and serum tumor necrosis factor [TNF]-\u03b1, interleukin [IL]-6, and IL-10 levels were analyzed with multiplex-high-sensitivity electrochemiluminescent ELISA.\nRESULTS: TLR2 levels varied among 59 SAB patients. On days 2-5, TLR2 levels were significantly higher in SAB survivors than in healthy controls (p\u2009=\u20090.040) and slightly but not significantly higher than non-survivors (p\u2009=\u20090.120), and SAB patients dying within 7 d had lower TLR2 levels than survivors (P\u2009=\u20090.077) although statistically insignificant. IL-6 and IL-10 levels were significantly higher in non-survivors than in survivors on days 2-5 post-bacteremia (P\u2009=\u20090.010 and P\u2009=\u20090.021, respectively), and those dying within 7 d of SAB (n\u2009=\u20093) displayed significantly higher IL-10/TNF-\u03b1 ratios than the survivors did (P\u2009=\u20090.007).\nCONCLUSION: TLR2 downregulation and IL-6 and IL-10 concentrations suggestive of immune dysregulation during early bacteremia may be associated with mortality from SAB. TLR2 expression levels and associated cytokine reactions during early-phase SAB may be potential prognostic factors in SAB, although larger studies are warranted.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12879-020-05641-z", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024946", 
        "issn": [
          "1471-2334"
        ], 
        "name": "BMC Infectious Diseases", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "keywords": [
      "Staphylococcus aureus bacteremia", 
      "Toll-like receptor 2", 
      "IL-10 levels", 
      "TLR2 levels", 
      "SAB patients", 
      "aureus bacteremia", 
      "IL-6", 
      "day 2", 
      "serum tumor necrosis factor", 
      "tertiary care medical center", 
      "IL-10/TNF", 
      "TLR2 mRNA levels", 
      "IL-10 concentrations", 
      "potential prognostic factors", 
      "tumor necrosis factor", 
      "TLR2 expression levels", 
      "SAB onset", 
      "TLR2 expression", 
      "immune dysregulation", 
      "cytokine reaction", 
      "prognostic factors", 
      "cytokine dysregulation", 
      "cytokine responses", 
      "early bacteremia", 
      "aureus infection", 
      "healthy controls", 
      "necrosis factor", 
      "immune response", 
      "real-time PCR", 
      "Medical Center", 
      "receptor 2", 
      "patients", 
      "larger study", 
      "bacteremia", 
      "survivors", 
      "mRNA levels", 
      "expression levels", 
      "mortality", 
      "host conditions", 
      "dysregulation", 
      "downregulation", 
      "levels", 
      "interleukin", 
      "TNF", 
      "cohort", 
      "infection", 
      "blood", 
      "ELISA", 
      "response", 
      "timepoints", 
      "outcomes", 
      "factors", 
      "onset", 
      "association", 
      "aureus", 
      "PCR", 
      "expression", 
      "differences", 
      "control", 
      "center", 
      "study", 
      "concentration", 
      "function", 
      "ratio", 
      "reaction", 
      "conditions", 
      "clinical SAB outcomes", 
      "SAB outcomes", 
      "prospective SAB cohort", 
      "SAB cohort", 
      "sensitivity electrochemiluminescent ELISA", 
      "electrochemiluminescent ELISA", 
      "SAB survivors", 
      "lower TLR2 levels", 
      "higher IL-10/TNF", 
      "TLR2 downregulation", 
      "early-phase SAB", 
      "Toll-like receptor 2 downregulation", 
      "receptor 2 downregulation"
    ], 
    "name": "Toll-like receptor 2 downregulation and cytokine dysregulation predict mortality in patients with Staphylococcus aureus bacteremia", 
    "pagination": "901", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1132949066"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12879-020-05641-z"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "33256638"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12879-020-05641-z", 
      "https://app.dimensions.ai/details/publication/pub.1132949066"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_865.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12879-020-05641-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12879-020-05641-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12879-020-05641-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12879-020-05641-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12879-020-05641-z'


 

This table displays all metadata directly associated to this object as RDF triples.

372 TRIPLES      22 PREDICATES      133 URIs      116 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12879-020-05641-z schema:about N12599068dcf345cfaa972333551cd89c
2 N1b3bf4db20ed4b7da437df5a588a8b36
3 N2637053bf8ab4f3db64a008234a96907
4 N29a5db34622c49509ad5ab928b07b4d2
5 N66fe5087f5d140fcba7e381710df562f
6 N7bcb3419516f4c82a1228d0af854814b
7 N7c1af5633aba47eea46f918b324a6649
8 N952d8958550044509c20a6144e2f8524
9 N97258910e44641cda47e786608cb0b37
10 N9873c57354c44e659953fce619449a74
11 Na93e6552a74549f680c3e755ae06b9c8
12 Nb50b9f922ca44ffcb4587bcaa713aad4
13 Nc386fcca967644c7843584df0b5a1e86
14 Nc507e24672b54552818cb71a0452f4ee
15 Nc8cc034b80574d91880ad1bd4fc7bf9c
16 Ncc0cd1292fcd4d8bb3c6cc1deaee85b7
17 Ndeb9dd70cf604b12a58edf737bad34a2
18 Nec07d47f6b9d4811ac0ef86caf43604f
19 Nfef51bd07fb64723b1caa672e1359244
20 anzsrc-for:11
21 anzsrc-for:1107
22 schema:author N447394d12f5c4d7cba2a7a1061c1fb23
23 schema:citation sg:pub.10.1007/bf01709751
24 sg:pub.10.1007/s00109-012-0926-8
25 sg:pub.10.1038/nature03253
26 sg:pub.10.1038/ncomms12304
27 sg:pub.10.1038/nprot.2008.73
28 sg:pub.10.1038/nri1391
29 sg:pub.10.1186/1471-2334-13-581
30 sg:pub.10.1186/1746-1596-4-12
31 sg:pub.10.1186/s12879-014-0580-6
32 schema:datePublished 2020-11-30
33 schema:datePublishedReg 2020-11-30
34 schema:description BACKGROUND: Staphylococcus aureus bacteremia (SAB) presents heterogeneously, owing to the differences in underlying host conditions and immune responses. Although Toll-like receptor 2 (TLR2) is important in recognizing S. aureus, its function during S. aureus infection remains controversial. We aimed to examine the association of TLR2 expression and associated cytokine responses with clinical SAB outcomes. METHODS: Patients from a prospective SAB cohort at two tertiary-care medical centers were enrolled. Blood was sampled at several timepoints (≤5 d, 6-9 d, 10-13 d, 14-19 d, and ≥ 20 d) after SAB onset. TLR2 mRNA levels were determined via real-time PCR and serum tumor necrosis factor [TNF]-α, interleukin [IL]-6, and IL-10 levels were analyzed with multiplex-high-sensitivity electrochemiluminescent ELISA. RESULTS: TLR2 levels varied among 59 SAB patients. On days 2-5, TLR2 levels were significantly higher in SAB survivors than in healthy controls (p = 0.040) and slightly but not significantly higher than non-survivors (p = 0.120), and SAB patients dying within 7 d had lower TLR2 levels than survivors (P = 0.077) although statistically insignificant. IL-6 and IL-10 levels were significantly higher in non-survivors than in survivors on days 2-5 post-bacteremia (P = 0.010 and P = 0.021, respectively), and those dying within 7 d of SAB (n = 3) displayed significantly higher IL-10/TNF-α ratios than the survivors did (P = 0.007). CONCLUSION: TLR2 downregulation and IL-6 and IL-10 concentrations suggestive of immune dysregulation during early bacteremia may be associated with mortality from SAB. TLR2 expression levels and associated cytokine reactions during early-phase SAB may be potential prognostic factors in SAB, although larger studies are warranted.
35 schema:genre article
36 schema:inLanguage en
37 schema:isAccessibleForFree true
38 schema:isPartOf N1653daae5a514edd9301e9c12bda9803
39 Nb64589273188483d832b022ec5028606
40 sg:journal.1024946
41 schema:keywords ELISA
42 IL-10 concentrations
43 IL-10 levels
44 IL-10/TNF
45 IL-6
46 Medical Center
47 PCR
48 SAB cohort
49 SAB onset
50 SAB outcomes
51 SAB patients
52 SAB survivors
53 Staphylococcus aureus bacteremia
54 TLR2 downregulation
55 TLR2 expression
56 TLR2 expression levels
57 TLR2 levels
58 TLR2 mRNA levels
59 TNF
60 Toll-like receptor 2
61 Toll-like receptor 2 downregulation
62 association
63 aureus
64 aureus bacteremia
65 aureus infection
66 bacteremia
67 blood
68 center
69 clinical SAB outcomes
70 cohort
71 concentration
72 conditions
73 control
74 cytokine dysregulation
75 cytokine reaction
76 cytokine responses
77 day 2
78 differences
79 downregulation
80 dysregulation
81 early bacteremia
82 early-phase SAB
83 electrochemiluminescent ELISA
84 expression
85 expression levels
86 factors
87 function
88 healthy controls
89 higher IL-10/TNF
90 host conditions
91 immune dysregulation
92 immune response
93 infection
94 interleukin
95 larger study
96 levels
97 lower TLR2 levels
98 mRNA levels
99 mortality
100 necrosis factor
101 onset
102 outcomes
103 patients
104 potential prognostic factors
105 prognostic factors
106 prospective SAB cohort
107 ratio
108 reaction
109 real-time PCR
110 receptor 2
111 receptor 2 downregulation
112 response
113 sensitivity electrochemiluminescent ELISA
114 serum tumor necrosis factor
115 study
116 survivors
117 tertiary care medical center
118 timepoints
119 tumor necrosis factor
120 schema:name Toll-like receptor 2 downregulation and cytokine dysregulation predict mortality in patients with Staphylococcus aureus bacteremia
121 schema:pagination 901
122 schema:productId N001f1f45fdb248a5ab1d138311d8d31a
123 N270d125e58ff4f5cbdb11352931d54ff
124 N86310cb747fa4b52a9178114393ef833
125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132949066
126 https://doi.org/10.1186/s12879-020-05641-z
127 schema:sdDatePublished 2022-01-01T18:54
128 schema:sdLicense https://scigraph.springernature.com/explorer/license/
129 schema:sdPublisher Nacdef65c3305447eb91aa9b4a3807796
130 schema:url https://doi.org/10.1186/s12879-020-05641-z
131 sgo:license sg:explorer/license/
132 sgo:sdDataset articles
133 rdf:type schema:ScholarlyArticle
134 N001f1f45fdb248a5ab1d138311d8d31a schema:name doi
135 schema:value 10.1186/s12879-020-05641-z
136 rdf:type schema:PropertyValue
137 N069c98ec364247c4805c7e2df4f3514c rdf:first sg:person.01002153707.23
138 rdf:rest Naf14cb69bba540498215f5dc7539bb3c
139 N12599068dcf345cfaa972333551cd89c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Male
141 rdf:type schema:DefinedTerm
142 N12defb87e82641a998a653e99b43966e rdf:first sg:person.0612662613.04
143 rdf:rest N3d141289a88445f79bb3a654a3feefb0
144 N1653daae5a514edd9301e9c12bda9803 schema:volumeNumber 20
145 rdf:type schema:PublicationVolume
146 N1b3bf4db20ed4b7da437df5a588a8b36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Bacteremia
148 rdf:type schema:DefinedTerm
149 N2637053bf8ab4f3db64a008234a96907 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Prospective Studies
151 rdf:type schema:DefinedTerm
152 N270d125e58ff4f5cbdb11352931d54ff schema:name dimensions_id
153 schema:value pub.1132949066
154 rdf:type schema:PropertyValue
155 N29a5db34622c49509ad5ab928b07b4d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name RNA, Messenger
157 rdf:type schema:DefinedTerm
158 N3d141289a88445f79bb3a654a3feefb0 rdf:first sg:person.016541652125.35
159 rdf:rest N470c79faf7e94f8c8376d469753ce0c1
160 N404657c203aa40ce9473243a77ad1885 rdf:first sg:person.01310554357.50
161 rdf:rest N557c0ef7b0f34718a0df31b12310d8d7
162 N447394d12f5c4d7cba2a7a1061c1fb23 rdf:first sg:person.0616675767.09
163 rdf:rest N8659b83f6b1e4abc8b12b0775d90dd06
164 N470c79faf7e94f8c8376d469753ce0c1 rdf:first sg:person.0665725307.41
165 rdf:rest N536a7392ebe14c8196b225fc7d82de03
166 N536a7392ebe14c8196b225fc7d82de03 rdf:first sg:person.0655170332.40
167 rdf:rest N404657c203aa40ce9473243a77ad1885
168 N557c0ef7b0f34718a0df31b12310d8d7 rdf:first sg:person.01210522174.08
169 rdf:rest Nee25698660854f82885bcbb63c16991f
170 N66fe5087f5d140fcba7e381710df562f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Down-Regulation
172 rdf:type schema:DefinedTerm
173 N6c7921a307fa4c99b25ff94588cc6cc3 schema:affiliation grid-institutes:grid.412480.b
174 schema:familyName Choi
175 schema:givenName Yoon Jung
176 rdf:type schema:Person
177 N7bcb3419516f4c82a1228d0af854814b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Humans
179 rdf:type schema:DefinedTerm
180 N7c1af5633aba47eea46f918b324a6649 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Cytokines
182 rdf:type schema:DefinedTerm
183 N86310cb747fa4b52a9178114393ef833 schema:name pubmed_id
184 schema:value 33256638
185 rdf:type schema:PropertyValue
186 N8659b83f6b1e4abc8b12b0775d90dd06 rdf:first sg:person.01235652043.72
187 rdf:rest Nced976e41d7b4683b204d876a068e5a7
188 N882a9ed01ea948b69a9fc6496fa3fde8 rdf:first sg:person.016150674734.79
189 rdf:rest N069c98ec364247c4805c7e2df4f3514c
190 N952d8958550044509c20a6144e2f8524 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Real-Time Polymerase Chain Reaction
192 rdf:type schema:DefinedTerm
193 N97258910e44641cda47e786608cb0b37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Tertiary Care Centers
195 rdf:type schema:DefinedTerm
196 N9873c57354c44e659953fce619449a74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Prognosis
198 rdf:type schema:DefinedTerm
199 Na93e6552a74549f680c3e755ae06b9c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Female
201 rdf:type schema:DefinedTerm
202 Nabc694ff4f604630b2d216ade20eb111 rdf:first sg:person.014062430341.86
203 rdf:rest rdf:nil
204 Nacdef65c3305447eb91aa9b4a3807796 schema:name Springer Nature - SN SciGraph project
205 rdf:type schema:Organization
206 Naf14cb69bba540498215f5dc7539bb3c rdf:first sg:person.0753553026.28
207 rdf:rest Nabc694ff4f604630b2d216ade20eb111
208 Nb50b9f922ca44ffcb4587bcaa713aad4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Adult
210 rdf:type schema:DefinedTerm
211 Nb64589273188483d832b022ec5028606 schema:issueNumber 1
212 rdf:type schema:PublicationIssue
213 Nc386fcca967644c7843584df0b5a1e86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Toll-Like Receptor 2
215 rdf:type schema:DefinedTerm
216 Nc507e24672b54552818cb71a0452f4ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Aged, 80 and over
218 rdf:type schema:DefinedTerm
219 Nc631ab6ce5a442feb55403c1302b2607 rdf:first sg:person.0647315516.77
220 rdf:rest N882a9ed01ea948b69a9fc6496fa3fde8
221 Nc8cc034b80574d91880ad1bd4fc7bf9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Aged
223 rdf:type schema:DefinedTerm
224 Ncc0cd1292fcd4d8bb3c6cc1deaee85b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name Survivors
226 rdf:type schema:DefinedTerm
227 Nccbdf99332864bce95187675a7e559c8 rdf:first sg:person.0635245473.97
228 rdf:rest N12defb87e82641a998a653e99b43966e
229 Nced976e41d7b4683b204d876a068e5a7 rdf:first N6c7921a307fa4c99b25ff94588cc6cc3
230 rdf:rest Nccbdf99332864bce95187675a7e559c8
231 Ndeb9dd70cf604b12a58edf737bad34a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
232 schema:name Middle Aged
233 rdf:type schema:DefinedTerm
234 Nec07d47f6b9d4811ac0ef86caf43604f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
235 schema:name Staphylococcal Infections
236 rdf:type schema:DefinedTerm
237 Nee25698660854f82885bcbb63c16991f rdf:first sg:person.01324716211.76
238 rdf:rest Nc631ab6ce5a442feb55403c1302b2607
239 Nfef51bd07fb64723b1caa672e1359244 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
240 schema:name Staphylococcus aureus
241 rdf:type schema:DefinedTerm
242 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
243 schema:name Medical and Health Sciences
244 rdf:type schema:DefinedTerm
245 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
246 schema:name Immunology
247 rdf:type schema:DefinedTerm
248 sg:journal.1024946 schema:issn 1471-2334
249 schema:name BMC Infectious Diseases
250 schema:publisher Springer Nature
251 rdf:type schema:Periodical
252 sg:person.01002153707.23 schema:affiliation grid-institutes:grid.412484.f
253 schema:familyName Kim
254 schema:givenName Nam-Joong
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002153707.23
256 rdf:type schema:Person
257 sg:person.01210522174.08 schema:affiliation grid-institutes:grid.412484.f
258 schema:familyName Choe
259 schema:givenName Pyoeng Gyun
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210522174.08
261 rdf:type schema:Person
262 sg:person.01235652043.72 schema:affiliation grid-institutes:grid.497724.b
263 schema:familyName Sung
264 schema:givenName Ji Yeon
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235652043.72
266 rdf:type schema:Person
267 sg:person.01310554357.50 schema:affiliation grid-institutes:grid.412480.b
268 schema:familyName Song
269 schema:givenName Kyoung-Ho
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310554357.50
271 rdf:type schema:Person
272 sg:person.01324716211.76 schema:affiliation grid-institutes:grid.412484.f
273 schema:familyName Park
274 schema:givenName Wan Beom
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324716211.76
276 rdf:type schema:Person
277 sg:person.014062430341.86 schema:affiliation grid-institutes:grid.412480.b
278 schema:familyName Bin Kim
279 schema:givenName Hong
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014062430341.86
281 rdf:type schema:Person
282 sg:person.016150674734.79 schema:affiliation grid-institutes:grid.412480.b
283 schema:familyName Park
284 schema:givenName Kyoung Un
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016150674734.79
286 rdf:type schema:Person
287 sg:person.016541652125.35 schema:affiliation grid-institutes:grid.412480.b
288 schema:familyName Ji
289 schema:givenName Eunjeong
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016541652125.35
291 rdf:type schema:Person
292 sg:person.0612662613.04 schema:affiliation grid-institutes:grid.412480.b
293 schema:familyName Ahn
294 schema:givenName Soyeon
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612662613.04
296 rdf:type schema:Person
297 sg:person.0616675767.09 schema:affiliation grid-institutes:grid.412480.b
298 schema:familyName Kim
299 schema:givenName Nak-Hyun
300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616675767.09
301 rdf:type schema:Person
302 sg:person.0635245473.97 schema:affiliation grid-institutes:grid.412484.f
303 schema:familyName Choi
304 schema:givenName Su-Jin
305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635245473.97
306 rdf:type schema:Person
307 sg:person.0647315516.77 schema:affiliation grid-institutes:grid.412480.b
308 schema:familyName Kim
309 schema:givenName Eu Suk
310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647315516.77
311 rdf:type schema:Person
312 sg:person.0655170332.40 schema:affiliation grid-institutes:grid.255649.9
313 schema:familyName Kim
314 schema:givenName Chung Jong
315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655170332.40
316 rdf:type schema:Person
317 sg:person.0665725307.41 schema:affiliation grid-institutes:grid.412480.b
318 schema:familyName Kim
319 schema:givenName Moonsuk
320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665725307.41
321 rdf:type schema:Person
322 sg:person.0753553026.28 schema:affiliation grid-institutes:grid.412484.f
323 schema:familyName Oh
324 schema:givenName Myoung-don
325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753553026.28
326 rdf:type schema:Person
327 sg:pub.10.1007/bf01709751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052044737
328 https://doi.org/10.1007/bf01709751
329 rdf:type schema:CreativeWork
330 sg:pub.10.1007/s00109-012-0926-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030283936
331 https://doi.org/10.1007/s00109-012-0926-8
332 rdf:type schema:CreativeWork
333 sg:pub.10.1038/nature03253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048773380
334 https://doi.org/10.1038/nature03253
335 rdf:type schema:CreativeWork
336 sg:pub.10.1038/ncomms12304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026509644
337 https://doi.org/10.1038/ncomms12304
338 rdf:type schema:CreativeWork
339 sg:pub.10.1038/nprot.2008.73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005355981
340 https://doi.org/10.1038/nprot.2008.73
341 rdf:type schema:CreativeWork
342 sg:pub.10.1038/nri1391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023753307
343 https://doi.org/10.1038/nri1391
344 rdf:type schema:CreativeWork
345 sg:pub.10.1186/1471-2334-13-581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027387041
346 https://doi.org/10.1186/1471-2334-13-581
347 rdf:type schema:CreativeWork
348 sg:pub.10.1186/1746-1596-4-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038474274
349 https://doi.org/10.1186/1746-1596-4-12
350 rdf:type schema:CreativeWork
351 sg:pub.10.1186/s12879-014-0580-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028229302
352 https://doi.org/10.1186/s12879-014-0580-6
353 rdf:type schema:CreativeWork
354 grid-institutes:grid.255649.9 schema:alternateName Present Address: Department of Internal Medicine, Ewha Womans University, Seoul Hospital, Seoul, Republic of Korea
355 schema:name Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 173 Gumi-ro, Bundang-gu, Seongnam, 463-707 Republic of Korea
356 Present Address: Department of Internal Medicine, Ewha Womans University, Seoul Hospital, Seoul, Republic of Korea
357 rdf:type schema:Organization
358 grid-institutes:grid.412480.b schema:alternateName Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 173 Gumi-ro, Bundang-gu, Seongnam, 463-707 Republic of Korea
359 Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea
360 Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
361 schema:name Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 173 Gumi-ro, Bundang-gu, Seongnam, 463-707 Republic of Korea
362 Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
363 Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea
364 Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
365 rdf:type schema:Organization
366 grid-institutes:grid.412484.f schema:alternateName Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
367 schema:name Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
368 rdf:type schema:Organization
369 grid-institutes:grid.497724.b schema:alternateName Present Address: Roche Korea, Seoul, Republic of Korea
370 schema:name Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea
371 Present Address: Roche Korea, Seoul, Republic of Korea
372 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...