Cryptococcal fungemia and probable histoplasmosis in a patient infected with HIV. Case report View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Deving Arias Ramos, John Alexander Alzate, Jhon Alejandro Rico Gallego, Natalia Acevedo Escalante

ABSTRACT

BACKGROUND: Those infected by human immunodeficiency virus (HIV) have a higher risk of opportunistic infections. The risk is related to the level of immunosuppression. We report a case of a young male with the unusual scenario of three opportunistic infections occurring simultaneously: Cryptococcosis, Histoplasmosis and Cryptosporidiosis. Histoplasmosis and cryptococcosis are major causes of morbimortality in immunocompromised patients due to HIV infection. CASE PRESENTATION: We report the case of a patient with HIV infection with a CD4 T lymphocyte cell (CD4) count of 2 cells/mm3, who presented with 6 months of diarrhea, non-productive dry cough, nocturnal diaphoresis, fever, weight loss, and a maculopapular rash. He had a concurrent infection with three opportunistic microorganisms: fungemia by cryptococcosis, disseminated histoplasmosis confirmed by detection of the antigen in urine and chronic diarrhea by cryptosporidiosis confirmed by direct observation in feces by modified Ziehl-Neelsen stain. The patient received antifungal treatment with a satisfactory outcome. CONCLUSIONS: There are still regions where HIV detection programs are deficient thus facilitating occurrence of HIV infection cases in advanced stages of immunosuppression. A high level of suspicion of systemic mycoses and concurrent infection by several opportunistic pathogens is required in severely immunocompromised patients. More... »

PAGES

704

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12879-018-3622-7

DOI

http://dx.doi.org/10.1186/s12879-018-3622-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110911611

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30591013


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