Extra-haematological manifestations related to human parvovirus B19 infection: retrospective study in 25 adults View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-07-04

AUTHORS

Marion Dollat, Benjamin Chaigne, Grégoire Cormier, Nathalie Costedoat-Chalumeau, François Lifermann, Alban Deroux, Emilie Berthoux, Emmanuelle Dernis, Thomas Sené, Gilles Blaison, Olivier Lambotte, Benjamin Terrier, Jérémie Sellam, Luc De Saint-Martin, Laurent Chiche, Nicolas Dupin, Luc Mouthon

ABSTRACT

BACKGROUND: To describe extra-haematological manifestations associated with human parvovirus B19 (HPV-B19) infection. METHODS: We conducted a nationwide multicentre study to retrospectively describe the characteristics and outcome of extra-haematological manifestations in French adults. RESULTS: Data from 25 patients followed from 2001 to 2016 were analysed. Median age was 37.9 years (range: 22.7-83.4), with a female predominance (sex ratio: 4/1). Only 3 patients had an underlying predisposing condition (hemoglobinopathy or pregnancy). The most common manifestations were joint (80%) and skin (60%) involvement. Four patients (16%) had renal involvement (endocapillary proliferative or membranoproliferative glomerulonephritis, focal segmental glomerulosclerosis). Three patients (12%) had peripheral nervous system involvement (mononeuritis, mononeuritis multiplex, Guillain-Barré syndrome) and 2 (8%) presented muscle involvement. Other manifestations included hemophagocytic lymphohistiocytosis (n = 1), myopericarditis and pleural effusion (n = 1), and lymphadenopathy and splenomegaly mimicking lymphoma with spleen infarcts (n = 1). Immunological abnormalities were frequent (56.5%). At 6 months, all patients were alive, and 54.2% were in complete remission. In 2 patients, joint involvement evolved into rheumatoid arthritis. Six patients (24%) received intravenous immunoglobulin (IVIg), with a good response in the 3 patients with peripheral nervous system involvement. CONCLUSIONS: HPV-B19 infection should be considered in a wide range of clinical manifestations. Although the prognosis is good, IVIg therapy should be discussed in patients with peripheral nerve involvement. However, its efficacy should be further investigated in prospective studies. More... »

PAGES

302

References to SciGraph publications

Journal

TITLE

BMC Infectious Diseases

ISSUE

1

VOLUME

18

Author Affiliations

  • Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes Rares d’Ile de France, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Descartes, Paris, France
  • Service de Rhumatologie, Centre Hospitalier Départemental Vendée, La Roche-sur-Yon, France
  • Service de Médecine Interne, Centre Hospitalier de Dax - Côte d’Argent, Dax, France
  • Service de Médecine Interne, Centre Hospitalier Universitaire Grenoble Alpes, Université Grenoble Alpes, Grenoble, France
  • Service de Médecine Interne, Centre Hospitalier Saint-Joseph Saint-Luc, Lyon, France
  • Service de Rhumatologie, Centre Hospitalier – Le Mans, Le Mans, France
  • Service de Médecine Interne, Hôpital Foch, Suresnes, France
  • Service de Médecine Interne, Centre Hospitalier Louis Pasteur, Colmar, France
  • Service de Médecine Interne et Immunologie, Hôpital Bicêtre, AP-HP, Université Paris-Sud, Le Kremlin-Bicêtre, France
  • Service de Rhumatologie, Hôpital Saint-Antoine, AP-HP, Université Pierre et Marie Curie, Paris, France
  • Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes Rares Nord et Ouest, Centre Hospitalier Régional et Universitaire de Brest, Université de Bretagne Occidentale, Brest, France
  • Service de Médecine Interne, Hôpital Européen, Marseille, France
  • Service de Dermatologie, Hôpital Cochin, AP-HP, Université Paris Descartes, Paris, France
  • Service de médecine interne, Hôpital Cochin, 27, rue du faubourg Saint-Jacques, 75679 Paris Cedex 14, France
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12879-018-3227-1

    DOI

    http://dx.doi.org/10.1186/s12879-018-3227-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105308597

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29973155


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