Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Guilherme Amaral Calvet, Edna Oliveira Kara, Silvana Pereira Giozza, Camila Helena Aguiar Bôtto-Menezes, Philippe Gaillard, Rafael Freitas de Oliveira Franca, Marcus Vinicius Guimarães de Lacerda, Marcia da Costa Castilho, Patrícia Brasil, Patrícia Carvalho de Sequeira, Maeve Brito de Mello, Ximena Pamela Diaz Bermudez, Kayvon Modjarrad, Robyn Meurant, Sihem Landoulsi, Adele Schwartz Benzaken, Ana Maria Bispo de Filippis, Nathalie Jeanne Nicole Broutet, for the ZIKABRA Study Team

ABSTRACT

BACKGROUND: Zika virus (ZIKV) has been identified in several body fluids of infected individuals. In most cases, it remained detected in blood from few days to 1 week after the onset of symptoms, and can persist longer in urine and in semen. ZIKV infection can have dramatic consequences such as microcephaly and Guillain-Barré syndrome. ZIKV sexual transmission has been documented. A better understanding of ZIKV presence and persistence across biologic compartments is needed to devise rational measures to prevent its transmission. METHODS: This observational cohort study will recruit non-pregnant participants aged 18 years and above with confirmed ZIKV infection [positive reverse transcriptase-polymerase chain reaction (RT-PCR) test in blood and/or urine]: symptomatic men and women in ZIKV infection acute phase, and their symptomatic or asymptomatic household/sexual infected contacts. Specimens of blood, urine, semen, vaginal secretion/menstrual blood, rectal swab, oral fluids, tears, sweat, urine and breast milk (if applicable) will be collected at pre-established intervals and tested for ZIKV RNA presence by RT-PCR, other co-infection (dengue, Chikungunya, HIV, hepatitis B and C, syphilis), antibody response (including immunoglobulins M and G), plaque reduction neutralization test (if simultaneously positive for ZIKV and dengue), and ZIKV culture and RNA sequencing. Data on socio-demographic characteristics and comorbidities will be collected in parallel. Participants will be followed up for 12 months. DISCUSSION: This prolonged longitudinal follow-up of ZIKV infected persons with regular biologic testing and data collection will offer a unique opportunity to investigate the presence and persistence of ZIKV in various biologic compartments, their clinical and immunological correlates as well as the possibility of ZIKV reactivation/reinfection over time. This valuable information will substantially contribute to the body of knowledge on ZIKV infection and serve as a base for the development of more effective recommendation on the prevention of ZIKV transmission. TRIAL REGISTRATION: NCT03106714 . Registration Date: April, 7, 2017. More... »

PAGES

49

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12879-018-2965-4

DOI

http://dx.doi.org/10.1186/s12879-018-2965-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100561282

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29357841


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Fluids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brazil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chikungunya Fever", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coinfection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dengue", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin G", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin M", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Milk, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neutralization Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Semen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zika Virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zika Virus Infection", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Calvet", 
        "givenName": "Guilherme Amaral", 
        "id": "sg:person.0751417546.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751417546.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "World Health Organization", 
          "id": "https://www.grid.ac/institutes/grid.3575.4", 
          "name": [
            "World Health Organization, Geneva, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kara", 
        "givenName": "Edna Oliveira", 
        "id": "sg:person.0653742462.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653742462.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Health", 
          "id": "https://www.grid.ac/institutes/grid.414596.b", 
          "name": [
            "Department of STI, AIDS and Viral Hepatitis, Secretary for Health Surveillance, Ministry of Health Brazil, Brasilia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giozza", 
        "givenName": "Silvana Pereira", 
        "id": "sg:person.01124552710.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124552710.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Tropical Medicine Foundation Doctor Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "B\u00f4tto-Menezes", 
        "givenName": "Camila Helena Aguiar", 
        "id": "sg:person.01200574706.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200574706.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "World Health Organization", 
          "id": "https://www.grid.ac/institutes/grid.3575.4", 
          "name": [
            "World Health Organization, Geneva, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gaillard", 
        "givenName": "Philippe", 
        "id": "sg:person.011007007557.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011007007557.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Aggeu Magalh\u00e3es Research Center, Oswaldo Cruz Foundation, Recife, Pernambuco, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Oliveira Franca", 
        "givenName": "Rafael Freitas", 
        "id": "sg:person.01021423627.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021423627.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Tropical Medicine Foundation Doctor Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Lacerda", 
        "givenName": "Marcus Vinicius Guimar\u00e3es", 
        "id": "sg:person.011421652101.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011421652101.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Tropical Medicine Foundation Doctor Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "da Costa Castilho", 
        "givenName": "Marcia", 
        "id": "sg:person.012631507133.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012631507133.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brasil", 
        "givenName": "Patr\u00edcia", 
        "id": "sg:person.0743146305.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743146305.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Flavivirus Laboratory, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Sequeira", 
        "givenName": "Patr\u00edcia Carvalho", 
        "id": "sg:person.0773423203.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773423203.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Communicable Diseases and Health Analysis, Pan American Health Organization/World Health Organization, Washington DC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Mello", 
        "givenName": "Maeve Brito", 
        "id": "sg:person.01343437556.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343437556.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bras\u00edlia", 
          "id": "https://www.grid.ac/institutes/grid.7632.0", 
          "name": [
            "Public Health Department, University of Brasilia, Pan American Health Organization/World Health Organization, Brasilia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bermudez", 
        "givenName": "Ximena Pamela Diaz", 
        "id": "sg:person.0665631277.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665631277.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "United States Army Medical Research and Materiel Command", 
          "id": "https://www.grid.ac/institutes/grid.420210.5", 
          "name": [
            "Walter Reed Army Institute of Research, Silver Spring, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Modjarrad", 
        "givenName": "Kayvon", 
        "id": "sg:person.0765602677.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765602677.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "World Health Organization", 
          "id": "https://www.grid.ac/institutes/grid.3575.4", 
          "name": [
            "World Health Organization, Geneva, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meurant", 
        "givenName": "Robyn", 
        "id": "sg:person.01165512647.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165512647.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "World Health Organization", 
          "id": "https://www.grid.ac/institutes/grid.3575.4", 
          "name": [
            "World Health Organization, Geneva, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Landoulsi", 
        "givenName": "Sihem", 
        "id": "sg:person.01345155625.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345155625.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Health", 
          "id": "https://www.grid.ac/institutes/grid.414596.b", 
          "name": [
            "Department of STI, AIDS and Viral Hepatitis, Secretary for Health Surveillance, Ministry of Health Brazil, Brasilia, Brazil", 
            "Tropical Medicine Foundation Doctor Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benzaken", 
        "givenName": "Adele Schwartz", 
        "id": "sg:person.01121120513.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121120513.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Flavivirus Laboratory, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Filippis", 
        "givenName": "Ana Maria Bispo", 
        "id": "sg:person.0603040431.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603040431.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "World Health Organization", 
          "id": "https://www.grid.ac/institutes/grid.3575.4", 
          "name": [
            "World Health Organization, Geneva, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Broutet", 
        "givenName": "Nathalie Jeanne Nicole", 
        "id": "sg:person.01221053346.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221053346.32"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "for the ZIKABRA Study Team", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmoa1600651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000811266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pntd.0004816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000846217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid2101.140894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002654415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pntd.0004636", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002803395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0035-9203(52)90042-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005056513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0805715", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012896659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid1705.101939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014845536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.14-0151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016616757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.288.16.1976-jwr1023-2-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018287089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid2006.140138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020464634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/cit227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020905017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid2102.141363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021969853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pntd.0004374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022352890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/rmv.712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024018802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid2205.160107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026907928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-422x-7-22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029351058", 
          "https://doi.org/10.1186/1743-422x-7-22"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid1509.090442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030480545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(16)30775-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031430428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcv.2015.04.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035260318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(16)00138-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040698227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(16)00624-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045002209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmc1604449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051374791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcv.2016.02.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052958287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/0022-1317-70-1-37", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060356937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.15585/mmwr.mm6508e2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067984188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2807/1560-7917.es.2016.21.10.30159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070925829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2807/1560-7917.es.2016.21.23.30254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070925911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2807/1560-7917.es.2016.21.9.30154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070926060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/iembs.2002.1053096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1094319086"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Zika virus (ZIKV) has been identified in several body fluids of infected individuals. In most cases, it remained detected in blood from few days to 1 week after the onset of symptoms, and can persist longer in urine and in semen. ZIKV infection can have dramatic consequences such as microcephaly and Guillain-Barr\u00e9 syndrome. ZIKV sexual transmission has been documented. A better understanding of ZIKV presence and persistence across biologic compartments is needed to devise rational measures to prevent its transmission.\nMETHODS: This observational cohort study will recruit non-pregnant participants aged 18\u00a0years and above with confirmed ZIKV infection [positive reverse transcriptase-polymerase chain reaction (RT-PCR) test in blood and/or urine]: symptomatic men and women in ZIKV infection acute phase, and their symptomatic or asymptomatic household/sexual infected contacts. Specimens of blood, urine, semen, vaginal secretion/menstrual blood, rectal swab, oral fluids, tears, sweat, urine and breast milk (if applicable) will be collected at pre-established intervals and tested for ZIKV RNA presence by RT-PCR, other co-infection (dengue, Chikungunya, HIV, hepatitis B and C, syphilis), antibody response (including immunoglobulins M and G), plaque reduction neutralization test (if simultaneously positive for ZIKV and dengue), and ZIKV culture and RNA sequencing. Data on socio-demographic characteristics and comorbidities will be collected in parallel. Participants will be followed up for 12\u00a0months.\nDISCUSSION: This prolonged longitudinal follow-up of ZIKV infected persons with regular biologic testing and data collection will offer a unique opportunity to investigate the presence and persistence of ZIKV in various biologic compartments, their clinical and immunological correlates as well as the possibility of ZIKV reactivation/reinfection over time. This valuable information will substantially contribute to the body of knowledge on ZIKV infection and serve as a base for the development of more effective recommendation on the prevention of ZIKV transmission.\nTRIAL REGISTRATION: NCT03106714 . Registration Date: April, 7, 2017.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12879-018-2965-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024946", 
        "issn": [
          "1471-2334"
        ], 
        "name": "BMC Infectious Diseases", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil", 
    "pagination": "49", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "bb58dff665a72e5c55569d5007fcaf1f18bdef8cd41fc0cd70e583bfef8bcd1c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29357841"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968551"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12879-018-2965-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100561282"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12879-018-2965-4", 
      "https://app.dimensions.ai/details/publication/pub.1100561282"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000493.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186/s12879-018-2965-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12879-018-2965-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12879-018-2965-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12879-018-2965-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12879-018-2965-4'


 

This table displays all metadata directly associated to this object as RDF triples.

373 TRIPLES      21 PREDICATES      75 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12879-018-2965-4 schema:about N020717ab83404122b4f8aa3f0de5d1a9
2 N03893b1c7f1d4a0583a04c77054ab1ad
3 N07cab3c633564eb4800203c040b372a2
4 N0e119e50d38d49ec811490146dda701c
5 N12b58db77f44465cb0693aaf5d41be51
6 N17ba96462ac846208a316f82094f9981
7 N330a02e358a34380842e9c9b0e3757b1
8 N5f505374ec3145a6bf8658508cc471d6
9 N67e96d25715f4721b3dd4736eab9484f
10 N8b867d983a7148649fcca734574e6e7b
11 N9b63c7050e99478e8baf3c4f4d06ee48
12 Nb617f45732964789b55fe4107168b815
13 Nc3c4227b7bce48169bd1ad5fb9f001d0
14 Nc6d32f72b5a0475a929be83477bd75c1
15 Ncf28715d69294980846d8fb43791ee70
16 Nea0d1c8174bd42a38a6b3362ab4a2492
17 Nedb700712962435993b28e3512a23287
18 anzsrc-for:11
19 anzsrc-for:1108
20 schema:author Nf276d0b96c8a4d44bf5db829e919911f
21 schema:citation sg:pub.10.1186/1743-422x-7-22
22 https://doi.org/10.1001/jama.288.16.1976-jwr1023-2-1
23 https://doi.org/10.1002/rmv.712
24 https://doi.org/10.1016/0035-9203(52)90042-4
25 https://doi.org/10.1016/j.jcv.2015.04.021
26 https://doi.org/10.1016/j.jcv.2016.02.009
27 https://doi.org/10.1016/s0140-6736(16)00624-3
28 https://doi.org/10.1016/s0140-6736(16)30775-9
29 https://doi.org/10.1016/s1473-3099(16)00138-9
30 https://doi.org/10.1056/nejmc1604449
31 https://doi.org/10.1056/nejmoa0805715
32 https://doi.org/10.1056/nejmoa1600651
33 https://doi.org/10.1093/cid/cit227
34 https://doi.org/10.1099/0022-1317-70-1-37
35 https://doi.org/10.1109/iembs.2002.1053096
36 https://doi.org/10.1371/journal.pntd.0004374
37 https://doi.org/10.1371/journal.pntd.0004636
38 https://doi.org/10.1371/journal.pntd.0004816
39 https://doi.org/10.15585/mmwr.mm6508e2
40 https://doi.org/10.2807/1560-7917.es.2016.21.10.30159
41 https://doi.org/10.2807/1560-7917.es.2016.21.23.30254
42 https://doi.org/10.2807/1560-7917.es.2016.21.9.30154
43 https://doi.org/10.3201/eid1509.090442
44 https://doi.org/10.3201/eid1705.101939
45 https://doi.org/10.3201/eid2006.140138
46 https://doi.org/10.3201/eid2101.140894
47 https://doi.org/10.3201/eid2102.141363
48 https://doi.org/10.3201/eid2205.160107
49 https://doi.org/10.4269/ajtmh.14-0151
50 schema:datePublished 2018-12
51 schema:datePublishedReg 2018-12-01
52 schema:description BACKGROUND: Zika virus (ZIKV) has been identified in several body fluids of infected individuals. In most cases, it remained detected in blood from few days to 1 week after the onset of symptoms, and can persist longer in urine and in semen. ZIKV infection can have dramatic consequences such as microcephaly and Guillain-Barré syndrome. ZIKV sexual transmission has been documented. A better understanding of ZIKV presence and persistence across biologic compartments is needed to devise rational measures to prevent its transmission. METHODS: This observational cohort study will recruit non-pregnant participants aged 18 years and above with confirmed ZIKV infection [positive reverse transcriptase-polymerase chain reaction (RT-PCR) test in blood and/or urine]: symptomatic men and women in ZIKV infection acute phase, and their symptomatic or asymptomatic household/sexual infected contacts. Specimens of blood, urine, semen, vaginal secretion/menstrual blood, rectal swab, oral fluids, tears, sweat, urine and breast milk (if applicable) will be collected at pre-established intervals and tested for ZIKV RNA presence by RT-PCR, other co-infection (dengue, Chikungunya, HIV, hepatitis B and C, syphilis), antibody response (including immunoglobulins M and G), plaque reduction neutralization test (if simultaneously positive for ZIKV and dengue), and ZIKV culture and RNA sequencing. Data on socio-demographic characteristics and comorbidities will be collected in parallel. Participants will be followed up for 12 months. DISCUSSION: This prolonged longitudinal follow-up of ZIKV infected persons with regular biologic testing and data collection will offer a unique opportunity to investigate the presence and persistence of ZIKV in various biologic compartments, their clinical and immunological correlates as well as the possibility of ZIKV reactivation/reinfection over time. This valuable information will substantially contribute to the body of knowledge on ZIKV infection and serve as a base for the development of more effective recommendation on the prevention of ZIKV transmission. TRIAL REGISTRATION: NCT03106714 . Registration Date: April, 7, 2017.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree true
56 schema:isPartOf N3a16a0be01f34537b817ca96378ef8f9
57 Nb830339402584ef49275d830e4293d8d
58 sg:journal.1024946
59 schema:name Study on the persistence of Zika virus (ZIKV) in body fluids of patients with ZIKV infection in Brazil
60 schema:pagination 49
61 schema:productId N3bdea0a505d5417dbdce2a96dbb91138
62 N3e4625debd5748a2959a810ae54084e9
63 Nade22a40c3604bfcb66e1279f754f4b0
64 Ne188eda81d9f464eb8e7fdae975ac560
65 Nfc9c9570c7a249eda429c10e2b3f3259
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100561282
67 https://doi.org/10.1186/s12879-018-2965-4
68 schema:sdDatePublished 2019-04-10T17:27
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N70d6eb56c2d04887b39d01673f7922a1
71 schema:url http://link.springer.com/10.1186/s12879-018-2965-4
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N00a736352f734caaa5e9086fa11471b9 rdf:first sg:person.0603040431.86
76 rdf:rest Nf7f7c04ace3a445aae7a30aeffb20984
77 N020717ab83404122b4f8aa3f0de5d1a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Zika Virus Infection
79 rdf:type schema:DefinedTerm
80 N03893b1c7f1d4a0583a04c77054ab1ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Zika Virus
82 rdf:type schema:DefinedTerm
83 N07cab3c633564eb4800203c040b372a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Milk, Human
85 rdf:type schema:DefinedTerm
86 N0e119e50d38d49ec811490146dda701c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Adult
88 rdf:type schema:DefinedTerm
89 N0ecd78030c9742c489c7f5212ec3bbd2 rdf:first sg:person.011007007557.35
90 rdf:rest N9fe903e1c84f4215a021657b6194cdcb
91 N0f3530c87c7c4151af617b3d5d664f7e rdf:first sg:person.0653742462.35
92 rdf:rest N595040cdb17c4ee1a044b093cd5008f6
93 N12b58db77f44465cb0693aaf5d41be51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Cohort Studies
95 rdf:type schema:DefinedTerm
96 N14f3072ba1534000a01276975ae357d1 rdf:first sg:person.01343437556.21
97 rdf:rest N6fc63b5a6f0441a2ad6d01839de5bf68
98 N17ba96462ac846208a316f82094f9981 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Body Fluids
100 rdf:type schema:DefinedTerm
101 N25524e09626a4438b975436c72bddc27 rdf:first sg:person.01345155625.90
102 rdf:rest Ne8fdc4efc00e4ddeaddf36bcc270f2ec
103 N330a02e358a34380842e9c9b0e3757b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Neutralization Tests
105 rdf:type schema:DefinedTerm
106 N3a16a0be01f34537b817ca96378ef8f9 schema:issueNumber 1
107 rdf:type schema:PublicationIssue
108 N3bdea0a505d5417dbdce2a96dbb91138 schema:name readcube_id
109 schema:value bb58dff665a72e5c55569d5007fcaf1f18bdef8cd41fc0cd70e583bfef8bcd1c
110 rdf:type schema:PropertyValue
111 N3e4625debd5748a2959a810ae54084e9 schema:name doi
112 schema:value 10.1186/s12879-018-2965-4
113 rdf:type schema:PropertyValue
114 N3f33794b486348eeacd2d31693884a25 schema:name Tropical Medicine Foundation Doctor Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil
115 rdf:type schema:Organization
116 N44cbe7e22719461eba064f2f3b04610c schema:name Flavivirus Laboratory, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
117 rdf:type schema:Organization
118 N4de29eecde4a462f824b349cbd847e11 rdf:first sg:person.0773423203.14
119 rdf:rest N14f3072ba1534000a01276975ae357d1
120 N595040cdb17c4ee1a044b093cd5008f6 rdf:first sg:person.01124552710.78
121 rdf:rest Nfae33502a33d48abb14561f4d59a1eef
122 N5f505374ec3145a6bf8658508cc471d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Chikungunya Fever
124 rdf:type schema:DefinedTerm
125 N67e96d25715f4721b3dd4736eab9484f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Humans
127 rdf:type schema:DefinedTerm
128 N6e8167eb971245b88aeaa2689f74f799 rdf:first sg:person.0765602677.62
129 rdf:rest Ne7ecb23a73624054a412e052f0df666b
130 N6fc63b5a6f0441a2ad6d01839de5bf68 rdf:first sg:person.0665631277.19
131 rdf:rest N6e8167eb971245b88aeaa2689f74f799
132 N70d6eb56c2d04887b39d01673f7922a1 schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 N71c20dc8a974442d8fc63806f1c48db1 schema:name Flavivirus Laboratory, Oswaldo Cruz Institute/Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
135 rdf:type schema:Organization
136 N7ead8d755e88439ba99f40508f37e222 schema:name Tropical Medicine Foundation Doctor Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil
137 rdf:type schema:Organization
138 N8b867d983a7148649fcca734574e6e7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Female
140 rdf:type schema:DefinedTerm
141 N8db664f34d504648b968e6cff1fff2bd schema:name Department of Communicable Diseases and Health Analysis, Pan American Health Organization/World Health Organization, Washington DC, USA
142 rdf:type schema:Organization
143 N94cf17d196a7414ea26fbf61ce5da058 rdf:first sg:person.0743146305.47
144 rdf:rest N4de29eecde4a462f824b349cbd847e11
145 N98875c244e314cda910c700b4b72dac7 rdf:first sg:person.011421652101.60
146 rdf:rest N9e84087fba1144b09337f97ec55a3073
147 N9b63c7050e99478e8baf3c4f4d06ee48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Semen
149 rdf:type schema:DefinedTerm
150 N9e84087fba1144b09337f97ec55a3073 rdf:first sg:person.012631507133.41
151 rdf:rest N94cf17d196a7414ea26fbf61ce5da058
152 N9fe903e1c84f4215a021657b6194cdcb rdf:first sg:person.01021423627.04
153 rdf:rest N98875c244e314cda910c700b4b72dac7
154 Naab21c75da44478b939967a3084627d6 rdf:first Nd8130875e81d47adb478832ce2a9cfd1
155 rdf:rest rdf:nil
156 Nade22a40c3604bfcb66e1279f754f4b0 schema:name pubmed_id
157 schema:value 29357841
158 rdf:type schema:PropertyValue
159 Nb617f45732964789b55fe4107168b815 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Brazil
161 rdf:type schema:DefinedTerm
162 Nb830339402584ef49275d830e4293d8d schema:volumeNumber 18
163 rdf:type schema:PublicationVolume
164 Nc3c4227b7bce48169bd1ad5fb9f001d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Immunoglobulin M
166 rdf:type schema:DefinedTerm
167 Nc6d32f72b5a0475a929be83477bd75c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Immunoglobulin G
169 rdf:type schema:DefinedTerm
170 Ncf28715d69294980846d8fb43791ee70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Male
172 rdf:type schema:DefinedTerm
173 Nd8130875e81d47adb478832ce2a9cfd1 schema:familyName for the ZIKABRA Study Team
174 rdf:type schema:Person
175 Ne188eda81d9f464eb8e7fdae975ac560 schema:name nlm_unique_id
176 schema:value 100968551
177 rdf:type schema:PropertyValue
178 Ne7ecb23a73624054a412e052f0df666b rdf:first sg:person.01165512647.51
179 rdf:rest N25524e09626a4438b975436c72bddc27
180 Ne8fdc4efc00e4ddeaddf36bcc270f2ec rdf:first sg:person.01121120513.00
181 rdf:rest N00a736352f734caaa5e9086fa11471b9
182 Nea0d1c8174bd42a38a6b3362ab4a2492 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Coinfection
184 rdf:type schema:DefinedTerm
185 Nedb700712962435993b28e3512a23287 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Dengue
187 rdf:type schema:DefinedTerm
188 Nf276d0b96c8a4d44bf5db829e919911f rdf:first sg:person.0751417546.24
189 rdf:rest N0f3530c87c7c4151af617b3d5d664f7e
190 Nf70e8d7e3b4c4912948b4313f2910259 schema:name Tropical Medicine Foundation Doctor Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil
191 rdf:type schema:Organization
192 Nf7f7c04ace3a445aae7a30aeffb20984 rdf:first sg:person.01221053346.32
193 rdf:rest Naab21c75da44478b939967a3084627d6
194 Nfae33502a33d48abb14561f4d59a1eef rdf:first sg:person.01200574706.16
195 rdf:rest N0ecd78030c9742c489c7f5212ec3bbd2
196 Nfc9c9570c7a249eda429c10e2b3f3259 schema:name dimensions_id
197 schema:value pub.1100561282
198 rdf:type schema:PropertyValue
199 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
200 schema:name Medical and Health Sciences
201 rdf:type schema:DefinedTerm
202 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
203 schema:name Medical Microbiology
204 rdf:type schema:DefinedTerm
205 sg:journal.1024946 schema:issn 1471-2334
206 schema:name BMC Infectious Diseases
207 rdf:type schema:Periodical
208 sg:person.01021423627.04 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
209 schema:familyName de Oliveira Franca
210 schema:givenName Rafael Freitas
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021423627.04
212 rdf:type schema:Person
213 sg:person.011007007557.35 schema:affiliation https://www.grid.ac/institutes/grid.3575.4
214 schema:familyName Gaillard
215 schema:givenName Philippe
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011007007557.35
217 rdf:type schema:Person
218 sg:person.01121120513.00 schema:affiliation https://www.grid.ac/institutes/grid.414596.b
219 schema:familyName Benzaken
220 schema:givenName Adele Schwartz
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121120513.00
222 rdf:type schema:Person
223 sg:person.01124552710.78 schema:affiliation https://www.grid.ac/institutes/grid.414596.b
224 schema:familyName Giozza
225 schema:givenName Silvana Pereira
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124552710.78
227 rdf:type schema:Person
228 sg:person.011421652101.60 schema:affiliation Nf70e8d7e3b4c4912948b4313f2910259
229 schema:familyName de Lacerda
230 schema:givenName Marcus Vinicius Guimarães
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011421652101.60
232 rdf:type schema:Person
233 sg:person.01165512647.51 schema:affiliation https://www.grid.ac/institutes/grid.3575.4
234 schema:familyName Meurant
235 schema:givenName Robyn
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165512647.51
237 rdf:type schema:Person
238 sg:person.01200574706.16 schema:affiliation N7ead8d755e88439ba99f40508f37e222
239 schema:familyName Bôtto-Menezes
240 schema:givenName Camila Helena Aguiar
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200574706.16
242 rdf:type schema:Person
243 sg:person.01221053346.32 schema:affiliation https://www.grid.ac/institutes/grid.3575.4
244 schema:familyName Broutet
245 schema:givenName Nathalie Jeanne Nicole
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221053346.32
247 rdf:type schema:Person
248 sg:person.012631507133.41 schema:affiliation N3f33794b486348eeacd2d31693884a25
249 schema:familyName da Costa Castilho
250 schema:givenName Marcia
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012631507133.41
252 rdf:type schema:Person
253 sg:person.01343437556.21 schema:affiliation N8db664f34d504648b968e6cff1fff2bd
254 schema:familyName de Mello
255 schema:givenName Maeve Brito
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343437556.21
257 rdf:type schema:Person
258 sg:person.01345155625.90 schema:affiliation https://www.grid.ac/institutes/grid.3575.4
259 schema:familyName Landoulsi
260 schema:givenName Sihem
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345155625.90
262 rdf:type schema:Person
263 sg:person.0603040431.86 schema:affiliation N71c20dc8a974442d8fc63806f1c48db1
264 schema:familyName de Filippis
265 schema:givenName Ana Maria Bispo
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603040431.86
267 rdf:type schema:Person
268 sg:person.0653742462.35 schema:affiliation https://www.grid.ac/institutes/grid.3575.4
269 schema:familyName Kara
270 schema:givenName Edna Oliveira
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653742462.35
272 rdf:type schema:Person
273 sg:person.0665631277.19 schema:affiliation https://www.grid.ac/institutes/grid.7632.0
274 schema:familyName Bermudez
275 schema:givenName Ximena Pamela Diaz
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665631277.19
277 rdf:type schema:Person
278 sg:person.0743146305.47 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
279 schema:familyName Brasil
280 schema:givenName Patrícia
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743146305.47
282 rdf:type schema:Person
283 sg:person.0751417546.24 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
284 schema:familyName Calvet
285 schema:givenName Guilherme Amaral
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751417546.24
287 rdf:type schema:Person
288 sg:person.0765602677.62 schema:affiliation https://www.grid.ac/institutes/grid.420210.5
289 schema:familyName Modjarrad
290 schema:givenName Kayvon
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765602677.62
292 rdf:type schema:Person
293 sg:person.0773423203.14 schema:affiliation N44cbe7e22719461eba064f2f3b04610c
294 schema:familyName de Sequeira
295 schema:givenName Patrícia Carvalho
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773423203.14
297 rdf:type schema:Person
298 sg:pub.10.1186/1743-422x-7-22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029351058
299 https://doi.org/10.1186/1743-422x-7-22
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1001/jama.288.16.1976-jwr1023-2-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018287089
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1002/rmv.712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024018802
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/0035-9203(52)90042-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005056513
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.jcv.2015.04.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035260318
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.jcv.2016.02.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052958287
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/s0140-6736(16)00624-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045002209
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/s0140-6736(16)30775-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031430428
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/s1473-3099(16)00138-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040698227
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1056/nejmc1604449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051374791
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1056/nejmoa0805715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012896659
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1056/nejmoa1600651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000811266
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1093/cid/cit227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020905017
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1099/0022-1317-70-1-37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060356937
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1109/iembs.2002.1053096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1094319086
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1371/journal.pntd.0004374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022352890
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1371/journal.pntd.0004636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002803395
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1371/journal.pntd.0004816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000846217
334 rdf:type schema:CreativeWork
335 https://doi.org/10.15585/mmwr.mm6508e2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067984188
336 rdf:type schema:CreativeWork
337 https://doi.org/10.2807/1560-7917.es.2016.21.10.30159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070925829
338 rdf:type schema:CreativeWork
339 https://doi.org/10.2807/1560-7917.es.2016.21.23.30254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070925911
340 rdf:type schema:CreativeWork
341 https://doi.org/10.2807/1560-7917.es.2016.21.9.30154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070926060
342 rdf:type schema:CreativeWork
343 https://doi.org/10.3201/eid1509.090442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030480545
344 rdf:type schema:CreativeWork
345 https://doi.org/10.3201/eid1705.101939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014845536
346 rdf:type schema:CreativeWork
347 https://doi.org/10.3201/eid2006.140138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020464634
348 rdf:type schema:CreativeWork
349 https://doi.org/10.3201/eid2101.140894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002654415
350 rdf:type schema:CreativeWork
351 https://doi.org/10.3201/eid2102.141363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021969853
352 rdf:type schema:CreativeWork
353 https://doi.org/10.3201/eid2205.160107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026907928
354 rdf:type schema:CreativeWork
355 https://doi.org/10.4269/ajtmh.14-0151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016616757
356 rdf:type schema:CreativeWork
357 https://www.grid.ac/institutes/grid.3575.4 schema:alternateName World Health Organization
358 schema:name World Health Organization, Geneva, Switzerland
359 rdf:type schema:Organization
360 https://www.grid.ac/institutes/grid.414596.b schema:alternateName Ministry of Health
361 schema:name Department of STI, AIDS and Viral Hepatitis, Secretary for Health Surveillance, Ministry of Health Brazil, Brasilia, Brazil
362 Tropical Medicine Foundation Doctor Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil
363 rdf:type schema:Organization
364 https://www.grid.ac/institutes/grid.418068.3 schema:alternateName Oswaldo Cruz Foundation
365 schema:name Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil
366 Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife, Pernambuco, Brazil
367 rdf:type schema:Organization
368 https://www.grid.ac/institutes/grid.420210.5 schema:alternateName United States Army Medical Research and Materiel Command
369 schema:name Walter Reed Army Institute of Research, Silver Spring, USA
370 rdf:type schema:Organization
371 https://www.grid.ac/institutes/grid.7632.0 schema:alternateName University of Brasília
372 schema:name Public Health Department, University of Brasilia, Pan American Health Organization/World Health Organization, Brasilia, Brazil
373 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...