CXCL9, a promising biomarker in the diagnosis of chronic Q fever View Full Text


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Article Info

DATE

2017-12

AUTHORS

Anne F. M. Jansen, Teske Schoffelen, Julien Textoris, Jean-Louis Mege, Marrigje Nabuurs-Franssen, Ruud P. H. Raijmakers, Mihai G. Netea, Leo A. B. Joosten, Chantal P. Bleeker-Rovers, Marcel van Deuren

ABSTRACT

BACKGROUND: In the aftermath of the largest Q fever outbreak in the world, diagnosing the potentially lethal complication chronic Q fever remains challenging. PCR, Coxiella burnetii IgG phase I antibodies, CRP and 18F-FDG-PET/CT scan are used for diagnosis and monitoring in clinical practice. We aimed to identify and test biomarkers in order to improve discriminative power of the diagnostic tests and monitoring of chronic Q fever. METHODS: We performed a transcriptome analysis on C. burnetii stimulated PBMCs of 4 healthy controls and 6 chronic Q fever patients and identified genes that were most differentially expressed. The gene products were determined using Luminex technology in whole blood samples stimulated with heat-killed C. burnetii and serum samples from chronic Q fever patients and control subjects. RESULTS: Gene expression of the chemokines CXCL9, CXCL10, CXCL11 and CCL8 was strongly up-regulated in C. burnetii stimulated PBMCs of chronic Q fever patients, in contrast to healthy controls. In whole blood cultures of chronic Q fever patients, production of all four chemokines was increased upon C. burnetii stimulation, but also healthy controls and past Q fever individuals showed increased production of CXCL9, CXCL10 and CCL8. However, CXCL9 and CXCL11 production was significantly higher for chronic Q fever patients compared to past Q fever individuals. In addition, CXCL9 serum concentrations in chronic Q fever patients were higher than in past Q fever individuals. CONCLUSION: CXCL9 protein, measured in serum or as C. burnetii stimulated production, is a promising biomarker for the diagnosis of chronic Q fever. More... »

PAGES

556

References to SciGraph publications

  • 2014-07. Serology in chronic Q fever is still surrounded by question marks in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2016-08. CXCL10 Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study in JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
  • 2013-12. Localizing chronic Q fever: a challenging query in BMC INFECTIOUS DISEASES
  • 2011-02. CXCR3 ligands: redundant, collaborative and antagonistic functions in IMMUNOLOGY AND CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12879-017-2656-6

    DOI

    http://dx.doi.org/10.1186/s12879-017-2656-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091133315

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28793883


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12879-017-2656-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12879-017-2656-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12879-017-2656-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12879-017-2656-6'


     

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