Magnetic hyperthermia enhance the treatment efficacy of peri-implant osteomyelitis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-07-25

AUTHORS

Chih-Hsiang Fang, Pei-I Tsai, Shu-Wei Huang, Jui-Sheng Sun, Jenny Zwei-Chieng Chang, Hsin-Hsin Shen, San-Yuan Chen, Feng Huei Lin, Lih-Tao Hsu, Yen-Chun Chen

ABSTRACT

BACKGROUND: When bacteria colony persist within a biofilm, suitable drugs are not yet available for the eradication of biofilm-producing bacteria. The aim of this study is to study the effect of magnetic nano-particles-induced hyperthermia on destroying biofilm and promoting bactericidal effects of antibiotics in the treatment of osteomyelitis. METHODS: Sixty 12-weeks-old male Wistar rats were used. A metallic 18G needle was implanted into the bone marrow cavity of distal femur after the injection of Methicillin-sensitive Staphylococcus aureus (MSSA). All animals were divided into 5 different treatment modalities. The microbiological evaluation, scanning electron microscope examination, radiographic examination and then micro-CT evaluation of peri-implant bone resorption were analyzed. RESULTS: The pathomorphological characteristics of biofilm formation were completed after 40-days induction of osteomyelitis. The inserted implants can be heated upto 75 °C by magnetic heating without any significant thermal damage on the surrounding tissue. We also demonstrated that systemic administration of vancomycin [VC (i.m.)] could not eradicate the bacteria; but, local administration of vancomycin into the femoral canal and the presence of magnetic nanoparticles hyperthermia did enhance the eradication of bacteria in a biofilm-based colony. In these two groups, the percent bone volume (BV/TV: %) was significantly higher than that of the positive control. CONCLUSIONS: For the treatment of chronic osteomyelitis, we developed a new modality to improve antibiotic efficacy; the protection effect of biofilms on bacteria could be destroyed by magnetic nanoparticles-induced hyperthermia and therapeutic effect of systemic antibiotics could be enhanced. More... »

PAGES

516

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12879-017-2621-4

DOI

http://dx.doi.org/10.1186/s12879-017-2621-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090892264

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28743235


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85 male Wistar rats
86 marrow cavity
87 methicillin-sensitive Staphylococcus aureus
88 microbiological evaluation
89 microscope examination
90 modalities
91 nanoparticle hyperthermia
92 nanoparticles-induced hyperthermia
93 needle
94 new modality
95 osteomyelitis
96 pathomorphological characteristics
97 percent bone volume
98 peri-implant bone resorption
99 peri-implant osteomyelitis
100 persist
101 positive control
102 presence
103 protection effect
104 radiographic examination
105 rats
106 resorption
107 significant thermal damage
108 sixties
109 study
110 suitable drug
111 systemic administration
112 systemic antibiotics
113 therapeutic effect
114 thermal damage
115 tissue
116 treatment
117 treatment efficacy
118 treatment modalities
119 treatment of osteomyelitis
120 vancomycin
121 volume
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