High burden of complicated skin and soft tissue infections in the Indigenous population of Central Australia due to dominant Panton ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Susan A.J. Harch, Eleanor MacMorran, Steven Y.C. Tong, Deborah C. Holt, Judith Wilson, Eugene Athan, Saliya Hewagama

ABSTRACT

BACKGROUND: Superficial skin and soft tissue infections (SSTIs) are common among the Indigenous population of the desert regions of Central Australia. However, the overall burden of disease and molecular epidemiology of Staphylococcus aureus complicated SSTIs has yet to be described in this unique population. METHODS: Alice Springs Hospital (ASH) admission data was interrogated to establish the population incidence of SSTIs. A prospective observational study was conducted on a subset of S. aureus complicated SSTIs (carbuncles and furuncles requiring surgical intervention) presenting during a one month period to further characterize the clinical and molecular epidemiology. High resolution melting analysis was used for clonal complex discrimination. Real-time polymerase chain reaction identifying the lukF component of the Panton Valentine leucocidin (pvl) gene determined pvl status. Clinical and outcome data was obtained from the ASH medical and Northern Territory shared electronic health records. RESULTS: SSTIs represented 2.1% of ASH admissions during 2014. 82.6% occurred in Indigenous patients (n = 382) with an estimated incidence of 18.9 per 1, 000 people years compared to the non-Indigenous population of 2.9 per 1000, with an incident rate ratio of 6.6 (95% confidence interval 5.1-8.5). Clinical and molecular analysis was performed on 50 isolates from 47 patients. Community-associated methicillin-resistant S. aureus (CA-MRSA) predominated (57% of isolates). The high burden of SSTIs is partly explained by the prevalence of pvl positive strains of S. aureus (90% isolates) for both CA-MRSA and methicillin-susceptible S. aureus (MSSA). ST93-MRSA and CC121-MSSA were the most prevalent clones. SSTIs due to ST93-MRSA were more likely to require further debridement (p = 0.039), however they also more frequently received inactive antimicrobial therapy (p < 0.001). CONCLUSIONS: ST93-MRSA and CC121-MSSA are the dominant causes of carbuncles and furuncles in Central Australia. Both of these virulent clones harbor pvl but the impact on clinical outcomes remains uncertain. The high prevalence of CA-MRSA supports empiric vancomycin use in this population when antimicrobial therapy is indicated. Prompt surgical intervention remains the cornerstone of treatment. More... »

PAGES

405

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12879-017-2460-3

DOI

http://dx.doi.org/10.1186/s12879-017-2460-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085907420

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28592231


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacterial Toxins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Community-Acquired Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Exotoxins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukocidins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methicillin Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methicillin-Resistant Staphylococcus aureus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Epidemiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Northern Territory", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Population Groups", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prevalence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Soft Tissue Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Staphylococcal Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "South Australia Pathology", 
          "id": "https://www.grid.ac/institutes/grid.414733.6", 
          "name": [
            "Alice Springs Hospital, Alice Springs, Northern Territory, Australia", 
            "SA Pathology, Rundle Mall, PO Box 14, 5000, Adelaide, South Australia, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harch", 
        "givenName": "Susan A.J.", 
        "id": "sg:person.014445134427.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014445134427.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Alice Springs Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413609.9", 
          "name": [
            "Alice Springs Hospital, Alice Springs, Northern Territory, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "MacMorran", 
        "givenName": "Eleanor", 
        "id": "sg:person.015242515027.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015242515027.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Darwin Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240634.7", 
          "name": [
            "Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia", 
            "Royal Darwin Hospital, Darwin, Northern Territory, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tong", 
        "givenName": "Steven Y.C.", 
        "id": "sg:person.015775213232.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015775213232.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charles Darwin University", 
          "id": "https://www.grid.ac/institutes/grid.1043.6", 
          "name": [
            "Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holt", 
        "givenName": "Deborah C.", 
        "id": "sg:person.01132723125.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132723125.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charles Darwin University", 
          "id": "https://www.grid.ac/institutes/grid.1043.6", 
          "name": [
            "Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilson", 
        "givenName": "Judith", 
        "id": "sg:person.010132404627.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010132404627.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Deakin University", 
          "id": "https://www.grid.ac/institutes/grid.1021.2", 
          "name": [
            "Deakin University, Geelong, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Athan", 
        "givenName": "Eugene", 
        "id": "sg:person.0717536361.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717536361.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Alice Springs Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413609.9", 
          "name": [
            "Alice Springs Hospital, Alice Springs, Northern Territory, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hewagama", 
        "givenName": "Saliya", 
        "id": "sg:person.01216651071.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216651071.60"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/1469-0691.12702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000326522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/655396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000532202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1445-5994.2011.02449.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001532034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12879-016-1698-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002886631", 
          "https://doi.org/10.1186/s12879-016-1698-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12879-016-1698-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002886631", 
          "https://doi.org/10.1186/s12879-016-1698-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2180-14-31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006642277", 
          "https://doi.org/10.1186/1471-2180-14-31"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0017936", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007062290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.00122-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016552187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0025887", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022142368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/ijs.0.062752-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023705855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/598218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024393706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmjopen-2013-003070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026613255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/588301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034170123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0019749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036299060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qco.0b013e3283431468", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036608145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qco.0b013e3283431468", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036608145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jit173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037655335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2334-12-249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040182312", 
          "https://doi.org/10.1186/1471-2334-12-249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0037212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040839980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-011-1281-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052050703", 
          "https://doi.org/10.1007/s10096-011-1281-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(12)70238-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052083781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12879-015-1071-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053531380", 
          "https://doi.org/10.1186/s12879-015-1071-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0950268814002611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054030503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0950268813001581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054087353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077378625", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079002967", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: Superficial skin and soft tissue infections (SSTIs) are common among the Indigenous population of the desert regions of Central Australia. However, the overall burden of disease and molecular epidemiology of Staphylococcus aureus complicated SSTIs has yet to be described in this unique population.\nMETHODS: Alice Springs Hospital (ASH) admission data was interrogated to establish the population incidence of SSTIs. A prospective observational study was conducted on a subset of S. aureus complicated SSTIs (carbuncles and furuncles requiring surgical intervention) presenting during a one month period to further characterize the clinical and molecular epidemiology. High resolution melting analysis was used for clonal complex discrimination. Real-time polymerase chain reaction identifying the lukF component of the Panton Valentine leucocidin (pvl) gene determined pvl status. Clinical and outcome data was obtained from the ASH medical and Northern Territory shared electronic health records.\nRESULTS: SSTIs represented 2.1% of ASH admissions during 2014. 82.6% occurred in Indigenous patients (n\u00a0=\u00a0382) with an estimated incidence of 18.9 per 1, 000 people years compared to the non-Indigenous population of 2.9 per 1000, with an incident rate ratio of 6.6 (95% confidence interval 5.1-8.5). Clinical and molecular analysis was performed on 50 isolates from 47 patients. Community-associated methicillin-resistant S. aureus (CA-MRSA) predominated (57% of isolates). The high burden of SSTIs is partly explained by the prevalence of pvl positive strains of S. aureus (90% isolates) for both CA-MRSA and methicillin-susceptible S. aureus (MSSA). ST93-MRSA and CC121-MSSA were the most prevalent clones. SSTIs due to ST93-MRSA were more likely to require further debridement (p\u00a0=\u00a00.039), however they also more frequently received inactive antimicrobial therapy (p\u00a0<\u00a00.001).\nCONCLUSIONS: ST93-MRSA and CC121-MSSA are the dominant causes of carbuncles and furuncles in Central Australia. Both of these virulent clones harbor pvl but the impact on clinical outcomes remains uncertain. The high prevalence of CA-MRSA supports empiric vancomycin use in this population when antimicrobial therapy is indicated. Prompt surgical intervention remains the cornerstone of treatment.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12879-017-2460-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024946", 
        "issn": [
          "1471-2334"
        ], 
        "name": "BMC Infectious Diseases", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "High burden of complicated skin and soft tissue infections in the Indigenous population of Central Australia due to dominant Panton Valentine leucocidin clones ST93-MRSA and CC121-MSSA", 
    "pagination": "405", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "23481cc1aa37bc97cbaaa5b2ab0f14e0669db44ee49774f7837cb7cf022fc00d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28592231"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968551"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12879-017-2460-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1085907420"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12879-017-2460-3", 
      "https://app.dimensions.ai/details/publication/pub.1085907420"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99843_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12879-017-2460-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12879-017-2460-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12879-017-2460-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12879-017-2460-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12879-017-2460-3'


 

This table displays all metadata directly associated to this object as RDF triples.

287 TRIPLES      21 PREDICATES      75 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12879-017-2460-3 schema:about N111f12e06ad140a08f43366fa5209fd6
2 N22cfc0614bfb4a3daae8e96c4dfffa7e
3 N27069d2414d646debe34a1aad1002139
4 N2c3403235a9f40198647431e368666b1
5 N32cb3c0730b24f0fa40826eed9049b5a
6 N3a049ceea3514993a3392abd7556f5be
7 N43efe80318ab4a968c144d95b30e991c
8 N4c1f6eee518249529ad005c1fe5d900a
9 N5799ef3642c244e2ba0af502b737a6a8
10 N6dac052685f24d349ec8a8291616008f
11 N87d9cd31968347b5a1f9ae09fa9a0602
12 N888cb79fef634ce2a79ace55bf900396
13 N8ddd2256f8fa465f87bc29a5485f2cb1
14 Nae42bba3265f4f829d40038fda24ce6a
15 Nb5a4c38f37b14088868a1c8170c3cd34
16 Nb785d38ae05643c2946dd33df3c2357b
17 Nc0aa387b6a0744f5884ad051eef9e7d1
18 Nd49a554c686a4abf8665ba160c1ba56b
19 Nd672aeaf9ab44b08b6e2ffbb3db3130d
20 Nee8bf984c9124be99e49852258ee33f6
21 Nf28dbf7e8482401ea3030e593c5386ce
22 Nf5ed4060681d478182953d647d76d9c2
23 anzsrc-for:11
24 anzsrc-for:1103
25 schema:author N98d8776eae134430955dddfd0d08b3b1
26 schema:citation sg:pub.10.1007/s10096-011-1281-3
27 sg:pub.10.1186/1471-2180-14-31
28 sg:pub.10.1186/1471-2334-12-249
29 sg:pub.10.1186/s12879-015-1071-0
30 sg:pub.10.1186/s12879-016-1698-5
31 https://app.dimensions.ai/details/publication/pub.1077378625
32 https://app.dimensions.ai/details/publication/pub.1079002967
33 https://doi.org/10.1016/s1473-3099(12)70238-4
34 https://doi.org/10.1017/s0950268813001581
35 https://doi.org/10.1017/s0950268814002611
36 https://doi.org/10.1086/588301
37 https://doi.org/10.1086/598218
38 https://doi.org/10.1086/655396
39 https://doi.org/10.1093/infdis/jit173
40 https://doi.org/10.1097/qco.0b013e3283431468
41 https://doi.org/10.1099/ijs.0.062752-0
42 https://doi.org/10.1111/1469-0691.12702
43 https://doi.org/10.1111/j.1445-5994.2011.02449.x
44 https://doi.org/10.1128/jcm.00122-09
45 https://doi.org/10.1136/bmjopen-2013-003070
46 https://doi.org/10.1371/journal.pone.0017936
47 https://doi.org/10.1371/journal.pone.0019749
48 https://doi.org/10.1371/journal.pone.0025887
49 https://doi.org/10.1371/journal.pone.0037212
50 schema:datePublished 2017-12
51 schema:datePublishedReg 2017-12-01
52 schema:description BACKGROUND: Superficial skin and soft tissue infections (SSTIs) are common among the Indigenous population of the desert regions of Central Australia. However, the overall burden of disease and molecular epidemiology of Staphylococcus aureus complicated SSTIs has yet to be described in this unique population. METHODS: Alice Springs Hospital (ASH) admission data was interrogated to establish the population incidence of SSTIs. A prospective observational study was conducted on a subset of S. aureus complicated SSTIs (carbuncles and furuncles requiring surgical intervention) presenting during a one month period to further characterize the clinical and molecular epidemiology. High resolution melting analysis was used for clonal complex discrimination. Real-time polymerase chain reaction identifying the lukF component of the Panton Valentine leucocidin (pvl) gene determined pvl status. Clinical and outcome data was obtained from the ASH medical and Northern Territory shared electronic health records. RESULTS: SSTIs represented 2.1% of ASH admissions during 2014. 82.6% occurred in Indigenous patients (n = 382) with an estimated incidence of 18.9 per 1, 000 people years compared to the non-Indigenous population of 2.9 per 1000, with an incident rate ratio of 6.6 (95% confidence interval 5.1-8.5). Clinical and molecular analysis was performed on 50 isolates from 47 patients. Community-associated methicillin-resistant S. aureus (CA-MRSA) predominated (57% of isolates). The high burden of SSTIs is partly explained by the prevalence of pvl positive strains of S. aureus (90% isolates) for both CA-MRSA and methicillin-susceptible S. aureus (MSSA). ST93-MRSA and CC121-MSSA were the most prevalent clones. SSTIs due to ST93-MRSA were more likely to require further debridement (p = 0.039), however they also more frequently received inactive antimicrobial therapy (p < 0.001). CONCLUSIONS: ST93-MRSA and CC121-MSSA are the dominant causes of carbuncles and furuncles in Central Australia. Both of these virulent clones harbor pvl but the impact on clinical outcomes remains uncertain. The high prevalence of CA-MRSA supports empiric vancomycin use in this population when antimicrobial therapy is indicated. Prompt surgical intervention remains the cornerstone of treatment.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree true
56 schema:isPartOf N54e39377676949a9903fc027a0ff5502
57 Nd6358386d0744c799bf289363a8406a3
58 sg:journal.1024946
59 schema:name High burden of complicated skin and soft tissue infections in the Indigenous population of Central Australia due to dominant Panton Valentine leucocidin clones ST93-MRSA and CC121-MSSA
60 schema:pagination 405
61 schema:productId N9893111ebf084d93a1988a0712202848
62 Nab017ca37145421fb13d369c626db172
63 Nccd1ec1c38734b1097b6de390b09fc7c
64 Nd8f10034d8d740c1a4063b2dcf9d5bc5
65 Nf3499300c9b94fcdb2686e60edcf80d1
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085907420
67 https://doi.org/10.1186/s12879-017-2460-3
68 schema:sdDatePublished 2019-04-11T09:42
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N69a01b78d3384216bd6edefb9113a194
71 schema:url https://link.springer.com/10.1186%2Fs12879-017-2460-3
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N0d0d43dabc9241e39185362063dd5e58 rdf:first sg:person.015775213232.74
76 rdf:rest N39048b19325a4ce2bf967c10460fc833
77 N0e3c7a7b472243c8bc05e7678a00cea6 rdf:first sg:person.010132404627.19
78 rdf:rest N61c33ec292e946e4a02f5724b38fe719
79 N111f12e06ad140a08f43366fa5209fd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Bacterial Toxins
81 rdf:type schema:DefinedTerm
82 N22cfc0614bfb4a3daae8e96c4dfffa7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Humans
84 rdf:type schema:DefinedTerm
85 N27069d2414d646debe34a1aad1002139 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Skin
87 rdf:type schema:DefinedTerm
88 N28dc931eac6e49e2b8631d458fce580c rdf:first sg:person.01216651071.60
89 rdf:rest rdf:nil
90 N2c3403235a9f40198647431e368666b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Young Adult
92 rdf:type schema:DefinedTerm
93 N32cb3c0730b24f0fa40826eed9049b5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Soft Tissue Infections
95 rdf:type schema:DefinedTerm
96 N39048b19325a4ce2bf967c10460fc833 rdf:first sg:person.01132723125.28
97 rdf:rest N0e3c7a7b472243c8bc05e7678a00cea6
98 N3a049ceea3514993a3392abd7556f5be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Female
100 rdf:type schema:DefinedTerm
101 N43efe80318ab4a968c144d95b30e991c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Child
103 rdf:type schema:DefinedTerm
104 N4c1f6eee518249529ad005c1fe5d900a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Leukocidins
106 rdf:type schema:DefinedTerm
107 N54e39377676949a9903fc027a0ff5502 schema:volumeNumber 17
108 rdf:type schema:PublicationVolume
109 N5799ef3642c244e2ba0af502b737a6a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Exotoxins
111 rdf:type schema:DefinedTerm
112 N61c33ec292e946e4a02f5724b38fe719 rdf:first sg:person.0717536361.06
113 rdf:rest N28dc931eac6e49e2b8631d458fce580c
114 N69a01b78d3384216bd6edefb9113a194 schema:name Springer Nature - SN SciGraph project
115 rdf:type schema:Organization
116 N6dac052685f24d349ec8a8291616008f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Adult
118 rdf:type schema:DefinedTerm
119 N87d9cd31968347b5a1f9ae09fa9a0602 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Adolescent
121 rdf:type schema:DefinedTerm
122 N888cb79fef634ce2a79ace55bf900396 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Community-Acquired Infections
124 rdf:type schema:DefinedTerm
125 N8ddd2256f8fa465f87bc29a5485f2cb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Population Groups
127 rdf:type schema:DefinedTerm
128 N9893111ebf084d93a1988a0712202848 schema:name pubmed_id
129 schema:value 28592231
130 rdf:type schema:PropertyValue
131 N98d8776eae134430955dddfd0d08b3b1 rdf:first sg:person.014445134427.31
132 rdf:rest Nb2beae55948a442aa4f2af9e0de67cb3
133 Nab017ca37145421fb13d369c626db172 schema:name doi
134 schema:value 10.1186/s12879-017-2460-3
135 rdf:type schema:PropertyValue
136 Nae42bba3265f4f829d40038fda24ce6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Male
138 rdf:type schema:DefinedTerm
139 Nb2beae55948a442aa4f2af9e0de67cb3 rdf:first sg:person.015242515027.77
140 rdf:rest N0d0d43dabc9241e39185362063dd5e58
141 Nb5a4c38f37b14088868a1c8170c3cd34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Prospective Studies
143 rdf:type schema:DefinedTerm
144 Nb785d38ae05643c2946dd33df3c2357b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Northern Territory
146 rdf:type schema:DefinedTerm
147 Nc0aa387b6a0744f5884ad051eef9e7d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Molecular Epidemiology
149 rdf:type schema:DefinedTerm
150 Nccd1ec1c38734b1097b6de390b09fc7c schema:name dimensions_id
151 schema:value pub.1085907420
152 rdf:type schema:PropertyValue
153 Nd49a554c686a4abf8665ba160c1ba56b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Staphylococcal Infections
155 rdf:type schema:DefinedTerm
156 Nd6358386d0744c799bf289363a8406a3 schema:issueNumber 1
157 rdf:type schema:PublicationIssue
158 Nd672aeaf9ab44b08b6e2ffbb3db3130d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Methicillin Resistance
160 rdf:type schema:DefinedTerm
161 Nd8f10034d8d740c1a4063b2dcf9d5bc5 schema:name readcube_id
162 schema:value 23481cc1aa37bc97cbaaa5b2ab0f14e0669db44ee49774f7837cb7cf022fc00d
163 rdf:type schema:PropertyValue
164 Nee8bf984c9124be99e49852258ee33f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Prevalence
166 rdf:type schema:DefinedTerm
167 Nf28dbf7e8482401ea3030e593c5386ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Methicillin-Resistant Staphylococcus aureus
169 rdf:type schema:DefinedTerm
170 Nf3499300c9b94fcdb2686e60edcf80d1 schema:name nlm_unique_id
171 schema:value 100968551
172 rdf:type schema:PropertyValue
173 Nf5ed4060681d478182953d647d76d9c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Middle Aged
175 rdf:type schema:DefinedTerm
176 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
177 schema:name Medical and Health Sciences
178 rdf:type schema:DefinedTerm
179 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
180 schema:name Clinical Sciences
181 rdf:type schema:DefinedTerm
182 sg:journal.1024946 schema:issn 1471-2334
183 schema:name BMC Infectious Diseases
184 rdf:type schema:Periodical
185 sg:person.010132404627.19 schema:affiliation https://www.grid.ac/institutes/grid.1043.6
186 schema:familyName Wilson
187 schema:givenName Judith
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010132404627.19
189 rdf:type schema:Person
190 sg:person.01132723125.28 schema:affiliation https://www.grid.ac/institutes/grid.1043.6
191 schema:familyName Holt
192 schema:givenName Deborah C.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132723125.28
194 rdf:type schema:Person
195 sg:person.01216651071.60 schema:affiliation https://www.grid.ac/institutes/grid.413609.9
196 schema:familyName Hewagama
197 schema:givenName Saliya
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216651071.60
199 rdf:type schema:Person
200 sg:person.014445134427.31 schema:affiliation https://www.grid.ac/institutes/grid.414733.6
201 schema:familyName Harch
202 schema:givenName Susan A.J.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014445134427.31
204 rdf:type schema:Person
205 sg:person.015242515027.77 schema:affiliation https://www.grid.ac/institutes/grid.413609.9
206 schema:familyName MacMorran
207 schema:givenName Eleanor
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015242515027.77
209 rdf:type schema:Person
210 sg:person.015775213232.74 schema:affiliation https://www.grid.ac/institutes/grid.240634.7
211 schema:familyName Tong
212 schema:givenName Steven Y.C.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015775213232.74
214 rdf:type schema:Person
215 sg:person.0717536361.06 schema:affiliation https://www.grid.ac/institutes/grid.1021.2
216 schema:familyName Athan
217 schema:givenName Eugene
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717536361.06
219 rdf:type schema:Person
220 sg:pub.10.1007/s10096-011-1281-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052050703
221 https://doi.org/10.1007/s10096-011-1281-3
222 rdf:type schema:CreativeWork
223 sg:pub.10.1186/1471-2180-14-31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006642277
224 https://doi.org/10.1186/1471-2180-14-31
225 rdf:type schema:CreativeWork
226 sg:pub.10.1186/1471-2334-12-249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040182312
227 https://doi.org/10.1186/1471-2334-12-249
228 rdf:type schema:CreativeWork
229 sg:pub.10.1186/s12879-015-1071-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053531380
230 https://doi.org/10.1186/s12879-015-1071-0
231 rdf:type schema:CreativeWork
232 sg:pub.10.1186/s12879-016-1698-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002886631
233 https://doi.org/10.1186/s12879-016-1698-5
234 rdf:type schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1077378625 schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1079002967 schema:CreativeWork
237 https://doi.org/10.1016/s1473-3099(12)70238-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052083781
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1017/s0950268813001581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054087353
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1017/s0950268814002611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054030503
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1086/588301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034170123
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1086/598218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024393706
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1086/655396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000532202
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1093/infdis/jit173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037655335
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1097/qco.0b013e3283431468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036608145
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1099/ijs.0.062752-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023705855
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1111/1469-0691.12702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000326522
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1111/j.1445-5994.2011.02449.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001532034
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1128/jcm.00122-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016552187
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1136/bmjopen-2013-003070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026613255
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1371/journal.pone.0017936 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007062290
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1371/journal.pone.0019749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036299060
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1371/journal.pone.0025887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022142368
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1371/journal.pone.0037212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040839980
270 rdf:type schema:CreativeWork
271 https://www.grid.ac/institutes/grid.1021.2 schema:alternateName Deakin University
272 schema:name Deakin University, Geelong, VIC, Australia
273 rdf:type schema:Organization
274 https://www.grid.ac/institutes/grid.1043.6 schema:alternateName Charles Darwin University
275 schema:name Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
276 rdf:type schema:Organization
277 https://www.grid.ac/institutes/grid.240634.7 schema:alternateName Royal Darwin Hospital
278 schema:name Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
279 Royal Darwin Hospital, Darwin, Northern Territory, Australia
280 rdf:type schema:Organization
281 https://www.grid.ac/institutes/grid.413609.9 schema:alternateName Alice Springs Hospital
282 schema:name Alice Springs Hospital, Alice Springs, Northern Territory, Australia
283 rdf:type schema:Organization
284 https://www.grid.ac/institutes/grid.414733.6 schema:alternateName South Australia Pathology
285 schema:name Alice Springs Hospital, Alice Springs, Northern Territory, Australia
286 SA Pathology, Rundle Mall, PO Box 14, 5000, Adelaide, South Australia, Australia
287 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...