Suspicion of respiratory tract infection with multidrug-resistant Enterobacteriaceae: epidemiology and risk factors from a Paediatric Intensive Care Unit View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Hanna Renk, Lenja Stoll, Felix Neunhoeffer, Florian Hölzl, Matthias Kumpf, Michael Hofbeck, Dominik Hartl

ABSTRACT

BACKGROUND: Multidrug-resistant (MDR) infections are a serious concern for children admitted to the Paediatric Intensive Care Unit (PICU). Tracheal colonization with MDR Enterobacteriaceae predisposes to respiratory infection, but underlying risk factors are poorly understood. This study aims to determine the incidence of children with suspected infection during mechanical ventilation and analyses risk factors for the finding of MDR Enterobacteriaceae in tracheal aspirates. METHODS: A retrospective single-centre analysis of Enterobacteriaceae isolates from the lower respiratory tract of ventilated PICU patients from 2005 to 2014 was performed. Resistance status was determined and clinical records were reviewed for potential risk factors. A classification and regression tree (CRT) to predict risk factors for infection with MDR Enterobacteriaceae was employed. The model was validated by simple and multivariable logistic regression. RESULTS: One hundred sixty-seven Enterobacteriaceae isolates in 123 children were identified. The most frequent isolates were Enterobacter spp., Klebsiella spp. and E.coli. Among these, 116 (69%) isolates were susceptible and 51 (31%) were MDR. In the CRT analysis, antibiotic exposure for ≥ 7 days and presence of gastrointestinal comorbidity were the most relevant predictors for an MDR isolate. Antibiotic exposure for ≥ 7 days was confirmed as a significant risk factor for infection with MDR Enterobacteriaceae by a multivariable logistic regression model. CONCLUSIONS: This study shows that critically-ill children with tracheal Enterobacteriaceae infection are at risk of carrying MDR isolates. Prior use of antibiotics for ≥ 7 days significantly increased the risk of finding MDR organisms in ventilated PICU patients with suspected infection. Our results imply that early identification of patients at risk, rapid microbiological diagnostics and tailored antibiotic therapy are essential to improve management of critically ill children infected with Enterobacteriaceae. More... »

PAGES

163

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12879-017-2251-x

DOI

http://dx.doi.org/10.1186/s12879-017-2251-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083853982

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28222699


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross Infection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Multiple, Bacterial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enterobacteriaceae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enterobacteriaceae Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant, Newborn", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intensive Care Units, Pediatric", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Logistic Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiration, Artificial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiratory Tract Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trachea", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University Children's Hospital T\u00fcbingen", 
          "id": "https://www.grid.ac/institutes/grid.488549.c", 
          "name": [
            "Dept. of Paediatric Cardiology, Pulmology and Intensive Care Medicine, University Children\u2019s Hospital T\u00fcbingen, Hoppe-Seyler Str. 1, 72076, T\u00fcbingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Renk", 
        "givenName": "Hanna", 
        "id": "sg:person.01274503375.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274503375.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Children's Hospital T\u00fcbingen", 
          "id": "https://www.grid.ac/institutes/grid.488549.c", 
          "name": [
            "Dept. of Paediatric Cardiology, Pulmology and Intensive Care Medicine, University Children\u2019s Hospital T\u00fcbingen, Hoppe-Seyler Str. 1, 72076, T\u00fcbingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stoll", 
        "givenName": "Lenja", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Children's Hospital T\u00fcbingen", 
          "id": "https://www.grid.ac/institutes/grid.488549.c", 
          "name": [
            "Dept. of Paediatric Cardiology, Pulmology and Intensive Care Medicine, University Children\u2019s Hospital T\u00fcbingen, Hoppe-Seyler Str. 1, 72076, T\u00fcbingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Neunhoeffer", 
        "givenName": "Felix", 
        "id": "sg:person.01361047077.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361047077.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of T\u00fcbingen", 
          "id": "https://www.grid.ac/institutes/grid.10392.39", 
          "name": [
            "Institute of Medical Microbiology and Hygiene, University of T\u00fcbingen, Elfriede-Aulhorn-Str.6, 72076, T\u00fcbingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "H\u00f6lzl", 
        "givenName": "Florian", 
        "id": "sg:person.0712517175.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712517175.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Children's Hospital T\u00fcbingen", 
          "id": "https://www.grid.ac/institutes/grid.488549.c", 
          "name": [
            "Dept. of Paediatric Cardiology, Pulmology and Intensive Care Medicine, University Children\u2019s Hospital T\u00fcbingen, Hoppe-Seyler Str. 1, 72076, T\u00fcbingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kumpf", 
        "givenName": "Matthias", 
        "id": "sg:person.01354547600.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354547600.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Children's Hospital T\u00fcbingen", 
          "id": "https://www.grid.ac/institutes/grid.488549.c", 
          "name": [
            "Dept. of Paediatric Cardiology, Pulmology and Intensive Care Medicine, University Children\u2019s Hospital T\u00fcbingen, Hoppe-Seyler Str. 1, 72076, T\u00fcbingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hofbeck", 
        "givenName": "Michael", 
        "id": "sg:person.0752260403.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752260403.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Children's Hospital T\u00fcbingen", 
          "id": "https://www.grid.ac/institutes/grid.488549.c", 
          "name": [
            "Dept. of Paediatrics, Pediatric Infectious Diseases, Immunology & Pneumology/Cystic fibrosis, University Children\u2019s Hospital T\u00fcbingen, Hoppe-Seyler Str. 1, 72076, T\u00fcbingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hartl", 
        "givenName": "Dominik", 
        "id": "sg:person.0774757173.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774757173.05"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/pcc.0000000000000106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000032528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pcc.0000000000000106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000032528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pcc.0000000000000106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000032528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc9062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000351540", 
          "https://doi.org/10.1186/cc9062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc9062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000351540", 
          "https://doi.org/10.1186/cc9062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2334-6-24", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005533375", 
          "https://doi.org/10.1186/1471-2334-6-24"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tim.2006.07.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006682930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s15010-009-9207-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006884090", 
          "https://doi.org/10.1007/s15010-009-9207-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s15010-009-9207-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006884090", 
          "https://doi.org/10.1007/s15010-009-9207-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jpids/piu011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009003158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/499406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011334085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pcc.0b013e3181b80875", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014955700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pcc.0b013e3181b80875", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014955700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pcc.0b013e3181b80875", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014955700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/1973947814y.0000000199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015427568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00103-012-1549-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015439707", 
          "https://doi.org/10.1007/s00103-012-1549-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhin.2015.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016006435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-0691.2011.03570.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017701285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhin.2010.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017771311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(02)00398-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017977898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jpids/piu010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018008071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/civ020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022088628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/512628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024226856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/ciu497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025322572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/inf.0b013e3181f111a2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025520744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/inf.0b013e3181f111a2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025520744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00246-014-0953-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025750640", 
          "https://doi.org/10.1007/s00246-014-0953-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/ciu069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026176821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s0021-75572005000100007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026336925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijantimicag.2015.07.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027873179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhin.2006.05.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028250387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci43918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032136570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci43918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032136570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/cmr.05041-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037544281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/cir203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048672860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s15010-007-6356-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051352624", 
          "https://doi.org/10.1007/s15010-007-6356-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/shk.0b013e3181818990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051781351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/shk.0b013e3181818990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051781351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1542/peds.103.4.719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067819891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1542/peds.110.3.481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067821697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1542/peds.2007-1826", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067826416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1542/peds.2008-1211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067827122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2223/1279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069342225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077056780", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077499522", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077927384", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078601985", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: Multidrug-resistant (MDR) infections are a serious concern for children admitted to the Paediatric Intensive Care Unit (PICU). Tracheal colonization with MDR Enterobacteriaceae predisposes to respiratory infection, but underlying risk factors are poorly understood. This study aims to determine the incidence of children with suspected infection during mechanical ventilation and analyses risk factors for the finding of MDR Enterobacteriaceae in tracheal aspirates.\nMETHODS: A retrospective single-centre analysis of Enterobacteriaceae isolates from the lower respiratory tract of ventilated PICU patients from 2005 to 2014 was performed. Resistance status was determined and clinical records were reviewed for potential risk factors. A classification and regression tree (CRT) to predict risk factors for infection with MDR Enterobacteriaceae was employed. The model was validated by simple and multivariable logistic regression.\nRESULTS: One hundred sixty-seven Enterobacteriaceae isolates in 123 children were identified. The most frequent isolates were Enterobacter spp., Klebsiella spp. and E.coli. Among these, 116 (69%) isolates were susceptible and 51 (31%) were MDR. In the CRT analysis, antibiotic exposure for\u2009\u2265\u20097\u00a0days and presence of gastrointestinal comorbidity were the most relevant predictors for an MDR isolate. Antibiotic exposure for\u2009\u2265\u20097\u00a0days was confirmed as a significant risk factor for infection with MDR Enterobacteriaceae by a multivariable logistic regression model.\nCONCLUSIONS: This study shows that critically-ill children with tracheal Enterobacteriaceae infection are at risk of carrying MDR isolates. Prior use of antibiotics for\u2009\u2265\u20097\u00a0days significantly increased the risk of finding MDR organisms in ventilated PICU patients with suspected infection. Our results imply that early identification of patients at risk, rapid microbiological diagnostics and tailored antibiotic therapy are essential to improve management of critically ill children infected with Enterobacteriaceae.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12879-017-2251-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024946", 
        "issn": [
          "1471-2334"
        ], 
        "name": "BMC Infectious Diseases", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Suspicion of respiratory tract infection with multidrug-resistant Enterobacteriaceae: epidemiology and risk factors from a Paediatric Intensive Care Unit", 
    "pagination": "163", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5e2aa6b943fcc58274af58a8848c35d396294241584dd3a161736661540ba6d4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28222699"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968551"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12879-017-2251-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1083853982"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12879-017-2251-x", 
      "https://app.dimensions.ai/details/publication/pub.1083853982"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89812_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12879-017-2251-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12879-017-2251-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12879-017-2251-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12879-017-2251-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12879-017-2251-x'


 

This table displays all metadata directly associated to this object as RDF triples.

305 TRIPLES      21 PREDICATES      86 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12879-017-2251-x schema:about N0505fe120d2b4b35b102d738206d0f42
2 N1d67be558aed4c109ca5aa3283d75147
3 N24f28232003e4caf8d34c9f5e6b652ff
4 N27eb5ab14dd841c4849e5397547b1b8a
5 N2a9b5d5fd4514c81aef6daecbc7bc367
6 N4e4990847b044c24a47cf37f297a910b
7 N5436c88a6d7643d5baeec95c6dcacbee
8 N55ac43a885dc4856823d35eb57ef4c6d
9 N59b689ae413842979c36fd9218f2becc
10 N75771f62356c4d378a842ce6dcc8724a
11 N84291b01dc07429d872f1a908f508b1c
12 N89e752981f2b4027a944782103251926
13 Na4c4eca1665a4302bda320480f36d60a
14 Nac434318ac654e32966dc7bf6644b2b3
15 Naeebd574210346949beefa79758a42b5
16 Nb9d6f2eb00af474fbca6ba366d84c9ba
17 Ne7524d040bfc4c8a86d58f6b039d04f7
18 Ne840da19e62244b0b9b282a9ae3a6176
19 Nf5d2210e26054a088cda954e04ff3530
20 anzsrc-for:11
21 anzsrc-for:1103
22 schema:author N5620a69f6a9542e89f38ec5739fcf1c3
23 schema:citation sg:pub.10.1007/s00103-012-1549-5
24 sg:pub.10.1007/s00246-014-0953-z
25 sg:pub.10.1007/s15010-007-6356-9
26 sg:pub.10.1007/s15010-009-9207-z
27 sg:pub.10.1186/1471-2334-6-24
28 sg:pub.10.1186/cc9062
29 https://app.dimensions.ai/details/publication/pub.1077056780
30 https://app.dimensions.ai/details/publication/pub.1077499522
31 https://app.dimensions.ai/details/publication/pub.1077927384
32 https://app.dimensions.ai/details/publication/pub.1078601985
33 https://doi.org/10.1016/j.ijantimicag.2015.07.010
34 https://doi.org/10.1016/j.jhin.2006.05.010
35 https://doi.org/10.1016/j.jhin.2010.03.008
36 https://doi.org/10.1016/j.jhin.2015.03.005
37 https://doi.org/10.1016/j.tim.2006.07.008
38 https://doi.org/10.1016/s1473-3099(02)00398-5
39 https://doi.org/10.1086/499406
40 https://doi.org/10.1086/512628
41 https://doi.org/10.1093/cid/cir203
42 https://doi.org/10.1093/cid/ciu069
43 https://doi.org/10.1093/cid/ciu497
44 https://doi.org/10.1093/cid/civ020
45 https://doi.org/10.1093/jpids/piu010
46 https://doi.org/10.1093/jpids/piu011
47 https://doi.org/10.1097/inf.0b013e3181f111a2
48 https://doi.org/10.1097/pcc.0000000000000106
49 https://doi.org/10.1097/pcc.0b013e3181b80875
50 https://doi.org/10.1097/shk.0b013e3181818990
51 https://doi.org/10.1111/j.1469-0691.2011.03570.x
52 https://doi.org/10.1128/cmr.05041-11
53 https://doi.org/10.1172/jci43918
54 https://doi.org/10.1179/1973947814y.0000000199
55 https://doi.org/10.1542/peds.103.4.719
56 https://doi.org/10.1542/peds.110.3.481
57 https://doi.org/10.1542/peds.2007-1826
58 https://doi.org/10.1542/peds.2008-1211
59 https://doi.org/10.1590/s0021-75572005000100007
60 https://doi.org/10.2223/1279
61 schema:datePublished 2017-12
62 schema:datePublishedReg 2017-12-01
63 schema:description BACKGROUND: Multidrug-resistant (MDR) infections are a serious concern for children admitted to the Paediatric Intensive Care Unit (PICU). Tracheal colonization with MDR Enterobacteriaceae predisposes to respiratory infection, but underlying risk factors are poorly understood. This study aims to determine the incidence of children with suspected infection during mechanical ventilation and analyses risk factors for the finding of MDR Enterobacteriaceae in tracheal aspirates. METHODS: A retrospective single-centre analysis of Enterobacteriaceae isolates from the lower respiratory tract of ventilated PICU patients from 2005 to 2014 was performed. Resistance status was determined and clinical records were reviewed for potential risk factors. A classification and regression tree (CRT) to predict risk factors for infection with MDR Enterobacteriaceae was employed. The model was validated by simple and multivariable logistic regression. RESULTS: One hundred sixty-seven Enterobacteriaceae isolates in 123 children were identified. The most frequent isolates were Enterobacter spp., Klebsiella spp. and E.coli. Among these, 116 (69%) isolates were susceptible and 51 (31%) were MDR. In the CRT analysis, antibiotic exposure for ≥ 7 days and presence of gastrointestinal comorbidity were the most relevant predictors for an MDR isolate. Antibiotic exposure for ≥ 7 days was confirmed as a significant risk factor for infection with MDR Enterobacteriaceae by a multivariable logistic regression model. CONCLUSIONS: This study shows that critically-ill children with tracheal Enterobacteriaceae infection are at risk of carrying MDR isolates. Prior use of antibiotics for ≥ 7 days significantly increased the risk of finding MDR organisms in ventilated PICU patients with suspected infection. Our results imply that early identification of patients at risk, rapid microbiological diagnostics and tailored antibiotic therapy are essential to improve management of critically ill children infected with Enterobacteriaceae.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree true
67 schema:isPartOf N34459c20b0c24d8da092f196e92dca98
68 N7c75da38165642a2b43a5200de66500d
69 sg:journal.1024946
70 schema:name Suspicion of respiratory tract infection with multidrug-resistant Enterobacteriaceae: epidemiology and risk factors from a Paediatric Intensive Care Unit
71 schema:pagination 163
72 schema:productId N049210e026be4241b5b3a9ba9900c533
73 N3a65f2d09be8400398fff67486ac9f01
74 N68bd2456aa584449ae2d1d91a8299a06
75 Nbcf6489feec34397a5e4c4e45da262a2
76 Nbf26f7fe6c4540148b235ad14e53c164
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083853982
78 https://doi.org/10.1186/s12879-017-2251-x
79 schema:sdDatePublished 2019-04-11T09:58
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N75986d5691bd4ed9bbd49b32766af6f9
82 schema:url https://link.springer.com/10.1186%2Fs12879-017-2251-x
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N049210e026be4241b5b3a9ba9900c533 schema:name doi
87 schema:value 10.1186/s12879-017-2251-x
88 rdf:type schema:PropertyValue
89 N0505fe120d2b4b35b102d738206d0f42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Enterobacteriaceae Infections
91 rdf:type schema:DefinedTerm
92 N1cfa2f23cb5a416189adb96481797dad schema:affiliation https://www.grid.ac/institutes/grid.488549.c
93 schema:familyName Stoll
94 schema:givenName Lenja
95 rdf:type schema:Person
96 N1d67be558aed4c109ca5aa3283d75147 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Adolescent
98 rdf:type schema:DefinedTerm
99 N20634325f58c4e69bf43b15477fdbf21 rdf:first sg:person.0712517175.06
100 rdf:rest N5e4b520748ea4e9ba3d9e4c0c734523f
101 N24f28232003e4caf8d34c9f5e6b652ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Cross Infection
103 rdf:type schema:DefinedTerm
104 N266f105e42134891a6fbad353edabe19 rdf:first sg:person.01361047077.74
105 rdf:rest N20634325f58c4e69bf43b15477fdbf21
106 N27eb5ab14dd841c4849e5397547b1b8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Infant
108 rdf:type schema:DefinedTerm
109 N2a9b5d5fd4514c81aef6daecbc7bc367 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Retrospective Studies
111 rdf:type schema:DefinedTerm
112 N34459c20b0c24d8da092f196e92dca98 schema:issueNumber 1
113 rdf:type schema:PublicationIssue
114 N3a65f2d09be8400398fff67486ac9f01 schema:name readcube_id
115 schema:value 5e2aa6b943fcc58274af58a8848c35d396294241584dd3a161736661540ba6d4
116 rdf:type schema:PropertyValue
117 N4e4990847b044c24a47cf37f297a910b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Intensive Care Units, Pediatric
119 rdf:type schema:DefinedTerm
120 N5436c88a6d7643d5baeec95c6dcacbee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Infant, Newborn
122 rdf:type schema:DefinedTerm
123 N55ac43a885dc4856823d35eb57ef4c6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Child
125 rdf:type schema:DefinedTerm
126 N5620a69f6a9542e89f38ec5739fcf1c3 rdf:first sg:person.01274503375.39
127 rdf:rest N689cb6dbe8554947bca3e9d2c49e9dd0
128 N58e626ac03614d5e9c7643d63550ffae rdf:first sg:person.0752260403.55
129 rdf:rest N76021cc91c7d4b5985df7a08b62e2ac5
130 N59b689ae413842979c36fd9218f2becc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Humans
132 rdf:type schema:DefinedTerm
133 N5e4b520748ea4e9ba3d9e4c0c734523f rdf:first sg:person.01354547600.16
134 rdf:rest N58e626ac03614d5e9c7643d63550ffae
135 N689cb6dbe8554947bca3e9d2c49e9dd0 rdf:first N1cfa2f23cb5a416189adb96481797dad
136 rdf:rest N266f105e42134891a6fbad353edabe19
137 N68bd2456aa584449ae2d1d91a8299a06 schema:name dimensions_id
138 schema:value pub.1083853982
139 rdf:type schema:PropertyValue
140 N75771f62356c4d378a842ce6dcc8724a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Respiration, Artificial
142 rdf:type schema:DefinedTerm
143 N75986d5691bd4ed9bbd49b32766af6f9 schema:name Springer Nature - SN SciGraph project
144 rdf:type schema:Organization
145 N76021cc91c7d4b5985df7a08b62e2ac5 rdf:first sg:person.0774757173.05
146 rdf:rest rdf:nil
147 N7c75da38165642a2b43a5200de66500d schema:volumeNumber 17
148 rdf:type schema:PublicationVolume
149 N84291b01dc07429d872f1a908f508b1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Female
151 rdf:type schema:DefinedTerm
152 N89e752981f2b4027a944782103251926 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Logistic Models
154 rdf:type schema:DefinedTerm
155 Na4c4eca1665a4302bda320480f36d60a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Trachea
157 rdf:type schema:DefinedTerm
158 Nac434318ac654e32966dc7bf6644b2b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Risk Factors
160 rdf:type schema:DefinedTerm
161 Naeebd574210346949beefa79758a42b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Respiratory Tract Infections
163 rdf:type schema:DefinedTerm
164 Nb9d6f2eb00af474fbca6ba366d84c9ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Child, Preschool
166 rdf:type schema:DefinedTerm
167 Nbcf6489feec34397a5e4c4e45da262a2 schema:name pubmed_id
168 schema:value 28222699
169 rdf:type schema:PropertyValue
170 Nbf26f7fe6c4540148b235ad14e53c164 schema:name nlm_unique_id
171 schema:value 100968551
172 rdf:type schema:PropertyValue
173 Ne7524d040bfc4c8a86d58f6b039d04f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Enterobacteriaceae
175 rdf:type schema:DefinedTerm
176 Ne840da19e62244b0b9b282a9ae3a6176 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Male
178 rdf:type schema:DefinedTerm
179 Nf5d2210e26054a088cda954e04ff3530 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Drug Resistance, Multiple, Bacterial
181 rdf:type schema:DefinedTerm
182 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
183 schema:name Medical and Health Sciences
184 rdf:type schema:DefinedTerm
185 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
186 schema:name Clinical Sciences
187 rdf:type schema:DefinedTerm
188 sg:journal.1024946 schema:issn 1471-2334
189 schema:name BMC Infectious Diseases
190 rdf:type schema:Periodical
191 sg:person.01274503375.39 schema:affiliation https://www.grid.ac/institutes/grid.488549.c
192 schema:familyName Renk
193 schema:givenName Hanna
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274503375.39
195 rdf:type schema:Person
196 sg:person.01354547600.16 schema:affiliation https://www.grid.ac/institutes/grid.488549.c
197 schema:familyName Kumpf
198 schema:givenName Matthias
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354547600.16
200 rdf:type schema:Person
201 sg:person.01361047077.74 schema:affiliation https://www.grid.ac/institutes/grid.488549.c
202 schema:familyName Neunhoeffer
203 schema:givenName Felix
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361047077.74
205 rdf:type schema:Person
206 sg:person.0712517175.06 schema:affiliation https://www.grid.ac/institutes/grid.10392.39
207 schema:familyName Hölzl
208 schema:givenName Florian
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712517175.06
210 rdf:type schema:Person
211 sg:person.0752260403.55 schema:affiliation https://www.grid.ac/institutes/grid.488549.c
212 schema:familyName Hofbeck
213 schema:givenName Michael
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752260403.55
215 rdf:type schema:Person
216 sg:person.0774757173.05 schema:affiliation https://www.grid.ac/institutes/grid.488549.c
217 schema:familyName Hartl
218 schema:givenName Dominik
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774757173.05
220 rdf:type schema:Person
221 sg:pub.10.1007/s00103-012-1549-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015439707
222 https://doi.org/10.1007/s00103-012-1549-5
223 rdf:type schema:CreativeWork
224 sg:pub.10.1007/s00246-014-0953-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1025750640
225 https://doi.org/10.1007/s00246-014-0953-z
226 rdf:type schema:CreativeWork
227 sg:pub.10.1007/s15010-007-6356-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051352624
228 https://doi.org/10.1007/s15010-007-6356-9
229 rdf:type schema:CreativeWork
230 sg:pub.10.1007/s15010-009-9207-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1006884090
231 https://doi.org/10.1007/s15010-009-9207-z
232 rdf:type schema:CreativeWork
233 sg:pub.10.1186/1471-2334-6-24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005533375
234 https://doi.org/10.1186/1471-2334-6-24
235 rdf:type schema:CreativeWork
236 sg:pub.10.1186/cc9062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000351540
237 https://doi.org/10.1186/cc9062
238 rdf:type schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1077056780 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1077499522 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1077927384 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1078601985 schema:CreativeWork
243 https://doi.org/10.1016/j.ijantimicag.2015.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027873179
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.jhin.2006.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028250387
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.jhin.2010.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017771311
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.jhin.2015.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016006435
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/j.tim.2006.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006682930
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s1473-3099(02)00398-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017977898
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1086/499406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011334085
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1086/512628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024226856
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1093/cid/cir203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048672860
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1093/cid/ciu069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026176821
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1093/cid/ciu497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025322572
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1093/cid/civ020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022088628
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1093/jpids/piu010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018008071
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1093/jpids/piu011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009003158
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1097/inf.0b013e3181f111a2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025520744
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1097/pcc.0000000000000106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000032528
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1097/pcc.0b013e3181b80875 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014955700
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1097/shk.0b013e3181818990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051781351
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1111/j.1469-0691.2011.03570.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017701285
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1128/cmr.05041-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037544281
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1172/jci43918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032136570
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1179/1973947814y.0000000199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015427568
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1542/peds.103.4.719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067819891
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1542/peds.110.3.481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067821697
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1542/peds.2007-1826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067826416
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1542/peds.2008-1211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067827122
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1590/s0021-75572005000100007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026336925
296 rdf:type schema:CreativeWork
297 https://doi.org/10.2223/1279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069342225
298 rdf:type schema:CreativeWork
299 https://www.grid.ac/institutes/grid.10392.39 schema:alternateName University of Tübingen
300 schema:name Institute of Medical Microbiology and Hygiene, University of Tübingen, Elfriede-Aulhorn-Str.6, 72076, Tübingen, Germany
301 rdf:type schema:Organization
302 https://www.grid.ac/institutes/grid.488549.c schema:alternateName University Children's Hospital Tübingen
303 schema:name Dept. of Paediatric Cardiology, Pulmology and Intensive Care Medicine, University Children’s Hospital Tübingen, Hoppe-Seyler Str. 1, 72076, Tübingen, Germany
304 Dept. of Paediatrics, Pediatric Infectious Diseases, Immunology & Pneumology/Cystic fibrosis, University Children’s Hospital Tübingen, Hoppe-Seyler Str. 1, 72076, Tübingen, Germany
305 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...