Epidemiology and outcome of sepsis in adult patients with Streptococcus pneumoniae infection in a Norwegian county 1993–2011: an observational study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Åsa Askim, Arne Mehl, Julie Paulsen, Andrew T. DeWan, Didrik F. Vestrheim, Bjørn Olav Åsvold, Jan Kristian Damås, Erik Solligård

ABSTRACT

BACKGROUND: Invasive pneumococcal disease (IPD) is responsible for significant mortality and morbidity worldwide. There are however few longitudinal studies on the changes in case fatality rate of IPD in recent years. We carried out a prospective observational study of patients with IPD in Nord Trøndelag county in Norway from 1993 to 2011 to study the clinical variables and disease outcome. The main outcome was all-cause mortality after 30 and 90 days. METHODS: Patients with positive blood cultures were registered prospectively by the microbiology laboratory and clinical variables were registered retrospectively from patients' hospital records. The severity of sepsis was assigned according to the 2001 International Sepsis Definition Conference criteria. The association between mortality and predictive factors was studied using a logistic regression model. RESULTS: The total number of patients was 414 with mean age of 67 years and 53 % were male. Comorbidity was assessed by the Charlson Comorbidity Index (CCI). A CCI-score of 0 was registered in 144 patients (34.8 %), whereas 190 had a score of 1-2 (45.9 %) and 80 (19.3 %) had a score ≥3. 68.8 % of the patients received appropriate antibiotics within the first 6 h. The 30-day mortality risk increased by age and was 3-fold higher for patients aged ≥80 years (24.9, 95 % CI 16.4-33.4 %) compared to patients aged <70 (8.0, 95 % CI 3.5-12.4 %). 110 patients, (26.6 %) had severe sepsis and 37 (8.9 %) had septic shock. The 30 day all-cause mortality risk for those with sepsis without organ failure was 5.4 % (95 % CI 2.7-8.0 %), 20.2 % (95 % CI 13.5-27.4 %) for those with severe sepsis and 35.0 % (95 % CI 21.6-49.0 %) for those with septic shock. The mortality risk did not differ between the first and the second halves of the study period with a 30-day mortality risk of 13.5 % (95 % CI 7.9-19.2 %) for 1993-2002 versus 11.8 % (95 % CI 8.2-15.3 %) for 2003-2011. CONCLUSION: IPD carries a high mortality despite early and appropriate antibiotics in most cases. We found no substantial decrease in case fatality rate during the study period of 18 years. Older age and higher severity of disease were important risk factors for death in IPD. More... »

PAGES

223

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12879-016-1553-8

DOI

http://dx.doi.org/10.1186/s12879-016-1553-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028340518

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27216810


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Bacterial Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Comorbidity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Logistic Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Medical Records", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Norway", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pneumococcal Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sepsis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Norwegian University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.5947.f", 
          "name": [
            "Clinic of Anaesthesia and Intensive Care, St Olav University Hospital, Trondheim, Norway", 
            "Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway", 
            "Middle Norway Sepsis Research Center, Norwegian University of Science and Technology, Trondheim, Norway", 
            "Faculty of medicine, Department of Circulation and Medical Imaging, Po box 8905, N-7491, Trondheim, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Askim", 
        "givenName": "\u00c5sa", 
        "id": "sg:person.01344203735.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344203735.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Norwegian University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.5947.f", 
          "name": [
            "Centre of Molecular Inflammation Research Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway", 
            "Department of Medicine, Levanger Hospital, Nord-Tr\u00f8ndelag Health Trust, Levanger, Norway", 
            "Middle Norway Sepsis Research Center, Norwegian University of Science and Technology, Trondheim, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mehl", 
        "givenName": "Arne", 
        "id": "sg:person.0774112712.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774112712.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Norwegian University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.5947.f", 
          "name": [
            "Centre of Molecular Inflammation Research Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway", 
            "Department of Medicine, Levanger Hospital, Nord-Tr\u00f8ndelag Health Trust, Levanger, Norway", 
            "Middle Norway Sepsis Research Center, Norwegian University of Science and Technology, Trondheim, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paulsen", 
        "givenName": "Julie", 
        "id": "sg:person.01156454512.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156454512.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "DeWan", 
        "givenName": "Andrew T.", 
        "id": "sg:person.0630705354.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630705354.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Norwegian Institute of Public Health", 
          "id": "https://www.grid.ac/institutes/grid.418193.6", 
          "name": [
            "Norwegian Institute of Public Health, Oslo, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vestrheim", 
        "givenName": "Didrik F.", 
        "id": "sg:person.0776217723.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776217723.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Norwegian University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.5947.f", 
          "name": [
            "Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway", 
            "Department of Endocrinology, St Olav University Hospital, Trondheim, Norway", 
            "Middle Norway Sepsis Research Center, Norwegian University of Science and Technology, Trondheim, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "\u00c5svold", 
        "givenName": "Bj\u00f8rn Olav", 
        "id": "sg:person.01225322155.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225322155.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Norwegian University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.5947.f", 
          "name": [
            "Centre of Molecular Inflammation Research Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway", 
            "Department of Infectious Diseases, St Olav University Hospital, Trondheim, Norway", 
            "Middle Norway Sepsis Research Center, Norwegian University of Science and Technology, Trondheim, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dam\u00e5s", 
        "givenName": "Jan Kristian", 
        "id": "sg:person.01070777560.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070777560.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Norwegian University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.5947.f", 
          "name": [
            "Clinic of Anaesthesia and Intensive Care, St Olav University Hospital, Trondheim, Norway", 
            "Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway", 
            "Middle Norway Sepsis Research Center, Norwegian University of Science and Technology, Trondheim, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sollig\u00e5rd", 
        "givenName": "Erik", 
        "id": "sg:person.01172227625.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172227625.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.medmal.2012.02.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000017870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vaccine.2013.10.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003879043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/shk.0b013e318182f98f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004539605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/shk.0b013e318182f98f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004539605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijid.2013.12.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004593885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(09)61114-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008951647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1462-5822.2011.01746.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010677326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2334-14-121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011272557", 
          "https://doi.org/10.1186/1471-2334-14-121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmc1314999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014174523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e31827e83af", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014463755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e31827e83af", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014463755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thoraxjnl-2012-203106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014634198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thoraxjnl-2012-203106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014634198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.2010.02332.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015078905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.12-0210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016413016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2334-13-346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020915243", 
          "https://doi.org/10.1186/1471-2334-13-346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0021-9681(87)90171-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020988115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-014-0570-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022113989", 
          "https://doi.org/10.1186/s13054-014-0570-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-014-0570-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022113989", 
          "https://doi.org/10.1186/s13054-014-0570-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ije/dys095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023271334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-014-3526-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030033981", 
          "https://doi.org/10.1007/s00134-014-3526-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jinf.2012.02.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033225089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vaccine.2009.12.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033644820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12879-015-0849-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034514699", 
          "https://doi.org/10.1186/s12879-015-0849-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12879-015-0849-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034514699", 
          "https://doi.org/10.1186/s12879-015-0849-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.00724-13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035073915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-003-1662-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038680632", 
          "https://doi.org/10.1007/s00134-003-1662-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/339809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041777901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e3181b030d9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043142598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e3181b030d9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043142598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/655828", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045592645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09059180.00008911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046289542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.epidem.2015.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047625895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/1469-0691.12461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050867441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-014-2269-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052618464", 
          "https://doi.org/10.1007/s10096-014-2269-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-014-2269-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052618464", 
          "https://doi.org/10.1007/s10096-014-2269-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-014-2269-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052618464", 
          "https://doi.org/10.1007/s10096-014-2269-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/cis971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053191023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0950268814001514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054003577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4045/tidsskr.13.0465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072170602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-137-10-200211190-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073705540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082814994", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "BACKGROUND: Invasive pneumococcal disease (IPD) is responsible for significant mortality and morbidity worldwide. There are however few longitudinal studies on the changes in case fatality rate of IPD in recent years. We carried out a prospective observational study of patients with IPD in Nord Tr\u00f8ndelag county in Norway from 1993 to 2011 to study the clinical variables and disease outcome. The main outcome was all-cause mortality after 30 and 90\u00a0days.\nMETHODS: Patients with positive blood cultures were registered prospectively by the microbiology laboratory and clinical variables were registered retrospectively from patients' hospital records. The severity of sepsis was assigned according to the 2001 International Sepsis Definition Conference criteria. The association between mortality and predictive factors was studied using a logistic regression model.\nRESULTS: The total number of patients was 414 with mean age of 67\u00a0years and 53\u00a0% were male. Comorbidity was assessed by the Charlson Comorbidity Index (CCI). A CCI-score of 0 was registered in 144 patients (34.8\u00a0%), whereas 190 had a score of 1-2 (45.9\u00a0%) and 80 (19.3\u00a0%) had a score \u22653. 68.8\u00a0% of the patients received appropriate antibiotics within the first 6\u00a0h. The 30-day mortality risk increased by age and was 3-fold higher for patients aged \u226580\u00a0years (24.9, 95\u00a0% CI 16.4-33.4\u00a0%) compared to patients aged <70 (8.0, 95\u00a0% CI 3.5-12.4\u00a0%). 110 patients, (26.6\u00a0%) had severe sepsis and 37 (8.9\u00a0%) had septic shock. The 30\u00a0day all-cause mortality risk for those with sepsis without organ failure was 5.4\u00a0% (95\u00a0% CI 2.7-8.0\u00a0%), 20.2\u00a0% (95\u00a0% CI 13.5-27.4\u00a0%) for those with severe sepsis and 35.0\u00a0% (95\u00a0% CI 21.6-49.0\u00a0%) for those with septic shock. The mortality risk did not differ between the first and the second halves of the study period with a 30-day mortality risk of 13.5\u00a0% (95\u00a0% CI 7.9-19.2\u00a0%) for 1993-2002 versus 11.8\u00a0% (95\u00a0% CI 8.2-15.3\u00a0%) for 2003-2011.\nCONCLUSION: IPD carries a high mortality despite early and appropriate antibiotics in most cases. We found no substantial decrease in case fatality rate during the study period of 18\u00a0years. Older age and higher severity of disease were important risk factors for death in IPD.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12879-016-1553-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024946", 
        "issn": [
          "1471-2334"
        ], 
        "name": "BMC Infectious Diseases", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Epidemiology and outcome of sepsis in adult patients with Streptococcus pneumoniae infection in a Norwegian county 1993\u20132011: an observational study", 
    "pagination": "223", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8702574f71112ff7dbf33b8914a79897d4f00fd87ea43cafcf528711a77bf99a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27216810"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968551"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12879-016-1553-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028340518"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12879-016-1553-8", 
      "https://app.dimensions.ai/details/publication/pub.1028340518"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000550.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs12879-016-1553-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12879-016-1553-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12879-016-1553-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12879-016-1553-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12879-016-1553-8'


 

This table displays all metadata directly associated to this object as RDF triples.

307 TRIPLES      21 PREDICATES      80 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12879-016-1553-8 schema:about N10ed8e22c07a431dad1d7208bd2a0295
2 N1d21d6fd2fee4b5cb923a1e56908f431
3 N2d5654f2d620460b8a1a11a7abfb41c3
4 N3199d45b376e416488d0dae8aa546c01
5 N37b33c2b67df4ec7a71c749f18621470
6 N399661ac6e6b4ca1a2563168663f77d9
7 N3d9f9db96a6e4f758cfafe09ba9777fd
8 N3eacc3f54d84491fa407730c2c5666ad
9 N441e8be6ae0f459d81cf09349e1ca9c0
10 N4deab28b10e0401caaf1edda656ff4a0
11 N63f6102bafa543078e7f91b10f8e66f0
12 N9b1f973d6e4a42c0a827db0d2e7d6108
13 Na92f410c4df9464986801f5298ff407a
14 Nb4c09f7fafcb40d4a2984ff8dce1ffd0
15 Nc918c109a9da4016910faf128a98a8fc
16 Ncf3a65db6dcc4e24b385f2231e4da01a
17 Nf7303900a59444c79766fc5a3c212048
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author N0923bf50d6494203bc25a72e9aeac1cb
21 schema:citation sg:pub.10.1007/s00134-003-1662-x
22 sg:pub.10.1007/s00134-014-3526-y
23 sg:pub.10.1007/s10096-014-2269-6
24 sg:pub.10.1186/1471-2334-13-346
25 sg:pub.10.1186/1471-2334-14-121
26 sg:pub.10.1186/s12879-015-0849-4
27 sg:pub.10.1186/s13054-014-0570-5
28 https://app.dimensions.ai/details/publication/pub.1082814994
29 https://doi.org/10.1016/0021-9681(87)90171-8
30 https://doi.org/10.1016/j.epidem.2015.01.001
31 https://doi.org/10.1016/j.ijid.2013.12.013
32 https://doi.org/10.1016/j.jinf.2012.02.017
33 https://doi.org/10.1016/j.medmal.2012.02.002
34 https://doi.org/10.1016/j.vaccine.2009.12.054
35 https://doi.org/10.1016/j.vaccine.2013.10.032
36 https://doi.org/10.1016/s0140-6736(09)61114-4
37 https://doi.org/10.1017/s0950268814001514
38 https://doi.org/10.1056/nejmc1314999
39 https://doi.org/10.1086/339809
40 https://doi.org/10.1086/655828
41 https://doi.org/10.1093/cid/cis971
42 https://doi.org/10.1093/ije/dys095
43 https://doi.org/10.1097/ccm.0b013e3181b030d9
44 https://doi.org/10.1097/ccm.0b013e31827e83af
45 https://doi.org/10.1097/shk.0b013e318182f98f
46 https://doi.org/10.1111/1469-0691.12461
47 https://doi.org/10.1111/j.1365-2796.2010.02332.x
48 https://doi.org/10.1111/j.1462-5822.2011.01746.x
49 https://doi.org/10.1128/iai.00724-13
50 https://doi.org/10.1136/thoraxjnl-2012-203106
51 https://doi.org/10.1183/09059180.00008911
52 https://doi.org/10.1378/chest.12-0210
53 https://doi.org/10.4045/tidsskr.13.0465
54 https://doi.org/10.7326/0003-4819-137-10-200211190-00007
55 schema:datePublished 2016-12
56 schema:datePublishedReg 2016-12-01
57 schema:description BACKGROUND: Invasive pneumococcal disease (IPD) is responsible for significant mortality and morbidity worldwide. There are however few longitudinal studies on the changes in case fatality rate of IPD in recent years. We carried out a prospective observational study of patients with IPD in Nord Trøndelag county in Norway from 1993 to 2011 to study the clinical variables and disease outcome. The main outcome was all-cause mortality after 30 and 90 days. METHODS: Patients with positive blood cultures were registered prospectively by the microbiology laboratory and clinical variables were registered retrospectively from patients' hospital records. The severity of sepsis was assigned according to the 2001 International Sepsis Definition Conference criteria. The association between mortality and predictive factors was studied using a logistic regression model. RESULTS: The total number of patients was 414 with mean age of 67 years and 53 % were male. Comorbidity was assessed by the Charlson Comorbidity Index (CCI). A CCI-score of 0 was registered in 144 patients (34.8 %), whereas 190 had a score of 1-2 (45.9 %) and 80 (19.3 %) had a score ≥3. 68.8 % of the patients received appropriate antibiotics within the first 6 h. The 30-day mortality risk increased by age and was 3-fold higher for patients aged ≥80 years (24.9, 95 % CI 16.4-33.4 %) compared to patients aged <70 (8.0, 95 % CI 3.5-12.4 %). 110 patients, (26.6 %) had severe sepsis and 37 (8.9 %) had septic shock. The 30 day all-cause mortality risk for those with sepsis without organ failure was 5.4 % (95 % CI 2.7-8.0 %), 20.2 % (95 % CI 13.5-27.4 %) for those with severe sepsis and 35.0 % (95 % CI 21.6-49.0 %) for those with septic shock. The mortality risk did not differ between the first and the second halves of the study period with a 30-day mortality risk of 13.5 % (95 % CI 7.9-19.2 %) for 1993-2002 versus 11.8 % (95 % CI 8.2-15.3 %) for 2003-2011. CONCLUSION: IPD carries a high mortality despite early and appropriate antibiotics in most cases. We found no substantial decrease in case fatality rate during the study period of 18 years. Older age and higher severity of disease were important risk factors for death in IPD.
58 schema:genre research_article
59 schema:inLanguage en
60 schema:isAccessibleForFree true
61 schema:isPartOf N165cf4809afb42b6a65b6258fefe83ec
62 N91d0e2d519a0441e86f95d56cb96f939
63 sg:journal.1024946
64 schema:name Epidemiology and outcome of sepsis in adult patients with Streptococcus pneumoniae infection in a Norwegian county 1993–2011: an observational study
65 schema:pagination 223
66 schema:productId N2514efdb197b49779a259eaa7595566f
67 N5a331a412dbe419b82c58a640919dbb7
68 Nb5ff320bd6034230840824a3e9b8aeb1
69 Ndd6bc0dadb9d4c9bbae7a705ca222e16
70 Nf070f217e05f4d23b038caad21e89d70
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028340518
72 https://doi.org/10.1186/s12879-016-1553-8
73 schema:sdDatePublished 2019-04-10T13:25
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher Nf1601788d2ba44ddac8e3ac0d5ea7154
76 schema:url http://link.springer.com/10.1186%2Fs12879-016-1553-8
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N071c1a0ae0d84004aa6687b91850f1b5 rdf:first sg:person.01070777560.27
81 rdf:rest Na2c85e49013649128c5d442b0a478e18
82 N0923bf50d6494203bc25a72e9aeac1cb rdf:first sg:person.01344203735.21
83 rdf:rest N382ed73a18aa41349483e2302deb03c9
84 N10ed8e22c07a431dad1d7208bd2a0295 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Comorbidity
86 rdf:type schema:DefinedTerm
87 N165cf4809afb42b6a65b6258fefe83ec schema:issueNumber 1
88 rdf:type schema:PublicationIssue
89 N173dee73d09648edab16d1cd7c2d387c rdf:first sg:person.0630705354.04
90 rdf:rest Nc78dbe41b2a94678a7b615578843da0c
91 N1d21d6fd2fee4b5cb923a1e56908f431 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Anti-Bacterial Agents
93 rdf:type schema:DefinedTerm
94 N2514efdb197b49779a259eaa7595566f schema:name doi
95 schema:value 10.1186/s12879-016-1553-8
96 rdf:type schema:PropertyValue
97 N2d5654f2d620460b8a1a11a7abfb41c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Humans
99 rdf:type schema:DefinedTerm
100 N3199d45b376e416488d0dae8aa546c01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Female
102 rdf:type schema:DefinedTerm
103 N37b33c2b67df4ec7a71c749f18621470 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Medical Records
105 rdf:type schema:DefinedTerm
106 N382ed73a18aa41349483e2302deb03c9 rdf:first sg:person.0774112712.80
107 rdf:rest N3ac5774b3c044ac6a293dce305e062ff
108 N399661ac6e6b4ca1a2563168663f77d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Norway
110 rdf:type schema:DefinedTerm
111 N3ac5774b3c044ac6a293dce305e062ff rdf:first sg:person.01156454512.24
112 rdf:rest N173dee73d09648edab16d1cd7c2d387c
113 N3d9f9db96a6e4f758cfafe09ba9777fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Prospective Studies
115 rdf:type schema:DefinedTerm
116 N3eacc3f54d84491fa407730c2c5666ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Logistic Models
118 rdf:type schema:DefinedTerm
119 N441e8be6ae0f459d81cf09349e1ca9c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Middle Aged
121 rdf:type schema:DefinedTerm
122 N4deab28b10e0401caaf1edda656ff4a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Retrospective Studies
124 rdf:type schema:DefinedTerm
125 N5a331a412dbe419b82c58a640919dbb7 schema:name readcube_id
126 schema:value 8702574f71112ff7dbf33b8914a79897d4f00fd87ea43cafcf528711a77bf99a
127 rdf:type schema:PropertyValue
128 N63f6102bafa543078e7f91b10f8e66f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Risk Factors
130 rdf:type schema:DefinedTerm
131 N8c84bc1d9fe440e4a2861979207c5073 rdf:first sg:person.01225322155.17
132 rdf:rest N071c1a0ae0d84004aa6687b91850f1b5
133 N91d0e2d519a0441e86f95d56cb96f939 schema:volumeNumber 16
134 rdf:type schema:PublicationVolume
135 N9b1f973d6e4a42c0a827db0d2e7d6108 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Aged, 80 and over
137 rdf:type schema:DefinedTerm
138 Na2c85e49013649128c5d442b0a478e18 rdf:first sg:person.01172227625.37
139 rdf:rest rdf:nil
140 Na92f410c4df9464986801f5298ff407a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Survival Analysis
142 rdf:type schema:DefinedTerm
143 Nb4c09f7fafcb40d4a2984ff8dce1ffd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Male
145 rdf:type schema:DefinedTerm
146 Nb5ff320bd6034230840824a3e9b8aeb1 schema:name dimensions_id
147 schema:value pub.1028340518
148 rdf:type schema:PropertyValue
149 Nc78dbe41b2a94678a7b615578843da0c rdf:first sg:person.0776217723.45
150 rdf:rest N8c84bc1d9fe440e4a2861979207c5073
151 Nc918c109a9da4016910faf128a98a8fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Pneumococcal Infections
153 rdf:type schema:DefinedTerm
154 Ncf3a65db6dcc4e24b385f2231e4da01a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Sepsis
156 rdf:type schema:DefinedTerm
157 Ndd6bc0dadb9d4c9bbae7a705ca222e16 schema:name nlm_unique_id
158 schema:value 100968551
159 rdf:type schema:PropertyValue
160 Nf070f217e05f4d23b038caad21e89d70 schema:name pubmed_id
161 schema:value 27216810
162 rdf:type schema:PropertyValue
163 Nf1601788d2ba44ddac8e3ac0d5ea7154 schema:name Springer Nature - SN SciGraph project
164 rdf:type schema:Organization
165 Nf7303900a59444c79766fc5a3c212048 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Aged
167 rdf:type schema:DefinedTerm
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
172 schema:name Clinical Sciences
173 rdf:type schema:DefinedTerm
174 sg:journal.1024946 schema:issn 1471-2334
175 schema:name BMC Infectious Diseases
176 rdf:type schema:Periodical
177 sg:person.01070777560.27 schema:affiliation https://www.grid.ac/institutes/grid.5947.f
178 schema:familyName Damås
179 schema:givenName Jan Kristian
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070777560.27
181 rdf:type schema:Person
182 sg:person.01156454512.24 schema:affiliation https://www.grid.ac/institutes/grid.5947.f
183 schema:familyName Paulsen
184 schema:givenName Julie
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156454512.24
186 rdf:type schema:Person
187 sg:person.01172227625.37 schema:affiliation https://www.grid.ac/institutes/grid.5947.f
188 schema:familyName Solligård
189 schema:givenName Erik
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172227625.37
191 rdf:type schema:Person
192 sg:person.01225322155.17 schema:affiliation https://www.grid.ac/institutes/grid.5947.f
193 schema:familyName Åsvold
194 schema:givenName Bjørn Olav
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225322155.17
196 rdf:type schema:Person
197 sg:person.01344203735.21 schema:affiliation https://www.grid.ac/institutes/grid.5947.f
198 schema:familyName Askim
199 schema:givenName Åsa
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344203735.21
201 rdf:type schema:Person
202 sg:person.0630705354.04 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
203 schema:familyName DeWan
204 schema:givenName Andrew T.
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630705354.04
206 rdf:type schema:Person
207 sg:person.0774112712.80 schema:affiliation https://www.grid.ac/institutes/grid.5947.f
208 schema:familyName Mehl
209 schema:givenName Arne
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774112712.80
211 rdf:type schema:Person
212 sg:person.0776217723.45 schema:affiliation https://www.grid.ac/institutes/grid.418193.6
213 schema:familyName Vestrheim
214 schema:givenName Didrik F.
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776217723.45
216 rdf:type schema:Person
217 sg:pub.10.1007/s00134-003-1662-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038680632
218 https://doi.org/10.1007/s00134-003-1662-x
219 rdf:type schema:CreativeWork
220 sg:pub.10.1007/s00134-014-3526-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1030033981
221 https://doi.org/10.1007/s00134-014-3526-y
222 rdf:type schema:CreativeWork
223 sg:pub.10.1007/s10096-014-2269-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052618464
224 https://doi.org/10.1007/s10096-014-2269-6
225 rdf:type schema:CreativeWork
226 sg:pub.10.1186/1471-2334-13-346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020915243
227 https://doi.org/10.1186/1471-2334-13-346
228 rdf:type schema:CreativeWork
229 sg:pub.10.1186/1471-2334-14-121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011272557
230 https://doi.org/10.1186/1471-2334-14-121
231 rdf:type schema:CreativeWork
232 sg:pub.10.1186/s12879-015-0849-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034514699
233 https://doi.org/10.1186/s12879-015-0849-4
234 rdf:type schema:CreativeWork
235 sg:pub.10.1186/s13054-014-0570-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022113989
236 https://doi.org/10.1186/s13054-014-0570-5
237 rdf:type schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1082814994 schema:CreativeWork
239 https://doi.org/10.1016/0021-9681(87)90171-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020988115
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/j.epidem.2015.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047625895
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.ijid.2013.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004593885
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.jinf.2012.02.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033225089
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.medmal.2012.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000017870
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.vaccine.2009.12.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033644820
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/j.vaccine.2013.10.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003879043
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0140-6736(09)61114-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008951647
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1017/s0950268814001514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054003577
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1056/nejmc1314999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014174523
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1086/339809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041777901
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1086/655828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045592645
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1093/cid/cis971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053191023
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1093/ije/dys095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023271334
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1097/ccm.0b013e3181b030d9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043142598
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1097/ccm.0b013e31827e83af schema:sameAs https://app.dimensions.ai/details/publication/pub.1014463755
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1097/shk.0b013e318182f98f schema:sameAs https://app.dimensions.ai/details/publication/pub.1004539605
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1111/1469-0691.12461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050867441
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1111/j.1365-2796.2010.02332.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015078905
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1111/j.1462-5822.2011.01746.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010677326
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1128/iai.00724-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035073915
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1136/thoraxjnl-2012-203106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014634198
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1183/09059180.00008911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046289542
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1378/chest.12-0210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016413016
286 rdf:type schema:CreativeWork
287 https://doi.org/10.4045/tidsskr.13.0465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072170602
288 rdf:type schema:CreativeWork
289 https://doi.org/10.7326/0003-4819-137-10-200211190-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073705540
290 rdf:type schema:CreativeWork
291 https://www.grid.ac/institutes/grid.418193.6 schema:alternateName Norwegian Institute of Public Health
292 schema:name Norwegian Institute of Public Health, Oslo, Norway
293 rdf:type schema:Organization
294 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
295 schema:name Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA
296 rdf:type schema:Organization
297 https://www.grid.ac/institutes/grid.5947.f schema:alternateName Norwegian University of Science and Technology
298 schema:name Centre of Molecular Inflammation Research Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
299 Clinic of Anaesthesia and Intensive Care, St Olav University Hospital, Trondheim, Norway
300 Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
301 Department of Endocrinology, St Olav University Hospital, Trondheim, Norway
302 Department of Infectious Diseases, St Olav University Hospital, Trondheim, Norway
303 Department of Medicine, Levanger Hospital, Nord-Trøndelag Health Trust, Levanger, Norway
304 Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway
305 Faculty of medicine, Department of Circulation and Medical Imaging, Po box 8905, N-7491, Trondheim, Norway
306 Middle Norway Sepsis Research Center, Norwegian University of Science and Technology, Trondheim, Norway
307 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...