Changes in microbiota during experimental human Rhinovirus infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-08-14

AUTHORS

J. J. Hofstra, S. Matamoros, M. A. van de Pol, B. de Wever, M. W. Tanck, H. Wendt-Knol, M. Deijs, L. van der Hoek, K. C. Wolthers, R. Molenkamp, C. E. Visser, P. J. Sterk, R. Lutter, M. D. de Jong

ABSTRACT

BackgroundHuman Rhinovirus (HRV) is responsible for the majority of common colds and is frequently accompanied by secondary bacterial infections through poorly understood mechanisms. We investigated the effects of experimental human HRV serotype 16 infection on the upper respiratory tract microbiota.MethodsSix healthy volunteers were infected with HRV16. We performed 16S ribosomal RNA-targeted pyrosequencing on throat swabs taken prior, during and after infection. We compared overall community diversity, phylogenetic structure of the ecosystem and relative abundances of the different bacteria between time points.ResultsDuring acute infection strong trends towards increases in the relative abundances of Haemophilus parainfluenzae and Neisseria subflava were observed, as well as a weaker trend towards increases of Staphylococcus aureus. No major differences were observed between day-1 and day 60, whereas differences between subjects were very high.ConclusionsHRV16 infection is associated with the increase of three genera known to be associated with secondary infections following HRV infections. The observed changes of upper respiratory tract microbiota could help explain why HRV infection predisposes to bacterial otitis media, sinusitis and pneumonia. More... »

PAGES

336

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12879-015-1081-y

DOI

http://dx.doi.org/10.1186/s12879-015-1081-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007345508

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26271750


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28 schema:description BackgroundHuman Rhinovirus (HRV) is responsible for the majority of common colds and is frequently accompanied by secondary bacterial infections through poorly understood mechanisms. We investigated the effects of experimental human HRV serotype 16 infection on the upper respiratory tract microbiota.MethodsSix healthy volunteers were infected with HRV16. We performed 16S ribosomal RNA-targeted pyrosequencing on throat swabs taken prior, during and after infection. We compared overall community diversity, phylogenetic structure of the ecosystem and relative abundances of the different bacteria between time points.ResultsDuring acute infection strong trends towards increases in the relative abundances of Haemophilus parainfluenzae and Neisseria subflava were observed, as well as a weaker trend towards increases of Staphylococcus aureus. No major differences were observed between day-1 and day 60, whereas differences between subjects were very high.ConclusionsHRV16 infection is associated with the increase of three genera known to be associated with secondary infections following HRV infections. The observed changes of upper respiratory tract microbiota could help explain why HRV infection predisposes to bacterial otitis media, sinusitis and pneumonia.
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34 schema:keywords HRV infection
35 HRV16
36 Haemophilus parainfluenzae
37 MethodsSix healthy volunteers
38 Neisseria subflava
39 RNA
40 Staphylococcus aureus
41 abundance
42 aureus
43 bacteria
44 bacterial infections
45 bacterial otitis media
46 changes
47 cold
48 common cold
49 community diversity
50 day 1
51 day 60
52 differences
53 different bacteria
54 diversity
55 ecosystems
56 effect
57 genus
58 healthy volunteers
59 human rhinovirus infection
60 increase
61 infection
62 major differences
63 majority
64 mechanism
65 medium
66 microbiota
67 observed changes
68 otitis media
69 overall community diversity
70 parainfluenzae
71 phylogenetic structure
72 pneumonia
73 point
74 pyrosequencing
75 relative abundance
76 respiratory tract microbiota
77 rhinovirus
78 rhinovirus infection
79 ribosomal RNA
80 secondary bacterial infection
81 secondary infection
82 sinusitis
83 strong trend
84 structure
85 subjects
86 swabs
87 throat swabs
88 time points
89 trends
90 upper respiratory tract microbiota
91 volunteers
92 weak trend
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