Is it time to switch to doxycycline from azithromycin for treating genital chlamydial infections in women? Modelling the impact of ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Andrew P Craig, Fabian YS Kong, Laxmi Yeruva, Jane S Hocking, Roger G Rank, David P Wilson, Basil Donovan

ABSTRACT

BACKGROUND: Single-dose azithromycin is recommended over multi-dose doxycycline as treatment for chlamydial infection. However, even with imperfect adherence, doxycycline is more effective in treating genital and rectal infection. Recently, it has been suggested that autoinoculation from the rectum to the genitals may be a source of persistent chlamydial infection in women. We estimated the impact autoinoculation may have on azithromycin and doxycycline effectiveness. METHODS: We estimate treatment effectiveness using a simple mathematical model, incorporating data on azithromycin and doxycycline efficacy from recent meta-analyses, and data on prevalence of rectal infection in women with genital chlamydial infection. RESULTS: When the possibility of autoinoculation is taken into account, we calculate that doxycycline effectiveness may be 97% compared to just 82% for azithromycin. CONCLUSIONS: Consideration should be given to re-evaluating azithromycin as the standard treatment for genital chlamydia in women. More... »

PAGES

200

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12879-015-0939-3

DOI

http://dx.doi.org/10.1186/s12879-015-0939-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003460137

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25925662


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