Polypharmacy among HIV positive older adults on anti-retroviral therapy attending an urban clinic in Uganda View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Michael Ssonko, Fiona Stanaway, Harriet K. Mayanja, Tabitha Namuleme, Robert Cumming, John L. Kyalimpa, Yvonne Karamagi, Barbara Mukasa, Vasi Naganathan

ABSTRACT

BACKGROUND: Polypharmacy has not been investigated in patients living with HIV in developing countries. The aims of this study were to determine the prevalence of polypharmacy, the factors associated with polypharmacy and whether polypharmacy was associated with adverse effects among older adults on anti-retroviral therapy (ART). METHODS: Cross-sectional study in older adults aged 50 and over on ART attending an outpatient HIV/AIDS care centre in Uganda. Demographic and clinical data collected on number and type of medications plus supplements, possible medication related side-effects, comorbidity, frailty, cognitive impairment, current CD4 count and viral load. RESULTS: Of 411 participants, 63 (15.3, 95% C.I. 11.9, 18.8) had polypharmacy (≥ 4 non- HIV medications). In multivariate analyses, polypharmacy was associated with one or more hospitalisations in the last year (Prevalence Ratio PR = 1.8, 95% C.I. 1.1, 3.1, p = 0.02), prescription by an internist (PR = 3.6, 95% C.I. 1.3, 10.5, p = 0.02) and frailty index scores of 5 to 6 (PR = 10.6, 95% C.I. 1.4, 78, p = 0.02), and 7 or more (PR = 17.4, 95% C.I. 2.4, 126.5, p = 0.005). Polypharmacy was not associated with frequency and severity of possible medication related side effects and falls. CONCLUSION: Polypharmacy is common among older HIV infected patients in sub-Saharan Africa. It's more prevalent among frail people, who have been in hospital in the last year and who have been seen by an internist. We found no evidence that polypharmacy results in any harm but this is worth exploring further. More... »

PAGES

125

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12877-018-0817-0

DOI

http://dx.doi.org/10.1186/s12877-018-0817-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104282753

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29843635


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-HIV Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Comorbidity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Sectional Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Frailty", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Seropositivity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hospitalization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polypharmacy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prevalence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uganda", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Urban Health Services", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Mildmay Uganda", 
          "id": "https://www.grid.ac/institutes/grid.463428.f", 
          "name": [
            "Mildmay Uganda, 12 Km Entebbe Road, Naziba Hill Lweza, P.O. Box 24985, Kampala, Uganda"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ssonko", 
        "givenName": "Michael", 
        "id": "sg:person.011313515575.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011313515575.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sydney", 
          "id": "https://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "Sydney School of Public Health, Sydney Medical School, University of Sydney, Sydney, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stanaway", 
        "givenName": "Fiona", 
        "id": "sg:person.01215301736.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215301736.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Makerere University", 
          "id": "https://www.grid.ac/institutes/grid.11194.3c", 
          "name": [
            "Makerere University College of Health Sciences, Kampala, Uganda"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mayanja", 
        "givenName": "Harriet K.", 
        "id": "sg:person.01066640211.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066640211.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mildmay Uganda", 
          "id": "https://www.grid.ac/institutes/grid.463428.f", 
          "name": [
            "Mildmay Uganda, 12 Km Entebbe Road, Naziba Hill Lweza, P.O. Box 24985, Kampala, Uganda"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Namuleme", 
        "givenName": "Tabitha", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sydney", 
          "id": "https://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "Sydney School of Public Health, Sydney Medical School, University of Sydney, Sydney, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cumming", 
        "givenName": "Robert", 
        "id": "sg:person.01301170017.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301170017.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mildmay Uganda", 
          "id": "https://www.grid.ac/institutes/grid.463428.f", 
          "name": [
            "Mildmay Uganda, 12 Km Entebbe Road, Naziba Hill Lweza, P.O. Box 24985, Kampala, Uganda"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kyalimpa", 
        "givenName": "John L.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mildmay Uganda", 
          "id": "https://www.grid.ac/institutes/grid.463428.f", 
          "name": [
            "Mildmay Uganda, 12 Km Entebbe Road, Naziba Hill Lweza, P.O. Box 24985, Kampala, Uganda"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karamagi", 
        "givenName": "Yvonne", 
        "id": "sg:person.01025752157.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025752157.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mildmay Uganda", 
          "id": "https://www.grid.ac/institutes/grid.463428.f", 
          "name": [
            "Mildmay Uganda, 12 Km Entebbe Road, Naziba Hill Lweza, P.O. Box 24985, Kampala, Uganda"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mukasa", 
        "givenName": "Barbara", 
        "id": "sg:person.01316712114.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316712114.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Concord Repatriation General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414685.a", 
          "name": [
            "Centre for Education and Research on Ageing, Sydney Medical School, Concord Clinical School, University of Sydney, Sydney, Australia", 
            "Ageing and Alzheimers Institute, Concord Hospital, Sydney, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Naganathan", 
        "givenName": "Vasi", 
        "id": "sg:person.0613721635.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613721635.32"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1177/0091270008322177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004127963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2325957413488204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005130804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2325957413488204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005130804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1741-6612.2008.00288.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011104125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32835584ea", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016628019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32835584ea", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016628019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/0278-6133.26.1.40", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017873515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0021-9681(87)90171-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020988115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200401001-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022770313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200401001-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022770313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/cir626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024022648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3182716e38", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025828369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3182716e38", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025828369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jgs.12695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026965048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.280.19.1690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029560558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1532-5415.2005.53455.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032597054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1532-5415.2005.53455.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032597054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bcp.12975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033107570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bcp.12975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033107570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bcp.12975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033107570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1060028013504075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035193214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1060028013504075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035193214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0003729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035435518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(08)60345-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036305533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/09540121.2015.1109583", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038575129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/clpt.2011.258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039672822", 
          "https://doi.org/10.1038/clpt.2011.258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkr248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044383959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.10351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050935684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.10351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050935684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2013.2963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053394941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/apc.2004.18.568", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059228422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/apc.2015.0199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059229724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200418001-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060145046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2471/blt.10.076349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070837678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2471/blt.10.076349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070837678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3851/imp1540", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071479144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12877-017-0621-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092156078", 
          "https://doi.org/10.1186/s12877-017-0621-2"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Polypharmacy has not been investigated in patients living with HIV in developing countries. The aims of this study were to determine the prevalence of polypharmacy, the factors associated with polypharmacy and whether polypharmacy was associated with adverse effects among older adults on anti-retroviral therapy (ART).\nMETHODS: Cross-sectional study in older adults aged 50 and over on ART attending an outpatient HIV/AIDS care centre in Uganda. Demographic and clinical data collected on number and type of medications plus supplements, possible medication related side-effects, comorbidity, frailty, cognitive impairment, current CD4 count and viral load.\nRESULTS: Of 411 participants, 63 (15.3, 95% C.I. 11.9, 18.8) had polypharmacy (\u2265 4 non- HIV medications). In multivariate analyses, polypharmacy was associated with one or more hospitalisations in the last year (Prevalence Ratio PR\u2009=\u20091.8, 95% C.I. 1.1, 3.1, p\u2009=\u20090.02), prescription by an internist (PR\u2009=\u20093.6, 95% C.I. 1.3, 10.5, p\u2009=\u20090.02) and frailty index scores of 5 to 6 (PR\u2009=\u200910.6, 95% C.I. 1.4, 78, p\u2009=\u20090.02), and 7 or more (PR\u2009=\u200917.4, 95% C.I. 2.4, 126.5, p\u2009=\u20090.005). Polypharmacy was not associated with frequency and severity of possible medication related side effects and falls.\nCONCLUSION: Polypharmacy is common among older HIV infected patients in sub-Saharan Africa. It's more prevalent among frail people, who have been in hospital in the last year and who have been seen by an internist. We found no evidence that polypharmacy results in any harm but this is worth exploring further.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12877-018-0817-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024943", 
        "issn": [
          "1471-2318"
        ], 
        "name": "BMC Geriatrics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Polypharmacy among HIV positive older adults on anti-retroviral therapy attending an urban clinic in Uganda", 
    "pagination": "125", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "17730b52cb8a25e69ef12c3380b8a61b0052d819af5f3ac244479fb6bababd8e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29843635"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968548"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12877-018-0817-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1104282753"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12877-018-0817-0", 
      "https://app.dimensions.ai/details/publication/pub.1104282753"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000352_0000000352/records_60348_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12877-018-0817-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12877-018-0817-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12877-018-0817-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12877-018-0817-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12877-018-0817-0'


 

This table displays all metadata directly associated to this object as RDF triples.

279 TRIPLES      21 PREDICATES      72 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12877-018-0817-0 schema:about N01106b25ee1e41d6a4856603ce02466b
2 N0dae3571d0764fee802fa3e7142de721
3 N0e12b3a0fdab45f58c2daa5fd92064bd
4 N3031b28bee284340a3f3478d841dfe29
5 N3a82382fe7a04e168a434c80814d4fe3
6 N4e5375ff67bf4cfa8ee6b7120e442294
7 N50ffa6d1b9514967802f13e83b21c6f7
8 N59c645d647a745599f384c6d6bbff7c4
9 N82826624c07242648805c9e7b56905b7
10 N90024dba3f9f41a6b892c6b2f6f016e6
11 Naec01fd6badc43889c917cb35ef09cd8
12 Ne72d0648cf8448a3893d092d9279049a
13 Nf157c1a9c4ba4aab8c74ed420a010cb0
14 Nf7a499d7d2d040598c9732abd8dfffb8
15 Nfc8dc91bf6f442f090729512ba9fe69d
16 Nfe05286b8d0940aea76a51fb835f95c7
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author Ndc1e2032ba5741ac8aa087291f289639
20 schema:citation sg:pub.10.1038/clpt.2011.258
21 sg:pub.10.1186/s12877-017-0621-2
22 https://doi.org/10.1001/jama.2013.2963
23 https://doi.org/10.1001/jama.280.19.1690
24 https://doi.org/10.1016/0021-9681(87)90171-8
25 https://doi.org/10.1016/s0140-6736(08)60345-1
26 https://doi.org/10.1037/0278-6133.26.1.40
27 https://doi.org/10.1080/09540121.2015.1109583
28 https://doi.org/10.1089/apc.2004.18.568
29 https://doi.org/10.1089/apc.2015.0199
30 https://doi.org/10.1093/cid/cir626
31 https://doi.org/10.1093/jac/dkr248
32 https://doi.org/10.1097/00002030-200401001-00004
33 https://doi.org/10.1097/00002030-200418001-00004
34 https://doi.org/10.1097/qad.0b013e32835584ea
35 https://doi.org/10.1097/qai.0b013e3182716e38
36 https://doi.org/10.1111/bcp.12975
37 https://doi.org/10.1111/j.1532-5415.2005.53455.x
38 https://doi.org/10.1111/j.1741-6612.2008.00288.x
39 https://doi.org/10.1111/jgs.12695
40 https://doi.org/10.1177/0091270008322177
41 https://doi.org/10.1177/1060028013504075
42 https://doi.org/10.1177/2325957413488204
43 https://doi.org/10.1345/aph.10351
44 https://doi.org/10.1371/journal.pone.0003729
45 https://doi.org/10.2471/blt.10.076349
46 https://doi.org/10.3851/imp1540
47 schema:datePublished 2018-12
48 schema:datePublishedReg 2018-12-01
49 schema:description BACKGROUND: Polypharmacy has not been investigated in patients living with HIV in developing countries. The aims of this study were to determine the prevalence of polypharmacy, the factors associated with polypharmacy and whether polypharmacy was associated with adverse effects among older adults on anti-retroviral therapy (ART). METHODS: Cross-sectional study in older adults aged 50 and over on ART attending an outpatient HIV/AIDS care centre in Uganda. Demographic and clinical data collected on number and type of medications plus supplements, possible medication related side-effects, comorbidity, frailty, cognitive impairment, current CD4 count and viral load. RESULTS: Of 411 participants, 63 (15.3, 95% C.I. 11.9, 18.8) had polypharmacy (≥ 4 non- HIV medications). In multivariate analyses, polypharmacy was associated with one or more hospitalisations in the last year (Prevalence Ratio PR = 1.8, 95% C.I. 1.1, 3.1, p = 0.02), prescription by an internist (PR = 3.6, 95% C.I. 1.3, 10.5, p = 0.02) and frailty index scores of 5 to 6 (PR = 10.6, 95% C.I. 1.4, 78, p = 0.02), and 7 or more (PR = 17.4, 95% C.I. 2.4, 126.5, p = 0.005). Polypharmacy was not associated with frequency and severity of possible medication related side effects and falls. CONCLUSION: Polypharmacy is common among older HIV infected patients in sub-Saharan Africa. It's more prevalent among frail people, who have been in hospital in the last year and who have been seen by an internist. We found no evidence that polypharmacy results in any harm but this is worth exploring further.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree true
53 schema:isPartOf N7af21e7584454bf3ae62475abb23248c
54 Nf9bf6365fe7748fea0b876603b80f10e
55 sg:journal.1024943
56 schema:name Polypharmacy among HIV positive older adults on anti-retroviral therapy attending an urban clinic in Uganda
57 schema:pagination 125
58 schema:productId N170eec6b82994ef6bea5692ab0ea8a0b
59 N27ee15da269f47808956294a38c7203e
60 N6787712abb9c4975a941c13d266eee7f
61 N6cece58c033c464bba959ef4ed621d91
62 Nce6b2ee4887e49af889d487e193f7cff
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104282753
64 https://doi.org/10.1186/s12877-018-0817-0
65 schema:sdDatePublished 2019-04-11T11:02
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher Nc670b74a0c3544a3850959b1ef244394
68 schema:url https://link.springer.com/10.1186%2Fs12877-018-0817-0
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N01106b25ee1e41d6a4856603ce02466b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name HIV
74 rdf:type schema:DefinedTerm
75 N086c951c6bd040ceb75e57ece145b4b4 rdf:first sg:person.01066640211.44
76 rdf:rest Nd8c714e0169548d2a23f709e57fa0a5f
77 N0dae3571d0764fee802fa3e7142de721 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Middle Aged
79 rdf:type schema:DefinedTerm
80 N0e12b3a0fdab45f58c2daa5fd92064bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Male
82 rdf:type schema:DefinedTerm
83 N170eec6b82994ef6bea5692ab0ea8a0b schema:name readcube_id
84 schema:value 17730b52cb8a25e69ef12c3380b8a61b0052d819af5f3ac244479fb6bababd8e
85 rdf:type schema:PropertyValue
86 N27ee15da269f47808956294a38c7203e schema:name dimensions_id
87 schema:value pub.1104282753
88 rdf:type schema:PropertyValue
89 N3031b28bee284340a3f3478d841dfe29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Aged
91 rdf:type schema:DefinedTerm
92 N33b63e96e8704ff8b1da1b5a964830ee rdf:first sg:person.01316712114.68
93 rdf:rest Na52a8808a6c74299960ee2f59fab8a2c
94 N3a82382fe7a04e168a434c80814d4fe3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name HIV Seropositivity
96 rdf:type schema:DefinedTerm
97 N3cf81436d0ff417da876eb1392d6413a rdf:first sg:person.01301170017.50
98 rdf:rest N9732c6081e0b4be391d50c0e148903b1
99 N4e5375ff67bf4cfa8ee6b7120e442294 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Polypharmacy
101 rdf:type schema:DefinedTerm
102 N50ffa6d1b9514967802f13e83b21c6f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Cross-Sectional Studies
104 rdf:type schema:DefinedTerm
105 N59c645d647a745599f384c6d6bbff7c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Prevalence
107 rdf:type schema:DefinedTerm
108 N6787712abb9c4975a941c13d266eee7f schema:name pubmed_id
109 schema:value 29843635
110 rdf:type schema:PropertyValue
111 N6cece58c033c464bba959ef4ed621d91 schema:name doi
112 schema:value 10.1186/s12877-018-0817-0
113 rdf:type schema:PropertyValue
114 N7af21e7584454bf3ae62475abb23248c schema:issueNumber 1
115 rdf:type schema:PublicationIssue
116 N7fe781ff412844ea89c47fa5f7517fea rdf:first sg:person.01025752157.06
117 rdf:rest N33b63e96e8704ff8b1da1b5a964830ee
118 N82826624c07242648805c9e7b56905b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Female
120 rdf:type schema:DefinedTerm
121 N8d587491fb4741509ae017273cc133a9 schema:affiliation https://www.grid.ac/institutes/grid.463428.f
122 schema:familyName Kyalimpa
123 schema:givenName John L.
124 rdf:type schema:Person
125 N90024dba3f9f41a6b892c6b2f6f016e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Uganda
127 rdf:type schema:DefinedTerm
128 N9732c6081e0b4be391d50c0e148903b1 rdf:first N8d587491fb4741509ae017273cc133a9
129 rdf:rest N7fe781ff412844ea89c47fa5f7517fea
130 N9b4fb8bf8a5f4d5ebf81af700653c289 rdf:first sg:person.01215301736.26
131 rdf:rest N086c951c6bd040ceb75e57ece145b4b4
132 Na52a8808a6c74299960ee2f59fab8a2c rdf:first sg:person.0613721635.32
133 rdf:rest rdf:nil
134 Naec01fd6badc43889c917cb35ef09cd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Urban Health Services
136 rdf:type schema:DefinedTerm
137 Nc670b74a0c3544a3850959b1ef244394 schema:name Springer Nature - SN SciGraph project
138 rdf:type schema:Organization
139 Nce6b2ee4887e49af889d487e193f7cff schema:name nlm_unique_id
140 schema:value 100968548
141 rdf:type schema:PropertyValue
142 Nd8c714e0169548d2a23f709e57fa0a5f rdf:first Nebdc311e25d04a62b9a4bd6b92a1c624
143 rdf:rest N3cf81436d0ff417da876eb1392d6413a
144 Ndc1e2032ba5741ac8aa087291f289639 rdf:first sg:person.011313515575.44
145 rdf:rest N9b4fb8bf8a5f4d5ebf81af700653c289
146 Ne72d0648cf8448a3893d092d9279049a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Comorbidity
148 rdf:type schema:DefinedTerm
149 Nebdc311e25d04a62b9a4bd6b92a1c624 schema:affiliation https://www.grid.ac/institutes/grid.463428.f
150 schema:familyName Namuleme
151 schema:givenName Tabitha
152 rdf:type schema:Person
153 Nf157c1a9c4ba4aab8c74ed420a010cb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Hospitalization
155 rdf:type schema:DefinedTerm
156 Nf7a499d7d2d040598c9732abd8dfffb8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Anti-HIV Agents
158 rdf:type schema:DefinedTerm
159 Nf9bf6365fe7748fea0b876603b80f10e schema:volumeNumber 18
160 rdf:type schema:PublicationVolume
161 Nfc8dc91bf6f442f090729512ba9fe69d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Frailty
163 rdf:type schema:DefinedTerm
164 Nfe05286b8d0940aea76a51fb835f95c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Humans
166 rdf:type schema:DefinedTerm
167 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
168 schema:name Medical and Health Sciences
169 rdf:type schema:DefinedTerm
170 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
171 schema:name Clinical Sciences
172 rdf:type schema:DefinedTerm
173 sg:journal.1024943 schema:issn 1471-2318
174 schema:name BMC Geriatrics
175 rdf:type schema:Periodical
176 sg:person.01025752157.06 schema:affiliation https://www.grid.ac/institutes/grid.463428.f
177 schema:familyName Karamagi
178 schema:givenName Yvonne
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025752157.06
180 rdf:type schema:Person
181 sg:person.01066640211.44 schema:affiliation https://www.grid.ac/institutes/grid.11194.3c
182 schema:familyName Mayanja
183 schema:givenName Harriet K.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066640211.44
185 rdf:type schema:Person
186 sg:person.011313515575.44 schema:affiliation https://www.grid.ac/institutes/grid.463428.f
187 schema:familyName Ssonko
188 schema:givenName Michael
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011313515575.44
190 rdf:type schema:Person
191 sg:person.01215301736.26 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
192 schema:familyName Stanaway
193 schema:givenName Fiona
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215301736.26
195 rdf:type schema:Person
196 sg:person.01301170017.50 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
197 schema:familyName Cumming
198 schema:givenName Robert
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301170017.50
200 rdf:type schema:Person
201 sg:person.01316712114.68 schema:affiliation https://www.grid.ac/institutes/grid.463428.f
202 schema:familyName Mukasa
203 schema:givenName Barbara
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316712114.68
205 rdf:type schema:Person
206 sg:person.0613721635.32 schema:affiliation https://www.grid.ac/institutes/grid.414685.a
207 schema:familyName Naganathan
208 schema:givenName Vasi
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613721635.32
210 rdf:type schema:Person
211 sg:pub.10.1038/clpt.2011.258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039672822
212 https://doi.org/10.1038/clpt.2011.258
213 rdf:type schema:CreativeWork
214 sg:pub.10.1186/s12877-017-0621-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092156078
215 https://doi.org/10.1186/s12877-017-0621-2
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1001/jama.2013.2963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053394941
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1001/jama.280.19.1690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029560558
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/0021-9681(87)90171-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020988115
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/s0140-6736(08)60345-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036305533
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1037/0278-6133.26.1.40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017873515
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1080/09540121.2015.1109583 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038575129
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1089/apc.2004.18.568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059228422
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1089/apc.2015.0199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059229724
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1093/cid/cir626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024022648
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1093/jac/dkr248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044383959
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1097/00002030-200401001-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022770313
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1097/00002030-200418001-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060145046
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1097/qad.0b013e32835584ea schema:sameAs https://app.dimensions.ai/details/publication/pub.1016628019
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1097/qai.0b013e3182716e38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025828369
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1111/bcp.12975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033107570
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1111/j.1532-5415.2005.53455.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032597054
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1111/j.1741-6612.2008.00288.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011104125
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1111/jgs.12695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026965048
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1177/0091270008322177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004127963
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1177/1060028013504075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035193214
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1177/2325957413488204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005130804
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1345/aph.10351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050935684
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1371/journal.pone.0003729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035435518
262 rdf:type schema:CreativeWork
263 https://doi.org/10.2471/blt.10.076349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070837678
264 rdf:type schema:CreativeWork
265 https://doi.org/10.3851/imp1540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071479144
266 rdf:type schema:CreativeWork
267 https://www.grid.ac/institutes/grid.1013.3 schema:alternateName University of Sydney
268 schema:name Sydney School of Public Health, Sydney Medical School, University of Sydney, Sydney, Australia
269 rdf:type schema:Organization
270 https://www.grid.ac/institutes/grid.11194.3c schema:alternateName Makerere University
271 schema:name Makerere University College of Health Sciences, Kampala, Uganda
272 rdf:type schema:Organization
273 https://www.grid.ac/institutes/grid.414685.a schema:alternateName Concord Repatriation General Hospital
274 schema:name Ageing and Alzheimers Institute, Concord Hospital, Sydney, Australia
275 Centre for Education and Research on Ageing, Sydney Medical School, Concord Clinical School, University of Sydney, Sydney, Australia
276 rdf:type schema:Organization
277 https://www.grid.ac/institutes/grid.463428.f schema:alternateName Mildmay Uganda
278 schema:name Mildmay Uganda, 12 Km Entebbe Road, Naziba Hill Lweza, P.O. Box 24985, Kampala, Uganda
279 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...