Hypercortisolism in patients with cholestasis is associated with disease severity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-12-07

AUTHORS

Verena Theiler-Schwetz, Hansjörg Schlager, Barbara Obermayer-Pietsch, Tatjana Stojakovic, Günter Fauler, Peter Fickert, Gernot Zollner

ABSTRACT

BackgroundCholestasis might lead to an impairment of adrenal function as suggested by in vitro and in vivo data as well as by clinical findings. Bile acid and adrenal steroid metabolism not only share the receptors farnesoid X receptor (FXR) and the G protein-coupled bile acid receptor 1 (TGR5), but supraphysiological bile acid levels were found to stimulate steroidogenesis independent of FXR and TGR5. Our previous experimental findings revealed that mice fed bile acids or subjected to common bile duct ligation develop hypercortisolemia. We thus aimed to assess adrenal gland function in patients with cholestasis.MethodsAdrenal gland function was assessed in 36 patients with cholestasis and in 32 patients without cholestasis by measuring total serum cortisol, adrenocorticotropic hormone (ACTH), as well as the increase of cortisol 20 and 30 min after administration of 1 µg of ACTH. Bile acid levels and bile acid pool composition were determined by high-resolution mass spectrometry.ResultsPatients with cholestasis per definition had markedly elevated levels of alkaline phosphatase (AP), bilirubin and serum bile acids. Baseline cortisol and maximum cortisol after ACTH stimulation were significantly higher in patients with cholestasis compared to controls. Increase of cortisol after ACTH stimulation and ACTH did not differ. In the cholestasis group, baseline cortisol correlated with bilirubin but not with AP, total serum bile acids and levels of conjugated and unconjugated bile acid species. Patients with duration of cholestasis < 6 months (n = 30) had significantly higher baseline cortisol levels than those with long standing cholestasis (> 6 months), together with higher bilirubin levels.ConclusionsWe find no evidence of adrenal insufficiency in non-cirrhotic patients with cholestasis. In contrast, patients with cholestasis show hypercortisolism associated with disease severity as mirrored by levels of bilirubin. Lack of ACTH increase in cholestasis suggests a direct effect of cholestasis on adrenals and not on the pituitary gland. Further studies are needed to elucidate the mechanism of cortisol elevation in patients with cholestasis and its clinical significance. More... »

PAGES

460

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12876-021-02045-4

DOI

http://dx.doi.org/10.1186/s12876-021-02045-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1143657877

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34876016


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholestasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cushing Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrocortisone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypothalamo-Hypophyseal System", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pituitary-Adrenal System", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, University Hospital Graz, Graz, Austria", 
          "id": "http://www.grid.ac/institutes/grid.411580.9", 
          "name": [
            "Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, University Hospital Graz, Graz, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Theiler-Schwetz", 
        "givenName": "Verena", 
        "id": "sg:person.011457756430.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011457756430.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, University Hospital Graz, Graz, Austria", 
          "id": "http://www.grid.ac/institutes/grid.411580.9", 
          "name": [
            "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, University Hospital Graz, Graz, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schlager", 
        "givenName": "Hansj\u00f6rg", 
        "id": "sg:person.012316737643.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012316737643.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, University Hospital Graz, Graz, Austria", 
          "id": "http://www.grid.ac/institutes/grid.411580.9", 
          "name": [
            "Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, University Hospital Graz, Graz, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Obermayer-Pietsch", 
        "givenName": "Barbara", 
        "id": "sg:person.01071524655.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071524655.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Clinical Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Graz, Graz, Austria", 
          "id": "http://www.grid.ac/institutes/grid.411580.9", 
          "name": [
            "Clinical Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Graz, Graz, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stojakovic", 
        "givenName": "Tatjana", 
        "id": "sg:person.01123135465.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123135465.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Clinical Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Graz, Graz, Austria", 
          "id": "http://www.grid.ac/institutes/grid.411580.9", 
          "name": [
            "Clinical Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Graz, Graz, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fauler", 
        "givenName": "G\u00fcnter", 
        "id": "sg:person.012647333607.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012647333607.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, University Hospital Graz, Graz, Austria", 
          "id": "http://www.grid.ac/institutes/grid.411580.9", 
          "name": [
            "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, University Hospital Graz, Graz, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fickert", 
        "givenName": "Peter", 
        "id": "sg:person.0730761372.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730761372.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, University Hospital Graz, Graz, Austria", 
          "id": "http://www.grid.ac/institutes/grid.411580.9", 
          "name": [
            "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, University Hospital Graz, Graz, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zollner", 
        "givenName": "Gernot", 
        "id": "sg:person.0756342377.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756342377.88"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2021-12-07", 
    "datePublishedReg": "2021-12-07", 
    "description": "BackgroundCholestasis might lead to an impairment of adrenal function as suggested by in vitro and in vivo data as well as by clinical findings. Bile acid and adrenal steroid metabolism not only share the receptors farnesoid X receptor (FXR) and the G protein-coupled bile acid receptor 1 (TGR5), but supraphysiological bile acid levels were found to stimulate steroidogenesis independent of FXR and TGR5. Our previous experimental findings revealed that mice fed bile acids or subjected to common bile duct ligation develop hypercortisolemia. We thus aimed to assess adrenal gland function in patients with cholestasis.MethodsAdrenal gland function was assessed in 36 patients with cholestasis and in 32 patients without cholestasis by measuring total serum cortisol, adrenocorticotropic hormone (ACTH), as well as the increase of cortisol 20 and 30\u00a0min after administration of 1\u00a0\u00b5g of ACTH. Bile acid levels and bile acid pool composition were determined by high-resolution mass spectrometry.ResultsPatients with cholestasis per definition had markedly elevated levels of alkaline phosphatase (AP), bilirubin and serum bile acids. Baseline cortisol and maximum cortisol after ACTH stimulation were significantly higher in patients with cholestasis compared to controls. Increase of cortisol after ACTH stimulation and ACTH did not differ. In the cholestasis group, baseline cortisol correlated with bilirubin but not with AP, total serum bile acids and levels of conjugated and unconjugated bile acid species. Patients with duration of cholestasis\u2009<\u20096\u00a0months (n\u2009=\u200930) had significantly higher baseline cortisol levels than those with long standing cholestasis (>\u20096\u00a0months), together with higher bilirubin levels.ConclusionsWe find no evidence of adrenal insufficiency in non-cirrhotic patients with cholestasis. In contrast, patients with cholestasis show hypercortisolism associated with disease severity as mirrored by levels of bilirubin. Lack of ACTH increase in cholestasis suggests a direct effect of cholestasis on adrenals and not on the pituitary gland. Further studies are needed to elucidate the mechanism of cortisol elevation in patients with cholestasis and its clinical significance.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12876-021-02045-4", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024942", 
        "issn": [
          "1471-230X"
        ], 
        "name": "BMC Gastroenterology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "keywords": [
      "farnesoid X receptor", 
      "bile acid levels", 
      "serum bile acids", 
      "adrenocorticotropic hormone", 
      "bile acids", 
      "ACTH stimulation", 
      "gland function", 
      "baseline cortisol", 
      "G protein-coupled bile acid receptor 1", 
      "disease severity", 
      "total serum bile acids", 
      "bile acid receptor 1", 
      "bile acid pool composition", 
      "common bile duct ligation", 
      "adrenal steroid metabolism", 
      "receptor farnesoid X receptor", 
      "duration of cholestasis", 
      "acid levels", 
      "total serum cortisol", 
      "non-cirrhotic patients", 
      "high bilirubin levels", 
      "adrenal gland function", 
      "levels of bilirubin", 
      "bile duct ligation", 
      "alkaline phosphatase", 
      "unconjugated bile acid species", 
      "higher baseline cortisol levels", 
      "increase of cortisol", 
      "bile acid species", 
      "baseline cortisol levels", 
      "cholestasis group", 
      "ACTH increase", 
      "adrenal insufficiency", 
      "adrenal function", 
      "bilirubin levels", 
      "clinical findings", 
      "serum cortisol", 
      "duct ligation", 
      "clinical significance", 
      "cholestasis", 
      "maximum cortisol", 
      "patients", 
      "cortisol levels", 
      "pituitary gland", 
      "receptor 1", 
      "steroid metabolism", 
      "X receptor", 
      "cortisol", 
      "cortisol elevation", 
      "elevated levels", 
      "bilirubin", 
      "hypercortisolism", 
      "Further studies", 
      "vivo data", 
      "severity", 
      "stimulation", 
      "direct effect", 
      "hypercortisolemia", 
      "pool composition", 
      "ResultsPatients", 
      "TGR5", 
      "levels", 
      "adrenals", 
      "insufficiency", 
      "findings", 
      "steroidogenesis", 
      "administration", 
      "hormone", 
      "impairment", 
      "months", 
      "receptors", 
      "gland", 
      "ligation", 
      "increase", 
      "acid", 
      "ConclusionsWe", 
      "metabolism", 
      "duration", 
      "elevation", 
      "high-resolution mass spectrometry", 
      "group", 
      "function", 
      "min", 
      "evidence", 
      "acid species", 
      "phosphatase", 
      "control", 
      "significance", 
      "study", 
      "mass spectrometry", 
      "contrast", 
      "lack", 
      "effect", 
      "mechanism", 
      "data", 
      "definition", 
      "spectrometry", 
      "previous experimental findings", 
      "experimental findings", 
      "species", 
      "composition"
    ], 
    "name": "Hypercortisolism in patients with cholestasis is associated with disease severity", 
    "pagination": "460", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1143657877"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12876-021-02045-4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "34876016"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12876-021-02045-4", 
      "https://app.dimensions.ai/details/publication/pub.1143657877"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T21:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_907.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12876-021-02045-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12876-021-02045-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12876-021-02045-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12876-021-02045-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12876-021-02045-4'


 

This table displays all metadata directly associated to this object as RDF triples.

243 TRIPLES      20 PREDICATES      135 URIs      127 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12876-021-02045-4 schema:about N26da1eacf71449838d467c6512cff2d4
2 N396e91836b2942c5802e6b0a6c03a88e
3 N49f6854760de47629ecb35004ff398da
4 N6263c20f385540a7b64113800a6106b1
5 N6b5420a559324d858bbbc7b47d2ec8ba
6 N6c60b2ab521b40e98bb023fcc98eb905
7 N952807e8f97c479c9a584ca0948d29c2
8 Nb4d61c7ff11e45e2a6218818b3c2fb43
9 Nf2b81ac3044046b4867c1b4c01a78153
10 anzsrc-for:11
11 anzsrc-for:1103
12 schema:author Ne67c3f85d0114b0fb38a486822df2146
13 schema:datePublished 2021-12-07
14 schema:datePublishedReg 2021-12-07
15 schema:description BackgroundCholestasis might lead to an impairment of adrenal function as suggested by in vitro and in vivo data as well as by clinical findings. Bile acid and adrenal steroid metabolism not only share the receptors farnesoid X receptor (FXR) and the G protein-coupled bile acid receptor 1 (TGR5), but supraphysiological bile acid levels were found to stimulate steroidogenesis independent of FXR and TGR5. Our previous experimental findings revealed that mice fed bile acids or subjected to common bile duct ligation develop hypercortisolemia. We thus aimed to assess adrenal gland function in patients with cholestasis.MethodsAdrenal gland function was assessed in 36 patients with cholestasis and in 32 patients without cholestasis by measuring total serum cortisol, adrenocorticotropic hormone (ACTH), as well as the increase of cortisol 20 and 30 min after administration of 1 µg of ACTH. Bile acid levels and bile acid pool composition were determined by high-resolution mass spectrometry.ResultsPatients with cholestasis per definition had markedly elevated levels of alkaline phosphatase (AP), bilirubin and serum bile acids. Baseline cortisol and maximum cortisol after ACTH stimulation were significantly higher in patients with cholestasis compared to controls. Increase of cortisol after ACTH stimulation and ACTH did not differ. In the cholestasis group, baseline cortisol correlated with bilirubin but not with AP, total serum bile acids and levels of conjugated and unconjugated bile acid species. Patients with duration of cholestasis < 6 months (n = 30) had significantly higher baseline cortisol levels than those with long standing cholestasis (> 6 months), together with higher bilirubin levels.ConclusionsWe find no evidence of adrenal insufficiency in non-cirrhotic patients with cholestasis. In contrast, patients with cholestasis show hypercortisolism associated with disease severity as mirrored by levels of bilirubin. Lack of ACTH increase in cholestasis suggests a direct effect of cholestasis on adrenals and not on the pituitary gland. Further studies are needed to elucidate the mechanism of cortisol elevation in patients with cholestasis and its clinical significance.
16 schema:genre article
17 schema:isAccessibleForFree true
18 schema:isPartOf N2e1ace9d9f4c4bc9a433d605ab392c42
19 N430baed27149421b9f1ee0e803c61ba2
20 sg:journal.1024942
21 schema:keywords ACTH increase
22 ACTH stimulation
23 ConclusionsWe
24 Further studies
25 G protein-coupled bile acid receptor 1
26 ResultsPatients
27 TGR5
28 X receptor
29 acid
30 acid levels
31 acid species
32 administration
33 adrenal function
34 adrenal gland function
35 adrenal insufficiency
36 adrenal steroid metabolism
37 adrenals
38 adrenocorticotropic hormone
39 alkaline phosphatase
40 baseline cortisol
41 baseline cortisol levels
42 bile acid levels
43 bile acid pool composition
44 bile acid receptor 1
45 bile acid species
46 bile acids
47 bile duct ligation
48 bilirubin
49 bilirubin levels
50 cholestasis
51 cholestasis group
52 clinical findings
53 clinical significance
54 common bile duct ligation
55 composition
56 contrast
57 control
58 cortisol
59 cortisol elevation
60 cortisol levels
61 data
62 definition
63 direct effect
64 disease severity
65 duct ligation
66 duration
67 duration of cholestasis
68 effect
69 elevated levels
70 elevation
71 evidence
72 experimental findings
73 farnesoid X receptor
74 findings
75 function
76 gland
77 gland function
78 group
79 high bilirubin levels
80 high-resolution mass spectrometry
81 higher baseline cortisol levels
82 hormone
83 hypercortisolemia
84 hypercortisolism
85 impairment
86 increase
87 increase of cortisol
88 insufficiency
89 lack
90 levels
91 levels of bilirubin
92 ligation
93 mass spectrometry
94 maximum cortisol
95 mechanism
96 metabolism
97 min
98 months
99 non-cirrhotic patients
100 patients
101 phosphatase
102 pituitary gland
103 pool composition
104 previous experimental findings
105 receptor 1
106 receptor farnesoid X receptor
107 receptors
108 serum bile acids
109 serum cortisol
110 severity
111 significance
112 species
113 spectrometry
114 steroid metabolism
115 steroidogenesis
116 stimulation
117 study
118 total serum bile acids
119 total serum cortisol
120 unconjugated bile acid species
121 vivo data
122 schema:name Hypercortisolism in patients with cholestasis is associated with disease severity
123 schema:pagination 460
124 schema:productId N0bd82f22e83947798b7203065200df81
125 N17219b5d4b834411ae42dd911efae1f4
126 N2c5785e61c4f4dcb8ac30a0d608b3b15
127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1143657877
128 https://doi.org/10.1186/s12876-021-02045-4
129 schema:sdDatePublished 2022-11-24T21:07
130 schema:sdLicense https://scigraph.springernature.com/explorer/license/
131 schema:sdPublisher Na862ea6289434bfd840f8139af60b154
132 schema:url https://doi.org/10.1186/s12876-021-02045-4
133 sgo:license sg:explorer/license/
134 sgo:sdDataset articles
135 rdf:type schema:ScholarlyArticle
136 N0bd82f22e83947798b7203065200df81 schema:name doi
137 schema:value 10.1186/s12876-021-02045-4
138 rdf:type schema:PropertyValue
139 N17219b5d4b834411ae42dd911efae1f4 schema:name pubmed_id
140 schema:value 34876016
141 rdf:type schema:PropertyValue
142 N26da1eacf71449838d467c6512cff2d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Mice
144 rdf:type schema:DefinedTerm
145 N2c5785e61c4f4dcb8ac30a0d608b3b15 schema:name dimensions_id
146 schema:value pub.1143657877
147 rdf:type schema:PropertyValue
148 N2e1ace9d9f4c4bc9a433d605ab392c42 schema:volumeNumber 21
149 rdf:type schema:PublicationVolume
150 N396e91836b2942c5802e6b0a6c03a88e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Cushing Syndrome
152 rdf:type schema:DefinedTerm
153 N430baed27149421b9f1ee0e803c61ba2 schema:issueNumber 1
154 rdf:type schema:PublicationIssue
155 N4836f2d770e64028895fe4f11d8ff046 rdf:first sg:person.01123135465.09
156 rdf:rest N5a05e6b81f864fac968004ff9b9c30a6
157 N49f6854760de47629ecb35004ff398da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Pituitary-Adrenal System
159 rdf:type schema:DefinedTerm
160 N5a05e6b81f864fac968004ff9b9c30a6 rdf:first sg:person.012647333607.10
161 rdf:rest N98e777d6ecf147439a09091be7ead5f2
162 N6263c20f385540a7b64113800a6106b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Severity of Illness Index
164 rdf:type schema:DefinedTerm
165 N6b5420a559324d858bbbc7b47d2ec8ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Animals
167 rdf:type schema:DefinedTerm
168 N6c60b2ab521b40e98bb023fcc98eb905 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Hydrocortisone
170 rdf:type schema:DefinedTerm
171 N952807e8f97c479c9a584ca0948d29c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Humans
173 rdf:type schema:DefinedTerm
174 N98e777d6ecf147439a09091be7ead5f2 rdf:first sg:person.0730761372.74
175 rdf:rest Necfc363e57d046829abb5ed47f4f64a2
176 Na862ea6289434bfd840f8139af60b154 schema:name Springer Nature - SN SciGraph project
177 rdf:type schema:Organization
178 Nac7e7501d6b24c48b5a7e945b67faeac rdf:first sg:person.01071524655.82
179 rdf:rest N4836f2d770e64028895fe4f11d8ff046
180 Nb4d61c7ff11e45e2a6218818b3c2fb43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Cholestasis
182 rdf:type schema:DefinedTerm
183 Ne611a709a3f649f8abbef20cae7dc86d rdf:first sg:person.012316737643.71
184 rdf:rest Nac7e7501d6b24c48b5a7e945b67faeac
185 Ne67c3f85d0114b0fb38a486822df2146 rdf:first sg:person.011457756430.96
186 rdf:rest Ne611a709a3f649f8abbef20cae7dc86d
187 Necfc363e57d046829abb5ed47f4f64a2 rdf:first sg:person.0756342377.88
188 rdf:rest rdf:nil
189 Nf2b81ac3044046b4867c1b4c01a78153 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Hypothalamo-Hypophyseal System
191 rdf:type schema:DefinedTerm
192 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
193 schema:name Medical and Health Sciences
194 rdf:type schema:DefinedTerm
195 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
196 schema:name Clinical Sciences
197 rdf:type schema:DefinedTerm
198 sg:journal.1024942 schema:issn 1471-230X
199 schema:name BMC Gastroenterology
200 schema:publisher Springer Nature
201 rdf:type schema:Periodical
202 sg:person.01071524655.82 schema:affiliation grid-institutes:grid.411580.9
203 schema:familyName Obermayer-Pietsch
204 schema:givenName Barbara
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071524655.82
206 rdf:type schema:Person
207 sg:person.01123135465.09 schema:affiliation grid-institutes:grid.411580.9
208 schema:familyName Stojakovic
209 schema:givenName Tatjana
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123135465.09
211 rdf:type schema:Person
212 sg:person.011457756430.96 schema:affiliation grid-institutes:grid.411580.9
213 schema:familyName Theiler-Schwetz
214 schema:givenName Verena
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011457756430.96
216 rdf:type schema:Person
217 sg:person.012316737643.71 schema:affiliation grid-institutes:grid.411580.9
218 schema:familyName Schlager
219 schema:givenName Hansjörg
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012316737643.71
221 rdf:type schema:Person
222 sg:person.012647333607.10 schema:affiliation grid-institutes:grid.411580.9
223 schema:familyName Fauler
224 schema:givenName Günter
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012647333607.10
226 rdf:type schema:Person
227 sg:person.0730761372.74 schema:affiliation grid-institutes:grid.411580.9
228 schema:familyName Fickert
229 schema:givenName Peter
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730761372.74
231 rdf:type schema:Person
232 sg:person.0756342377.88 schema:affiliation grid-institutes:grid.411580.9
233 schema:familyName Zollner
234 schema:givenName Gernot
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756342377.88
236 rdf:type schema:Person
237 grid-institutes:grid.411580.9 schema:alternateName Clinical Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Graz, Graz, Austria
238 Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, University Hospital Graz, Graz, Austria
239 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, University Hospital Graz, Graz, Austria
240 schema:name Clinical Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Graz, Graz, Austria
241 Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, University Hospital Graz, Graz, Austria
242 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, University Hospital Graz, Graz, Austria
243 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...