Association between platelet count and mucosal healing in Japanese patients with ulcerative colitis: a cross-sectional study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-11-16

AUTHORS

Shinya Furukawa, Sen Yagi, Kana Shiraishi, Kenichirou Mori, Tomoyuki Ninomiya, Keitarou Kawasaki, Yuji Mizukami, Seiyuu Suzuki, Masayoshi Uraoka, Naozumi Shibata, Sanae Nakamura, Satoshi Imamine, Hidehiro Murakami, Katsuhisa Ohashi, Masamoto Torisu, Aki Hasebe, Harumi Yano, Masato Murakami, Eiji Takeshita, Yoshio Ikeda, Yoichi Hiasa

ABSTRACT

BackgroundMucosal healing (MH) has been indicated as the therapeutic goal for ulcerative colitis (UC). Platelet count is known as an inflammation evaluation. However, the association between platelet count and MH among patients with UC is still scarce. We therefore assessed this issue among Japanese patients with UC.MethodsThe study subjects consisted of 345 Japanese patients with UC. Platelet count was divided into quartiles on the basis of the distribution of all study subjects (low, moderate, high, and very high). Several endoscope specialists were responsible for evaluating MH and partial MH, which was defined as a Mayo endoscopic subscore of 0 and 0–1, respectively. Estimations of crude odds ratios (ORs) and their 95% confidence intervals (CIs) for partial MH and MH in relation to platelet count were performed using logistic regression analysis. Age, sex, CRP, steroid use, and anti-Tumor necrosis factor α (TNFα) preparation were selected a priori as potential confounding factors.ResultsThe percentage of partial MH and MH were 63.2 and 26.1%, respectively. Moderate and very high was independently inversely associated with partial MH (moderate: OR 0.40 [95%CI 0.19–0.810], very high: OR 0.37 [95%CI 0.17–0.77], p for trend = 0.034). Similarly, moderate, high, and very high were independently inversely associated with MH (moderate: OR 0.37 [95% CI 0.18–0.73], high: OR 0.41 [95% CI 0.19–0.83], and very high: OR 0.45 [95% CI 0.21–0.94], p for trend = 0.033) after adjustment for confounding factors.ConclusionsAmong patients with UC, platelet count was independently inversely associated with MH More... »

PAGES

384

References to SciGraph publications

  • 2007-12-01. Reticulated platelet levels in patients with ulcerative colitis in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • 2001-01. The CD40/CD154 receptor/ligand dyadRID="†"ID="†" Review in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2001-03-01. Mean platelet volume: a useful marker of inflammatory bowel disease activity in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2009-12-01. Clinical implications of mucosal healing for the management of IBD in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • Journal

    TITLE

    BMC Gastroenterology

    ISSUE

    1

    VOLUME

    20

    Author Affiliations

  • Health Services Center, Ehime University, 790-8577, Bunkyo,Matsuyama, Ehime, Japan
  • Department of Internal Medicine, Saiseikai Matsuyama Hospital, 791-8026, Matsuyama, Ehime, Japan
  • Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, 791-0205, Toon, Ehime, Japan
  • Department of Gastroenterology, Ehime Prefectural Central Hospital, 790-0024, Matsuyama, Ehime, Japan
  • Department of Internal Medicine, Saiseikai Imabari Hospital, 799-1592, Imabari, Ehime, Japan
  • Department of Gastroenterology, Matsuyama Shimin Hospital, 790-0067, Matsuyama, Ehime, Japan
  • Department of Gastroenterology, Sumitomo Besshi Hospital, 792-8543, Niihama, Ehime, Japan
  • Uraoka Gastrointestinal Clinic, 790-0852, Matsuyama, Ehime, Japan
  • Department of Gastroenterology, Ehime Prefectural Niihama Hospital, 792-0042, Niihama, Ehime, Japan
  • Department of Gastroenterology, NTT Matsuyama Hospital, 790-0802, Matsuyama, Ehime, Japan
  • Department of Internal Medicine, Shiritsu Oozu Hospital, 795-0013, Oozu, Ehime, Japan
  • Ohashi Clinic Participating in Gastro-Enterology and Ano-Proctology, 792-0856, Niihama, Ehime, Japan
  • Department of Internal Medicine, Saiseikai Saijo Hospital, 793-00257, Saijo, Ehime, Japan
  • Department of Gastroenterology, Shikoku Cancer Center, 791-0280, Matsuyama, Ehime, Japan
  • Department of Gastroenterology, Saijo City Shuso Hospital, 793-0027, Saijo, Ehime, Japan
  • Department of Gastroenterology, Murakamikinen Hospital, 793-0030, Saijo, Ehime, Japan
  • Department of Inflammatory Bowel Diseases and Therapeutics, Ehime University Graduate School of Medicine, 791-0205, Matsuyama, Ehime, Japan
  • Endoscopy Center, Ehime University Hospital, 791-0205, Toon, Ehime, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12876-020-01538-y

    DOI

    http://dx.doi.org/10.1186/s12876-020-01538-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1132664537

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33198664


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        "description": "BackgroundMucosal healing (MH) has been indicated as the therapeutic goal for ulcerative colitis (UC). Platelet count is known as an inflammation evaluation. However, the association between platelet count and MH among patients with UC is still scarce. We therefore assessed this issue among Japanese patients with UC.MethodsThe study subjects consisted of 345 Japanese patients with UC. Platelet count was divided into quartiles on the basis of the distribution of all study subjects (low, moderate, high, and very high). Several endoscope specialists were responsible for evaluating MH and partial MH, which was defined as a Mayo endoscopic subscore of 0 and 0\u20131, respectively. Estimations of crude odds ratios (ORs) and their 95% confidence intervals (CIs) for partial MH and MH in relation to platelet count were performed using logistic regression analysis. Age, sex, CRP, steroid use, and anti-Tumor necrosis factor \u03b1 (TNF\u03b1) preparation were selected a priori as potential confounding factors.ResultsThe percentage of partial MH and MH were 63.2 and 26.1%, respectively. Moderate and very high was independently inversely associated with partial MH (moderate: OR 0.40 [95%CI 0.19\u20130.810], very high: OR 0.37 [95%CI 0.17\u20130.77], p for trend\u2009=\u20090.034). Similarly, moderate, high, and very high were independently inversely associated with MH (moderate: OR 0.37 [95% CI 0.18\u20130.73], high: OR 0.41 [95% CI 0.19\u20130.83], and very high: OR 0.45 [95% CI 0.21\u20130.94], p for trend\u2009=\u20090.033) after adjustment for confounding factors.ConclusionsAmong patients with UC, platelet count was independently inversely associated with MH", 
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    18 schema:description BackgroundMucosal healing (MH) has been indicated as the therapeutic goal for ulcerative colitis (UC). Platelet count is known as an inflammation evaluation. However, the association between platelet count and MH among patients with UC is still scarce. We therefore assessed this issue among Japanese patients with UC.MethodsThe study subjects consisted of 345 Japanese patients with UC. Platelet count was divided into quartiles on the basis of the distribution of all study subjects (low, moderate, high, and very high). Several endoscope specialists were responsible for evaluating MH and partial MH, which was defined as a Mayo endoscopic subscore of 0 and 0–1, respectively. Estimations of crude odds ratios (ORs) and their 95% confidence intervals (CIs) for partial MH and MH in relation to platelet count were performed using logistic regression analysis. Age, sex, CRP, steroid use, and anti-Tumor necrosis factor α (TNFα) preparation were selected a priori as potential confounding factors.ResultsThe percentage of partial MH and MH were 63.2 and 26.1%, respectively. Moderate and very high was independently inversely associated with partial MH (moderate: OR 0.40 [95%CI 0.19–0.810], very high: OR 0.37 [95%CI 0.17–0.77], p for trend = 0.034). Similarly, moderate, high, and very high were independently inversely associated with MH (moderate: OR 0.37 [95% CI 0.18–0.73], high: OR 0.41 [95% CI 0.19–0.83], and very high: OR 0.45 [95% CI 0.21–0.94], p for trend = 0.033) after adjustment for confounding factors.ConclusionsAmong patients with UC, platelet count was independently inversely associated with MH
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