Rapidly declining trend of signet ring cell cancer of the stomach may parallel the infection rate of Helicobacter pylori View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-11-08

AUTHORS

Hiroshi Ohyama, Dai Yoshimura, Yosuke Hirotsu, Kenji Amemiya, Hiroyuki Amano, Yuko Miura, Hiroshi Ashizawa, Keiko Nakagomi, Shinya Takaoka, Kenji Hosoda, Yoji Suzuki, Toshio Oyama, Masao Hada, Yuichiro Kojima, Hitoshi Mochizuki, Masao Omata

ABSTRACT

BACKGROUND: Studies indicate that gastric cancer (GC) incidence has decreased, whereas signet ring cell carcinoma (SRC) incidence has increased. However, recent trends in GC incidence are unclear. We used our hospital cancer registry to evaluate the changes in the incidence of GC, SRC, and non-SRC (NSRC) over time in comparison to changes in the H. pylori infection rates over time. METHODS: We identified 2532 patients with GC enrolled in our registry between January 2007 and December 2018 and statistically analyzed SRC and NSRC incidence. The H. pylori infection rate in patients with SRC was determined by serum anti-H. pylori antibody testing, urea breath test, biopsy specimen culture, and immunohistochemical analysis (IHC) of gastric tissue. Additionally, genomic detection of H. pylori was performed in SRCs by extracting DNA from formalin-fixed paraffin-embedded gastric tissue and targeting 16S ribosomal RNA of H. pylori. RESULTS: Overall, 211 patients had SRC (8.3%). Compared with patients with NSRC, those with SRC were younger (P < 0.001) and more likely to be female (P < 0.001). Time series analysis using an autoregressive integrated moving average model revealed a significant decrease in SRC (P < 0.001) incidence; NSRC incidence showed no decline. There was no difference in H. pylori infection prevalence between the SRC and NSRC groups. IHC and genomic methods detected H. pylori in 30 of 37 (81.1%) SRCs. CONCLUSIONS: Reduction in H. pylori infection prevalence may be associated with the decrease in the incidence of SRC, which was higher than that of NSRC. More... »

PAGES

178

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12876-019-1094-x

DOI

http://dx.doi.org/10.1186/s12876-019-1094-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1122421679

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31703565


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25 schema:description BACKGROUND: Studies indicate that gastric cancer (GC) incidence has decreased, whereas signet ring cell carcinoma (SRC) incidence has increased. However, recent trends in GC incidence are unclear. We used our hospital cancer registry to evaluate the changes in the incidence of GC, SRC, and non-SRC (NSRC) over time in comparison to changes in the H. pylori infection rates over time. METHODS: We identified 2532 patients with GC enrolled in our registry between January 2007 and December 2018 and statistically analyzed SRC and NSRC incidence. The H. pylori infection rate in patients with SRC was determined by serum anti-H. pylori antibody testing, urea breath test, biopsy specimen culture, and immunohistochemical analysis (IHC) of gastric tissue. Additionally, genomic detection of H. pylori was performed in SRCs by extracting DNA from formalin-fixed paraffin-embedded gastric tissue and targeting 16S ribosomal RNA of H. pylori. RESULTS: Overall, 211 patients had SRC (8.3%). Compared with patients with NSRC, those with SRC were younger (P <  0.001) and more likely to be female (P <  0.001). Time series analysis using an autoregressive integrated moving average model revealed a significant decrease in SRC (P <  0.001) incidence; NSRC incidence showed no decline. There was no difference in H. pylori infection prevalence between the SRC and NSRC groups. IHC and genomic methods detected H. pylori in 30 of 37 (81.1%) SRCs. CONCLUSIONS: Reduction in H. pylori infection prevalence may be associated with the decrease in the incidence of SRC, which was higher than that of NSRC.
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33 DNA
34 GC
35 GC incidence
36 Helicobacter pylori
37 NSRC
38 NSRC groups
39 NSRC incidence
40 Overall
41 RNA
42 Src
43 analysis
44 antibody testing
45 average model
46 biopsy specimen culture
47 breath test
48 cancer
49 cancer incidence
50 carcinoma incidence
51 cell cancer
52 cell carcinoma (SRC) incidence
53 changes
54 comparison
55 culture
56 decline
57 decrease
58 detection
59 differences
60 formalin
61 gastric cancer incidence
62 gastric tissue
63 genomic detection
64 genomic methods
65 group
66 hospital cancer registry
67 immunohistochemical analysis
68 incidence
69 incidence of GC
70 incidence of SRC
71 infection prevalence
72 infection rate
73 method
74 model
75 paraffin-embedded gastric tissues
76 patients
77 prevalence
78 pylori
79 pylori antibody testing
80 pylori infection prevalence
81 pylori infection rate
82 rate
83 recent trends
84 reduction
85 registry
86 ribosomal RNA
87 ring cell cancer
88 ring cell carcinoma (SRC) incidence
89 series analysis
90 signet ring cell cancer
91 signet ring cell carcinoma (SRC) incidence
92 significant decrease
93 specimen cultures
94 stomach
95 study
96 test
97 testing
98 time
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100 tissue
101 trends
102 urea breath test
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