Impact of nutrition and rotavirus infection on the infant gut microbiota in a humanized pig model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Anand Kumar, Anastasia N. Vlasova, Loic Deblais, Huang-Chi Huang, Asela Wijeratne, Sukumar Kandasamy, David D. Fischer, Stephanie N. Langel, Francine Chimelo Paim, Moyasar A. Alhamo, Lulu Shao, Linda J. Saif, Gireesh Rajashekara

ABSTRACT

BACKGROUND: Human rotavirus (HRV) is a major cause of viral gastroenteritis in infants; particularly in developing countries where malnutrition is prevalent. Malnutrition perturbs the infant gut microbiota leading to sub-optimal functioning of the immune system and further predisposing infants to enteric infections. Therefore, we hypothesized that malnutrition exacerbates rotavirus disease severity in infants. METHODS: In the present study, we used a neonatal germ free (GF) piglets transplanted with a two-month-old human infant's fecal microbiota (HIFM) on protein deficient and sufficient diets. We report the effects of malnourishment on the HRV infection and the HIFM pig microbiota in feces, intestinal and systemic tissues, using MiSeq 16S gene sequencing (V4-V5 region). RESULTS: Microbiota analysis indicated that the HIFM transplantation resulted in a microbial composition in pigs similar to that of the original infant feces. This model was then used to understand the interconnections between microbiota diversity, diet, and HRV infection. Post HRV infection, HIFM pigs on the deficient diet had lower body weights, developed more severe diarrhea and increased virus shedding compared to HIFM pigs on sufficient diet. However, HRV induced diarrhea and shedding was more pronounced in non-colonized GF pigs compared to HIFM pigs on either sufficient or deficient diet, suggesting that the microbiota alone moderated HRV infection. HRV infected pigs on sufficient diet showed increased microbiota diversity in intestinal tissues; whereas, greater diversity was observed in systemic tissues of HRV infected pigs fed with deficient diet. CONCLUSIONS: These results suggest that proper nourishment improves the microbiota quality in the intestines, alleviates HRV disease and lower probability of systemic translocation of potential opportunistic pathogens/pathobionts. In conclusion, our findings further support the role for microbiota and proper nutrition in limiting enteric diseases. More... »

PAGES

93

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12876-018-0810-2

DOI

http://dx.doi.org/10.1186/s12876-018-0810-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105047634

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29929472


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444 https://www.grid.ac/institutes/grid.21925.3d schema:alternateName University of Pittsburgh
445 schema:name Food Animal Research Program, The Ohio Agricultural Research and Development Center,Veterinary Preventive Medicine Department, The Ohio State University, 1680 Madison Avenue, 44691, Wooster, OH, USA
446 Present address: Hillman Cancer Center, University of Pittsburgh, 4200 Fifth Ave, 15260, Pittsburgh, PA, USA
447 rdf:type schema:Organization
448 https://www.grid.ac/institutes/grid.261331.4 schema:alternateName The Ohio State University
449 schema:name Food Animal Research Program, The Ohio Agricultural Research and Development Center,Veterinary Preventive Medicine Department, The Ohio State University, 1680 Madison Avenue, 44691, Wooster, OH, USA
450 The Molecular and Cellular Imaging Center, The Ohio State University, Wooster, OH, USA
451 rdf:type schema:Organization
 




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