Telbivudine versus entecavir in patients with undetectable hepatitis B virus DNA: a randomized trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Jihyun An, Young-Suk Lim, Gi-Ae Kim, Seong-bong Han, Wonhee Jeong, Danbi Lee, Ju Hyun Shim, Han Chu Lee, Yung Sang Lee

ABSTRACT

BACKGROUND: Telbivudine has been suggested to induce hepatitis B surface antigen (HBsAg) decline to the similar degree as pegylated interferon. We aimed to investigate whether telbivudine could further decrease HBsAg titer in patients who maintain undetectable serum hepatitis B virus (HBV) DNA after initial entecavir treatment. METHODS: In this open-label trial, patients who had serum HBsAg and HBV DNA levels ≥1,000 IU/mL and <60 IU/mL, respectively, following entecavir (0.5 mg/day) treatment for HBeAg-positive chronic hepatitis B were randomized to either switch treatment to telbivudine (600 mg/day, n = 47) or continue entecavir (n = 50) for 48 weeks. RESULTS: The baseline characteristics were comparable between groups including HBsAg levels (median, 3.41 log10 IU/mL). All patients had undetectable HBV DNA and normal alanine aminotransferase level. At week 48, the mean change in serum HBsAg levels was not significantly different between the telbivudine and entecavir groups (-0.03 log10 IU/mL vs. -0.05 log10 IU/mL; P = 0.57). No patient experienced HBsAg seroclearance or HBsAg decline >0.5 log10 IU/mL. Eleven patients (23.4%) in the telbivudine group, but none in the entecavir group, experienced virologic breakthrough (P < 0.001). Seven patients (14.9%) exhibited genotypic resistance mutations (M204I +/- L180M) during the virologic breakthrough. CONCLUSION: Sequential therapy with entecavir followed by telbivudine resulted in a high rate of virologic breakthrough and drug-resistance without any beneficial effect on HBsAg decline. These results do not support the use of low genetic barrier drugs as a switch treatment strategy in patients who achieve virologic response with high genetic barrier drugs. TRIAL REGISTRATION: NCT01595685 (date of trial registration: May 8, 2012). More... »

PAGES

15

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12876-017-0572-2

DOI

http://dx.doi.org/10.1186/s12876-017-0572-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053954450

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28103819


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antiviral Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guanine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis B", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis B Surface Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis B virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Telbivudine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thymidine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Load", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Asan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, 05505, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "An", 
        "givenName": "Jihyun", 
        "id": "sg:person.01125744406.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125744406.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Asan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, 05505, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lim", 
        "givenName": "Young-Suk", 
        "id": "sg:person.01334266467.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334266467.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Asan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Health Screening and Promotion Center, Asan Medical Center, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Gi-Ae", 
        "id": "sg:person.0666666240.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666666240.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gachon University", 
          "id": "https://www.grid.ac/institutes/grid.256155.0", 
          "name": [
            "Department of Applied Statistics, Gachon University, Seongnam-si, Gyeonggi-do, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Seong-bong", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Asan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, 05505, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jeong", 
        "givenName": "Wonhee", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Asan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, 05505, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Danbi", 
        "id": "sg:person.015374452220.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015374452220.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Asan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, 05505, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shim", 
        "givenName": "Ju Hyun", 
        "id": "sg:person.01254665016.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254665016.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Asan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, 05505, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Han Chu", 
        "id": "sg:person.01025651424.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025651424.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Asan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, 05505, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Yung Sang", 
        "id": "sg:person.0666206756.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666206756.24"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/hep.23327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000029068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cgh.2013.01.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005646619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000096313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013951874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.antiviral.2011.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015199029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2008.10.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018138810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.23190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018751116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2012.02.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020630462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3346/jkms.2005.20.5.816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021646851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3346/jkms.2005.20.5.816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021646851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2010.10.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022883056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2012.11.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023356491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2008.12.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023524079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.21612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026290747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2013-305517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028286833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2014-307237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029483454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2008.07.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031304194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2008.05.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031803613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2015.09.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033473489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2010.07.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034237807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2014.08.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036017867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.24192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036488271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2006.05.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037562150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2011.06.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038162613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.23905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042371922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.23905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042371922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(06)69347-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044838790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2014.08.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045672586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.24364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045965058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.26686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048440183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2007.08.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052216645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2009.01.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052355415"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: Telbivudine has been suggested to induce hepatitis B surface antigen (HBsAg) decline to the similar degree as pegylated interferon. We aimed to investigate whether telbivudine could further decrease HBsAg titer in patients who maintain undetectable serum hepatitis B virus (HBV) DNA after initial entecavir treatment.\nMETHODS: In this open-label trial, patients who had serum HBsAg and HBV DNA levels \u22651,000\u00a0IU/mL and <60\u00a0IU/mL, respectively, following entecavir (0.5\u00a0mg/day) treatment for HBeAg-positive chronic hepatitis B were randomized to either switch treatment to telbivudine (600\u00a0mg/day, n\u2009=\u200947) or continue entecavir (n\u2009=\u200950) for 48\u00a0weeks.\nRESULTS: The baseline characteristics were comparable between groups including HBsAg levels (median, 3.41 log10 IU/mL). All patients had undetectable HBV DNA and normal alanine aminotransferase level. At week 48, the mean change in serum HBsAg levels was not significantly different between the telbivudine and entecavir groups (-0.03 log10 IU/mL vs. -0.05 log10 IU/mL; P\u2009=\u20090.57). No patient experienced HBsAg seroclearance or HBsAg decline >0.5 log10 IU/mL. Eleven patients (23.4%) in the telbivudine group, but none in the entecavir group, experienced virologic breakthrough (P\u2009<\u20090.001). Seven patients (14.9%) exhibited genotypic resistance mutations (M204I +/- L180M) during the virologic breakthrough.\nCONCLUSION: Sequential therapy with entecavir followed by telbivudine resulted in a high rate of virologic breakthrough and drug-resistance without any beneficial effect on HBsAg decline. These results do not support the use of low genetic barrier drugs as a switch treatment strategy in patients who achieve virologic response with high genetic barrier drugs.\nTRIAL REGISTRATION: NCT01595685 (date of trial registration: May 8, 2012).", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12876-017-0572-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024942", 
        "issn": [
          "1471-230X"
        ], 
        "name": "BMC Gastroenterology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Telbivudine versus entecavir in patients with undetectable hepatitis B virus DNA: a randomized trial", 
    "pagination": "15", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9ad672619666fc8879a974f02bc3b2ef2af542cd7f4f3796e49cf6a0ca1367a8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28103819"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968547"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12876-017-0572-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1053954450"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12876-017-0572-2", 
      "https://app.dimensions.ai/details/publication/pub.1053954450"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113664_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12876-017-0572-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12876-017-0572-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12876-017-0572-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12876-017-0572-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12876-017-0572-2'


 

This table displays all metadata directly associated to this object as RDF triples.

269 TRIPLES      21 PREDICATES      72 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12876-017-0572-2 schema:about N317a757c5d1047ef8310d56aea816e75
2 N356803ae1e104b79ae04d63bd59ca0bc
3 N3b31a9732f8f4f6eaf23d3362b1d4724
4 N52e40fa77605438ab983752aa427b8ae
5 N59c9ec5e63444b99ae0c2d0d09110ae5
6 N7638860b6f6142bc825ace32f9aaef0a
7 N7b8d1135bb6845a5ac9326997d08279b
8 N83b6ff0a4ad842f9954581f303079884
9 N8849c0e736a84a3d975bd09a08cb95e4
10 N9804bb5b25a242b7811c44bb7e0651a0
11 Nea8610c13c0b42229b0c81031806f2fc
12 Nf14e898671d741d3aac0e54723f0d2cb
13 Nf7fa64f0c97349089024d0b332484936
14 Nfa34a702314b4ccca27ba17a13de3617
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N8ec69e966505492a851436a153727d90
18 schema:citation https://doi.org/10.1002/hep.21612
19 https://doi.org/10.1002/hep.23190
20 https://doi.org/10.1002/hep.23327
21 https://doi.org/10.1002/hep.23905
22 https://doi.org/10.1002/hep.24192
23 https://doi.org/10.1002/hep.24364
24 https://doi.org/10.1002/hep.26686
25 https://doi.org/10.1016/j.antiviral.2011.04.008
26 https://doi.org/10.1016/j.cgh.2013.01.026
27 https://doi.org/10.1016/j.jhep.2006.05.013
28 https://doi.org/10.1016/j.jhep.2008.12.019
29 https://doi.org/10.1016/j.jhep.2009.01.016
30 https://doi.org/10.1016/j.jhep.2010.07.046
31 https://doi.org/10.1016/j.jhep.2011.06.006
32 https://doi.org/10.1016/j.jhep.2012.02.010
33 https://doi.org/10.1016/j.jhep.2012.11.039
34 https://doi.org/10.1016/j.jhep.2014.08.021
35 https://doi.org/10.1016/j.jhep.2014.08.031
36 https://doi.org/10.1016/s0140-6736(06)69347-1
37 https://doi.org/10.1053/j.gastro.2007.08.025
38 https://doi.org/10.1053/j.gastro.2008.05.031
39 https://doi.org/10.1053/j.gastro.2008.07.008
40 https://doi.org/10.1053/j.gastro.2008.10.026
41 https://doi.org/10.1053/j.gastro.2010.10.011
42 https://doi.org/10.1053/j.gastro.2015.09.043
43 https://doi.org/10.1136/gutjnl-2013-305517
44 https://doi.org/10.1136/gutjnl-2014-307237
45 https://doi.org/10.1159/000096313
46 https://doi.org/10.3346/jkms.2005.20.5.816
47 schema:datePublished 2017-12
48 schema:datePublishedReg 2017-12-01
49 schema:description BACKGROUND: Telbivudine has been suggested to induce hepatitis B surface antigen (HBsAg) decline to the similar degree as pegylated interferon. We aimed to investigate whether telbivudine could further decrease HBsAg titer in patients who maintain undetectable serum hepatitis B virus (HBV) DNA after initial entecavir treatment. METHODS: In this open-label trial, patients who had serum HBsAg and HBV DNA levels ≥1,000 IU/mL and <60 IU/mL, respectively, following entecavir (0.5 mg/day) treatment for HBeAg-positive chronic hepatitis B were randomized to either switch treatment to telbivudine (600 mg/day, n = 47) or continue entecavir (n = 50) for 48 weeks. RESULTS: The baseline characteristics were comparable between groups including HBsAg levels (median, 3.41 log10 IU/mL). All patients had undetectable HBV DNA and normal alanine aminotransferase level. At week 48, the mean change in serum HBsAg levels was not significantly different between the telbivudine and entecavir groups (-0.03 log10 IU/mL vs. -0.05 log10 IU/mL; P = 0.57). No patient experienced HBsAg seroclearance or HBsAg decline >0.5 log10 IU/mL. Eleven patients (23.4%) in the telbivudine group, but none in the entecavir group, experienced virologic breakthrough (P < 0.001). Seven patients (14.9%) exhibited genotypic resistance mutations (M204I +/- L180M) during the virologic breakthrough. CONCLUSION: Sequential therapy with entecavir followed by telbivudine resulted in a high rate of virologic breakthrough and drug-resistance without any beneficial effect on HBsAg decline. These results do not support the use of low genetic barrier drugs as a switch treatment strategy in patients who achieve virologic response with high genetic barrier drugs. TRIAL REGISTRATION: NCT01595685 (date of trial registration: May 8, 2012).
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree true
53 schema:isPartOf Nae1bdd93788a45c4925eeda256a5dd40
54 Nb1c76fa4a9294eeebadb34b0e08c8606
55 sg:journal.1024942
56 schema:name Telbivudine versus entecavir in patients with undetectable hepatitis B virus DNA: a randomized trial
57 schema:pagination 15
58 schema:productId N1c4ee63123734bf1b5fd73f6c6c11c05
59 N27b1e51c10cd4272b8ea055e52f4152c
60 N3417c4c8b5a04384a27563de320a4efe
61 N635f6e1ad8f34e77b676e29ef26b4b32
62 Nf2d7366980474613b4a3b782229e7de8
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053954450
64 https://doi.org/10.1186/s12876-017-0572-2
65 schema:sdDatePublished 2019-04-11T10:34
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N59ae84b5dc204392acccecbc8630cf7d
68 schema:url https://link.springer.com/10.1186%2Fs12876-017-0572-2
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N05f1382968a84788878129ef3e9918f1 rdf:first sg:person.0666206756.24
73 rdf:rest rdf:nil
74 N1c4ee63123734bf1b5fd73f6c6c11c05 schema:name nlm_unique_id
75 schema:value 100968547
76 rdf:type schema:PropertyValue
77 N21390deec25141969422cd7dd2b36a08 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
78 schema:familyName Jeong
79 schema:givenName Wonhee
80 rdf:type schema:Person
81 N27b1e51c10cd4272b8ea055e52f4152c schema:name dimensions_id
82 schema:value pub.1053954450
83 rdf:type schema:PropertyValue
84 N2dcb3ef569a14654b2f15a03ec819d78 rdf:first sg:person.01254665016.18
85 rdf:rest Nc5e42866e39040f38d680788b67ae3e0
86 N317a757c5d1047ef8310d56aea816e75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Male
88 rdf:type schema:DefinedTerm
89 N3417c4c8b5a04384a27563de320a4efe schema:name doi
90 schema:value 10.1186/s12876-017-0572-2
91 rdf:type schema:PropertyValue
92 N356803ae1e104b79ae04d63bd59ca0bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Viral Load
94 rdf:type schema:DefinedTerm
95 N3b31a9732f8f4f6eaf23d3362b1d4724 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Hepatitis B Surface Antigens
97 rdf:type schema:DefinedTerm
98 N52e40fa77605438ab983752aa427b8ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name DNA, Viral
100 rdf:type schema:DefinedTerm
101 N59ae84b5dc204392acccecbc8630cf7d schema:name Springer Nature - SN SciGraph project
102 rdf:type schema:Organization
103 N59c9ec5e63444b99ae0c2d0d09110ae5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Guanine
105 rdf:type schema:DefinedTerm
106 N616a25aab266478ab1041c46519af052 schema:affiliation https://www.grid.ac/institutes/grid.256155.0
107 schema:familyName Han
108 schema:givenName Seong-bong
109 rdf:type schema:Person
110 N635f6e1ad8f34e77b676e29ef26b4b32 schema:name readcube_id
111 schema:value 9ad672619666fc8879a974f02bc3b2ef2af542cd7f4f3796e49cf6a0ca1367a8
112 rdf:type schema:PropertyValue
113 N73455eb252374078831b135d85d1cf70 rdf:first sg:person.0666666240.83
114 rdf:rest N78f0bc4a0d7f4473a5d48f1143fc8b99
115 N7638860b6f6142bc825ace32f9aaef0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Hepatitis B virus
117 rdf:type schema:DefinedTerm
118 N78f0bc4a0d7f4473a5d48f1143fc8b99 rdf:first N616a25aab266478ab1041c46519af052
119 rdf:rest Na16fe175173244b6855cc30790c20d35
120 N7b8d1135bb6845a5ac9326997d08279b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Thymidine
122 rdf:type schema:DefinedTerm
123 N83b6ff0a4ad842f9954581f303079884 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Humans
125 rdf:type schema:DefinedTerm
126 N8849c0e736a84a3d975bd09a08cb95e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Middle Aged
128 rdf:type schema:DefinedTerm
129 N8ec69e966505492a851436a153727d90 rdf:first sg:person.01125744406.17
130 rdf:rest N8f4e0e73c3074f0e963bb51307394ded
131 N8f4e0e73c3074f0e963bb51307394ded rdf:first sg:person.01334266467.44
132 rdf:rest N73455eb252374078831b135d85d1cf70
133 N9804bb5b25a242b7811c44bb7e0651a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Telbivudine
135 rdf:type schema:DefinedTerm
136 Na16fe175173244b6855cc30790c20d35 rdf:first N21390deec25141969422cd7dd2b36a08
137 rdf:rest Nf27d590340ed458ba8ec9ab932b3b786
138 Nae1bdd93788a45c4925eeda256a5dd40 schema:volumeNumber 17
139 rdf:type schema:PublicationVolume
140 Nb1c76fa4a9294eeebadb34b0e08c8606 schema:issueNumber 1
141 rdf:type schema:PublicationIssue
142 Nc5e42866e39040f38d680788b67ae3e0 rdf:first sg:person.01025651424.41
143 rdf:rest N05f1382968a84788878129ef3e9918f1
144 Nea8610c13c0b42229b0c81031806f2fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Antiviral Agents
146 rdf:type schema:DefinedTerm
147 Nf14e898671d741d3aac0e54723f0d2cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Female
149 rdf:type schema:DefinedTerm
150 Nf27d590340ed458ba8ec9ab932b3b786 rdf:first sg:person.015374452220.41
151 rdf:rest N2dcb3ef569a14654b2f15a03ec819d78
152 Nf2d7366980474613b4a3b782229e7de8 schema:name pubmed_id
153 schema:value 28103819
154 rdf:type schema:PropertyValue
155 Nf7fa64f0c97349089024d0b332484936 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Hepatitis B
157 rdf:type schema:DefinedTerm
158 Nfa34a702314b4ccca27ba17a13de3617 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Drug Resistance, Viral
160 rdf:type schema:DefinedTerm
161 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
162 schema:name Medical and Health Sciences
163 rdf:type schema:DefinedTerm
164 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
165 schema:name Clinical Sciences
166 rdf:type schema:DefinedTerm
167 sg:journal.1024942 schema:issn 1471-230X
168 schema:name BMC Gastroenterology
169 rdf:type schema:Periodical
170 sg:person.01025651424.41 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
171 schema:familyName Lee
172 schema:givenName Han Chu
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025651424.41
174 rdf:type schema:Person
175 sg:person.01125744406.17 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
176 schema:familyName An
177 schema:givenName Jihyun
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125744406.17
179 rdf:type schema:Person
180 sg:person.01254665016.18 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
181 schema:familyName Shim
182 schema:givenName Ju Hyun
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254665016.18
184 rdf:type schema:Person
185 sg:person.01334266467.44 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
186 schema:familyName Lim
187 schema:givenName Young-Suk
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334266467.44
189 rdf:type schema:Person
190 sg:person.015374452220.41 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
191 schema:familyName Lee
192 schema:givenName Danbi
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015374452220.41
194 rdf:type schema:Person
195 sg:person.0666206756.24 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
196 schema:familyName Lee
197 schema:givenName Yung Sang
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666206756.24
199 rdf:type schema:Person
200 sg:person.0666666240.83 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
201 schema:familyName Kim
202 schema:givenName Gi-Ae
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666666240.83
204 rdf:type schema:Person
205 https://doi.org/10.1002/hep.21612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026290747
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1002/hep.23190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018751116
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1002/hep.23327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000029068
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1002/hep.23905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042371922
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1002/hep.24192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036488271
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1002/hep.24364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045965058
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1002/hep.26686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048440183
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.antiviral.2011.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015199029
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.cgh.2013.01.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005646619
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.jhep.2006.05.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037562150
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.jhep.2008.12.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023524079
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/j.jhep.2009.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052355415
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/j.jhep.2010.07.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034237807
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/j.jhep.2011.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038162613
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.jhep.2012.02.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020630462
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/j.jhep.2012.11.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023356491
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/j.jhep.2014.08.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036017867
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/j.jhep.2014.08.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045672586
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/s0140-6736(06)69347-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044838790
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1053/j.gastro.2007.08.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052216645
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1053/j.gastro.2008.05.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031803613
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1053/j.gastro.2008.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031304194
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1053/j.gastro.2008.10.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018138810
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1053/j.gastro.2010.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022883056
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1053/j.gastro.2015.09.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033473489
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1136/gutjnl-2013-305517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028286833
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1136/gutjnl-2014-307237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029483454
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1159/000096313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013951874
260 rdf:type schema:CreativeWork
261 https://doi.org/10.3346/jkms.2005.20.5.816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021646851
262 rdf:type schema:CreativeWork
263 https://www.grid.ac/institutes/grid.256155.0 schema:alternateName Gachon University
264 schema:name Department of Applied Statistics, Gachon University, Seongnam-si, Gyeonggi-do, Republic of Korea
265 rdf:type schema:Organization
266 https://www.grid.ac/institutes/grid.413967.e schema:alternateName Asan Medical Center
267 schema:name Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, 05505, Seoul, Korea
268 Health Screening and Promotion Center, Asan Medical Center, Seoul, Republic of Korea
269 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...