Cardiotoxicity evaluation using magnetic resonance imaging in breast Cancer patients (CareBest): study protocol for a prospective trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-06-03

AUTHORS

Yoo Jin Hong, Gun Min Kim, Kyunghwa Han, Pan Ki Kim, Su An Lee, Eunkyung An, Ji Yeon Lee, Hye-Jeong Lee, Jin Hur, Young Jin Kim, Min Jung Kim, Byoung Wook Choi

ABSTRACT

BackgroundCardiovascular disease is second only to cancer recurrence as a determinant of lifespan in cancer survivors, and cancer therapy-related cardiac dysfunction is a clinically important risk factor. We aim to investigate the use of cardiac magnetic resonance imaging (MRI) to evaluate early tissue changes and perform functional assessment of chemo- and radiation-induced cardiotoxicity and to identify MRI prognostic indicators of cardiotoxicity in breast cancer patients.MethodsA 3-min cardiac imaging protocol will be added to the breast MRI examination to diagnose cardiotoxicity in breast cancer patients. Standardized MRI-based evaluation of breast cancer and the left ventricular myocardium will be performed at baseline and at 3, 6, and 12 months and 2 years or more after cancer treatment. We will analyze both ventricular volume and ejection fraction (EF), strain of left ventricle (LV), native T1, extracellular volume fraction (ECV), and T2 values acquired in the mid LV.DiscussionThe primary result of this study will be the comparison of the prognostic value of MRI parameters (native T1, ECV, both ventricular systolic function and LV strain) for cardiotoxicity. The endpoint is defined as the occurrence of a major adverse cardiac event (MACE). The secondary outcome will be an assessment of the temporal relationships between contractile dysfunction and microstructural injury over 4 years using MRI. This study will assess the usefulness of quantitative MRI to diagnose cardiotoxicity and will clarify the temporal relationships between contractile dysfunction and microstructural injury of the LV myocardium using MRI during breast cancer treatment.Trial registrationThe protocol was registered at clinicaltrials.gov (Clinical trial no. NCT03301389) on October 4, 2017. More... »

PAGES

264

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12872-020-01497-y

DOI

http://dx.doi.org/10.1186/s12872-020-01497-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1128196299

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32493217


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29 schema:description BackgroundCardiovascular disease is second only to cancer recurrence as a determinant of lifespan in cancer survivors, and cancer therapy-related cardiac dysfunction is a clinically important risk factor. We aim to investigate the use of cardiac magnetic resonance imaging (MRI) to evaluate early tissue changes and perform functional assessment of chemo- and radiation-induced cardiotoxicity and to identify MRI prognostic indicators of cardiotoxicity in breast cancer patients.MethodsA 3-min cardiac imaging protocol will be added to the breast MRI examination to diagnose cardiotoxicity in breast cancer patients. Standardized MRI-based evaluation of breast cancer and the left ventricular myocardium will be performed at baseline and at 3, 6, and 12 months and 2 years or more after cancer treatment. We will analyze both ventricular volume and ejection fraction (EF), strain of left ventricle (LV), native T1, extracellular volume fraction (ECV), and T2 values acquired in the mid LV.DiscussionThe primary result of this study will be the comparison of the prognostic value of MRI parameters (native T1, ECV, both ventricular systolic function and LV strain) for cardiotoxicity. The endpoint is defined as the occurrence of a major adverse cardiac event (MACE). The secondary outcome will be an assessment of the temporal relationships between contractile dysfunction and microstructural injury over 4 years using MRI. This study will assess the usefulness of quantitative MRI to diagnose cardiotoxicity and will clarify the temporal relationships between contractile dysfunction and microstructural injury of the LV myocardium using MRI during breast cancer treatment.Trial registrationThe protocol was registered at clinicaltrials.gov (Clinical trial no. NCT03301389) on October 4, 2017.
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35 schema:keywords BackgroundCardiovascular disease
36 LV myocardium
37 MRI examinations
38 MRI parameters
39 MethodsA
40 Secondary outcomes
41 T1
42 T2 values
43 adverse cardiac events
44 assessment
45 baseline
46 breast MRI examinations
47 breast cancer
48 breast cancer patients
49 breast cancer treatment
50 cancer
51 cancer patients
52 cancer recurrence
53 cancer survivors
54 cancer therapy-related cardiac dysfunction
55 cancer treatment
56 cardiac dysfunction
57 cardiac events
58 cardiac magnetic resonance imaging
59 cardiotoxicity
60 cardiotoxicity evaluation
61 changes
62 chemo
63 comparison
64 contractile dysfunction
65 determinants
66 determinants of lifespan
67 disease
68 dysfunction
69 early tissue changes
70 ejection fraction
71 endpoint
72 evaluation
73 events
74 examination
75 extracellular volume fraction
76 factors
77 fraction
78 functional assessment
79 imaging
80 imaging protocol
81 important risk factor
82 indicators
83 injury
84 left ventricle
85 left ventricular myocardium
86 lifespan
87 magnetic resonance
88 magnetic resonance imaging
89 major adverse cardiac events
90 microstructural injury
91 mid-left ventricle
92 months
93 myocardium
94 native T1
95 occurrence
96 outcomes
97 parameters
98 patients
99 primary results
100 prognostic indicator
101 prognostic value
102 prospective trial
103 protocol
104 quantitative magnetic resonance imaging
105 radiation-induced cardiotoxicity
106 recurrence
107 relationship
108 resonance
109 resonance imaging
110 results
111 risk factors
112 standardized magnetic resonance imaging
113 strains
114 study
115 survivors
116 temporal relationship
117 tissue changes
118 treatment
119 trials
120 use
121 usefulness
122 values
123 ventricle
124 ventricular myocardium
125 ventricular volume
126 volume
127 volume fraction
128 years
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