Part 1 – Coronary angiography with gadofosveset trisodium: a prospective feasibility study evaluating injection techniques for steady-state imaging View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12-22

AUTHORS

Mark A. Ahlman, Fabio S. Raman, Scott R. Penzak, Jianing Pang, Zhaoyang Fan, Songtao Liu, Neville Gai, Debiao Li, David A. Bluemke

ABSTRACT

BackgroundThe purpose of this study was to define an optimal injection protocol for 5–10 min duration navigator-based coronary MR angiography using an intravascular gadolinium-based contrast agent (GBCA), which is better suited for steady-state coronary MR angiography than conventional GBCAs.MethodsUsing projections from pharmacokinetic models of the intravascular concentration of gadofosveset, a dual-injection protocol was formulated and tested on 14 healthy human subjects. Modified Look-Locker inversion recovery (MOLLI) sequences were used for T1 mapping at 3 Tesla to evaluate the concentration of tracer in the aorta over the scanning interval.ResultsPharmacokinetic models for a bolus plus slow infusion technique at a 5, 10, and 15 min steady state intravascular concentration was compared to single bolus curves. The 70 %/30 % bolus/slow infusion technique resulted in the highest intravascular concentration over a 5 min scan duration. Similarly, the 60 %/40 % bolus/slow infusion technique was projected to be ideal for image acquisition duration of 5–10 min. These models were confirmed with T1 maps on normal volunteers. Arterial-venous mixing of contrast was achieved within 90 s of the beginning of the bolus.ConclusionsGadofosveset injection is optimized for the lowest intravascular T1 time for 5–10 min duration MR angiography by bolus injection of 60–70 % of the total dose followed by slow infusion of the remainder of the total dose. This protocol achieves rapid and prolonged steady state intravascular concentrations of the GBCA that may be useful for prolonged image acquisition, such as required for navigator-based coronary MR angiography at 3 Tesla.Trial registrationClinicalTrials.gov identifier: NCT01130545NCT01130545, registered as of May 25, 2010. More... »

PAGES

177

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12872-015-0176-0

DOI

http://dx.doi.org/10.1186/s12872-015-0176-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038342339

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26695065


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