TNFAIP1 contributes to the neurotoxicity induced by Aβ25–35 in Neuro2a cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Ning Liu, Zhanyang Yu, Yu Xun, Miaomiao Li, Xiaoning Peng, Ye Xiao, Xiang Hu, Yi Sun, Manjun Yang, Shiquan Gan, Shishan Yuan, Xiaoying Wang, Shuanglin Xiang, Jian Zhang

ABSTRACT

BACKGROUND: Amyloid-beta (Aβ) accumulation is a hallmark of Alzheimer's disease (AD) that can lead to neuronal dysfunction and apoptosis. Tumor necrosis factor, alpha-induced protein 1 (TNFAIP1) is an apoptotic protein that was robustly induced in the transgenic C. elegans AD brains. However, the roles of TNFAIP1 in AD have not been investigated. RESULTS: We found TNFAIP1 protein and mRNA levels were dramatically elevated in primary mouse cortical neurons and Neuro2a (N2a) cells exposed to Aβ25-35. Knockdown and overexpression of TNFAIP1 significantly attenuated and exacerbated Aβ25-35-induced neurotoxicity in N2a cells, respectively. Further studies showed that TNFAIP1 knockdown significantly blocked Aβ25-35-induced cleaved caspase 3, whereas TNFAIP1 overexpression enhanced Aβ25-35-induced cleaved caspase 3, suggesting that TNFAIP1 plays an important role in Aβ25-35-induced neuronal apoptosis. Moreover, we observed that TNFAIP1 was capable of inhibiting the levels of phosphorylated Akt and CREB, and also anti-apoptotic protein Bcl-2. TNFAIP1 overexpression enhanced the inhibitory effect of Aβ25-35 on the levels of p-CREB and Bcl-2, while TNFAIP1 knockdown reversed Aβ25-35-induced attenuation in the levels of p-CREB and Bcl-2. CONCLUSION: These results suggested that TNFAIP1 contributes to Aβ25-35-induced neurotoxicity by attenuating Akt/CREB signaling pathway, and Bcl-2 expression. More... »

PAGES

51

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12868-016-0286-3

DOI

http://dx.doi.org/10.1186/s12868-016-0286-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038515496

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27430312


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amyloid beta-Peptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspase 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebral Cortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic AMP Response Element-Binding Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Knockdown Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Fragments", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-akt", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-bcl-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Real-Time Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hunan Normal University", 
          "id": "https://www.grid.ac/institutes/grid.411427.5", 
          "name": [
            "College of Medicine, Hunan Normal University, Changsha, China", 
            "Key Laboratory of Protein Chemistry and Development Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University, 410081, Changsha, China", 
            "Neuroprotection Research Laboratory, Department of Neurology and Radiology, Massachusetts General Hospital, Neuroscience Program, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Ning", 
        "id": "sg:person.01074213273.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074213273.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Neuroprotection Research Laboratory, Department of Neurology and Radiology, Massachusetts General Hospital, Neuroscience Program, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Zhanyang", 
        "id": "sg:person.01254045647.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254045647.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hunan Normal University", 
          "id": "https://www.grid.ac/institutes/grid.411427.5", 
          "name": [
            "Key Laboratory of Protein Chemistry and Development Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University, 410081, Changsha, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xun", 
        "givenName": "Yu", 
        "id": "sg:person.01065667214.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065667214.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hunan Normal University", 
          "id": "https://www.grid.ac/institutes/grid.411427.5", 
          "name": [
            "Key Laboratory of Protein Chemistry and Development Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University, 410081, Changsha, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Miaomiao", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hunan Normal University", 
          "id": "https://www.grid.ac/institutes/grid.411427.5", 
          "name": [
            "College of Medicine, Hunan Normal University, Changsha, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peng", 
        "givenName": "Xiaoning", 
        "id": "sg:person.0711153672.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711153672.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hunan Normal University", 
          "id": "https://www.grid.ac/institutes/grid.411427.5", 
          "name": [
            "Key Laboratory of Protein Chemistry and Development Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University, 410081, Changsha, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xiao", 
        "givenName": "Ye", 
        "id": "sg:person.0751440614.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751440614.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hunan Normal University", 
          "id": "https://www.grid.ac/institutes/grid.411427.5", 
          "name": [
            "Key Laboratory of Protein Chemistry and Development Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University, 410081, Changsha, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hu", 
        "givenName": "Xiang", 
        "id": "sg:person.01011501230.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011501230.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Xiangya Hospital of Central South University", 
          "id": "https://www.grid.ac/institutes/grid.452708.c", 
          "name": [
            "Department of Pathology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Yi", 
        "id": "sg:person.011656725777.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011656725777.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hunan Normal University", 
          "id": "https://www.grid.ac/institutes/grid.411427.5", 
          "name": [
            "Key Laboratory of Protein Chemistry and Development Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University, 410081, Changsha, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Manjun", 
        "id": "sg:person.0606475162.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606475162.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hunan Normal University", 
          "id": "https://www.grid.ac/institutes/grid.411427.5", 
          "name": [
            "Key Laboratory of Protein Chemistry and Development Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University, 410081, Changsha, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gan", 
        "givenName": "Shiquan", 
        "id": "sg:person.0720173071.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720173071.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hunan Normal University", 
          "id": "https://www.grid.ac/institutes/grid.411427.5", 
          "name": [
            "College of Medicine, Hunan Normal University, Changsha, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yuan", 
        "givenName": "Shishan", 
        "id": "sg:person.01240321647.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240321647.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Neuroprotection Research Laboratory, Department of Neurology and Radiology, Massachusetts General Hospital, Neuroscience Program, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Xiaoying", 
        "id": "sg:person.01047640437.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047640437.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hunan Normal University", 
          "id": "https://www.grid.ac/institutes/grid.411427.5", 
          "name": [
            "Key Laboratory of Protein Chemistry and Development Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University, 410081, Changsha, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xiang", 
        "givenName": "Shuanglin", 
        "id": "sg:person.01300366141.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300366141.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hunan Normal University", 
          "id": "https://www.grid.ac/institutes/grid.411427.5", 
          "name": [
            "Key Laboratory of Protein Chemistry and Development Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University, 410081, Changsha, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Jian", 
        "id": "sg:person.01252137055.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252137055.03"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.90.17.7951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000921868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11033-009-9588-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002776000", 
          "https://doi.org/10.1007/s11033-009-9588-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11033-009-9588-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002776000", 
          "https://doi.org/10.1007/s11033-009-9588-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(91)90052-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003143181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0047-6374(00)00172-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004166252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0953-816x.2004.03365.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006315968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a006270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008498688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.24617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010338485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.24617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010338485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-006-5540-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011401337", 
          "https://doi.org/10.1007/s10495-006-5540-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-006-5540-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011401337", 
          "https://doi.org/10.1007/s10495-006-5540-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(99)01808-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011552303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2006.08.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015633488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.37.22687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015949245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4989-14.2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017186316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m010450200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017574597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awn125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019953574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2013.04.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023038223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11033-009-9863-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025387269", 
          "https://doi.org/10.1007/s11033-009-9863-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11033-009-9863-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025387269", 
          "https://doi.org/10.1007/s11033-009-9863-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.expneurol.2009.09.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030246116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra022366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031327510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35040009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031504511", 
          "https://doi.org/10.1038/35040009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35040009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031504511", 
          "https://doi.org/10.1038/35040009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35040009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031504511", 
          "https://doi.org/10.1038/35040009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1074069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036442968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.1723-05.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037780969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jez.a.150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042735591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(99)00212-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046855600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.49.32377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047393667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0197-4580(02)00224-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053045841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0197-4580(02)00224-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053045841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1566067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062491586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1567205052772768", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069188575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijmm.2014.1742", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071507899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijmm.2014.1742", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071507899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/auto.6.3.11261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072290667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.21-12-04125.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074834211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075948846", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-2012-120865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078634117"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "BACKGROUND: Amyloid-beta (A\u03b2) accumulation is a hallmark of Alzheimer's disease (AD) that can lead to neuronal dysfunction and apoptosis. Tumor necrosis factor, alpha-induced protein 1 (TNFAIP1) is an apoptotic protein that was robustly induced in the transgenic C. elegans AD brains. However, the roles of TNFAIP1 in AD have not been investigated.\nRESULTS: We found TNFAIP1 protein and mRNA levels were dramatically elevated in primary mouse cortical neurons and Neuro2a (N2a) cells exposed to A\u03b225-35. Knockdown and overexpression of TNFAIP1 significantly attenuated and exacerbated A\u03b225-35-induced neurotoxicity in N2a cells, respectively. Further studies showed that TNFAIP1 knockdown significantly blocked A\u03b225-35-induced cleaved caspase 3, whereas TNFAIP1 overexpression enhanced A\u03b225-35-induced cleaved caspase 3, suggesting that TNFAIP1 plays an important role in A\u03b225-35-induced neuronal apoptosis. Moreover, we observed that TNFAIP1 was capable of inhibiting the levels of phosphorylated Akt and CREB, and also anti-apoptotic protein Bcl-2. TNFAIP1 overexpression enhanced the inhibitory effect of A\u03b225-35 on the levels of p-CREB and Bcl-2, while TNFAIP1 knockdown reversed A\u03b225-35-induced attenuation in the levels of p-CREB and Bcl-2.\nCONCLUSION: These results suggested that TNFAIP1 contributes to A\u03b225-35-induced neurotoxicity by attenuating Akt/CREB signaling pathway, and Bcl-2 expression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12868-016-0286-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024257", 
        "issn": [
          "1471-2202"
        ], 
        "name": "BMC Neuroscience", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "TNFAIP1 contributes to the neurotoxicity induced by A\u03b225\u201335 in Neuro2a cells", 
    "pagination": "51", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b778aac0b4990c0b6c915718139a2e33533e9606688dc47bc7c2f748b394e997"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27430312"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100966986"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12868-016-0286-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038515496"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12868-016-0286-3", 
      "https://app.dimensions.ai/details/publication/pub.1038515496"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70043_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12868-016-0286-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12868-016-0286-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12868-016-0286-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12868-016-0286-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12868-016-0286-3'


 

This table displays all metadata directly associated to this object as RDF triples.

350 TRIPLES      21 PREDICATES      82 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12868-016-0286-3 schema:about N01588a6fb6234a1e8c942dc22b84a7a9
2 N192abfe7fe864b71972c4006cf48112c
3 N1b2115ef25264b83849604acf079c9bf
4 N322106551d1c41c5aecba52bf5dca1b5
5 N39bdc7754c7740e7ab2a3c4a11ac77bb
6 N54c54034b3af44b2ba70756458f07155
7 N8581d9c70873447192c28fb061dc255e
8 N8bb24a729b46450b808a7eba83a65301
9 N8bb4ab941f744d2385cdb2171a0051bd
10 N8d12f3cc66394808973902ea6fdb8f7b
11 N9a0f6d858b0c4c0591452d3151b12869
12 N9d1c76f24e52493a8837c44e773b4986
13 Nace297deb0984f1eb1a28b2c41ea8a2d
14 Nb5dd58a7a15b46cb9e756c97d45bc0e5
15 Nbe790081a51745dfa1ae527341c05562
16 Nc0703ee37b5543e08e98a1965818533d
17 Ndb6efebbcbb245c5872dc7aea44d02bc
18 Ndbd82ba694074c0baee08e482c353f05
19 Ne0fca77dc04e4c4f98203aa909242266
20 Nfae531c2809e46489ffcf3f5ec250874
21 Nfef1d66a4cd84d5f84facfe3710fbe51
22 anzsrc-for:06
23 anzsrc-for:0601
24 schema:author N36f0615a841f45c3b4cc955a33633fe6
25 schema:citation sg:pub.10.1007/s10495-006-5540-1
26 sg:pub.10.1007/s11033-009-9588-1
27 sg:pub.10.1007/s11033-009-9863-1
28 sg:pub.10.1038/35040009
29 https://app.dimensions.ai/details/publication/pub.1075948846
30 https://doi.org/10.1002/ijc.24617
31 https://doi.org/10.1002/jez.a.150
32 https://doi.org/10.1016/0896-6273(91)90052-2
33 https://doi.org/10.1016/j.expneurol.2009.09.005
34 https://doi.org/10.1016/j.freeradbiomed.2006.08.015
35 https://doi.org/10.1016/j.nbd.2013.04.015
36 https://doi.org/10.1016/s0006-8993(99)01808-9
37 https://doi.org/10.1016/s0047-6374(00)00172-x
38 https://doi.org/10.1016/s0197-4580(02)00224-5
39 https://doi.org/10.1016/s0306-4522(99)00212-2
40 https://doi.org/10.1056/nejmra022366
41 https://doi.org/10.1073/pnas.90.17.7951
42 https://doi.org/10.1074/jbc.271.37.22687
43 https://doi.org/10.1074/jbc.273.49.32377
44 https://doi.org/10.1074/jbc.m010450200
45 https://doi.org/10.1093/brain/awn125
46 https://doi.org/10.1101/cshperspect.a006270
47 https://doi.org/10.1111/j.0953-816x.2004.03365.x
48 https://doi.org/10.1126/science.1074069
49 https://doi.org/10.1126/science.1566067
50 https://doi.org/10.1523/jneurosci.1723-05.2005
51 https://doi.org/10.1523/jneurosci.21-12-04125.2001
52 https://doi.org/10.1523/jneurosci.4989-14.2015
53 https://doi.org/10.2174/1567205052772768
54 https://doi.org/10.3233/jad-2012-120865
55 https://doi.org/10.3892/ijmm.2014.1742
56 https://doi.org/10.4161/auto.6.3.11261
57 schema:datePublished 2016-12
58 schema:datePublishedReg 2016-12-01
59 schema:description BACKGROUND: Amyloid-beta (Aβ) accumulation is a hallmark of Alzheimer's disease (AD) that can lead to neuronal dysfunction and apoptosis. Tumor necrosis factor, alpha-induced protein 1 (TNFAIP1) is an apoptotic protein that was robustly induced in the transgenic C. elegans AD brains. However, the roles of TNFAIP1 in AD have not been investigated. RESULTS: We found TNFAIP1 protein and mRNA levels were dramatically elevated in primary mouse cortical neurons and Neuro2a (N2a) cells exposed to Aβ25-35. Knockdown and overexpression of TNFAIP1 significantly attenuated and exacerbated Aβ25-35-induced neurotoxicity in N2a cells, respectively. Further studies showed that TNFAIP1 knockdown significantly blocked Aβ25-35-induced cleaved caspase 3, whereas TNFAIP1 overexpression enhanced Aβ25-35-induced cleaved caspase 3, suggesting that TNFAIP1 plays an important role in Aβ25-35-induced neuronal apoptosis. Moreover, we observed that TNFAIP1 was capable of inhibiting the levels of phosphorylated Akt and CREB, and also anti-apoptotic protein Bcl-2. TNFAIP1 overexpression enhanced the inhibitory effect of Aβ25-35 on the levels of p-CREB and Bcl-2, while TNFAIP1 knockdown reversed Aβ25-35-induced attenuation in the levels of p-CREB and Bcl-2. CONCLUSION: These results suggested that TNFAIP1 contributes to Aβ25-35-induced neurotoxicity by attenuating Akt/CREB signaling pathway, and Bcl-2 expression.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree true
63 schema:isPartOf N264c7a54245a43ea93e350897cdbad40
64 N4f8135afe23c441ab2520a495cef597e
65 sg:journal.1024257
66 schema:name TNFAIP1 contributes to the neurotoxicity induced by Aβ25–35 in Neuro2a cells
67 schema:pagination 51
68 schema:productId N2bc6a7d601814d738621623f9b818f65
69 N3c1f0603050743b98280eeb06dba89a1
70 N66905609798248a8992077b4aabb6cfb
71 N7ae0631f4e74443c81109556abe56d2f
72 Nae205745f304419cad1a663543817332
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038515496
74 https://doi.org/10.1186/s12868-016-0286-3
75 schema:sdDatePublished 2019-04-11T12:39
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N269664583ecb4b9284b373eb3574b9af
78 schema:url https://link.springer.com/10.1186%2Fs12868-016-0286-3
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N01588a6fb6234a1e8c942dc22b84a7a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Cyclic AMP Response Element-Binding Protein
84 rdf:type schema:DefinedTerm
85 N192abfe7fe864b71972c4006cf48112c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Animals
87 rdf:type schema:DefinedTerm
88 N1b2115ef25264b83849604acf079c9bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Peptide Fragments
90 rdf:type schema:DefinedTerm
91 N1ca843bfbd7142e9acdbca1ebae65831 rdf:first sg:person.01252137055.03
92 rdf:rest rdf:nil
93 N21c4e4865f194713b0c3022ede4bbd6b rdf:first sg:person.0606475162.50
94 rdf:rest Nc5ac6b6aa23341ba919f54c4578fc384
95 N264c7a54245a43ea93e350897cdbad40 schema:issueNumber 1
96 rdf:type schema:PublicationIssue
97 N269664583ecb4b9284b373eb3574b9af schema:name Springer Nature - SN SciGraph project
98 rdf:type schema:Organization
99 N2bc6a7d601814d738621623f9b818f65 schema:name readcube_id
100 schema:value b778aac0b4990c0b6c915718139a2e33533e9606688dc47bc7c2f748b394e997
101 rdf:type schema:PropertyValue
102 N322106551d1c41c5aecba52bf5dca1b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Cell Line, Tumor
104 rdf:type schema:DefinedTerm
105 N340463c68d8f4adf9b2ef5d14970bdb7 rdf:first sg:person.0711153672.64
106 rdf:rest Ncde646473de54ad6b1870f21505af3f9
107 N36f0615a841f45c3b4cc955a33633fe6 rdf:first sg:person.01074213273.58
108 rdf:rest N3e91f74a4b8c443ebfd05b5e1d3eb1b5
109 N39bdc7754c7740e7ab2a3c4a11ac77bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Amyloid beta-Peptides
111 rdf:type schema:DefinedTerm
112 N3c1f0603050743b98280eeb06dba89a1 schema:name nlm_unique_id
113 schema:value 100966986
114 rdf:type schema:PropertyValue
115 N3d9736cca06946ba9bebed3eb5f8fd56 rdf:first sg:person.01011501230.20
116 rdf:rest N757092275282468c87942fa43ee6f991
117 N3e91f74a4b8c443ebfd05b5e1d3eb1b5 rdf:first sg:person.01254045647.18
118 rdf:rest Nf7667440e8d44aecbaa81f2a269db135
119 N42c14533faa04150b6cf3cb07a3bc4e9 rdf:first sg:person.01047640437.43
120 rdf:rest N586edbe836a14b3da7aa8e7afe77034f
121 N4f8135afe23c441ab2520a495cef597e schema:volumeNumber 17
122 rdf:type schema:PublicationVolume
123 N54c54034b3af44b2ba70756458f07155 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Female
125 rdf:type schema:DefinedTerm
126 N569936e03eec48a59149cc45c3dc4d29 schema:affiliation https://www.grid.ac/institutes/grid.411427.5
127 schema:familyName Li
128 schema:givenName Miaomiao
129 rdf:type schema:Person
130 N586edbe836a14b3da7aa8e7afe77034f rdf:first sg:person.01300366141.62
131 rdf:rest N1ca843bfbd7142e9acdbca1ebae65831
132 N66905609798248a8992077b4aabb6cfb schema:name dimensions_id
133 schema:value pub.1038515496
134 rdf:type schema:PropertyValue
135 N727bd1c0b9b64e229fd18630ac830340 rdf:first N569936e03eec48a59149cc45c3dc4d29
136 rdf:rest N340463c68d8f4adf9b2ef5d14970bdb7
137 N757092275282468c87942fa43ee6f991 rdf:first sg:person.011656725777.97
138 rdf:rest N21c4e4865f194713b0c3022ede4bbd6b
139 N77cebe8d68924b0b84fce2b02bebcfb8 schema:name Neuroprotection Research Laboratory, Department of Neurology and Radiology, Massachusetts General Hospital, Neuroscience Program, Harvard Medical School, Boston, MA, USA
140 rdf:type schema:Organization
141 N7ae0631f4e74443c81109556abe56d2f schema:name doi
142 schema:value 10.1186/s12868-016-0286-3
143 rdf:type schema:PropertyValue
144 N8581d9c70873447192c28fb061dc255e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Proto-Oncogene Proteins c-bcl-2
146 rdf:type schema:DefinedTerm
147 N8bb24a729b46450b808a7eba83a65301 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Caspase 3
149 rdf:type schema:DefinedTerm
150 N8bb4ab941f744d2385cdb2171a0051bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name RNA, Messenger
152 rdf:type schema:DefinedTerm
153 N8d12f3cc66394808973902ea6fdb8f7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Mice, Inbred C57BL
155 rdf:type schema:DefinedTerm
156 N9679d2f9fdb34ed1a7c7a7603fd10360 schema:name Neuroprotection Research Laboratory, Department of Neurology and Radiology, Massachusetts General Hospital, Neuroscience Program, Harvard Medical School, Boston, MA, USA
157 rdf:type schema:Organization
158 N9a0f6d858b0c4c0591452d3151b12869 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Blotting, Western
160 rdf:type schema:DefinedTerm
161 N9c6c7e69ef1240d6bc50eb59f5ba17a8 rdf:first sg:person.01240321647.60
162 rdf:rest N42c14533faa04150b6cf3cb07a3bc4e9
163 N9d1c76f24e52493a8837c44e773b4986 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Neurons
165 rdf:type schema:DefinedTerm
166 Nace297deb0984f1eb1a28b2c41ea8a2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Apoptosis
168 rdf:type schema:DefinedTerm
169 Nae205745f304419cad1a663543817332 schema:name pubmed_id
170 schema:value 27430312
171 rdf:type schema:PropertyValue
172 Nb5dd58a7a15b46cb9e756c97d45bc0e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Proto-Oncogene Proteins c-akt
174 rdf:type schema:DefinedTerm
175 Nbe790081a51745dfa1ae527341c05562 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Phosphorylation
177 rdf:type schema:DefinedTerm
178 Nc0703ee37b5543e08e98a1965818533d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Cerebral Cortex
180 rdf:type schema:DefinedTerm
181 Nc5ac6b6aa23341ba919f54c4578fc384 rdf:first sg:person.0720173071.67
182 rdf:rest N9c6c7e69ef1240d6bc50eb59f5ba17a8
183 Ncde646473de54ad6b1870f21505af3f9 rdf:first sg:person.0751440614.52
184 rdf:rest N3d9736cca06946ba9bebed3eb5f8fd56
185 Ndb6efebbcbb245c5872dc7aea44d02bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Gene Knockdown Techniques
187 rdf:type schema:DefinedTerm
188 Ndbd82ba694074c0baee08e482c353f05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Proteins
190 rdf:type schema:DefinedTerm
191 Ne0fca77dc04e4c4f98203aa909242266 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Signal Transduction
193 rdf:type schema:DefinedTerm
194 Nf7667440e8d44aecbaa81f2a269db135 rdf:first sg:person.01065667214.00
195 rdf:rest N727bd1c0b9b64e229fd18630ac830340
196 Nfae531c2809e46489ffcf3f5ec250874 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Real-Time Polymerase Chain Reaction
198 rdf:type schema:DefinedTerm
199 Nfef1d66a4cd84d5f84facfe3710fbe51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Cell Survival
201 rdf:type schema:DefinedTerm
202 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
203 schema:name Biological Sciences
204 rdf:type schema:DefinedTerm
205 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
206 schema:name Biochemistry and Cell Biology
207 rdf:type schema:DefinedTerm
208 sg:journal.1024257 schema:issn 1471-2202
209 schema:name BMC Neuroscience
210 rdf:type schema:Periodical
211 sg:person.01011501230.20 schema:affiliation https://www.grid.ac/institutes/grid.411427.5
212 schema:familyName Hu
213 schema:givenName Xiang
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011501230.20
215 rdf:type schema:Person
216 sg:person.01047640437.43 schema:affiliation N9679d2f9fdb34ed1a7c7a7603fd10360
217 schema:familyName Wang
218 schema:givenName Xiaoying
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047640437.43
220 rdf:type schema:Person
221 sg:person.01065667214.00 schema:affiliation https://www.grid.ac/institutes/grid.411427.5
222 schema:familyName Xun
223 schema:givenName Yu
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065667214.00
225 rdf:type schema:Person
226 sg:person.01074213273.58 schema:affiliation https://www.grid.ac/institutes/grid.411427.5
227 schema:familyName Liu
228 schema:givenName Ning
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074213273.58
230 rdf:type schema:Person
231 sg:person.011656725777.97 schema:affiliation https://www.grid.ac/institutes/grid.452708.c
232 schema:familyName Sun
233 schema:givenName Yi
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011656725777.97
235 rdf:type schema:Person
236 sg:person.01240321647.60 schema:affiliation https://www.grid.ac/institutes/grid.411427.5
237 schema:familyName Yuan
238 schema:givenName Shishan
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240321647.60
240 rdf:type schema:Person
241 sg:person.01252137055.03 schema:affiliation https://www.grid.ac/institutes/grid.411427.5
242 schema:familyName Zhang
243 schema:givenName Jian
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252137055.03
245 rdf:type schema:Person
246 sg:person.01254045647.18 schema:affiliation N77cebe8d68924b0b84fce2b02bebcfb8
247 schema:familyName Yu
248 schema:givenName Zhanyang
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254045647.18
250 rdf:type schema:Person
251 sg:person.01300366141.62 schema:affiliation https://www.grid.ac/institutes/grid.411427.5
252 schema:familyName Xiang
253 schema:givenName Shuanglin
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300366141.62
255 rdf:type schema:Person
256 sg:person.0606475162.50 schema:affiliation https://www.grid.ac/institutes/grid.411427.5
257 schema:familyName Yang
258 schema:givenName Manjun
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606475162.50
260 rdf:type schema:Person
261 sg:person.0711153672.64 schema:affiliation https://www.grid.ac/institutes/grid.411427.5
262 schema:familyName Peng
263 schema:givenName Xiaoning
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711153672.64
265 rdf:type schema:Person
266 sg:person.0720173071.67 schema:affiliation https://www.grid.ac/institutes/grid.411427.5
267 schema:familyName Gan
268 schema:givenName Shiquan
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720173071.67
270 rdf:type schema:Person
271 sg:person.0751440614.52 schema:affiliation https://www.grid.ac/institutes/grid.411427.5
272 schema:familyName Xiao
273 schema:givenName Ye
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751440614.52
275 rdf:type schema:Person
276 sg:pub.10.1007/s10495-006-5540-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011401337
277 https://doi.org/10.1007/s10495-006-5540-1
278 rdf:type schema:CreativeWork
279 sg:pub.10.1007/s11033-009-9588-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002776000
280 https://doi.org/10.1007/s11033-009-9588-1
281 rdf:type schema:CreativeWork
282 sg:pub.10.1007/s11033-009-9863-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025387269
283 https://doi.org/10.1007/s11033-009-9863-1
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/35040009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031504511
286 https://doi.org/10.1038/35040009
287 rdf:type schema:CreativeWork
288 https://app.dimensions.ai/details/publication/pub.1075948846 schema:CreativeWork
289 https://doi.org/10.1002/ijc.24617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010338485
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1002/jez.a.150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042735591
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/0896-6273(91)90052-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003143181
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.expneurol.2009.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030246116
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.freeradbiomed.2006.08.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015633488
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.nbd.2013.04.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023038223
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/s0006-8993(99)01808-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011552303
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/s0047-6374(00)00172-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004166252
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/s0197-4580(02)00224-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053045841
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/s0306-4522(99)00212-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046855600
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1056/nejmra022366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031327510
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1073/pnas.90.17.7951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000921868
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1074/jbc.271.37.22687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015949245
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1074/jbc.273.49.32377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047393667
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1074/jbc.m010450200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017574597
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1093/brain/awn125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019953574
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1101/cshperspect.a006270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008498688
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1111/j.0953-816x.2004.03365.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006315968
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1126/science.1074069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036442968
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1126/science.1566067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062491586
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1523/jneurosci.1723-05.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037780969
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1523/jneurosci.21-12-04125.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074834211
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1523/jneurosci.4989-14.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017186316
334 rdf:type schema:CreativeWork
335 https://doi.org/10.2174/1567205052772768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069188575
336 rdf:type schema:CreativeWork
337 https://doi.org/10.3233/jad-2012-120865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078634117
338 rdf:type schema:CreativeWork
339 https://doi.org/10.3892/ijmm.2014.1742 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071507899
340 rdf:type schema:CreativeWork
341 https://doi.org/10.4161/auto.6.3.11261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072290667
342 rdf:type schema:CreativeWork
343 https://www.grid.ac/institutes/grid.411427.5 schema:alternateName Hunan Normal University
344 schema:name College of Medicine, Hunan Normal University, Changsha, China
345 Key Laboratory of Protein Chemistry and Development Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University, 410081, Changsha, China
346 Neuroprotection Research Laboratory, Department of Neurology and Radiology, Massachusetts General Hospital, Neuroscience Program, Harvard Medical School, Boston, MA, USA
347 rdf:type schema:Organization
348 https://www.grid.ac/institutes/grid.452708.c schema:alternateName Second Xiangya Hospital of Central South University
349 schema:name Department of Pathology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
350 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...