Defects in the retina of Niemann-pick type C 1 mutant mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Xin Yan, Lucy Ma, Marina Hovakimyan, Jan Lukas, Andreas Wree, Marcus Frank, Rudolf Guthoff, Arndt Rolfs, Martin Witt, Jiankai Luo

ABSTRACT

BACKGROUND: Niemann-Pick type C1 (NPC1) disease is an inherited lysosomal storage disease caused by mutation of the Npc1 gene, resulting in a progressive accumulation of unesterified cholesterol and glycolipids in lysosomes of multiple tissues and leading to neurodegeneration and other disease. In Npc1 mutant mice, retinal degeneration including impaired visual function, lipofuscin accumulation in the pigment epithelium and ganglion cells as well as photoreceptor defects has been found. However, the pathologies of other individual cell types of the retina in Npc1 mutant mice are still not fully clear. We hypothesized that horizontal cells, amacrine cells, bipolar cells and glial cells are also affected in the retina of Npc1 mutant mice. RESULTS: Immunohistochemistry and electron microscopy were used to investigate pathologies of ganglion cells, horizontal cells, amacrine cells, bipolar cells, and optic nerves as well as altered activity of glial cells in Npc1 mutant mice. Electron microscopy reveals that electron-dense inclusions are generally accumulated in ganglion cells, bipolar cells, Müller cells, and in the optic nerve. Furthermore, abnormal arborisation and ectopic processes of horizontal and amacrine cells as well as defective bipolar cells are observed by immunohistochemistry for specific cellular markers. Furthermore, hyperactivity of glial cells, including astrocytes, microglial cells, and Müller cells, is also revealed. CONCLUSIONS: Our data extend previous findings to show multiple defects in the retina of Npc1 mutant mice, suggesting an important role of Npc1 protein in the normal function of the retina. More... »

PAGES

126

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12868-014-0126-2

DOI

http://dx.doi.org/10.1186/s12868-014-0126-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029738878

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25472750


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