Defects in the retina of Niemann-pick type C 1 mutant mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Xin Yan, Lucy Ma, Marina Hovakimyan, Jan Lukas, Andreas Wree, Marcus Frank, Rudolf Guthoff, Arndt Rolfs, Martin Witt, Jiankai Luo

ABSTRACT

BACKGROUND: Niemann-Pick type C1 (NPC1) disease is an inherited lysosomal storage disease caused by mutation of the Npc1 gene, resulting in a progressive accumulation of unesterified cholesterol and glycolipids in lysosomes of multiple tissues and leading to neurodegeneration and other disease. In Npc1 mutant mice, retinal degeneration including impaired visual function, lipofuscin accumulation in the pigment epithelium and ganglion cells as well as photoreceptor defects has been found. However, the pathologies of other individual cell types of the retina in Npc1 mutant mice are still not fully clear. We hypothesized that horizontal cells, amacrine cells, bipolar cells and glial cells are also affected in the retina of Npc1 mutant mice. RESULTS: Immunohistochemistry and electron microscopy were used to investigate pathologies of ganglion cells, horizontal cells, amacrine cells, bipolar cells, and optic nerves as well as altered activity of glial cells in Npc1 mutant mice. Electron microscopy reveals that electron-dense inclusions are generally accumulated in ganglion cells, bipolar cells, Müller cells, and in the optic nerve. Furthermore, abnormal arborisation and ectopic processes of horizontal and amacrine cells as well as defective bipolar cells are observed by immunohistochemistry for specific cellular markers. Furthermore, hyperactivity of glial cells, including astrocytes, microglial cells, and Müller cells, is also revealed. CONCLUSIONS: Our data extend previous findings to show multiple defects in the retina of Npc1 mutant mice, suggesting an important role of Npc1 protein in the normal function of the retina. More... »

PAGES

126

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12868-014-0126-2

DOI

http://dx.doi.org/10.1186/s12868-014-0126-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029738878

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25472750


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Electron", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuroglia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Niemann-Pick Disease, Type C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Optic Nerve", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retina", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsmedizin Rostock", 
          "id": "https://www.grid.ac/institutes/grid.413108.f", 
          "name": [
            "Albrecht-Kossel-Institute for Neuroregeneration, Rostock University Medical Center, Gehlsheimer Strasse 20, D-18147, Rostock, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yan", 
        "givenName": "Xin", 
        "id": "sg:person.0727715437.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727715437.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsmedizin Rostock", 
          "id": "https://www.grid.ac/institutes/grid.413108.f", 
          "name": [
            "Albrecht-Kossel-Institute for Neuroregeneration, Rostock University Medical Center, Gehlsheimer Strasse 20, D-18147, Rostock, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ma", 
        "givenName": "Lucy", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsmedizin Rostock", 
          "id": "https://www.grid.ac/institutes/grid.413108.f", 
          "name": [
            "Institute for Biomedical Engineering, Rostock University Medical Center, F.-Barnewitz Strasse 4, D-18119, Rostock, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hovakimyan", 
        "givenName": "Marina", 
        "id": "sg:person.01252121125.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252121125.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsmedizin Rostock", 
          "id": "https://www.grid.ac/institutes/grid.413108.f", 
          "name": [
            "Albrecht-Kossel-Institute for Neuroregeneration, Rostock University Medical Center, Gehlsheimer Strasse 20, D-18147, Rostock, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lukas", 
        "givenName": "Jan", 
        "id": "sg:person.01076057406.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076057406.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsmedizin Rostock", 
          "id": "https://www.grid.ac/institutes/grid.413108.f", 
          "name": [
            "Department of Anatomy, Rostock University Medical Center, Gertrudenstrsse 9, D-18055, Rostock, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wree", 
        "givenName": "Andreas", 
        "id": "sg:person.0650145475.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650145475.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsmedizin Rostock", 
          "id": "https://www.grid.ac/institutes/grid.413108.f", 
          "name": [
            "Electron Microscopy Center, Rostock University Medical Center, Strempelstr. 14, D-18057, Rostock, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frank", 
        "givenName": "Marcus", 
        "id": "sg:person.0630156355.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630156355.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsmedizin Rostock", 
          "id": "https://www.grid.ac/institutes/grid.413108.f", 
          "name": [
            "Department of Ophthalmology, Rostock University Medical Center, Doberaner Strasse 140, D-18057, Rostock, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guthoff", 
        "givenName": "Rudolf", 
        "id": "sg:person.0752065426.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752065426.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsmedizin Rostock", 
          "id": "https://www.grid.ac/institutes/grid.413108.f", 
          "name": [
            "Albrecht-Kossel-Institute for Neuroregeneration, Rostock University Medical Center, Gehlsheimer Strasse 20, D-18147, Rostock, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rolfs", 
        "givenName": "Arndt", 
        "id": "sg:person.01224402677.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224402677.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsmedizin Rostock", 
          "id": "https://www.grid.ac/institutes/grid.413108.f", 
          "name": [
            "Department of Anatomy, Rostock University Medical Center, Gertrudenstrsse 9, D-18055, Rostock, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Witt", 
        "givenName": "Martin", 
        "id": "sg:person.0761631006.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761631006.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsmedizin Rostock", 
          "id": "https://www.grid.ac/institutes/grid.413108.f", 
          "name": [
            "Albrecht-Kossel-Institute for Neuroregeneration, Rostock University Medical Center, Gehlsheimer Strasse 20, D-18147, Rostock, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luo", 
        "givenName": "Jiankai", 
        "id": "sg:person.0575766712.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575766712.41"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/(sici)1096-9861(19980525)395:1<43::aid-cne4>3.0.co;2-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000169260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4165-09.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000370630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1004077215", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4419-1672-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004077215", 
          "https://doi.org/10.1007/978-1-4419-1672-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4419-1672-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004077215", 
          "https://doi.org/10.1007/978-1-4419-1672-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bjo.2006.100602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004241059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.survophthal.2005.11.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005072957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2910-12.2013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005310687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m205406200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005968263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4835(78)90022-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006225404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajo.2004.07.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010069393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbalip.2004.08.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010085308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2009.09.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010916042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archophthalmol.2011.134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012094959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012560945", 
          "https://doi.org/10.1038/nrn1497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012560945", 
          "https://doi.org/10.1038/nrn1497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.5529-07.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016334024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnen/64.4.323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017935475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnen/63.6.660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019053843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exer.2007.01.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019204742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20050460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019449709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20050460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019449709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.10522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019574906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbalip.2004.08.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022726167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09675", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023954681", 
          "https://doi.org/10.1038/nature09675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0340399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024635741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0340399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024635741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00417-008-0962-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024642707", 
          "https://doi.org/10.1007/s00417-008-0962-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00417-008-0962-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024642707", 
          "https://doi.org/10.1007/s00417-008-0962-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0161-6420(78)35592-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026665949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0372-07.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027120724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1167/iovs.06-0190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027520564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2011.12.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028077223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(04)00157-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028877449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cbf.2833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033871271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mcn.2009.10.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034350101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2010.02.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035210616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.22659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039141162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.ne.02.030179.001125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039346804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830111013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039869042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0082216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040338292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11011-011-9263-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041810022", 
          "https://doi.org/10.1007/s11011-011-9263-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.preteyeres.2006.05.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042635974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0267-12.2012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042796474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.112.6.1241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043627374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exer.2005.12.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046379771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/chem.200801160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050068116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-4886(03)00345-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053067760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-4886(03)00345-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053067760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s095252380000242x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054899850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.277.5323.228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062557331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.277.5323.232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062557332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.290.5500.2298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062572556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075078896", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "BACKGROUND: Niemann-Pick type C1 (NPC1) disease is an inherited lysosomal storage disease caused by mutation of the Npc1 gene, resulting in a progressive accumulation of unesterified cholesterol and glycolipids in lysosomes of multiple tissues and leading to neurodegeneration and other disease. In Npc1 mutant mice, retinal degeneration including impaired visual function, lipofuscin accumulation in the pigment epithelium and ganglion cells as well as photoreceptor defects has been found. However, the pathologies of other individual cell types of the retina in Npc1 mutant mice are still not fully clear. We hypothesized that horizontal cells, amacrine cells, bipolar cells and glial cells are also affected in the retina of Npc1 mutant mice.\nRESULTS: Immunohistochemistry and electron microscopy were used to investigate pathologies of ganglion cells, horizontal cells, amacrine cells, bipolar cells, and optic nerves as well as altered activity of glial cells in Npc1 mutant mice. Electron microscopy reveals that electron-dense inclusions are generally accumulated in ganglion cells, bipolar cells, M\u00fcller cells, and in the optic nerve. Furthermore, abnormal arborisation and ectopic processes of horizontal and amacrine cells as well as defective bipolar cells are observed by immunohistochemistry for specific cellular markers. Furthermore, hyperactivity of glial cells, including astrocytes, microglial cells, and M\u00fcller cells, is also revealed.\nCONCLUSIONS: Our data extend previous findings to show multiple defects in the retina of Npc1 mutant mice, suggesting an important role of Npc1 protein in the normal function of the retina.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12868-014-0126-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024257", 
        "issn": [
          "1471-2202"
        ], 
        "name": "BMC Neuroscience", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "name": "Defects in the retina of Niemann-pick type C 1 mutant mice", 
    "pagination": "126", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8dabae1575ac844295c40b7c92ec9087f3ca5bca5525f6d5b3a8d1029fc42e6d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25472750"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100966986"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12868-014-0126-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1029738878"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12868-014-0126-2", 
      "https://app.dimensions.ai/details/publication/pub.1029738878"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89789_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs12868-014-0126-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12868-014-0126-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12868-014-0126-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12868-014-0126-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12868-014-0126-2'


 

This table displays all metadata directly associated to this object as RDF triples.

329 TRIPLES      21 PREDICATES      89 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12868-014-0126-2 schema:about N3808f7ecfa8c4edd8985204ff5866831
2 N3997c50f4967476d9cd12d873c33efc0
3 N4f5ac9f8e7d54ee1b98d9464c01b75ab
4 N5d64d3fa7c734829bbcb77d313715222
5 N6416b47662cc4deb9b32393c8738f761
6 Na6b2ec2ca6164dcd80045ddb9931487e
7 Nb2f9624d2d21460aafe2e98f52ab9874
8 Nbd6c3c25f0da49f498cafe417e04a39e
9 Nbe4a74d4bd83414289bb02b51bd20ab3
10 Nd186a9a6f2064c518a4d22d4f92593ed
11 Necf6f6fa427546cd9ea257e3152ce07e
12 Nfadefb404d314956bef0f99d36097efe
13 anzsrc-for:11
14 anzsrc-for:1109
15 schema:author Naa0255e3016449d88b39a437e175f283
16 schema:citation sg:pub.10.1007/978-1-4419-1672-3
17 sg:pub.10.1007/s00417-008-0962-9
18 sg:pub.10.1007/s11011-011-9263-9
19 sg:pub.10.1038/nature09675
20 sg:pub.10.1038/nrn1497
21 https://app.dimensions.ai/details/publication/pub.1004077215
22 https://app.dimensions.ai/details/publication/pub.1075078896
23 https://doi.org/10.1001/archophthalmol.2011.134
24 https://doi.org/10.1002/(sici)1096-9861(19980525)395:1<43::aid-cne4>3.0.co;2-h
25 https://doi.org/10.1002/cbf.2833
26 https://doi.org/10.1002/chem.200801160
27 https://doi.org/10.1002/cne.10522
28 https://doi.org/10.1002/eji.1830111013
29 https://doi.org/10.1002/glia.22659
30 https://doi.org/10.1016/0014-4835(78)90022-2
31 https://doi.org/10.1016/j.ajo.2004.07.053
32 https://doi.org/10.1016/j.bbalip.2004.08.006
33 https://doi.org/10.1016/j.bbalip.2004.08.012
34 https://doi.org/10.1016/j.bbrc.2010.02.007
35 https://doi.org/10.1016/j.exer.2005.12.020
36 https://doi.org/10.1016/j.exer.2007.01.006
37 https://doi.org/10.1016/j.mcn.2009.10.007
38 https://doi.org/10.1016/j.nbd.2011.12.027
39 https://doi.org/10.1016/j.neuron.2009.09.027
40 https://doi.org/10.1016/j.preteyeres.2006.05.003
41 https://doi.org/10.1016/j.survophthal.2005.11.007
42 https://doi.org/10.1016/s0014-4886(03)00345-5
43 https://doi.org/10.1016/s0161-6420(78)35592-5
44 https://doi.org/10.1016/s0896-6273(04)00157-6
45 https://doi.org/10.1017/s095252380000242x
46 https://doi.org/10.1042/bj20050460
47 https://doi.org/10.1042/bst0340399
48 https://doi.org/10.1074/jbc.m205406200
49 https://doi.org/10.1083/jcb.112.6.1241
50 https://doi.org/10.1093/jnen/63.6.660
51 https://doi.org/10.1093/jnen/64.4.323
52 https://doi.org/10.1126/science.277.5323.228
53 https://doi.org/10.1126/science.277.5323.232
54 https://doi.org/10.1126/science.290.5500.2298
55 https://doi.org/10.1136/bjo.2006.100602
56 https://doi.org/10.1146/annurev.ne.02.030179.001125
57 https://doi.org/10.1167/iovs.06-0190
58 https://doi.org/10.1371/journal.pone.0082216
59 https://doi.org/10.1523/jneurosci.0267-12.2012
60 https://doi.org/10.1523/jneurosci.0372-07.2007
61 https://doi.org/10.1523/jneurosci.2910-12.2013
62 https://doi.org/10.1523/jneurosci.4165-09.2010
63 https://doi.org/10.1523/jneurosci.5529-07.2008
64 schema:datePublished 2014-12
65 schema:datePublishedReg 2014-12-01
66 schema:description BACKGROUND: Niemann-Pick type C1 (NPC1) disease is an inherited lysosomal storage disease caused by mutation of the Npc1 gene, resulting in a progressive accumulation of unesterified cholesterol and glycolipids in lysosomes of multiple tissues and leading to neurodegeneration and other disease. In Npc1 mutant mice, retinal degeneration including impaired visual function, lipofuscin accumulation in the pigment epithelium and ganglion cells as well as photoreceptor defects has been found. However, the pathologies of other individual cell types of the retina in Npc1 mutant mice are still not fully clear. We hypothesized that horizontal cells, amacrine cells, bipolar cells and glial cells are also affected in the retina of Npc1 mutant mice. RESULTS: Immunohistochemistry and electron microscopy were used to investigate pathologies of ganglion cells, horizontal cells, amacrine cells, bipolar cells, and optic nerves as well as altered activity of glial cells in Npc1 mutant mice. Electron microscopy reveals that electron-dense inclusions are generally accumulated in ganglion cells, bipolar cells, Müller cells, and in the optic nerve. Furthermore, abnormal arborisation and ectopic processes of horizontal and amacrine cells as well as defective bipolar cells are observed by immunohistochemistry for specific cellular markers. Furthermore, hyperactivity of glial cells, including astrocytes, microglial cells, and Müller cells, is also revealed. CONCLUSIONS: Our data extend previous findings to show multiple defects in the retina of Npc1 mutant mice, suggesting an important role of Npc1 protein in the normal function of the retina.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree true
70 schema:isPartOf N2a32e52ae7234d6da25d7dd1be010ccb
71 N914bc22e614341938ceba424879a2e47
72 sg:journal.1024257
73 schema:name Defects in the retina of Niemann-pick type C 1 mutant mice
74 schema:pagination 126
75 schema:productId N8fa9c197bdc04ff0b955410f3add7c05
76 N98decf5dc5344eea87cc355c676c6415
77 Na6cecb2b2c7d49f98c611427a2363606
78 Nc9c3c09a911248619cbb4ac47e4023f9
79 Nd32f83d9ba404aad940cd5cd9828a034
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029738878
81 https://doi.org/10.1186/s12868-014-0126-2
82 schema:sdDatePublished 2019-04-11T09:51
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N01923f73bf9c4acfb9d0b78b8daaea44
85 schema:url http://link.springer.com/10.1186%2Fs12868-014-0126-2
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N01923f73bf9c4acfb9d0b78b8daaea44 schema:name Springer Nature - SN SciGraph project
90 rdf:type schema:Organization
91 N1dbf809de3f0489ca48dbd9d85e85e80 rdf:first Nc94115cb832a4040a12ac2a25e11ddb8
92 rdf:rest Nc7adfc7087a54229b4bb02a4615714b0
93 N2a32e52ae7234d6da25d7dd1be010ccb schema:volumeNumber 15
94 rdf:type schema:PublicationVolume
95 N30f7812650ca439d9ec2fe6735230d65 rdf:first sg:person.0650145475.37
96 rdf:rest N546179667d1b4b34b8294ccd740c11c3
97 N3808f7ecfa8c4edd8985204ff5866831 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Mice, Knockout
99 rdf:type schema:DefinedTerm
100 N3997c50f4967476d9cd12d873c33efc0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Niemann-Pick Disease, Type C
102 rdf:type schema:DefinedTerm
103 N3ada4506e30a4a7997127c52d4e435cb rdf:first sg:person.0752065426.87
104 rdf:rest Ncc4c8f777b624f8fa887af6d953b4ce0
105 N4f5ac9f8e7d54ee1b98d9464c01b75ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Retina
107 rdf:type schema:DefinedTerm
108 N546179667d1b4b34b8294ccd740c11c3 rdf:first sg:person.0630156355.21
109 rdf:rest N3ada4506e30a4a7997127c52d4e435cb
110 N5d64d3fa7c734829bbcb77d313715222 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Neurons
112 rdf:type schema:DefinedTerm
113 N6416b47662cc4deb9b32393c8738f761 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Proteins
115 rdf:type schema:DefinedTerm
116 N68794275a10b4009a73d351c082d2eac rdf:first sg:person.0575766712.41
117 rdf:rest rdf:nil
118 N8fa9c197bdc04ff0b955410f3add7c05 schema:name doi
119 schema:value 10.1186/s12868-014-0126-2
120 rdf:type schema:PropertyValue
121 N914bc22e614341938ceba424879a2e47 schema:issueNumber 1
122 rdf:type schema:PublicationIssue
123 N98decf5dc5344eea87cc355c676c6415 schema:name pubmed_id
124 schema:value 25472750
125 rdf:type schema:PropertyValue
126 Na6b2ec2ca6164dcd80045ddb9931487e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Apoptosis
128 rdf:type schema:DefinedTerm
129 Na6cecb2b2c7d49f98c611427a2363606 schema:name dimensions_id
130 schema:value pub.1029738878
131 rdf:type schema:PropertyValue
132 Naa0255e3016449d88b39a437e175f283 rdf:first sg:person.0727715437.09
133 rdf:rest N1dbf809de3f0489ca48dbd9d85e85e80
134 Nb2f9624d2d21460aafe2e98f52ab9874 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Immunohistochemistry
136 rdf:type schema:DefinedTerm
137 Nbd6c3c25f0da49f498cafe417e04a39e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Disease Models, Animal
139 rdf:type schema:DefinedTerm
140 Nbe4a74d4bd83414289bb02b51bd20ab3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Microscopy, Electron
142 rdf:type schema:DefinedTerm
143 Nc7adfc7087a54229b4bb02a4615714b0 rdf:first sg:person.01252121125.72
144 rdf:rest Nd2f66302cce248d484f15f4c4fa5da7e
145 Nc94115cb832a4040a12ac2a25e11ddb8 schema:affiliation https://www.grid.ac/institutes/grid.413108.f
146 schema:familyName Ma
147 schema:givenName Lucy
148 rdf:type schema:Person
149 Nc9c3c09a911248619cbb4ac47e4023f9 schema:name readcube_id
150 schema:value 8dabae1575ac844295c40b7c92ec9087f3ca5bca5525f6d5b3a8d1029fc42e6d
151 rdf:type schema:PropertyValue
152 Ncc4c8f777b624f8fa887af6d953b4ce0 rdf:first sg:person.01224402677.22
153 rdf:rest Nec0e7cfe638841f591bac1c1223beabd
154 Nd186a9a6f2064c518a4d22d4f92593ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Neuroglia
156 rdf:type schema:DefinedTerm
157 Nd2f66302cce248d484f15f4c4fa5da7e rdf:first sg:person.01076057406.54
158 rdf:rest N30f7812650ca439d9ec2fe6735230d65
159 Nd32f83d9ba404aad940cd5cd9828a034 schema:name nlm_unique_id
160 schema:value 100966986
161 rdf:type schema:PropertyValue
162 Nec0e7cfe638841f591bac1c1223beabd rdf:first sg:person.0761631006.22
163 rdf:rest N68794275a10b4009a73d351c082d2eac
164 Necf6f6fa427546cd9ea257e3152ce07e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Optic Nerve
166 rdf:type schema:DefinedTerm
167 Nfadefb404d314956bef0f99d36097efe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Animals
169 rdf:type schema:DefinedTerm
170 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
171 schema:name Medical and Health Sciences
172 rdf:type schema:DefinedTerm
173 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
174 schema:name Neurosciences
175 rdf:type schema:DefinedTerm
176 sg:journal.1024257 schema:issn 1471-2202
177 schema:name BMC Neuroscience
178 rdf:type schema:Periodical
179 sg:person.01076057406.54 schema:affiliation https://www.grid.ac/institutes/grid.413108.f
180 schema:familyName Lukas
181 schema:givenName Jan
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076057406.54
183 rdf:type schema:Person
184 sg:person.01224402677.22 schema:affiliation https://www.grid.ac/institutes/grid.413108.f
185 schema:familyName Rolfs
186 schema:givenName Arndt
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224402677.22
188 rdf:type schema:Person
189 sg:person.01252121125.72 schema:affiliation https://www.grid.ac/institutes/grid.413108.f
190 schema:familyName Hovakimyan
191 schema:givenName Marina
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252121125.72
193 rdf:type schema:Person
194 sg:person.0575766712.41 schema:affiliation https://www.grid.ac/institutes/grid.413108.f
195 schema:familyName Luo
196 schema:givenName Jiankai
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575766712.41
198 rdf:type schema:Person
199 sg:person.0630156355.21 schema:affiliation https://www.grid.ac/institutes/grid.413108.f
200 schema:familyName Frank
201 schema:givenName Marcus
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630156355.21
203 rdf:type schema:Person
204 sg:person.0650145475.37 schema:affiliation https://www.grid.ac/institutes/grid.413108.f
205 schema:familyName Wree
206 schema:givenName Andreas
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650145475.37
208 rdf:type schema:Person
209 sg:person.0727715437.09 schema:affiliation https://www.grid.ac/institutes/grid.413108.f
210 schema:familyName Yan
211 schema:givenName Xin
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727715437.09
213 rdf:type schema:Person
214 sg:person.0752065426.87 schema:affiliation https://www.grid.ac/institutes/grid.413108.f
215 schema:familyName Guthoff
216 schema:givenName Rudolf
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752065426.87
218 rdf:type schema:Person
219 sg:person.0761631006.22 schema:affiliation https://www.grid.ac/institutes/grid.413108.f
220 schema:familyName Witt
221 schema:givenName Martin
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761631006.22
223 rdf:type schema:Person
224 sg:pub.10.1007/978-1-4419-1672-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004077215
225 https://doi.org/10.1007/978-1-4419-1672-3
226 rdf:type schema:CreativeWork
227 sg:pub.10.1007/s00417-008-0962-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024642707
228 https://doi.org/10.1007/s00417-008-0962-9
229 rdf:type schema:CreativeWork
230 sg:pub.10.1007/s11011-011-9263-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041810022
231 https://doi.org/10.1007/s11011-011-9263-9
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/nature09675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023954681
234 https://doi.org/10.1038/nature09675
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/nrn1497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012560945
237 https://doi.org/10.1038/nrn1497
238 rdf:type schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1004077215 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1075078896 schema:CreativeWork
241 https://doi.org/10.1001/archophthalmol.2011.134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012094959
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1002/(sici)1096-9861(19980525)395:1<43::aid-cne4>3.0.co;2-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1000169260
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1002/cbf.2833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033871271
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1002/chem.200801160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050068116
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1002/cne.10522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019574906
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1002/eji.1830111013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039869042
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1002/glia.22659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039141162
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/0014-4835(78)90022-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006225404
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.ajo.2004.07.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010069393
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.bbalip.2004.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022726167
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.bbalip.2004.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010085308
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.bbrc.2010.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035210616
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.exer.2005.12.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046379771
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.exer.2007.01.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019204742
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.mcn.2009.10.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034350101
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.nbd.2011.12.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028077223
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.neuron.2009.09.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010916042
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.preteyeres.2006.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042635974
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.survophthal.2005.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005072957
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s0014-4886(03)00345-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053067760
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/s0161-6420(78)35592-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026665949
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/s0896-6273(04)00157-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028877449
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1017/s095252380000242x schema:sameAs https://app.dimensions.ai/details/publication/pub.1054899850
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1042/bj20050460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019449709
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1042/bst0340399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024635741
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1074/jbc.m205406200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005968263
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1083/jcb.112.6.1241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043627374
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1093/jnen/63.6.660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019053843
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1093/jnen/64.4.323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017935475
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1126/science.277.5323.228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062557331
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1126/science.277.5323.232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062557332
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1126/science.290.5500.2298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062572556
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1136/bjo.2006.100602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004241059
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1146/annurev.ne.02.030179.001125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039346804
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1167/iovs.06-0190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027520564
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1371/journal.pone.0082216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040338292
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1523/jneurosci.0267-12.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042796474
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1523/jneurosci.0372-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027120724
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1523/jneurosci.2910-12.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005310687
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1523/jneurosci.4165-09.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000370630
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1523/jneurosci.5529-07.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016334024
322 rdf:type schema:CreativeWork
323 https://www.grid.ac/institutes/grid.413108.f schema:alternateName Universitätsmedizin Rostock
324 schema:name Albrecht-Kossel-Institute for Neuroregeneration, Rostock University Medical Center, Gehlsheimer Strasse 20, D-18147, Rostock, Germany
325 Department of Anatomy, Rostock University Medical Center, Gertrudenstrsse 9, D-18055, Rostock, Germany
326 Department of Ophthalmology, Rostock University Medical Center, Doberaner Strasse 140, D-18057, Rostock, Germany
327 Electron Microscopy Center, Rostock University Medical Center, Strempelstr. 14, D-18057, Rostock, Germany
328 Institute for Biomedical Engineering, Rostock University Medical Center, F.-Barnewitz Strasse 4, D-18119, Rostock, Germany
329 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...