Metformin reverse minocycline to inhibit minocycline-resistant Acinetobacter baumannii by destroy the outer membrane and enhance membrane potential in vitro View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-09-12

AUTHORS

Tingting Guo, Xiaoli Sun, Jie Yang, Liying Yang, Mengying Li, Yuhang Wang, Hongmei Jiao, Guocai Li

ABSTRACT

BackgroundAcinetobacter baumannii (A. baumannii) is an opportunistic pathogen and has emerged as one of the most troublesome pathogens. Drug resistance in A. baumannii has been reported on a global scale. Minocycline was found to be active against multi-drug resistant A. baumannii and was approved by the FDA for the infections caused by sensitive strains of A. baumannii. However, the emergence of minocycline resistance and its toxic effects still need to be addressed. Therefore, this study aimed to evaluate the synergistic effects of metformin combined with minocycline on minocycline-resistant A. baumannii.ResultsThe effect of metformin on the antibacterial activity of minocycline was determined by checkerboard and time-killing assay. Further, it was observed by biofilm formation assay that metformin combination with minocycline can inhibit the formation of biofilm. Outer membrane integrity, membrane permeability, membrane potential and reactive oxygen species (ROS) were monitored to explore the underlying synergistic mechanisms of metformin on minocycline. And the results shown that metformin can destroy the outer membrane of A. baumannii, enhance its membrane potential, but does not affect the membrane permeability and ROS.ConclusionThese findings suggested that the combination of metformin and minocycline has the potential for rejuvenating the activity of minocycline against minocycline-resistant A. baumannii. More... »

PAGES

215

References to SciGraph publications

  • 2018-07-23. Curcumin alleviates persistence of Acinetobacter baumannii against colistin in SCIENTIFIC REPORTS
  • 2018-05-08. Biofilm formation is not associated with worse outcome in Acinetobacter baumannii bacteraemic pneumonia in SCIENTIFIC REPORTS
  • 2007-12. An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii in NATURE REVIEWS MICROBIOLOGY
  • 2015-10-14. Association between Use of Oral Anti-Diabetic Drugs and the Risk of Sepsis: A Nested Case-Control Study in SCIENTIFIC REPORTS
  • 2018-01-20. Highly synergistic activity of melittin with imipenem and colistin in biofilm inhibition against multidrug-resistant strong biofilm producer strains of Acinetobacter baumannii in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2014-01-07. Metformin—mode of action and clinical implications for diabetes and cancer in NATURE REVIEWS ENDOCRINOLOGY
  • 2016-01-20. Antibacterial drug discovery in the resistance era in NATURE
  • 2019-02-04. Metformin and gut microbiota: their interactions and their impact on diabetes in HORMONES
  • 2015-03-07. Metformin as a potential combination therapy with existing front-line antibiotics for Tuberculosis in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2012-08-28. Emergence of extensively drug-resistant Acinetobacter baumannii complex over 10 years: Nationwide data from the Taiwan Surveillance of Antimicrobial Resistance (TSAR) program in BMC INFECTIOUS DISEASES
  • 2014-06-25. Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance in NATURE
  • 2021-05-10. Mechanistic insights into synergy between nalidixic acid and tetracycline against clinical isolates of Acinetobacter baumannii and Escherichia coli in COMMUNICATIONS BIOLOGY
  • 2017-08-02. Metformin: clinical use in type 2 diabetes in DIABETOLOGIA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12866-022-02629-4

    DOI

    http://dx.doi.org/10.1186/s12866-022-02629-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1150918658

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/36089583


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Acinetobacter Infections", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Acinetobacter baumannii", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Membrane Potentials", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Metformin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Minocycline", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reactive Oxygen Species", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, 225001, Yangzhou, China", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Microbiology, Medical College, Yangzhou University, 225001, Yangzhou, China", 
                "Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, 225009, Yangzhou, China", 
                "Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, 225001, Yangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guo", 
            "givenName": "Tingting", 
            "id": "sg:person.011630426731.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011630426731.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology, Medical College, Yangzhou University, 225001, Yangzhou, China", 
              "id": "http://www.grid.ac/institutes/grid.268415.c", 
              "name": [
                "Department of Microbiology, Medical College, Yangzhou University, 225001, Yangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sun", 
            "givenName": "Xiaoli", 
            "id": "sg:person.013660323070.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013660323070.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology, Medical College, Yangzhou University, 225001, Yangzhou, China", 
              "id": "http://www.grid.ac/institutes/grid.268415.c", 
              "name": [
                "Department of Microbiology, Medical College, Yangzhou University, 225001, Yangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Jie", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology, Medical College, Yangzhou University, 225001, Yangzhou, China", 
              "id": "http://www.grid.ac/institutes/grid.268415.c", 
              "name": [
                "Department of Microbiology, Medical College, Yangzhou University, 225001, Yangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Liying", 
            "id": "sg:person.015253264070.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015253264070.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pharmacy, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, 215101, Suzhou, Jiangsu, China", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Microbiology, Medical College, Yangzhou University, 225001, Yangzhou, China", 
                "Department of Pharmacy, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, 215101, Suzhou, Jiangsu, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Mengying", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology, Medical College, Yangzhou University, 225001, Yangzhou, China", 
              "id": "http://www.grid.ac/institutes/grid.268415.c", 
              "name": [
                "Department of Microbiology, Medical College, Yangzhou University, 225001, Yangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Yuhang", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology, Medical College, Yangzhou University, 225001, Yangzhou, China", 
              "id": "http://www.grid.ac/institutes/grid.268415.c", 
              "name": [
                "Department of Microbiology, Medical College, Yangzhou University, 225001, Yangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jiao", 
            "givenName": "Hongmei", 
            "id": "sg:person.01274532446.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274532446.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, 225001, Yangzhou, China", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Microbiology, Medical College, Yangzhou University, 225001, Yangzhou, China", 
                "Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, 225009, Yangzhou, China", 
                "Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, 225001, Yangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Guocai", 
            "id": "sg:person.0730457225.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730457225.08"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/s41598-018-25661-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103771671", 
              "https://doi.org/10.1038/s41598-018-25661-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12967-015-0443-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043671802", 
              "https://doi.org/10.1186/s12967-015-0443-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep15260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034095958", 
              "https://doi.org/10.1038/srep15260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2334-12-200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044149623", 
              "https://doi.org/10.1186/1471-2334-12-200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-017-4336-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090953071", 
              "https://doi.org/10.1007/s00125-017-4336-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature17042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038585164", 
              "https://doi.org/10.1038/nature17042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-29291-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105646384", 
              "https://doi.org/10.1038/s41598-018-29291-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10096-018-3189-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100477413", 
              "https://doi.org/10.1007/s10096-018-3189-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro1789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011612018", 
              "https://doi.org/10.1038/nrmicro1789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrendo.2013.256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041130626", 
              "https://doi.org/10.1038/nrendo.2013.256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s42003-021-02074-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1137880852", 
              "https://doi.org/10.1038/s42003-021-02074-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s42000-019-00093-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111918754", 
              "https://doi.org/10.1007/s42000-019-00093-w"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13445", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039580452", 
              "https://doi.org/10.1038/nature13445"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2022-09-12", 
        "datePublishedReg": "2022-09-12", 
        "description": "BackgroundAcinetobacter baumannii (A. baumannii) is an opportunistic pathogen and has emerged as one of the most troublesome pathogens. Drug resistance in A. baumannii has been reported on a global scale. Minocycline was found to be active against multi-drug resistant A. baumannii and was approved by the FDA for the infections caused by sensitive strains of A. baumannii. However, the emergence of minocycline resistance and its toxic effects still need to be addressed. Therefore, this study aimed to evaluate the synergistic effects of metformin combined with minocycline on minocycline-resistant A. baumannii.ResultsThe effect of metformin on the antibacterial activity of minocycline was determined by checkerboard and time-killing assay. Further, it was observed by biofilm formation assay that metformin combination with minocycline can inhibit the formation of biofilm. Outer membrane integrity, membrane permeability, membrane potential and reactive oxygen species (ROS) were monitored to explore the underlying synergistic mechanisms of metformin on minocycline. And the results shown that metformin can destroy the outer membrane of A. baumannii, enhance its membrane potential, but does not affect the membrane permeability and ROS.ConclusionThese findings suggested that the combination of metformin and minocycline has the potential for rejuvenating the activity of minocycline against minocycline-resistant A. baumannii.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s12866-022-02629-4", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1024253", 
            "issn": [
              "1471-2180"
            ], 
            "name": "BMC Microbiology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "22"
          }
        ], 
        "keywords": [
          "A. baumannii", 
          "reactive oxygen species", 
          "multi-drug resistant A. baumannii", 
          "resistant A. baumannii", 
          "activity of minocycline", 
          "effect of metformin", 
          "combination of metformin", 
          "time-kill assays", 
          "metformin combination", 
          "membrane potential", 
          "Acinetobacter baumannii", 
          "minocycline", 
          "metformin", 
          "ConclusionThese findings", 
          "baumannii", 
          "drug resistance", 
          "minocycline resistance", 
          "troublesome pathogens", 
          "opportunistic pathogen", 
          "toxic effects", 
          "sensitive strains", 
          "oxygen species", 
          "membrane permeability", 
          "pathogens", 
          "antibacterial activity", 
          "infection", 
          "synergistic mechanism", 
          "FDA", 
          "formation of biofilms", 
          "activity", 
          "effect", 
          "biofilm formation", 
          "synergistic effect", 
          "assays", 
          "resistance", 
          "membrane integrity", 
          "membrane", 
          "findings", 
          "combination", 
          "outer membrane", 
          "potential", 
          "study", 
          "permeability", 
          "checkerboard", 
          "strains", 
          "outer membrane integrity", 
          "mechanism", 
          "biofilms", 
          "integrity", 
          "scale", 
          "results", 
          "formation", 
          "emergence", 
          "species", 
          "global scale"
        ], 
        "name": "Metformin reverse minocycline to inhibit minocycline-resistant Acinetobacter baumannii by destroy the outer membrane and enhance membrane potential in vitro", 
        "pagination": "215", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1150918658"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12866-022-02629-4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "36089583"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12866-022-02629-4", 
          "https://app.dimensions.ai/details/publication/pub.1150918658"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T21:09", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_924.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s12866-022-02629-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12866-022-02629-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12866-022-02629-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12866-022-02629-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12866-022-02629-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    248 TRIPLES      21 PREDICATES      100 URIs      79 LITERALS      14 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12866-022-02629-4 schema:about N215b3cf001d84bbaae38cac036d34945
    2 N234f5a2c2a8d43559b13f4a6868265bd
    3 N67cc76fb0fe04178b5e8042c59a5bbcb
    4 N6db8c9a3004d49498424ab0c2cb733b5
    5 N960f3e2077e74a02bc8d2f08ffd31928
    6 Na8d9f4f693b84ed08b6c0c41843f0936
    7 Ndc955378ccd0429fa7798a97ef8f717d
    8 anzsrc-for:11
    9 anzsrc-for:1108
    10 schema:author N7c06b9707f534a699fbc602b2fed9b68
    11 schema:citation sg:pub.10.1007/s00125-017-4336-x
    12 sg:pub.10.1007/s10096-018-3189-7
    13 sg:pub.10.1007/s42000-019-00093-w
    14 sg:pub.10.1038/nature13445
    15 sg:pub.10.1038/nature17042
    16 sg:pub.10.1038/nrendo.2013.256
    17 sg:pub.10.1038/nrmicro1789
    18 sg:pub.10.1038/s41598-018-25661-9
    19 sg:pub.10.1038/s41598-018-29291-z
    20 sg:pub.10.1038/s42003-021-02074-5
    21 sg:pub.10.1038/srep15260
    22 sg:pub.10.1186/1471-2334-12-200
    23 sg:pub.10.1186/s12967-015-0443-y
    24 schema:datePublished 2022-09-12
    25 schema:datePublishedReg 2022-09-12
    26 schema:description BackgroundAcinetobacter baumannii (A. baumannii) is an opportunistic pathogen and has emerged as one of the most troublesome pathogens. Drug resistance in A. baumannii has been reported on a global scale. Minocycline was found to be active against multi-drug resistant A. baumannii and was approved by the FDA for the infections caused by sensitive strains of A. baumannii. However, the emergence of minocycline resistance and its toxic effects still need to be addressed. Therefore, this study aimed to evaluate the synergistic effects of metformin combined with minocycline on minocycline-resistant A. baumannii.ResultsThe effect of metformin on the antibacterial activity of minocycline was determined by checkerboard and time-killing assay. Further, it was observed by biofilm formation assay that metformin combination with minocycline can inhibit the formation of biofilm. Outer membrane integrity, membrane permeability, membrane potential and reactive oxygen species (ROS) were monitored to explore the underlying synergistic mechanisms of metformin on minocycline. And the results shown that metformin can destroy the outer membrane of A. baumannii, enhance its membrane potential, but does not affect the membrane permeability and ROS.ConclusionThese findings suggested that the combination of metformin and minocycline has the potential for rejuvenating the activity of minocycline against minocycline-resistant A. baumannii.
    27 schema:genre article
    28 schema:isAccessibleForFree true
    29 schema:isPartOf Ne4b2dca113b240cf83fa7925a80860a7
    30 Nf83b25e19c2f4986a1d9840b1a7941f9
    31 sg:journal.1024253
    32 schema:keywords A. baumannii
    33 Acinetobacter baumannii
    34 ConclusionThese findings
    35 FDA
    36 activity
    37 activity of minocycline
    38 antibacterial activity
    39 assays
    40 baumannii
    41 biofilm formation
    42 biofilms
    43 checkerboard
    44 combination
    45 combination of metformin
    46 drug resistance
    47 effect
    48 effect of metformin
    49 emergence
    50 findings
    51 formation
    52 formation of biofilms
    53 global scale
    54 infection
    55 integrity
    56 mechanism
    57 membrane
    58 membrane integrity
    59 membrane permeability
    60 membrane potential
    61 metformin
    62 metformin combination
    63 minocycline
    64 minocycline resistance
    65 multi-drug resistant A. baumannii
    66 opportunistic pathogen
    67 outer membrane
    68 outer membrane integrity
    69 oxygen species
    70 pathogens
    71 permeability
    72 potential
    73 reactive oxygen species
    74 resistance
    75 resistant A. baumannii
    76 results
    77 scale
    78 sensitive strains
    79 species
    80 strains
    81 study
    82 synergistic effect
    83 synergistic mechanism
    84 time-kill assays
    85 toxic effects
    86 troublesome pathogens
    87 schema:name Metformin reverse minocycline to inhibit minocycline-resistant Acinetobacter baumannii by destroy the outer membrane and enhance membrane potential in vitro
    88 schema:pagination 215
    89 schema:productId N7af3d27334264f8b83de8a48ff8357eb
    90 N81c82be1b105453896a89bf6452384f2
    91 Na604cfd039af48ab8004d88a2d3f2e4a
    92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1150918658
    93 https://doi.org/10.1186/s12866-022-02629-4
    94 schema:sdDatePublished 2022-11-24T21:09
    95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    96 schema:sdPublisher Nb493e31d972d4eab9c0525a70ef5b6c3
    97 schema:url https://doi.org/10.1186/s12866-022-02629-4
    98 sgo:license sg:explorer/license/
    99 sgo:sdDataset articles
    100 rdf:type schema:ScholarlyArticle
    101 N114a7c21c256466994dc3270f29c73e4 rdf:first sg:person.0730457225.08
    102 rdf:rest rdf:nil
    103 N215b3cf001d84bbaae38cac036d34945 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Reactive Oxygen Species
    105 rdf:type schema:DefinedTerm
    106 N234f5a2c2a8d43559b13f4a6868265bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Acinetobacter baumannii
    108 rdf:type schema:DefinedTerm
    109 N24607a6e9da443e0a1716d534b5aab99 schema:affiliation grid-institutes:grid.268415.c
    110 schema:familyName Yang
    111 schema:givenName Jie
    112 rdf:type schema:Person
    113 N2819a57de41a449db26758500e39afa5 rdf:first Na46208a8a50f43498557ace366ee4e11
    114 rdf:rest N2b97e9572fbe486d877c2ea4e14f63e5
    115 N2b97e9572fbe486d877c2ea4e14f63e5 rdf:first sg:person.01274532446.17
    116 rdf:rest N114a7c21c256466994dc3270f29c73e4
    117 N67cc76fb0fe04178b5e8042c59a5bbcb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Minocycline
    119 rdf:type schema:DefinedTerm
    120 N6db8c9a3004d49498424ab0c2cb733b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Acinetobacter Infections
    122 rdf:type schema:DefinedTerm
    123 N76ede43121cb4f5681cdfce8cbae7299 rdf:first N24607a6e9da443e0a1716d534b5aab99
    124 rdf:rest Nb0784bcbc56443d3bd92177eed46a24e
    125 N7af3d27334264f8b83de8a48ff8357eb schema:name doi
    126 schema:value 10.1186/s12866-022-02629-4
    127 rdf:type schema:PropertyValue
    128 N7c06b9707f534a699fbc602b2fed9b68 rdf:first sg:person.011630426731.55
    129 rdf:rest N86ce646802f642658c2fb57724431030
    130 N7fbdf2f2660e44afa21111d33e773b2e schema:affiliation grid-institutes:None
    131 schema:familyName Li
    132 schema:givenName Mengying
    133 rdf:type schema:Person
    134 N81c82be1b105453896a89bf6452384f2 schema:name dimensions_id
    135 schema:value pub.1150918658
    136 rdf:type schema:PropertyValue
    137 N8458847b9b9a4d4d8b288490cef06a3c rdf:first N7fbdf2f2660e44afa21111d33e773b2e
    138 rdf:rest N2819a57de41a449db26758500e39afa5
    139 N86ce646802f642658c2fb57724431030 rdf:first sg:person.013660323070.02
    140 rdf:rest N76ede43121cb4f5681cdfce8cbae7299
    141 N960f3e2077e74a02bc8d2f08ffd31928 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Membrane Potentials
    143 rdf:type schema:DefinedTerm
    144 Na46208a8a50f43498557ace366ee4e11 schema:affiliation grid-institutes:grid.268415.c
    145 schema:familyName Wang
    146 schema:givenName Yuhang
    147 rdf:type schema:Person
    148 Na604cfd039af48ab8004d88a2d3f2e4a schema:name pubmed_id
    149 schema:value 36089583
    150 rdf:type schema:PropertyValue
    151 Na8d9f4f693b84ed08b6c0c41843f0936 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Humans
    153 rdf:type schema:DefinedTerm
    154 Nb0784bcbc56443d3bd92177eed46a24e rdf:first sg:person.015253264070.29
    155 rdf:rest N8458847b9b9a4d4d8b288490cef06a3c
    156 Nb493e31d972d4eab9c0525a70ef5b6c3 schema:name Springer Nature - SN SciGraph project
    157 rdf:type schema:Organization
    158 Ndc955378ccd0429fa7798a97ef8f717d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Metformin
    160 rdf:type schema:DefinedTerm
    161 Ne4b2dca113b240cf83fa7925a80860a7 schema:volumeNumber 22
    162 rdf:type schema:PublicationVolume
    163 Nf83b25e19c2f4986a1d9840b1a7941f9 schema:issueNumber 1
    164 rdf:type schema:PublicationIssue
    165 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    166 schema:name Medical and Health Sciences
    167 rdf:type schema:DefinedTerm
    168 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
    169 schema:name Medical Microbiology
    170 rdf:type schema:DefinedTerm
    171 sg:journal.1024253 schema:issn 1471-2180
    172 schema:name BMC Microbiology
    173 schema:publisher Springer Nature
    174 rdf:type schema:Periodical
    175 sg:person.011630426731.55 schema:affiliation grid-institutes:None
    176 schema:familyName Guo
    177 schema:givenName Tingting
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011630426731.55
    179 rdf:type schema:Person
    180 sg:person.01274532446.17 schema:affiliation grid-institutes:grid.268415.c
    181 schema:familyName Jiao
    182 schema:givenName Hongmei
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274532446.17
    184 rdf:type schema:Person
    185 sg:person.013660323070.02 schema:affiliation grid-institutes:grid.268415.c
    186 schema:familyName Sun
    187 schema:givenName Xiaoli
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013660323070.02
    189 rdf:type schema:Person
    190 sg:person.015253264070.29 schema:affiliation grid-institutes:grid.268415.c
    191 schema:familyName Yang
    192 schema:givenName Liying
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015253264070.29
    194 rdf:type schema:Person
    195 sg:person.0730457225.08 schema:affiliation grid-institutes:None
    196 schema:familyName Li
    197 schema:givenName Guocai
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730457225.08
    199 rdf:type schema:Person
    200 sg:pub.10.1007/s00125-017-4336-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1090953071
    201 https://doi.org/10.1007/s00125-017-4336-x
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1007/s10096-018-3189-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100477413
    204 https://doi.org/10.1007/s10096-018-3189-7
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1007/s42000-019-00093-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1111918754
    207 https://doi.org/10.1007/s42000-019-00093-w
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/nature13445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039580452
    210 https://doi.org/10.1038/nature13445
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/nature17042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038585164
    213 https://doi.org/10.1038/nature17042
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/nrendo.2013.256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041130626
    216 https://doi.org/10.1038/nrendo.2013.256
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/nrmicro1789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011612018
    219 https://doi.org/10.1038/nrmicro1789
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/s41598-018-25661-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103771671
    222 https://doi.org/10.1038/s41598-018-25661-9
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/s41598-018-29291-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1105646384
    225 https://doi.org/10.1038/s41598-018-29291-z
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/s42003-021-02074-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1137880852
    228 https://doi.org/10.1038/s42003-021-02074-5
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/srep15260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034095958
    231 https://doi.org/10.1038/srep15260
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1186/1471-2334-12-200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044149623
    234 https://doi.org/10.1186/1471-2334-12-200
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1186/s12967-015-0443-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1043671802
    237 https://doi.org/10.1186/s12967-015-0443-y
    238 rdf:type schema:CreativeWork
    239 grid-institutes:None schema:alternateName Department of Pharmacy, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, 215101, Suzhou, Jiangsu, China
    240 Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, 225001, Yangzhou, China
    241 schema:name Department of Microbiology, Medical College, Yangzhou University, 225001, Yangzhou, China
    242 Department of Pharmacy, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, 215101, Suzhou, Jiangsu, China
    243 Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, 225001, Yangzhou, China
    244 Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, 225009, Yangzhou, China
    245 rdf:type schema:Organization
    246 grid-institutes:grid.268415.c schema:alternateName Department of Microbiology, Medical College, Yangzhou University, 225001, Yangzhou, China
    247 schema:name Department of Microbiology, Medical College, Yangzhou University, 225001, Yangzhou, China
    248 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...