The antimicrobial effect of a novel peptide LL-1 on Escherichia coli by increasing membrane permeability View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-09-19

AUTHORS

Lingling Zhou, Kaiqi Lian, Mengting Wang, Xueyi Jing, Yuanchen Zhang, Jinling Cao

ABSTRACT

BackgroundThe widespread use of antibiotics has led to the emergence of many drug-resistant strains; thus, the development of new antibacterial drugs is essential with antimicrobial peptides becoming the focus of research. This study assessed the antibacterial effect of a novel antimicrobial peptide, named LL-1 on Escherichia coli (E.coli) by determining the minimum inhibitory concentration (MIC) and the antibacterial curve. The interaction between LL-1 and E. coli DNA was then detected by nucleic acid gel electrophoresis. The effect of LL-1 on the E. coli cell membrane was assessed by detecting the leakage of β-galactosidase, nucleic acid and protein. The influence of LL-1 on the intracellular ATP of E. coli was analysed by determining the concentration of intracellular ATP. Finally, the bacteria and colonies of E. coli treated with LL-1 were observed using scanning and transmission electron microscopy.ResultsThe results suggested that the MIC value was 3.125 µg/ml, and the antibacterial effect was dose-dependent. LL-1 dose-dependently combined with E. coli DNA. LL-1 resulted in the leakage of intracellular β-galactosidase, nucleic acid and protein, and decreased intracellular ATP concentrations of E. coli. Two MIC of LL-1 caused E. coli to shrink, resulting in a rough surface, plasmolysis, and bacterial adhesion.ConclusionThis study indicated that LL-1 had a good bactericidal effect on E. coli by mainly increasing the permeability of the cell membrane, leading to leakage of the intracellular content. This will lay the foundation for an in-depth study on the antibacterial mechanism of LL-1 against E. coli and its clinical application. More... »

PAGES

220

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12866-022-02621-y

DOI

http://dx.doi.org/10.1186/s12866-022-02621-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1151113908

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/36117157


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