Effects of artificial honey and epigallocatechin-3-gallate on streptococcus pyogenes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-08-26

AUTHORS

Xiaoge Jiang, An Lin, Shijia Li, Yangyang Shi, Fangjie Zhou, Grace Gomez Felix Gomez, Richard L. Gregory, Chaoliang Zhang, Song Chen, Ruijie Huang

ABSTRACT

BackgroundStreptococcus pyogenes is an important global human pathogen that causes pharyngitis, and antibacterial therapy has become an important part of the overall therapy for pharyngitis. As natural derivatives, honey and green tea are often recommended for patients with pharyngitis in traditional Chinese medicine without experimental theoretical basis on wether the combined effect of honey and green tea on pharyngitis is better than they alone. The aims of this study were to explore the effects of artificial honey (AH) and epigallocatechin-3-gallate (EGCG) on S. pyogenes and elucidate the possible mechanisms, which were investigated using MIC (the minimum inhibitory concentration), FIC (fractional inhibitory concentration) index, growth pattern, biofilm formation and RT-qPCR.ResultsThe MIC of AH on S. pyogenes was 12.5% (v/v) and the MIC of EGCG was 1250 μg/ml. The FIC index of AH and EGCG was 0.5. The planktonic cell growth, growth pattern and biofilm formation assays showed that AH and EGCG mixture had stronger inhibitory effect on S. pyogenes than they alone. RT-qPCR confirmed that the expression of hasA and luxS gene were inhibited by AH and EGCG mixture.ConclusionsAH and EGCG mixture can inhibit the planktonic cell growth, biofilm formation and some virulence genes expression of S. pyogenes, better than they alone. The combination of honey and green tea have the potential to treat pharyngitis as natural derivatives, avoiding drug resistance and double infection. More... »

PAGES

207

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12866-022-02611-0

DOI

http://dx.doi.org/10.1186/s12866-022-02611-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1150535980

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/36028794


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biofilms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Catechin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Honey", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pharyngitis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Streptococcus pyogenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tea", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Orthodontics Dentistry, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China", 
          "id": "http://www.grid.ac/institutes/grid.13291.38", 
          "name": [
            "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China", 
            "Department of Orthodontics Dentistry, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jiang", 
        "givenName": "Xiaoge", 
        "id": "sg:person.016277402645.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016277402645.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China", 
          "id": "http://www.grid.ac/institutes/grid.13291.38", 
          "name": [
            "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China", 
            "Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "An", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthodontics Dentistry, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China", 
          "id": "http://www.grid.ac/institutes/grid.13291.38", 
          "name": [
            "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China", 
            "Department of Orthodontics Dentistry, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Shijia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endodontic Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China", 
          "id": "http://www.grid.ac/institutes/grid.13291.38", 
          "name": [
            "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China", 
            "Department of Endodontic Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Yangyang", 
        "id": "sg:person.014275615557.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014275615557.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endodontic Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China", 
          "id": "http://www.grid.ac/institutes/grid.13291.38", 
          "name": [
            "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China", 
            "Department of Endodontic Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Fangjie", 
        "id": "sg:person.012337574443.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012337574443.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oral Biology, School of Dentistry, Indiana University, Indianapolis, USA", 
          "id": "http://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Department of Oral Biology, School of Dentistry, Indiana University, Indianapolis, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Felix Gomez", 
        "givenName": "Grace Gomez", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oral Biology, School of Dentistry, Indiana University, Indianapolis, USA", 
          "id": "http://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Department of Oral Biology, School of Dentistry, Indiana University, Indianapolis, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gregory", 
        "givenName": "Richard L.", 
        "id": "sg:person.0614452305.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614452305.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China", 
          "id": "http://www.grid.ac/institutes/grid.13291.38", 
          "name": [
            "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Chaoliang", 
        "id": "sg:person.0675226724.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675226724.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthodontics Dentistry, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China", 
          "id": "http://www.grid.ac/institutes/grid.13291.38", 
          "name": [
            "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China", 
            "Department of Orthodontics Dentistry, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Song", 
        "id": "sg:person.01151127324.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151127324.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oral Biology, School of Dentistry, Indiana University, Indianapolis, USA", 
          "id": "http://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China", 
            "Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China", 
            "Department of Oral Biology, School of Dentistry, Indiana University, Indianapolis, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Ruijie", 
        "id": "sg:person.014560716667.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014560716667.41"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1210840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025301290", 
          "https://doi.org/10.1038/sj.onc.1210840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-009-0763-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033394455", 
          "https://doi.org/10.1007/s10096-009-0763-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2466-12-70", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045371213", 
          "https://doi.org/10.1186/1471-2466-12-70"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2022-08-26", 
    "datePublishedReg": "2022-08-26", 
    "description": "BackgroundStreptococcus pyogenes is an important global human pathogen that causes pharyngitis, and antibacterial therapy has become an important part of the overall therapy for pharyngitis. As natural derivatives, honey and green tea are often recommended for patients with pharyngitis in traditional Chinese medicine without experimental theoretical basis on wether the combined effect of honey and green tea on pharyngitis is better than they alone. The aims of this study were to explore the effects of artificial honey (AH) and epigallocatechin-3-gallate (EGCG) on S. pyogenes and elucidate the possible mechanisms, which were investigated using MIC (the minimum inhibitory concentration), FIC (fractional inhibitory concentration) index, growth pattern, biofilm formation and RT-qPCR.ResultsThe MIC of AH on S. pyogenes was 12.5% (v/v) and the MIC of EGCG was 1250\u00a0\u03bcg/ml. The FIC index of AH and EGCG was 0.5. The planktonic cell growth, growth pattern and biofilm formation assays showed that AH and EGCG mixture had stronger inhibitory effect on S. pyogenes than they alone. RT-qPCR confirmed that the expression of hasA and luxS gene were inhibited by AH and EGCG mixture.ConclusionsAH and EGCG mixture can inhibit the planktonic cell growth, biofilm formation and some virulence genes expression of S. pyogenes, better than they alone. The combination of honey and green tea have the potential to treat pharyngitis as natural derivatives, avoiding drug resistance and double infection.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12866-022-02611-0", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8906998", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024253", 
        "issn": [
          "1471-2180"
        ], 
        "name": "BMC Microbiology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "keywords": [
      "S. pyogenes", 
      "FIC index", 
      "green tea", 
      "important global human pathogen", 
      "RT-qPCR", 
      "combination of honey", 
      "effect of honey", 
      "traditional Chinese medicine", 
      "artificial honey", 
      "global human pathogen", 
      "cell growth", 
      "overall therapy", 
      "pharyngitis", 
      "planktonic cell growth", 
      "antibacterial therapy", 
      "strong inhibitory effect", 
      "natural derivatives", 
      "drug resistance", 
      "double infection", 
      "MIC of EGCG", 
      "formation assays", 
      "inhibitory effect", 
      "Chinese medicine", 
      "growth pattern", 
      "Streptococcus pyogenes", 
      "pyogenes", 
      "therapy", 
      "MIC", 
      "biofilm formation assays", 
      "human pathogens", 
      "EGCG", 
      "virulence gene expression", 
      "possible mechanism", 
      "biofilm formation", 
      "gene expression", 
      "ConclusionsAH", 
      "tea", 
      "patients", 
      "expression", 
      "infection", 
      "index", 
      "effect", 
      "medicine", 
      "assays", 
      "pathogens", 
      "aim", 
      "honey", 
      "patterns", 
      "study", 
      "genes", 
      "resistance", 
      "wethers", 
      "mechanism", 
      "growth", 
      "important part", 
      "combination", 
      "derivatives", 
      "potential", 
      "formation", 
      "lux genes", 
      "part", 
      "basis", 
      "HasA", 
      "theoretical basis", 
      "mixture"
    ], 
    "name": "Effects of artificial honey and epigallocatechin-3-gallate on streptococcus pyogenes", 
    "pagination": "207", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1150535980"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12866-022-02611-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "36028794"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12866-022-02611-0", 
      "https://app.dimensions.ai/details/publication/pub.1150535980"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:44", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_934.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12866-022-02611-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12866-022-02611-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12866-022-02611-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12866-022-02611-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12866-022-02611-0'


 

This table displays all metadata directly associated to this object as RDF triples.

246 TRIPLES      21 PREDICATES      102 URIs      91 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12866-022-02611-0 schema:about N070ccfb6c90e4dfcb59ca0956d610d4b
2 N15f280f3dbae4e8f9ec2963718bc912e
3 N215ecde5c2834894a1a89c33e475e228
4 N2b547c1f6539470bbe29cda3d50b4681
5 N47ee89df929940b283fc0425183dff62
6 N8b933971771c4a239752fd8d84dd3cb7
7 Na88bf9b5a51c40c191272db0f2be6c97
8 Nb2867775adaf4e7c8cc96f07f6eafd4b
9 Ned9205fd45fe47019c39652bd8a0c2dd
10 anzsrc-for:11
11 anzsrc-for:1108
12 schema:author N72bbff7a5bf044998532f1ae5c5761cc
13 schema:citation sg:pub.10.1007/s10096-009-0763-z
14 sg:pub.10.1038/sj.onc.1210840
15 sg:pub.10.1186/1471-2466-12-70
16 schema:datePublished 2022-08-26
17 schema:datePublishedReg 2022-08-26
18 schema:description BackgroundStreptococcus pyogenes is an important global human pathogen that causes pharyngitis, and antibacterial therapy has become an important part of the overall therapy for pharyngitis. As natural derivatives, honey and green tea are often recommended for patients with pharyngitis in traditional Chinese medicine without experimental theoretical basis on wether the combined effect of honey and green tea on pharyngitis is better than they alone. The aims of this study were to explore the effects of artificial honey (AH) and epigallocatechin-3-gallate (EGCG) on S. pyogenes and elucidate the possible mechanisms, which were investigated using MIC (the minimum inhibitory concentration), FIC (fractional inhibitory concentration) index, growth pattern, biofilm formation and RT-qPCR.ResultsThe MIC of AH on S. pyogenes was 12.5% (v/v) and the MIC of EGCG was 1250 μg/ml. The FIC index of AH and EGCG was 0.5. The planktonic cell growth, growth pattern and biofilm formation assays showed that AH and EGCG mixture had stronger inhibitory effect on S. pyogenes than they alone. RT-qPCR confirmed that the expression of hasA and luxS gene were inhibited by AH and EGCG mixture.ConclusionsAH and EGCG mixture can inhibit the planktonic cell growth, biofilm formation and some virulence genes expression of S. pyogenes, better than they alone. The combination of honey and green tea have the potential to treat pharyngitis as natural derivatives, avoiding drug resistance and double infection.
19 schema:genre article
20 schema:isAccessibleForFree true
21 schema:isPartOf N61bf2f4d381147b9aa2f076ea74df1ad
22 Nac4dea6b29d34863988ac23ab89ede71
23 sg:journal.1024253
24 schema:keywords Chinese medicine
25 ConclusionsAH
26 EGCG
27 FIC index
28 HasA
29 MIC
30 MIC of EGCG
31 RT-qPCR
32 S. pyogenes
33 Streptococcus pyogenes
34 aim
35 antibacterial therapy
36 artificial honey
37 assays
38 basis
39 biofilm formation
40 biofilm formation assays
41 cell growth
42 combination
43 combination of honey
44 derivatives
45 double infection
46 drug resistance
47 effect
48 effect of honey
49 expression
50 formation
51 formation assays
52 gene expression
53 genes
54 global human pathogen
55 green tea
56 growth
57 growth pattern
58 honey
59 human pathogens
60 important global human pathogen
61 important part
62 index
63 infection
64 inhibitory effect
65 lux genes
66 mechanism
67 medicine
68 mixture
69 natural derivatives
70 overall therapy
71 part
72 pathogens
73 patients
74 patterns
75 pharyngitis
76 planktonic cell growth
77 possible mechanism
78 potential
79 pyogenes
80 resistance
81 strong inhibitory effect
82 study
83 tea
84 theoretical basis
85 therapy
86 traditional Chinese medicine
87 virulence gene expression
88 wethers
89 schema:name Effects of artificial honey and epigallocatechin-3-gallate on streptococcus pyogenes
90 schema:pagination 207
91 schema:productId N088357eb805541729c6aaa9006d6e1be
92 N822d601caa0941838ffca0ec2fede7fc
93 Ncee0cbfb4da64f4dbbb1cefd436d74d4
94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1150535980
95 https://doi.org/10.1186/s12866-022-02611-0
96 schema:sdDatePublished 2022-12-01T06:44
97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
98 schema:sdPublisher N80967eb3a76848698b24bd7263e94085
99 schema:url https://doi.org/10.1186/s12866-022-02611-0
100 sgo:license sg:explorer/license/
101 sgo:sdDataset articles
102 rdf:type schema:ScholarlyArticle
103 N070ccfb6c90e4dfcb59ca0956d610d4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Tea
105 rdf:type schema:DefinedTerm
106 N088357eb805541729c6aaa9006d6e1be schema:name dimensions_id
107 schema:value pub.1150535980
108 rdf:type schema:PropertyValue
109 N15f280f3dbae4e8f9ec2963718bc912e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Biofilms
111 rdf:type schema:DefinedTerm
112 N1f1bd219e43e4a3c8e3746782e465343 rdf:first Nbafd7e9268e14ff2bdbc7a2a15cb84d4
113 rdf:rest N99c3841ae4bf4d6894f5a3862ce71db6
114 N215ecde5c2834894a1a89c33e475e228 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Humans
116 rdf:type schema:DefinedTerm
117 N2a7ab4ba11b94401a73757a5933cb9b9 rdf:first sg:person.0614452305.65
118 rdf:rest N3b6b164745424feebc0c8715da10c513
119 N2b547c1f6539470bbe29cda3d50b4681 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Streptococcus pyogenes
121 rdf:type schema:DefinedTerm
122 N3b6b164745424feebc0c8715da10c513 rdf:first sg:person.0675226724.96
123 rdf:rest N9544e9edcf3d4591a4fd3d2adafac01d
124 N47ee89df929940b283fc0425183dff62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Catechin
126 rdf:type schema:DefinedTerm
127 N61bf2f4d381147b9aa2f076ea74df1ad schema:issueNumber 1
128 rdf:type schema:PublicationIssue
129 N6b5ab3d72d9f4526983bb5b5f90b93ca schema:affiliation grid-institutes:grid.257413.6
130 schema:familyName Felix Gomez
131 schema:givenName Grace Gomez
132 rdf:type schema:Person
133 N72bbff7a5bf044998532f1ae5c5761cc rdf:first sg:person.016277402645.44
134 rdf:rest Na708f28d3acb4d7486dff02e5a0ea2c3
135 N72edf734aa7a4d7d8afee15ff889b65a rdf:first N6b5ab3d72d9f4526983bb5b5f90b93ca
136 rdf:rest N2a7ab4ba11b94401a73757a5933cb9b9
137 N80967eb3a76848698b24bd7263e94085 schema:name Springer Nature - SN SciGraph project
138 rdf:type schema:Organization
139 N822d601caa0941838ffca0ec2fede7fc schema:name pubmed_id
140 schema:value 36028794
141 rdf:type schema:PropertyValue
142 N8613e543c16e47199c467a4ff2f21ef9 rdf:first sg:person.012337574443.41
143 rdf:rest N72edf734aa7a4d7d8afee15ff889b65a
144 N8b933971771c4a239752fd8d84dd3cb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Animals
146 rdf:type schema:DefinedTerm
147 N9544e9edcf3d4591a4fd3d2adafac01d rdf:first sg:person.01151127324.35
148 rdf:rest Nd1bee071e6f34a92800a72554322cee6
149 N99c3841ae4bf4d6894f5a3862ce71db6 rdf:first sg:person.014275615557.30
150 rdf:rest N8613e543c16e47199c467a4ff2f21ef9
151 Na708f28d3acb4d7486dff02e5a0ea2c3 rdf:first Ncd88cc5f3c8a49aebf1499b70b815ecc
152 rdf:rest N1f1bd219e43e4a3c8e3746782e465343
153 Na88bf9b5a51c40c191272db0f2be6c97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Male
155 rdf:type schema:DefinedTerm
156 Nac4dea6b29d34863988ac23ab89ede71 schema:volumeNumber 22
157 rdf:type schema:PublicationVolume
158 Nb2867775adaf4e7c8cc96f07f6eafd4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Honey
160 rdf:type schema:DefinedTerm
161 Nbafd7e9268e14ff2bdbc7a2a15cb84d4 schema:affiliation grid-institutes:grid.13291.38
162 schema:familyName Li
163 schema:givenName Shijia
164 rdf:type schema:Person
165 Ncd88cc5f3c8a49aebf1499b70b815ecc schema:affiliation grid-institutes:grid.13291.38
166 schema:familyName Lin
167 schema:givenName An
168 rdf:type schema:Person
169 Ncee0cbfb4da64f4dbbb1cefd436d74d4 schema:name doi
170 schema:value 10.1186/s12866-022-02611-0
171 rdf:type schema:PropertyValue
172 Nd1bee071e6f34a92800a72554322cee6 rdf:first sg:person.014560716667.41
173 rdf:rest rdf:nil
174 Ned9205fd45fe47019c39652bd8a0c2dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Pharyngitis
176 rdf:type schema:DefinedTerm
177 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
178 schema:name Medical and Health Sciences
179 rdf:type schema:DefinedTerm
180 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
181 schema:name Medical Microbiology
182 rdf:type schema:DefinedTerm
183 sg:grant.8906998 http://pending.schema.org/fundedItem sg:pub.10.1186/s12866-022-02611-0
184 rdf:type schema:MonetaryGrant
185 sg:journal.1024253 schema:issn 1471-2180
186 schema:name BMC Microbiology
187 schema:publisher Springer Nature
188 rdf:type schema:Periodical
189 sg:person.01151127324.35 schema:affiliation grid-institutes:grid.13291.38
190 schema:familyName Chen
191 schema:givenName Song
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151127324.35
193 rdf:type schema:Person
194 sg:person.012337574443.41 schema:affiliation grid-institutes:grid.13291.38
195 schema:familyName Zhou
196 schema:givenName Fangjie
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012337574443.41
198 rdf:type schema:Person
199 sg:person.014275615557.30 schema:affiliation grid-institutes:grid.13291.38
200 schema:familyName Shi
201 schema:givenName Yangyang
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014275615557.30
203 rdf:type schema:Person
204 sg:person.014560716667.41 schema:affiliation grid-institutes:grid.257413.6
205 schema:familyName Huang
206 schema:givenName Ruijie
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014560716667.41
208 rdf:type schema:Person
209 sg:person.016277402645.44 schema:affiliation grid-institutes:grid.13291.38
210 schema:familyName Jiang
211 schema:givenName Xiaoge
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016277402645.44
213 rdf:type schema:Person
214 sg:person.0614452305.65 schema:affiliation grid-institutes:grid.257413.6
215 schema:familyName Gregory
216 schema:givenName Richard L.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614452305.65
218 rdf:type schema:Person
219 sg:person.0675226724.96 schema:affiliation grid-institutes:grid.13291.38
220 schema:familyName Zhang
221 schema:givenName Chaoliang
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675226724.96
223 rdf:type schema:Person
224 sg:pub.10.1007/s10096-009-0763-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1033394455
225 https://doi.org/10.1007/s10096-009-0763-z
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/sj.onc.1210840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025301290
228 https://doi.org/10.1038/sj.onc.1210840
229 rdf:type schema:CreativeWork
230 sg:pub.10.1186/1471-2466-12-70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045371213
231 https://doi.org/10.1186/1471-2466-12-70
232 rdf:type schema:CreativeWork
233 grid-institutes:grid.13291.38 schema:alternateName Department of Endodontic Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China
234 Department of Orthodontics Dentistry, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China
235 Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China
236 State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China
237 schema:name Department of Endodontic Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China
238 Department of Orthodontics Dentistry, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China
239 Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China
240 State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China
241 rdf:type schema:Organization
242 grid-institutes:grid.257413.6 schema:alternateName Department of Oral Biology, School of Dentistry, Indiana University, Indianapolis, USA
243 schema:name Department of Oral Biology, School of Dentistry, Indiana University, Indianapolis, USA
244 Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China
245 State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China
246 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...