Severe fever with thrombocytopenia syndrome virus replicates in brain tissues and damages neurons in newborn mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-08-20

AUTHORS

Rui Chen, Qiang Li, Hongmei Chen, Hongguang Yang, Xuemin Wei, Mengting Chen, Hongling Wen

ABSTRACT

Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-borne phlebovirus with a high fatality rate of 12–30%, which has an expanding endemic and caused thousands of infections every year. Central nervous system (CNS) manifestations are an important risk factor of SFTS outcome death. Further understanding of the process of how SFTSV invades the brain is critical for developing effective anti-SFTS encephalitis therapeutics. We obeserved changes of viral load in the brain at different time points after intraperitoneal infection of SFTSV in newborn C57/BL6 mice. The virus invaded the brain at 3 h post-infection (hpi). Notably, the viral load increased exponentially after 24 hpi. In addition, it was found that in addition to macrophages, SFTSV infected neurons and replicated in the brain. These findings provide insights into the CNS manifestations of severe SFTS, which may lead to drug development and encephalitis therapeutics. More... »

PAGES

204

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12866-022-02609-8

DOI

http://dx.doi.org/10.1186/s12866-022-02609-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1150382232

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35987890


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