Comparative genotyping and phenotyping of Aspergillus fumigatus isolates from humans, dogs and the environment View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Ivan D. Valdes, Joris van den Berg, Annika Haagsman, Natalia Escobar, Jacques F. Meis, Ferry Hagen, Pieter Jan Haas, Jos Houbraken, Han A. B. Wösten, Hans de Cock

ABSTRACT

BACKGROUND: Aspergillus fumigatus is a ubiquitous saprotrophic fungus and an opportunistic pathogen of humans and animals. Humans and animals can inhale hundreds of A. fumigatus spores daily. Normally this is harmless for humans, but in case of immunodeficiency, invasive pulmonary aspergillosis (IPA) can develop with a high mortality rate. A. fumigatus also causes non-invasive mycoses like sino-nasal aspergillosis (SNA) in dogs. RESULTS: In this study we compared A. fumigatus isolates from humans with suspected IPA, dogs with SNA, and a set of environmental isolates. Phylogenetic inference based on calmodulin (CaM) and beta-tubulin (benA) sequences did not reveal A. fumigatus sub-groups linked to the origin of the isolates. Genotyping and microsatellite analysis showed that each dog was infected by one A. fumigatus genotype, whereas human patients had mixed infections. Azole resistance was determined by antifungal susceptibility testing and sequencing of the cyp51A gene. A total of 12 out of 29 human isolates and 1 out of 27 environmental isolates were azole resistant. Of the azole resistant strains, 11 human isolates showed TR34/L98H (n = 6) or TR46/Y121F/T289A (n = 5). Phenotypically, isolates from dogs were more variable in growth speed and morphology when compared to those isolated from human and the environment. CONCLUSIONS: 1. A. fumigatus from dogs with SNA are phenotypically very diverse in contrast to their environmental and human counterparts. 2. Phenotypic variability can be induced during the chronic infection process in the sinus of the dogs. The basis of this heterogeneity might be due to genomic differences and/or epigenetic variations. 3. Differences in dogs is a could be a result of within-host adaption and might be triggered by environmental factors in the sinus, however this hypothesis still needs to be tested. More... »

PAGES

118

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12866-018-1244-2

DOI

http://dx.doi.org/10.1186/s12866-018-1244-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107066651

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30223790


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Utrecht University", 
          "id": "https://www.grid.ac/institutes/grid.5477.1", 
          "name": [
            "Microbiology, Department of Biology, Utrecht University, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Valdes", 
        "givenName": "Ivan D.", 
        "id": "sg:person.010002220704.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010002220704.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Utrecht University", 
          "id": "https://www.grid.ac/institutes/grid.5477.1", 
          "name": [
            "Microbiology, Department of Biology, Utrecht University, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van den Berg", 
        "givenName": "Joris", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Utrecht University", 
          "id": "https://www.grid.ac/institutes/grid.5477.1", 
          "name": [
            "Veterinary Medicine, Utrecht University, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haagsman", 
        "givenName": "Annika", 
        "id": "sg:person.0747710273.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747710273.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Utrecht University", 
          "id": "https://www.grid.ac/institutes/grid.5477.1", 
          "name": [
            "Microbiology, Department of Biology, Utrecht University, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Escobar", 
        "givenName": "Natalia", 
        "id": "sg:person.01152150371.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152150371.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Canisius-Wilhelmina Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.413327.0", 
          "name": [
            "Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands", 
            "Centre of Expertise in Mycology Radboudumc/CWZ, Nijmegen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meis", 
        "givenName": "Jacques F.", 
        "id": "sg:person.0710122137.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710122137.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Westerdijk Fungal Biodiversity Institute", 
          "id": "https://www.grid.ac/institutes/grid.418704.e", 
          "name": [
            "Westerdijk Institute, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hagen", 
        "givenName": "Ferry", 
        "id": "sg:person.0756407145.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756407145.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Utrecht", 
          "id": "https://www.grid.ac/institutes/grid.7692.a", 
          "name": [
            "University Medical Center Utrecht, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haas", 
        "givenName": "Pieter Jan", 
        "id": "sg:person.0667623242.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667623242.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Westerdijk Fungal Biodiversity Institute", 
          "id": "https://www.grid.ac/institutes/grid.418704.e", 
          "name": [
            "Westerdijk Institute, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Houbraken", 
        "givenName": "Jos", 
        "id": "sg:person.01114530330.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114530330.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Utrecht University", 
          "id": "https://www.grid.ac/institutes/grid.5477.1", 
          "name": [
            "Microbiology, Department of Biology, Utrecht University, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "W\u00f6sten", 
        "givenName": "Han A. B.", 
        "id": "sg:person.015070275637.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015070275637.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Utrecht University", 
          "id": "https://www.grid.ac/institutes/grid.5477.1", 
          "name": [
            "Microbiology, Department of Biology, Utrecht University, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Cock", 
        "givenName": "Hans", 
        "id": "sg:person.0630175362.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630175362.46"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1128/cmr.00014-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000145306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0732-8893(99)00026-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000515803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1748-5827.2012.01245.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001957690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.48.7.2747-2750.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002674779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0010080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005434414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vetmic.2005.11.065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005823211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2222.1984.tb02215.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006104254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006596531", 
          "https://doi.org/10.1038/nature04332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006596531", 
          "https://doi.org/10.1038/nature04332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006596531", 
          "https://doi.org/10.1038/nature04332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/myc.12440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010090156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.01092-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010879476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2180-7-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012045377", 
          "https://doi.org/10.1186/1471-2180-7-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1003743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013009192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/civ885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013086270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.47.3.1120-1124.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016835036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017306751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/myc.12047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019561578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmi.2016.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020459082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3852/mycologia.97.6.1316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020889012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.43.8.4112-4120.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022041685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dku364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023027258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0064871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023174844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/mmy/myw005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023581403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-294x.2004.02209.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023611179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2222.1976.tb01899.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023781388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcpa.2004.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025202781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.0050219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025922691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.simyco.2014.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027191620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/cit320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034724653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035817137", 
          "https://doi.org/10.1038/nmeth.2089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mbio.00536-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038257304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rstb.2015.0460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039784265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.02423-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040709991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.02636-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041738435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7717/peerj.281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042956549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkv177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043369728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molbev/msw046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043817932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/fmb.11.4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044326844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkn402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045311381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2010.08283.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046618694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2010.08283.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046618694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atmosenv.2008.01.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049423324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-294x.2011.05364.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049506277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(16)30138-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052706359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cvsm.2007.05.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053194398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/02681219480000701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058311552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/13693780400005866", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058387515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/13693780802056038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058388010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/cmr.12.2.310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074354971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02974381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078642890", 
          "https://doi.org/10.1007/bf02974381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082406285", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082491007", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15572536.2006.11832738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084167855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jix210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085312205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jix210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085312205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/1462-2920.14055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100779900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fgb.2018.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101175780"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Aspergillus fumigatus is a ubiquitous saprotrophic fungus and an opportunistic pathogen of humans and animals. Humans and animals can inhale hundreds of A. fumigatus spores daily. Normally this is harmless for humans, but in case of immunodeficiency, invasive pulmonary aspergillosis (IPA) can develop with a high mortality rate. A. fumigatus also causes non-invasive mycoses like sino-nasal aspergillosis (SNA) in dogs.\nRESULTS: In this study we compared A. fumigatus isolates from humans with suspected IPA, dogs with SNA, and a set of environmental isolates. Phylogenetic inference based on calmodulin (CaM) and beta-tubulin (benA) sequences did not reveal A. fumigatus sub-groups linked to the origin of the isolates. Genotyping and microsatellite analysis showed that each dog was infected by one A. fumigatus genotype, whereas human patients had mixed infections. Azole resistance was determined by antifungal susceptibility testing and sequencing of the cyp51A gene. A total of 12 out of 29 human isolates and 1 out of 27 environmental isolates were azole resistant. Of the azole resistant strains, 11 human isolates showed TR34/L98H (n\u2009=\u20096) or TR46/Y121F/T289A (n\u2009=\u20095). Phenotypically, isolates from dogs were more variable in growth speed and morphology when compared to those isolated from human and the environment.\nCONCLUSIONS: 1. A. fumigatus from dogs with SNA are phenotypically very diverse in contrast to their environmental and human counterparts. 2. Phenotypic variability can be induced during the chronic infection process in the sinus of the dogs. The basis of this heterogeneity might be due to genomic differences and/or epigenetic variations. 3. Differences in dogs is a could be a result of within-host adaption and might be triggered by environmental factors in the sinus, however this hypothesis still needs to be tested.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12866-018-1244-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024253", 
        "issn": [
          "1471-2180"
        ], 
        "name": "BMC Microbiology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Comparative genotyping and phenotyping of Aspergillus fumigatus isolates from humans, dogs and the environment", 
    "pagination": "118", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "165d28e7f87d32c8f8ea70ab95e15594d31f2830e720bb0d6c48a353a0a06393"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30223790"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100966981"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12866-018-1244-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1107066651"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12866-018-1244-2", 
      "https://app.dimensions.ai/details/publication/pub.1107066651"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000535.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs12866-018-1244-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12866-018-1244-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12866-018-1244-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12866-018-1244-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12866-018-1244-2'


 

This table displays all metadata directly associated to this object as RDF triples.

305 TRIPLES      21 PREDICATES      83 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12866-018-1244-2 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author Nd13fda7417a44b3fb2da03264a75a0f4
4 schema:citation sg:pub.10.1007/bf02974381
5 sg:pub.10.1038/nature04332
6 sg:pub.10.1038/nmeth.2089
7 sg:pub.10.1186/1471-2180-7-5
8 https://app.dimensions.ai/details/publication/pub.1082406285
9 https://app.dimensions.ai/details/publication/pub.1082491007
10 https://doi.org/10.1016/j.atmosenv.2008.01.009
11 https://doi.org/10.1016/j.cmi.2016.04.001
12 https://doi.org/10.1016/j.cvsm.2007.05.005
13 https://doi.org/10.1016/j.fgb.2018.02.003
14 https://doi.org/10.1016/j.jcpa.2004.11.002
15 https://doi.org/10.1016/j.simyco.2014.07.004
16 https://doi.org/10.1016/j.vetmic.2005.11.065
17 https://doi.org/10.1016/s0732-8893(99)00026-7
18 https://doi.org/10.1016/s1473-3099(16)30138-4
19 https://doi.org/10.1080/02681219480000701
20 https://doi.org/10.1080/13693780400005866
21 https://doi.org/10.1080/13693780802056038
22 https://doi.org/10.1080/15572536.2006.11832738
23 https://doi.org/10.1093/cid/cit320
24 https://doi.org/10.1093/cid/civ885
25 https://doi.org/10.1093/infdis/jix210
26 https://doi.org/10.1093/jac/dkn402
27 https://doi.org/10.1093/jac/dku364
28 https://doi.org/10.1093/jac/dkv177
29 https://doi.org/10.1093/mmy/myw005
30 https://doi.org/10.1093/molbev/msw046
31 https://doi.org/10.1098/rstb.2015.0460
32 https://doi.org/10.1111/1462-2920.14055
33 https://doi.org/10.1111/j.1365-2141.2010.08283.x
34 https://doi.org/10.1111/j.1365-2222.1976.tb01899.x
35 https://doi.org/10.1111/j.1365-2222.1984.tb02215.x
36 https://doi.org/10.1111/j.1365-294x.2004.02209.x
37 https://doi.org/10.1111/j.1365-294x.2011.05364.x
38 https://doi.org/10.1111/j.1748-5827.2012.01245.x
39 https://doi.org/10.1111/myc.12047
40 https://doi.org/10.1111/myc.12440
41 https://doi.org/10.1128/aac.01092-06
42 https://doi.org/10.1128/aac.47.3.1120-1124.2003
43 https://doi.org/10.1128/aac.48.7.2747-2750.2004
44 https://doi.org/10.1128/cmr.00014-09
45 https://doi.org/10.1128/cmr.12.2.310
46 https://doi.org/10.1128/jcm.02423-06
47 https://doi.org/10.1128/jcm.02636-14
48 https://doi.org/10.1128/jcm.43.8.4112-4120.2005
49 https://doi.org/10.1128/mbio.00536-15
50 https://doi.org/10.1371/journal.pgen.1000046
51 https://doi.org/10.1371/journal.pmed.0050219
52 https://doi.org/10.1371/journal.pone.0010080
53 https://doi.org/10.1371/journal.pone.0064871
54 https://doi.org/10.1371/journal.ppat.1003743
55 https://doi.org/10.2217/fmb.11.4
56 https://doi.org/10.3852/mycologia.97.6.1316
57 https://doi.org/10.7717/peerj.281
58 schema:datePublished 2018-12
59 schema:datePublishedReg 2018-12-01
60 schema:description BACKGROUND: Aspergillus fumigatus is a ubiquitous saprotrophic fungus and an opportunistic pathogen of humans and animals. Humans and animals can inhale hundreds of A. fumigatus spores daily. Normally this is harmless for humans, but in case of immunodeficiency, invasive pulmonary aspergillosis (IPA) can develop with a high mortality rate. A. fumigatus also causes non-invasive mycoses like sino-nasal aspergillosis (SNA) in dogs. RESULTS: In this study we compared A. fumigatus isolates from humans with suspected IPA, dogs with SNA, and a set of environmental isolates. Phylogenetic inference based on calmodulin (CaM) and beta-tubulin (benA) sequences did not reveal A. fumigatus sub-groups linked to the origin of the isolates. Genotyping and microsatellite analysis showed that each dog was infected by one A. fumigatus genotype, whereas human patients had mixed infections. Azole resistance was determined by antifungal susceptibility testing and sequencing of the cyp51A gene. A total of 12 out of 29 human isolates and 1 out of 27 environmental isolates were azole resistant. Of the azole resistant strains, 11 human isolates showed TR34/L98H (n = 6) or TR46/Y121F/T289A (n = 5). Phenotypically, isolates from dogs were more variable in growth speed and morphology when compared to those isolated from human and the environment. CONCLUSIONS: 1. A. fumigatus from dogs with SNA are phenotypically very diverse in contrast to their environmental and human counterparts. 2. Phenotypic variability can be induced during the chronic infection process in the sinus of the dogs. The basis of this heterogeneity might be due to genomic differences and/or epigenetic variations. 3. Differences in dogs is a could be a result of within-host adaption and might be triggered by environmental factors in the sinus, however this hypothesis still needs to be tested.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf N34402127f7a247c9a44f50012b274e36
65 N76fa672c641a416a891a04bd79fcd42e
66 sg:journal.1024253
67 schema:name Comparative genotyping and phenotyping of Aspergillus fumigatus isolates from humans, dogs and the environment
68 schema:pagination 118
69 schema:productId N0e5c1b30d8114cb3b6ecd5448def9179
70 N197e30a7705441b69973141575b8a8b7
71 N6b97f93b6b6a49d1af607f0634a994f0
72 N7849d598738f449a822470d5539d6681
73 Nbf07337fcacc47af86449f0ae35a4feb
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107066651
75 https://doi.org/10.1186/s12866-018-1244-2
76 schema:sdDatePublished 2019-04-10T22:37
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher N1293eafe54c94c79958f568959ca0400
79 schema:url http://link.springer.com/10.1186%2Fs12866-018-1244-2
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N0c8ff6bd79044e8e9a6155d12b39b6c3 rdf:first sg:person.0710122137.54
84 rdf:rest N37da6f797075473d973193a09416cb65
85 N0e5c1b30d8114cb3b6ecd5448def9179 schema:name nlm_unique_id
86 schema:value 100966981
87 rdf:type schema:PropertyValue
88 N1293eafe54c94c79958f568959ca0400 schema:name Springer Nature - SN SciGraph project
89 rdf:type schema:Organization
90 N197e30a7705441b69973141575b8a8b7 schema:name dimensions_id
91 schema:value pub.1107066651
92 rdf:type schema:PropertyValue
93 N20cba066108e42adabbc7fd8ba28aa95 schema:affiliation https://www.grid.ac/institutes/grid.5477.1
94 schema:familyName van den Berg
95 schema:givenName Joris
96 rdf:type schema:Person
97 N310b70144f25442e976c18f6c48da1e7 rdf:first sg:person.01152150371.21
98 rdf:rest N0c8ff6bd79044e8e9a6155d12b39b6c3
99 N32319e599a5a4bb59f34eeaae61c47b7 rdf:first sg:person.015070275637.88
100 rdf:rest Ne25a7cab3f9748b383fdc6eae2db205c
101 N333c8d3a96a54e3791e38a7c15b0643c rdf:first sg:person.01114530330.50
102 rdf:rest N32319e599a5a4bb59f34eeaae61c47b7
103 N34402127f7a247c9a44f50012b274e36 schema:volumeNumber 18
104 rdf:type schema:PublicationVolume
105 N37da6f797075473d973193a09416cb65 rdf:first sg:person.0756407145.33
106 rdf:rest Nf673492264b744fb8b9a51a2f006f751
107 N6b97f93b6b6a49d1af607f0634a994f0 schema:name doi
108 schema:value 10.1186/s12866-018-1244-2
109 rdf:type schema:PropertyValue
110 N76fa672c641a416a891a04bd79fcd42e schema:issueNumber 1
111 rdf:type schema:PublicationIssue
112 N7849d598738f449a822470d5539d6681 schema:name pubmed_id
113 schema:value 30223790
114 rdf:type schema:PropertyValue
115 Na3d018a3e99a4c57a4ee4511dd2967ec rdf:first N20cba066108e42adabbc7fd8ba28aa95
116 rdf:rest Nacc7d868bc044195a4f1b0805266f5bf
117 Nacc7d868bc044195a4f1b0805266f5bf rdf:first sg:person.0747710273.15
118 rdf:rest N310b70144f25442e976c18f6c48da1e7
119 Nbf07337fcacc47af86449f0ae35a4feb schema:name readcube_id
120 schema:value 165d28e7f87d32c8f8ea70ab95e15594d31f2830e720bb0d6c48a353a0a06393
121 rdf:type schema:PropertyValue
122 Nd13fda7417a44b3fb2da03264a75a0f4 rdf:first sg:person.010002220704.31
123 rdf:rest Na3d018a3e99a4c57a4ee4511dd2967ec
124 Ne25a7cab3f9748b383fdc6eae2db205c rdf:first sg:person.0630175362.46
125 rdf:rest rdf:nil
126 Nf673492264b744fb8b9a51a2f006f751 rdf:first sg:person.0667623242.19
127 rdf:rest N333c8d3a96a54e3791e38a7c15b0643c
128 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
129 schema:name Biological Sciences
130 rdf:type schema:DefinedTerm
131 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
132 schema:name Genetics
133 rdf:type schema:DefinedTerm
134 sg:journal.1024253 schema:issn 1471-2180
135 schema:name BMC Microbiology
136 rdf:type schema:Periodical
137 sg:person.010002220704.31 schema:affiliation https://www.grid.ac/institutes/grid.5477.1
138 schema:familyName Valdes
139 schema:givenName Ivan D.
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010002220704.31
141 rdf:type schema:Person
142 sg:person.01114530330.50 schema:affiliation https://www.grid.ac/institutes/grid.418704.e
143 schema:familyName Houbraken
144 schema:givenName Jos
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114530330.50
146 rdf:type schema:Person
147 sg:person.01152150371.21 schema:affiliation https://www.grid.ac/institutes/grid.5477.1
148 schema:familyName Escobar
149 schema:givenName Natalia
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152150371.21
151 rdf:type schema:Person
152 sg:person.015070275637.88 schema:affiliation https://www.grid.ac/institutes/grid.5477.1
153 schema:familyName Wösten
154 schema:givenName Han A. B.
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015070275637.88
156 rdf:type schema:Person
157 sg:person.0630175362.46 schema:affiliation https://www.grid.ac/institutes/grid.5477.1
158 schema:familyName de Cock
159 schema:givenName Hans
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630175362.46
161 rdf:type schema:Person
162 sg:person.0667623242.19 schema:affiliation https://www.grid.ac/institutes/grid.7692.a
163 schema:familyName Haas
164 schema:givenName Pieter Jan
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667623242.19
166 rdf:type schema:Person
167 sg:person.0710122137.54 schema:affiliation https://www.grid.ac/institutes/grid.413327.0
168 schema:familyName Meis
169 schema:givenName Jacques F.
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710122137.54
171 rdf:type schema:Person
172 sg:person.0747710273.15 schema:affiliation https://www.grid.ac/institutes/grid.5477.1
173 schema:familyName Haagsman
174 schema:givenName Annika
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747710273.15
176 rdf:type schema:Person
177 sg:person.0756407145.33 schema:affiliation https://www.grid.ac/institutes/grid.418704.e
178 schema:familyName Hagen
179 schema:givenName Ferry
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756407145.33
181 rdf:type schema:Person
182 sg:pub.10.1007/bf02974381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078642890
183 https://doi.org/10.1007/bf02974381
184 rdf:type schema:CreativeWork
185 sg:pub.10.1038/nature04332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006596531
186 https://doi.org/10.1038/nature04332
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/nmeth.2089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035817137
189 https://doi.org/10.1038/nmeth.2089
190 rdf:type schema:CreativeWork
191 sg:pub.10.1186/1471-2180-7-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012045377
192 https://doi.org/10.1186/1471-2180-7-5
193 rdf:type schema:CreativeWork
194 https://app.dimensions.ai/details/publication/pub.1082406285 schema:CreativeWork
195 https://app.dimensions.ai/details/publication/pub.1082491007 schema:CreativeWork
196 https://doi.org/10.1016/j.atmosenv.2008.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049423324
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.cmi.2016.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020459082
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.cvsm.2007.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053194398
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.fgb.2018.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101175780
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.jcpa.2004.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025202781
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.simyco.2014.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027191620
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.vetmic.2005.11.065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005823211
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/s0732-8893(99)00026-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000515803
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/s1473-3099(16)30138-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052706359
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1080/02681219480000701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058311552
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1080/13693780400005866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058387515
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1080/13693780802056038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058388010
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1080/15572536.2006.11832738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084167855
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1093/cid/cit320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034724653
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1093/cid/civ885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013086270
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1093/infdis/jix210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085312205
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1093/jac/dkn402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045311381
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1093/jac/dku364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023027258
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1093/jac/dkv177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043369728
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1093/mmy/myw005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023581403
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1093/molbev/msw046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043817932
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1098/rstb.2015.0460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039784265
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1111/1462-2920.14055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100779900
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1111/j.1365-2141.2010.08283.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046618694
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1111/j.1365-2222.1976.tb01899.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023781388
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1111/j.1365-2222.1984.tb02215.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006104254
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1111/j.1365-294x.2004.02209.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023611179
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1111/j.1365-294x.2011.05364.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049506277
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1111/j.1748-5827.2012.01245.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001957690
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1111/myc.12047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019561578
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1111/myc.12440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010090156
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1128/aac.01092-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010879476
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1128/aac.47.3.1120-1124.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016835036
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1128/aac.48.7.2747-2750.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002674779
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1128/cmr.00014-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000145306
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1128/cmr.12.2.310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074354971
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1128/jcm.02423-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040709991
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1128/jcm.02636-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041738435
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1128/jcm.43.8.4112-4120.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022041685
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1128/mbio.00536-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038257304
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1371/journal.pgen.1000046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017306751
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1371/journal.pmed.0050219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025922691
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1371/journal.pone.0010080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005434414
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1371/journal.pone.0064871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023174844
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1371/journal.ppat.1003743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013009192
285 rdf:type schema:CreativeWork
286 https://doi.org/10.2217/fmb.11.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044326844
287 rdf:type schema:CreativeWork
288 https://doi.org/10.3852/mycologia.97.6.1316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020889012
289 rdf:type schema:CreativeWork
290 https://doi.org/10.7717/peerj.281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042956549
291 rdf:type schema:CreativeWork
292 https://www.grid.ac/institutes/grid.413327.0 schema:alternateName Canisius-Wilhelmina Ziekenhuis
293 schema:name Centre of Expertise in Mycology Radboudumc/CWZ, Nijmegen, The Netherlands
294 Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands
295 rdf:type schema:Organization
296 https://www.grid.ac/institutes/grid.418704.e schema:alternateName Westerdijk Fungal Biodiversity Institute
297 schema:name Westerdijk Institute, Utrecht, The Netherlands
298 rdf:type schema:Organization
299 https://www.grid.ac/institutes/grid.5477.1 schema:alternateName Utrecht University
300 schema:name Microbiology, Department of Biology, Utrecht University, Utrecht, The Netherlands
301 Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
302 rdf:type schema:Organization
303 https://www.grid.ac/institutes/grid.7692.a schema:alternateName University Medical Center Utrecht
304 schema:name University Medical Center Utrecht, Utrecht, The Netherlands
305 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...