The altered gut microbiota in adults with cystic fibrosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-03-09

AUTHORS

D.G. Burke, F. Fouhy, M. J. Harrison, M. C. Rea, P. D. Cotter, O. O’Sullivan, C. Stanton, C. Hill, F. Shanahan, B. J. Plant, R. P. Ross

ABSTRACT

BACKGROUND: Cystic Fibrosis (CF) is an autosomal recessive disease that affects the function of a number of organs, principally the lungs, but also the gastrointestinal tract. The manifestations of cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction in the gastrointestinal tract, as well as frequent antibiotic exposure, undoubtedly disrupts the gut microbiota. To analyse the effects of CF and its management on the microbiome, we compared the gut microbiota of 43 individuals with CF during a period of stability, to that of 69 non-CF controls using 454-pyrosequencing of the 16S rRNA gene. The impact of clinical parameters, including antibiotic therapy, on the results was also assessed. RESULTS: The CF-associated microbiome had reduced microbial diversity, an increase in Firmicutes and a reduction in Bacteroidetes compared to the non-CF controls. While the greatest number of differences in taxonomic abundances of the intestinal microbiota was observed between individuals with CF and the healthy controls, gut microbiota differences were also reported between people with CF when grouped by clinical parameters including % predicted FEV1 (measure of lung dysfunction) and the number of intravenous (IV) antibiotic courses in the previous 12 months. Notably, CF individuals presenting with severe lung dysfunction (% predicted FEV1 ≤ 40%) had significantly (p < 0.05) reduced gut microbiota diversity relative to those presenting with mild or moderate dysfunction. A significant negative correlation (-0.383, Simpson's Diversity Index) was also observed between the number of IV antibiotic courses and gut microbiota diversity. CONCLUSIONS: This is one of the largest single-centre studies on gut microbiota in stable adults with CF and demonstrates the significantly altered gut microbiota, including reduced microbial diversity seen in CF patients compared to healthy controls. The data show the impact that CF and it's management have on gut microbiota, presenting the opportunity to develop CF specific probiotics to minimise microbiota alterations. More... »

PAGES

58

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12866-017-0968-8

DOI

http://dx.doi.org/10.1186/s12866-017-0968-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084250140

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28279152


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38 schema:description BACKGROUND: Cystic Fibrosis (CF) is an autosomal recessive disease that affects the function of a number of organs, principally the lungs, but also the gastrointestinal tract. The manifestations of cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction in the gastrointestinal tract, as well as frequent antibiotic exposure, undoubtedly disrupts the gut microbiota. To analyse the effects of CF and its management on the microbiome, we compared the gut microbiota of 43 individuals with CF during a period of stability, to that of 69 non-CF controls using 454-pyrosequencing of the 16S rRNA gene. The impact of clinical parameters, including antibiotic therapy, on the results was also assessed. RESULTS: The CF-associated microbiome had reduced microbial diversity, an increase in Firmicutes and a reduction in Bacteroidetes compared to the non-CF controls. While the greatest number of differences in taxonomic abundances of the intestinal microbiota was observed between individuals with CF and the healthy controls, gut microbiota differences were also reported between people with CF when grouped by clinical parameters including % predicted FEV<sub>1</sub> (measure of lung dysfunction) and the number of intravenous (IV) antibiotic courses in the previous 12 months. Notably, CF individuals presenting with severe lung dysfunction (% predicted FEV<sub>1</sub> ≤ 40%) had significantly (p &lt; 0.05) reduced gut microbiota diversity relative to those presenting with mild or moderate dysfunction. A significant negative correlation (-0.383, Simpson's Diversity Index) was also observed between the number of IV antibiotic courses and gut microbiota diversity. CONCLUSIONS: This is one of the largest single-centre studies on gut microbiota in stable adults with CF and demonstrates the significantly altered gut microbiota, including reduced microbial diversity seen in CF patients compared to healthy controls. The data show the impact that CF and it's management have on gut microbiota, presenting the opportunity to develop CF specific probiotics to minimise microbiota alterations.
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46 CF individuals
47 CF patients
48 CF specific probiotics
49 CF-associated microbiome
50 FEV
51 Firmicutes
52 abundance
53 adults
54 alterations
55 altered gut microbiota
56 antibiotic courses
57 antibiotic exposure
58 antibiotic therapy
59 autosomal recessive disease
60 clinical parameters
61 conductance regulator (CFTR) dysfunction
62 control
63 correlation
64 course
65 cystic fibrosis
66 cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction
67 data
68 differences
69 disease
70 diversity
71 dysfunction
72 effect
73 effects of CF
74 exposure
75 fibrosis
76 fibrosis transmembrane conductance regulator (CFTR) dysfunction
77 frequent antibiotic exposure
78 function
79 gastrointestinal tract
80 genes
81 greater number
82 gut microbiota
83 gut microbiota differences
84 gut microbiota diversity
85 healthy controls
86 impact
87 increase
88 individuals
89 intestinal microbiota
90 intravenous antibiotic courses
91 large single-center study
92 lung
93 lung dysfunction
94 management
95 manifestations
96 microbial diversity
97 microbiome
98 microbiota
99 microbiota alterations
100 microbiota differences
101 microbiota diversity
102 moderate dysfunction
103 months
104 negative correlation
105 non-CF controls
106 number
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108 opportunities
109 organs
110 parameters
111 patients
112 people
113 period
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115 probiotics
116 rRNA gene
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120 results
121 severe lung dysfunction
122 significant negative correlation
123 single-center study
124 specific probiotics
125 stability
126 stable adults
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128 taxonomic abundance
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