Increased levels of interleukin 31 (IL-31) in osteoporosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Lia Ginaldi, Massimo De Martinis, Fedra Ciccarelli, Salvatore Saitta, Selene Imbesi, Carmen Mannucci, Sebastiano Gangemi

ABSTRACT

BACKGROUND: Several inflammatory cytokines play a key part in the induction of osteoporosis. Until now, involvement of the Th2 cytokine interleukin-31 (IL-31) in osteoporosis hadn't yet been studied. IL-31 is a proinflammatory cytokine mediating multiple immune functions, whose involvement in a wide range of diseases, such as atopic dermatitis, inflammatory bowel diseases and cutaneous lymphomas, is now emerging. Given the important role of IL-31 in inflammation, we measured its serum levels in postmenopausal osteoporotic patients. METHODS AND RESULTS: In fifty-six postmenopausal females with osteoporosis and 26 healthy controls, bone mineral density (BMD) measurements were performed by using calcaneal quantitative ultrasound (QUS) technique, confirmed at the lumbar spine and hip by dual energy X-ray absorptiometry (DXA). Both patients and controls were divided according to age (less or more than 65 years) and disease severity (T-score levels and presence of fractures). Serum IL-31 levels were measured by ELISA technique. Osteoporotic patients exhibited elevated levels of serum IL-31 compared with healthy controls (43.12 ± 6.97 vs 29.58 ± 6.09 pg/ml; p < 0.049). IL-31 expression was higher in over 65 years old patients compared to age-matched controls (45 ± 11.05 vs. 17.92 ± 5.92; p < 0.01), whereas in younger subjects no statistically significant differences were detected between patients and controls (37.91 ± 6.9 vs 32.08 ± 8.2). No statistically significant differences were found between IL-31 levels in patients affected by mild (T-score > -3) compared to severe (T-score < -3) osteoporosis (59.17 ± 9.22 vs 37.91 ± 10.52), neither between fractured and unfractured osteoporotic women (33.75 ± 9.16 vs 51.25 ± 8.9). CONCLUSIONS: We showed for the first time an increase of IL-31 serum levels in postmenopausal women with decreased BMD. Although they did not reflect the severity of osteoporosis and/or the presence of fractures, they clearly correlated with age, as reflected by the higher levels of this cytokine in aged patients. More... »

PAGES

60

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12865-015-0125-9

DOI

http://dx.doi.org/10.1186/s12865-015-0125-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022116232

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26449657


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteoporosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteoporotic Fractures", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of L'Aquila", 
          "id": "https://www.grid.ac/institutes/grid.158820.6", 
          "name": [
            "Department of Life, Health, & Environmental Sciences, University of L\u2019Aquila, L\u2019Aquila, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ginaldi", 
        "givenName": "Lia", 
        "id": "sg:person.01153372214.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153372214.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of L'Aquila", 
          "id": "https://www.grid.ac/institutes/grid.158820.6", 
          "name": [
            "Department of Life, Health, & Environmental Sciences, University of L\u2019Aquila, L\u2019Aquila, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Martinis", 
        "givenName": "Massimo", 
        "id": "sg:person.01226255524.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226255524.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of L'Aquila", 
          "id": "https://www.grid.ac/institutes/grid.158820.6", 
          "name": [
            "Department of Life, Health, & Environmental Sciences, University of L\u2019Aquila, L\u2019Aquila, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ciccarelli", 
        "givenName": "Fedra", 
        "id": "sg:person.01274121520.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274121520.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Messina", 
          "id": "https://www.grid.ac/institutes/grid.10438.3e", 
          "name": [
            "Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saitta", 
        "givenName": "Salvatore", 
        "id": "sg:person.01146316342.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146316342.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Messina", 
          "id": "https://www.grid.ac/institutes/grid.10438.3e", 
          "name": [
            "Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Imbesi", 
        "givenName": "Selene", 
        "id": "sg:person.01206536226.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206536226.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Messina", 
          "id": "https://www.grid.ac/institutes/grid.10438.3e", 
          "name": [
            "Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mannucci", 
        "givenName": "Carmen", 
        "id": "sg:person.01100017107.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100017107.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Messina", 
          "id": "https://www.grid.ac/institutes/grid.10438.3e", 
          "name": [
            "Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gangemi", 
        "givenName": "Sebastiano", 
        "id": "sg:person.01124243150.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124243150.17"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jaci.2013.10.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000719675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08820139.2013.822764", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004834247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cytogfr.2014.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006730686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1398-9995.2009.02255.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008081021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1398-9995.2009.02255.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008081021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(02)08761-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008292619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mehy.2010.09.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008496290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000342426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009402052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2006.07.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009851648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11926-012-0253-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013100695", 
          "https://doi.org/10.1007/s11926-012-0253-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20061791", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015992506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/039463201002300304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018839944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/039463201002300304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018839944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11914-014-0195-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018907526", 
          "https://doi.org/10.1007/s11914-014-0195-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-09-179416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019187569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11914-009-0023-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019320651", 
          "https://doi.org/10.1007/s11914-009-0023-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11914-009-0023-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019320651", 
          "https://doi.org/10.1007/s11914-009-0023-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11914-009-0023-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019320651", 
          "https://doi.org/10.1007/s11914-009-0023-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.2010.086595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020025101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m201140200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020099613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000289202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020244237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2005.10.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022840169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4158/ep.12.4.436", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024320636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2006.07.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024523229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m609655200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028945052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2013.03.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030304745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00011-006-6034-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030404192", 
          "https://doi.org/10.1007/s00011-006-6034-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0029815", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030709919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.27.19301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032864787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032909877", 
          "https://doi.org/10.1038/ni1084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032909877", 
          "https://doi.org/10.1038/ni1084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.2011.10487.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036431299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejcb.2011.07.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037271337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.0111020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037384605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037818919", 
          "https://doi.org/10.1038/nri2062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.2012.11047.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039467014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cytogfr.2008.08.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041400583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/gerona/gls163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042885656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exphem.2007.01.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044140683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bone.2012.06.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045271812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2006.118679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046299854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.11613/bm.2013.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047034265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0044552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048094543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/dxq027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048347993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1196/annals.1402.068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048755964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2005.02.055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053679497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2010-1268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064250823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2340/00015555-1191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070751308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2340/00015555-1345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070751454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074815411", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "BACKGROUND: Several inflammatory cytokines play a key part in the induction of osteoporosis. Until now, involvement of the Th2 cytokine interleukin-31 (IL-31) in osteoporosis hadn't yet been studied. IL-31 is a proinflammatory cytokine mediating multiple immune functions, whose involvement in a wide range of diseases, such as atopic dermatitis, inflammatory bowel diseases and cutaneous lymphomas, is now emerging. Given the important role of IL-31 in inflammation, we measured its serum levels in postmenopausal osteoporotic patients.\nMETHODS AND RESULTS: In fifty-six postmenopausal females with osteoporosis and 26 healthy controls, bone mineral density (BMD) measurements were performed by using calcaneal quantitative ultrasound (QUS) technique, confirmed at the lumbar spine and hip by dual energy X-ray absorptiometry (DXA). Both patients and controls were divided according to age (less or more than 65 years) and disease severity (T-score levels and presence of fractures). Serum IL-31 levels were measured by ELISA technique. Osteoporotic patients exhibited elevated levels of serum IL-31 compared with healthy controls (43.12\u2009\u00b1\u20096.97 vs 29.58\u2009\u00b1\u20096.09 pg/ml; p\u2009<\u20090.049). IL-31 expression was higher in over 65 years old patients compared to age-matched controls (45\u2009\u00b1\u200911.05 vs. 17.92\u2009\u00b1\u20095.92; p\u2009<\u20090.01), whereas in younger subjects no statistically significant differences were detected between patients and controls (37.91\u2009\u00b1\u20096.9 vs 32.08\u2009\u00b1\u20098.2). No statistically significant differences were found between IL-31 levels in patients affected by mild (T-score\u2009>\u2009-3) compared to severe (T-score\u2009<\u2009-3) osteoporosis (59.17\u2009\u00b1\u20099.22 vs 37.91\u2009\u00b1\u200910.52), neither between fractured and unfractured osteoporotic women (33.75\u2009\u00b1\u20099.16 vs 51.25\u2009\u00b1\u20098.9).\nCONCLUSIONS: We showed for the first time an increase of IL-31 serum levels in postmenopausal women with decreased BMD. Although they did not reflect the severity of osteoporosis and/or the presence of fractures, they clearly correlated with age, as reflected by the higher levels of this cytokine in aged patients.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12865-015-0125-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024252", 
        "issn": [
          "1471-2172"
        ], 
        "name": "BMC Immunology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Increased levels of interleukin 31 (IL-31) in osteoporosis", 
    "pagination": "60", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "695e05083047a48d1eea4b4f7599ba5e482e3c4f36fbd48dc5926ab40e0842bd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26449657"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100966980"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12865-015-0125-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022116232"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12865-015-0125-9", 
      "https://app.dimensions.ai/details/publication/pub.1022116232"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000512.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs12865-015-0125-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12865-015-0125-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12865-015-0125-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12865-015-0125-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12865-015-0125-9'


 

This table displays all metadata directly associated to this object as RDF triples.

285 TRIPLES      21 PREDICATES      82 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12865-015-0125-9 schema:about N02efd2ed023c4f9c9c0fc4a078fa07c6
2 N07336dde748a443a9e73e4720c4d3238
3 N222560a8dd6e467cbc4a5e74bc580608
4 N3177b758ac5e459faaf1e2a036454994
5 N374e85d5789d47429b5697d3e3cb9e43
6 N868b6462f5224154aa0ef72e615dd02a
7 Nc8be6d1ab3084df6873ea7b245dd50a1
8 Ned0c7a860f80417baa0b7cd56ff78b90
9 anzsrc-for:11
10 anzsrc-for:1103
11 schema:author N5ce1f82219c94dee82fd213c63e6e307
12 schema:citation sg:pub.10.1007/s00011-006-6034-x
13 sg:pub.10.1007/s11914-009-0023-2
14 sg:pub.10.1007/s11914-014-0195-2
15 sg:pub.10.1007/s11926-012-0253-7
16 sg:pub.10.1038/ni1084
17 sg:pub.10.1038/nri2062
18 https://app.dimensions.ai/details/publication/pub.1074815411
19 https://doi.org/10.1016/j.bone.2012.06.024
20 https://doi.org/10.1016/j.cytogfr.2008.08.003
21 https://doi.org/10.1016/j.cytogfr.2014.01.002
22 https://doi.org/10.1016/j.ejcb.2011.07.006
23 https://doi.org/10.1016/j.exphem.2007.01.028
24 https://doi.org/10.1016/j.febslet.2005.02.055
25 https://doi.org/10.1016/j.jaci.2005.10.033
26 https://doi.org/10.1016/j.jaci.2006.07.015
27 https://doi.org/10.1016/j.jaci.2013.03.050
28 https://doi.org/10.1016/j.jaci.2013.10.048
29 https://doi.org/10.1016/j.mehy.2010.09.023
30 https://doi.org/10.1016/j.neuroscience.2006.07.009
31 https://doi.org/10.1016/s0140-6736(02)08761-5
32 https://doi.org/10.1074/jbc.274.27.19301
33 https://doi.org/10.1074/jbc.m201140200
34 https://doi.org/10.1074/jbc.m609655200
35 https://doi.org/10.1084/jem.20061791
36 https://doi.org/10.1093/gerona/gls163
37 https://doi.org/10.1093/intimm/dxq027
38 https://doi.org/10.1111/j.1365-2133.2011.10487.x
39 https://doi.org/10.1111/j.1365-2133.2012.11047.x
40 https://doi.org/10.1111/j.1398-9995.2009.02255.x
41 https://doi.org/10.1136/gut.2006.118679
42 https://doi.org/10.1136/jcp.2010.086595
43 https://doi.org/10.1159/000289202
44 https://doi.org/10.1159/000342426
45 https://doi.org/10.11613/bm.2013.007
46 https://doi.org/10.1177/039463201002300304
47 https://doi.org/10.1182/blood-2008-09-179416
48 https://doi.org/10.1189/jlb.0111020
49 https://doi.org/10.1196/annals.1402.068
50 https://doi.org/10.1210/en.2010-1268
51 https://doi.org/10.1371/journal.pone.0029815
52 https://doi.org/10.1371/journal.pone.0044552
53 https://doi.org/10.2340/00015555-1191
54 https://doi.org/10.2340/00015555-1345
55 https://doi.org/10.3109/08820139.2013.822764
56 https://doi.org/10.4158/ep.12.4.436
57 schema:datePublished 2015-12
58 schema:datePublishedReg 2015-12-01
59 schema:description BACKGROUND: Several inflammatory cytokines play a key part in the induction of osteoporosis. Until now, involvement of the Th2 cytokine interleukin-31 (IL-31) in osteoporosis hadn't yet been studied. IL-31 is a proinflammatory cytokine mediating multiple immune functions, whose involvement in a wide range of diseases, such as atopic dermatitis, inflammatory bowel diseases and cutaneous lymphomas, is now emerging. Given the important role of IL-31 in inflammation, we measured its serum levels in postmenopausal osteoporotic patients. METHODS AND RESULTS: In fifty-six postmenopausal females with osteoporosis and 26 healthy controls, bone mineral density (BMD) measurements were performed by using calcaneal quantitative ultrasound (QUS) technique, confirmed at the lumbar spine and hip by dual energy X-ray absorptiometry (DXA). Both patients and controls were divided according to age (less or more than 65 years) and disease severity (T-score levels and presence of fractures). Serum IL-31 levels were measured by ELISA technique. Osteoporotic patients exhibited elevated levels of serum IL-31 compared with healthy controls (43.12 ± 6.97 vs 29.58 ± 6.09 pg/ml; p < 0.049). IL-31 expression was higher in over 65 years old patients compared to age-matched controls (45 ± 11.05 vs. 17.92 ± 5.92; p < 0.01), whereas in younger subjects no statistically significant differences were detected between patients and controls (37.91 ± 6.9 vs 32.08 ± 8.2). No statistically significant differences were found between IL-31 levels in patients affected by mild (T-score > -3) compared to severe (T-score < -3) osteoporosis (59.17 ± 9.22 vs 37.91 ± 10.52), neither between fractured and unfractured osteoporotic women (33.75 ± 9.16 vs 51.25 ± 8.9). CONCLUSIONS: We showed for the first time an increase of IL-31 serum levels in postmenopausal women with decreased BMD. Although they did not reflect the severity of osteoporosis and/or the presence of fractures, they clearly correlated with age, as reflected by the higher levels of this cytokine in aged patients.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree true
63 schema:isPartOf N77f770dd1a07475681dad8423f55a7a3
64 Nb4e1b95b8a87477cbcef74c18f8add18
65 sg:journal.1024252
66 schema:name Increased levels of interleukin 31 (IL-31) in osteoporosis
67 schema:pagination 60
68 schema:productId N1c06d197f7d446d48c271fe0e0654622
69 N7fd87ec9d16448f0a6f2f1e09d21171e
70 Na85d0d66018b4b1583a00f673bd9046d
71 Nb134e2783ff04975b6c5342407442fea
72 Nd4ac75e4210145e69adaacc59dfa8ca7
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022116232
74 https://doi.org/10.1186/s12865-015-0125-9
75 schema:sdDatePublished 2019-04-10T13:16
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher Ne50941526ee240feb9c82487b3448af3
78 schema:url http://link.springer.com/10.1186%2Fs12865-015-0125-9
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N02efd2ed023c4f9c9c0fc4a078fa07c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Aged
84 rdf:type schema:DefinedTerm
85 N07336dde748a443a9e73e4720c4d3238 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Osteoporosis
87 rdf:type schema:DefinedTerm
88 N1c06d197f7d446d48c271fe0e0654622 schema:name pubmed_id
89 schema:value 26449657
90 rdf:type schema:PropertyValue
91 N222560a8dd6e467cbc4a5e74bc580608 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Osteoporotic Fractures
93 rdf:type schema:DefinedTerm
94 N3177b758ac5e459faaf1e2a036454994 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Female
96 rdf:type schema:DefinedTerm
97 N374e85d5789d47429b5697d3e3cb9e43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Middle Aged
99 rdf:type schema:DefinedTerm
100 N5ce1f82219c94dee82fd213c63e6e307 rdf:first sg:person.01153372214.03
101 rdf:rest N9dcf8e21e6714efea67fa53d4209cbf4
102 N6491f97897384077adef237509014a61 rdf:first sg:person.01124243150.17
103 rdf:rest rdf:nil
104 N6f0962a76dda4157b61003f034d83512 rdf:first sg:person.01146316342.72
105 rdf:rest Nce69466d448145659082f4f7edd03f35
106 N77f770dd1a07475681dad8423f55a7a3 schema:volumeNumber 16
107 rdf:type schema:PublicationVolume
108 N7fd87ec9d16448f0a6f2f1e09d21171e schema:name nlm_unique_id
109 schema:value 100966980
110 rdf:type schema:PropertyValue
111 N868b6462f5224154aa0ef72e615dd02a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Humans
113 rdf:type schema:DefinedTerm
114 N88877917c02b4c70b85b03e64bc0cedc rdf:first sg:person.01274121520.08
115 rdf:rest N6f0962a76dda4157b61003f034d83512
116 N9dcf8e21e6714efea67fa53d4209cbf4 rdf:first sg:person.01226255524.50
117 rdf:rest N88877917c02b4c70b85b03e64bc0cedc
118 Na85d0d66018b4b1583a00f673bd9046d schema:name readcube_id
119 schema:value 695e05083047a48d1eea4b4f7599ba5e482e3c4f36fbd48dc5926ab40e0842bd
120 rdf:type schema:PropertyValue
121 Nb134e2783ff04975b6c5342407442fea schema:name doi
122 schema:value 10.1186/s12865-015-0125-9
123 rdf:type schema:PropertyValue
124 Nb4e1b95b8a87477cbcef74c18f8add18 schema:issueNumber 1
125 rdf:type schema:PublicationIssue
126 Nc8be6d1ab3084df6873ea7b245dd50a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Case-Control Studies
128 rdf:type schema:DefinedTerm
129 Nce69466d448145659082f4f7edd03f35 rdf:first sg:person.01206536226.95
130 rdf:rest Necd0f1563617484eb60c1aaffda7d25f
131 Nd4ac75e4210145e69adaacc59dfa8ca7 schema:name dimensions_id
132 schema:value pub.1022116232
133 rdf:type schema:PropertyValue
134 Ne50941526ee240feb9c82487b3448af3 schema:name Springer Nature - SN SciGraph project
135 rdf:type schema:Organization
136 Necd0f1563617484eb60c1aaffda7d25f rdf:first sg:person.01100017107.95
137 rdf:rest N6491f97897384077adef237509014a61
138 Ned0c7a860f80417baa0b7cd56ff78b90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Interleukins
140 rdf:type schema:DefinedTerm
141 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
142 schema:name Medical and Health Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
145 schema:name Clinical Sciences
146 rdf:type schema:DefinedTerm
147 sg:journal.1024252 schema:issn 1471-2172
148 schema:name BMC Immunology
149 rdf:type schema:Periodical
150 sg:person.01100017107.95 schema:affiliation https://www.grid.ac/institutes/grid.10438.3e
151 schema:familyName Mannucci
152 schema:givenName Carmen
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100017107.95
154 rdf:type schema:Person
155 sg:person.01124243150.17 schema:affiliation https://www.grid.ac/institutes/grid.10438.3e
156 schema:familyName Gangemi
157 schema:givenName Sebastiano
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124243150.17
159 rdf:type schema:Person
160 sg:person.01146316342.72 schema:affiliation https://www.grid.ac/institutes/grid.10438.3e
161 schema:familyName Saitta
162 schema:givenName Salvatore
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146316342.72
164 rdf:type schema:Person
165 sg:person.01153372214.03 schema:affiliation https://www.grid.ac/institutes/grid.158820.6
166 schema:familyName Ginaldi
167 schema:givenName Lia
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153372214.03
169 rdf:type schema:Person
170 sg:person.01206536226.95 schema:affiliation https://www.grid.ac/institutes/grid.10438.3e
171 schema:familyName Imbesi
172 schema:givenName Selene
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206536226.95
174 rdf:type schema:Person
175 sg:person.01226255524.50 schema:affiliation https://www.grid.ac/institutes/grid.158820.6
176 schema:familyName De Martinis
177 schema:givenName Massimo
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226255524.50
179 rdf:type schema:Person
180 sg:person.01274121520.08 schema:affiliation https://www.grid.ac/institutes/grid.158820.6
181 schema:familyName Ciccarelli
182 schema:givenName Fedra
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274121520.08
184 rdf:type schema:Person
185 sg:pub.10.1007/s00011-006-6034-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030404192
186 https://doi.org/10.1007/s00011-006-6034-x
187 rdf:type schema:CreativeWork
188 sg:pub.10.1007/s11914-009-0023-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019320651
189 https://doi.org/10.1007/s11914-009-0023-2
190 rdf:type schema:CreativeWork
191 sg:pub.10.1007/s11914-014-0195-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018907526
192 https://doi.org/10.1007/s11914-014-0195-2
193 rdf:type schema:CreativeWork
194 sg:pub.10.1007/s11926-012-0253-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013100695
195 https://doi.org/10.1007/s11926-012-0253-7
196 rdf:type schema:CreativeWork
197 sg:pub.10.1038/ni1084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032909877
198 https://doi.org/10.1038/ni1084
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/nri2062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037818919
201 https://doi.org/10.1038/nri2062
202 rdf:type schema:CreativeWork
203 https://app.dimensions.ai/details/publication/pub.1074815411 schema:CreativeWork
204 https://doi.org/10.1016/j.bone.2012.06.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045271812
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.cytogfr.2008.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041400583
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.cytogfr.2014.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006730686
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.ejcb.2011.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037271337
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.exphem.2007.01.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044140683
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.febslet.2005.02.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053679497
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.jaci.2005.10.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022840169
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/j.jaci.2006.07.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009851648
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/j.jaci.2013.03.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030304745
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.jaci.2013.10.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000719675
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.mehy.2010.09.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008496290
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.neuroscience.2006.07.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024523229
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/s0140-6736(02)08761-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008292619
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1074/jbc.274.27.19301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032864787
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1074/jbc.m201140200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020099613
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1074/jbc.m609655200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028945052
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1084/jem.20061791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015992506
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1093/gerona/gls163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042885656
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1093/intimm/dxq027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048347993
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1111/j.1365-2133.2011.10487.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036431299
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1111/j.1365-2133.2012.11047.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039467014
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1111/j.1398-9995.2009.02255.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008081021
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1136/gut.2006.118679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046299854
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1136/jcp.2010.086595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020025101
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1159/000289202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020244237
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1159/000342426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009402052
255 rdf:type schema:CreativeWork
256 https://doi.org/10.11613/bm.2013.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047034265
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1177/039463201002300304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018839944
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1182/blood-2008-09-179416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019187569
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1189/jlb.0111020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037384605
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1196/annals.1402.068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048755964
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1210/en.2010-1268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064250823
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1371/journal.pone.0029815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030709919
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1371/journal.pone.0044552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048094543
271 rdf:type schema:CreativeWork
272 https://doi.org/10.2340/00015555-1191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070751308
273 rdf:type schema:CreativeWork
274 https://doi.org/10.2340/00015555-1345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070751454
275 rdf:type schema:CreativeWork
276 https://doi.org/10.3109/08820139.2013.822764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004834247
277 rdf:type schema:CreativeWork
278 https://doi.org/10.4158/ep.12.4.436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024320636
279 rdf:type schema:CreativeWork
280 https://www.grid.ac/institutes/grid.10438.3e schema:alternateName University of Messina
281 schema:name Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
282 rdf:type schema:Organization
283 https://www.grid.ac/institutes/grid.158820.6 schema:alternateName University of L'Aquila
284 schema:name Department of Life, Health, & Environmental Sciences, University of L’Aquila, L’Aquila, Italy
285 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...