Multiple genetic loci define Ca++ utilization by bloodstream malaria parasites View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-01-16

AUTHORS

Liana Apolis, Joanna Olivas, Prakash Srinivasan, Ambuj K. Kushwaha, Sanjay A. Desai

ABSTRACT

BACKGROUND: Bloodstream malaria parasites require Ca++ for their development, but the sites and mechanisms of Ca++ utilization are not well understood. We hypothesized that there may be differences in Ca++ uptake or utilization by genetically distinct lines of P. falciparum. These differences, if identified, may provide insights into molecular mechanisms. RESULTS: Dose response studies with the Ca++ chelator EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid) revealed stable differences in Ca++ requirement for six geographically divergent parasite lines used in previous genetic crosses, with the largest difference seen between the parents of the HB3 x Dd2 cross. Genetic mapping of Ca++ requirement yielded complex inheritance in 34 progeny clones with a single significant locus on chromosome 7 and possible contributions from other loci. Although encoded by a gene in the significant locus and a proposed Ca++ target, PfCRT (P. falciparum chloroquine resistance transporter), the primary determinant of clinical resistance to the antimalarial drug chloroquine, does not appear to contribute to this quantitative trait. Stage-specific application of extracellular EGTA also excluded determinants associated with merozoite egress and erythrocyte reinvasion. CONCLUSIONS: We have identified differences in Ca++ utilization amongst P. falciparum lines. These differences are under genetic regulation, segregating as a complex trait in genetic cross progeny. Ca++ uptake and utilization throughout the bloodstream asexual cycle of malaria parasites represents an unexplored target for therapeutic intervention. More... »

PAGES

47

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12864-018-5418-y

DOI

http://dx.doi.org/10.1186/s12864-018-5418-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111461158

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30651090


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crosses, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Egtazic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Association Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Loci", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Haplotypes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inheritance Patterns", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Malaria, Falciparum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Transport Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Merozoites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Parasites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasmodium falciparum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protozoan Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Florida State University College of Medicine, Tallahassee, Florida, USA", 
          "id": "http://www.grid.ac/institutes/grid.255986.5", 
          "name": [
            "The Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD USA", 
            "Florida State University College of Medicine, Tallahassee, Florida, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Apolis", 
        "givenName": "Liana", 
        "id": "sg:person.010543365452.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010543365452.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD USA", 
          "id": "http://www.grid.ac/institutes/grid.419681.3", 
          "name": [
            "The Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olivas", 
        "givenName": "Joanna", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department Molecular Microbiology and Immunology, Johns Hopkins Malaria Research Institute, Baltimore, MD USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD USA", 
            "Department Molecular Microbiology and Immunology, Johns Hopkins Malaria Research Institute, Baltimore, MD USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Srinivasan", 
        "givenName": "Prakash", 
        "id": "sg:person.01072576766.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072576766.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD USA", 
          "id": "http://www.grid.ac/institutes/grid.419681.3", 
          "name": [
            "The Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kushwaha", 
        "givenName": "Ambuj K.", 
        "id": "sg:person.01267527235.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267527235.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD USA", 
          "id": "http://www.grid.ac/institutes/grid.419681.3", 
          "name": [
            "The Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Desai", 
        "givenName": "Sanjay A.", 
        "id": "sg:person.01042777607.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042777607.26"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ncomms3261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024177574", 
          "https://doi.org/10.1038/ncomms3261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms3862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045147401", 
          "https://doi.org/10.1038/ncomms3862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-12-41", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010826761", 
          "https://doi.org/10.1186/1475-2875-12-41"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-11-577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042464911", 
          "https://doi.org/10.1186/1471-2164-11-577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12154-009-0029-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035691415", 
          "https://doi.org/10.1007/s12154-009-0029-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms2725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025644367", 
          "https://doi.org/10.1038/ncomms2725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12936-018-2210-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100800986", 
          "https://doi.org/10.1186/s12936-018-2210-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35036035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023407245", 
          "https://doi.org/10.1038/35036035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-13-184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003501563", 
          "https://doi.org/10.1186/1475-2875-13-184"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-01-16", 
    "datePublishedReg": "2019-01-16", 
    "description": "BACKGROUND: Bloodstream malaria parasites require Ca++ for their development, but the sites and mechanisms of Ca++ utilization are not well understood. We hypothesized that there may be differences in Ca++ uptake or utilization by genetically distinct lines of P. falciparum. These differences, if identified, may provide insights into molecular mechanisms.\nRESULTS: Dose response studies with the Ca++ chelator EGTA (ethylene glycol-bis(\u03b2-aminoethyl ether)-N,N,N',N'-tetraacetic acid) revealed stable differences in Ca++ requirement for six geographically divergent parasite lines used in previous genetic crosses, with the largest difference seen between the parents of the HB3 x Dd2 cross. Genetic mapping of Ca++ requirement yielded complex inheritance in 34 progeny clones with a single significant locus on chromosome 7 and possible contributions from other loci. Although encoded by a gene in the significant locus and a proposed Ca++ target, PfCRT (P. falciparum chloroquine resistance transporter), the primary determinant of clinical resistance to the antimalarial drug chloroquine, does not appear to contribute to this quantitative trait. Stage-specific application of extracellular EGTA also excluded determinants associated with merozoite egress and erythrocyte reinvasion.\nCONCLUSIONS: We have identified differences in Ca++ utilization amongst P. falciparum lines. These differences are under genetic regulation, segregating as a complex trait in genetic cross progeny. Ca++ uptake and utilization throughout the bloodstream asexual cycle of malaria parasites represents an unexplored target for therapeutic intervention.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12864-018-5418-y", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2723129", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1023790", 
        "issn": [
          "1471-2164"
        ], 
        "name": "BMC Genomics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "keywords": [
      "significant loci", 
      "malaria parasites", 
      "single significant locus", 
      "genetic mapping", 
      "complex traits", 
      "genetic crosses", 
      "genetic regulation", 
      "mechanism of Ca", 
      "quantitative traits", 
      "complex inheritance", 
      "molecular mechanisms", 
      "chromosome 7", 
      "merozoite egress", 
      "cross progeny", 
      "asexual cycle", 
      "parasite lines", 
      "progeny clones", 
      "loci", 
      "unexplored target", 
      "falciparum lines", 
      "parasites", 
      "traits", 
      "extracellular EGTA", 
      "chelator EGTA", 
      "distinct lines", 
      "primary determinant", 
      "cross", 
      "dose-response study", 
      "antimalarial drug chloroquine", 
      "stable differences", 
      "genes", 
      "progeny", 
      "reinvasion", 
      "clinical resistance", 
      "uptake", 
      "clones", 
      "therapeutic intervention", 
      "target", 
      "drug chloroquine", 
      "lines", 
      "inheritance", 
      "regulation", 
      "EGTA", 
      "mechanism", 
      "egress", 
      "falciparum", 
      "Ca", 
      "possible contribution", 
      "pfcrt", 
      "determinants", 
      "large differences", 
      "sites", 
      "insights", 
      "response studies", 
      "differences", 
      "chloroquine", 
      "mapping", 
      "cycle", 
      "resistance", 
      "intervention", 
      "utilization", 
      "development", 
      "parents", 
      "defines", 
      "study", 
      "requirements", 
      "contribution", 
      "applications", 
      "Bloodstream malaria parasites", 
      "divergent parasite lines", 
      "previous genetic crosses", 
      "HB3 x Dd2 cross", 
      "x Dd2 cross", 
      "Dd2 cross", 
      "Stage-specific application", 
      "erythrocyte reinvasion", 
      "genetic cross progeny", 
      "bloodstream asexual cycle", 
      "Multiple genetic loci define", 
      "genetic loci define", 
      "loci define"
    ], 
    "name": "Multiple genetic loci define Ca++ utilization by bloodstream malaria parasites", 
    "pagination": "47", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111461158"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12864-018-5418-y"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30651090"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12864-018-5418-y", 
      "https://app.dimensions.ai/details/publication/pub.1111461158"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_808.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12864-018-5418-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12864-018-5418-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12864-018-5418-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12864-018-5418-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12864-018-5418-y'


 

This table displays all metadata directly associated to this object as RDF triples.

279 TRIPLES      22 PREDICATES      132 URIs      115 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12864-018-5418-y schema:about N0ca5e87fc9144f8c905eb6817e9727c6
2 N296a73bffb474b79b24b6b8e7df59312
3 N2c34d2d5263a4b03bc87113a74e31b0e
4 N34df2d1a443b4156842f391a9e63d4e6
5 N3c2ccae1dce84c99b85435a05fe2f685
6 N5befb829b38b4a919d8e729b6c4dc628
7 N719ed83c793f45feb32afd340f9da09e
8 N7f45f74de1f4410bb776ca45adc06797
9 N878026deb43c41018070015952aea0b2
10 N9906b895c3ae47cd9437f0b38de57c02
11 Nac45265736e34c81823887c0ea38b3e7
12 Nb15ae9c06c5843c1a5710ea1275e4a8c
13 Nb5c3e5a248094dc7a47f51df0bde811e
14 Ndbbad6c12bea4892981897ac4acb4199
15 Nf218f8acbcca44d7a351c20397ba384f
16 Nfd4a90b4e1714520a7f95d458b97e197
17 anzsrc-for:06
18 anzsrc-for:0604
19 schema:author N0d878c5920c34a459b7d10a4987dfadf
20 schema:citation sg:pub.10.1007/s12154-009-0029-3
21 sg:pub.10.1038/35036035
22 sg:pub.10.1038/ncomms2725
23 sg:pub.10.1038/ncomms3261
24 sg:pub.10.1038/ncomms3862
25 sg:pub.10.1186/1471-2164-11-577
26 sg:pub.10.1186/1475-2875-12-41
27 sg:pub.10.1186/1475-2875-13-184
28 sg:pub.10.1186/s12936-018-2210-z
29 schema:datePublished 2019-01-16
30 schema:datePublishedReg 2019-01-16
31 schema:description BACKGROUND: Bloodstream malaria parasites require Ca<sup>++</sup> for their development, but the sites and mechanisms of Ca<sup>++</sup> utilization are not well understood. We hypothesized that there may be differences in Ca<sup>++</sup> uptake or utilization by genetically distinct lines of P. falciparum. These differences, if identified, may provide insights into molecular mechanisms. RESULTS: Dose response studies with the Ca<sup>++</sup> chelator EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid) revealed stable differences in Ca<sup>++</sup> requirement for six geographically divergent parasite lines used in previous genetic crosses, with the largest difference seen between the parents of the HB3 x Dd2 cross. Genetic mapping of Ca<sup>++</sup> requirement yielded complex inheritance in 34 progeny clones with a single significant locus on chromosome 7 and possible contributions from other loci. Although encoded by a gene in the significant locus and a proposed Ca<sup>++</sup> target, PfCRT (P. falciparum chloroquine resistance transporter), the primary determinant of clinical resistance to the antimalarial drug chloroquine, does not appear to contribute to this quantitative trait. Stage-specific application of extracellular EGTA also excluded determinants associated with merozoite egress and erythrocyte reinvasion. CONCLUSIONS: We have identified differences in Ca<sup>++</sup> utilization amongst P. falciparum lines. These differences are under genetic regulation, segregating as a complex trait in genetic cross progeny. Ca<sup>++</sup> uptake and utilization throughout the bloodstream asexual cycle of malaria parasites represents an unexplored target for therapeutic intervention.
32 schema:genre article
33 schema:inLanguage en
34 schema:isAccessibleForFree true
35 schema:isPartOf N0020b578b1e1406ebcbd216d34643c23
36 Nf00b28a2849e4873bbae810c8785773b
37 sg:journal.1023790
38 schema:keywords Bloodstream malaria parasites
39 Ca
40 Dd2 cross
41 EGTA
42 HB3 x Dd2 cross
43 Multiple genetic loci define
44 Stage-specific application
45 antimalarial drug chloroquine
46 applications
47 asexual cycle
48 bloodstream asexual cycle
49 chelator EGTA
50 chloroquine
51 chromosome 7
52 clinical resistance
53 clones
54 complex inheritance
55 complex traits
56 contribution
57 cross
58 cross progeny
59 cycle
60 defines
61 determinants
62 development
63 differences
64 distinct lines
65 divergent parasite lines
66 dose-response study
67 drug chloroquine
68 egress
69 erythrocyte reinvasion
70 extracellular EGTA
71 falciparum
72 falciparum lines
73 genes
74 genetic cross progeny
75 genetic crosses
76 genetic loci define
77 genetic mapping
78 genetic regulation
79 inheritance
80 insights
81 intervention
82 large differences
83 lines
84 loci
85 loci define
86 malaria parasites
87 mapping
88 mechanism
89 mechanism of Ca
90 merozoite egress
91 molecular mechanisms
92 parasite lines
93 parasites
94 parents
95 pfcrt
96 possible contribution
97 previous genetic crosses
98 primary determinant
99 progeny
100 progeny clones
101 quantitative traits
102 regulation
103 reinvasion
104 requirements
105 resistance
106 response studies
107 significant loci
108 single significant locus
109 sites
110 stable differences
111 study
112 target
113 therapeutic intervention
114 traits
115 unexplored target
116 uptake
117 utilization
118 x Dd2 cross
119 schema:name Multiple genetic loci define Ca++ utilization by bloodstream malaria parasites
120 schema:pagination 47
121 schema:productId N65a87370ffa04bdc943862e4c996f961
122 N8e21edff31f04a5a86242dcff21600bb
123 Nb734d61a92c74f4685d49c9c1b129c8a
124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111461158
125 https://doi.org/10.1186/s12864-018-5418-y
126 schema:sdDatePublished 2021-12-01T19:45
127 schema:sdLicense https://scigraph.springernature.com/explorer/license/
128 schema:sdPublisher N329eb18ca2f14d6a9fbd7e7d2c692a04
129 schema:url https://doi.org/10.1186/s12864-018-5418-y
130 sgo:license sg:explorer/license/
131 sgo:sdDataset articles
132 rdf:type schema:ScholarlyArticle
133 N0020b578b1e1406ebcbd216d34643c23 schema:issueNumber 1
134 rdf:type schema:PublicationIssue
135 N0ca5e87fc9144f8c905eb6817e9727c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Animals
137 rdf:type schema:DefinedTerm
138 N0d878c5920c34a459b7d10a4987dfadf rdf:first sg:person.010543365452.25
139 rdf:rest N9d041302071a4ca2b8d7d93e3fb81059
140 N1a1179af48e2465c9d1506383035ea41 rdf:first sg:person.01042777607.26
141 rdf:rest rdf:nil
142 N296a73bffb474b79b24b6b8e7df59312 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Genetic Association Studies
144 rdf:type schema:DefinedTerm
145 N2c34d2d5263a4b03bc87113a74e31b0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Calcium
147 rdf:type schema:DefinedTerm
148 N329eb18ca2f14d6a9fbd7e7d2c692a04 schema:name Springer Nature - SN SciGraph project
149 rdf:type schema:Organization
150 N34df2d1a443b4156842f391a9e63d4e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Plasmodium falciparum
152 rdf:type schema:DefinedTerm
153 N3c2ccae1dce84c99b85435a05fe2f685 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Female
155 rdf:type schema:DefinedTerm
156 N526b92e6f8ac4134babbb3b1ef7332f6 rdf:first sg:person.01267527235.03
157 rdf:rest N1a1179af48e2465c9d1506383035ea41
158 N5befb829b38b4a919d8e729b6c4dc628 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Protozoan Proteins
160 rdf:type schema:DefinedTerm
161 N65a87370ffa04bdc943862e4c996f961 schema:name doi
162 schema:value 10.1186/s12864-018-5418-y
163 rdf:type schema:PropertyValue
164 N719ed83c793f45feb32afd340f9da09e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Malaria, Falciparum
166 rdf:type schema:DefinedTerm
167 N7f45f74de1f4410bb776ca45adc06797 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Egtazic Acid
169 rdf:type schema:DefinedTerm
170 N878026deb43c41018070015952aea0b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Parasites
172 rdf:type schema:DefinedTerm
173 N8e21edff31f04a5a86242dcff21600bb schema:name dimensions_id
174 schema:value pub.1111461158
175 rdf:type schema:PropertyValue
176 N914b4f9188d94d70b75c359fd11b05f1 schema:affiliation grid-institutes:grid.419681.3
177 schema:familyName Olivas
178 schema:givenName Joanna
179 rdf:type schema:Person
180 N9906b895c3ae47cd9437f0b38de57c02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Haplotypes
182 rdf:type schema:DefinedTerm
183 N9abec6bc361f4def847950b5fc074c5f rdf:first sg:person.01072576766.73
184 rdf:rest N526b92e6f8ac4134babbb3b1ef7332f6
185 N9d041302071a4ca2b8d7d93e3fb81059 rdf:first N914b4f9188d94d70b75c359fd11b05f1
186 rdf:rest N9abec6bc361f4def847950b5fc074c5f
187 Nac45265736e34c81823887c0ea38b3e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Crosses, Genetic
189 rdf:type schema:DefinedTerm
190 Nb15ae9c06c5843c1a5710ea1275e4a8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Merozoites
192 rdf:type schema:DefinedTerm
193 Nb5c3e5a248094dc7a47f51df0bde811e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Male
195 rdf:type schema:DefinedTerm
196 Nb734d61a92c74f4685d49c9c1b129c8a schema:name pubmed_id
197 schema:value 30651090
198 rdf:type schema:PropertyValue
199 Ndbbad6c12bea4892981897ac4acb4199 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Inheritance Patterns
201 rdf:type schema:DefinedTerm
202 Nf00b28a2849e4873bbae810c8785773b schema:volumeNumber 20
203 rdf:type schema:PublicationVolume
204 Nf218f8acbcca44d7a351c20397ba384f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Genetic Loci
206 rdf:type schema:DefinedTerm
207 Nfd4a90b4e1714520a7f95d458b97e197 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Membrane Transport Proteins
209 rdf:type schema:DefinedTerm
210 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
211 schema:name Biological Sciences
212 rdf:type schema:DefinedTerm
213 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
214 schema:name Genetics
215 rdf:type schema:DefinedTerm
216 sg:grant.2723129 http://pending.schema.org/fundedItem sg:pub.10.1186/s12864-018-5418-y
217 rdf:type schema:MonetaryGrant
218 sg:journal.1023790 schema:issn 1471-2164
219 schema:name BMC Genomics
220 schema:publisher Springer Nature
221 rdf:type schema:Periodical
222 sg:person.01042777607.26 schema:affiliation grid-institutes:grid.419681.3
223 schema:familyName Desai
224 schema:givenName Sanjay A.
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042777607.26
226 rdf:type schema:Person
227 sg:person.010543365452.25 schema:affiliation grid-institutes:grid.255986.5
228 schema:familyName Apolis
229 schema:givenName Liana
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010543365452.25
231 rdf:type schema:Person
232 sg:person.01072576766.73 schema:affiliation grid-institutes:grid.21107.35
233 schema:familyName Srinivasan
234 schema:givenName Prakash
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072576766.73
236 rdf:type schema:Person
237 sg:person.01267527235.03 schema:affiliation grid-institutes:grid.419681.3
238 schema:familyName Kushwaha
239 schema:givenName Ambuj K.
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267527235.03
241 rdf:type schema:Person
242 sg:pub.10.1007/s12154-009-0029-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035691415
243 https://doi.org/10.1007/s12154-009-0029-3
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/35036035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023407245
246 https://doi.org/10.1038/35036035
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/ncomms2725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025644367
249 https://doi.org/10.1038/ncomms2725
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/ncomms3261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024177574
252 https://doi.org/10.1038/ncomms3261
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/ncomms3862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045147401
255 https://doi.org/10.1038/ncomms3862
256 rdf:type schema:CreativeWork
257 sg:pub.10.1186/1471-2164-11-577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042464911
258 https://doi.org/10.1186/1471-2164-11-577
259 rdf:type schema:CreativeWork
260 sg:pub.10.1186/1475-2875-12-41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010826761
261 https://doi.org/10.1186/1475-2875-12-41
262 rdf:type schema:CreativeWork
263 sg:pub.10.1186/1475-2875-13-184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003501563
264 https://doi.org/10.1186/1475-2875-13-184
265 rdf:type schema:CreativeWork
266 sg:pub.10.1186/s12936-018-2210-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1100800986
267 https://doi.org/10.1186/s12936-018-2210-z
268 rdf:type schema:CreativeWork
269 grid-institutes:grid.21107.35 schema:alternateName Department Molecular Microbiology and Immunology, Johns Hopkins Malaria Research Institute, Baltimore, MD USA
270 schema:name Department Molecular Microbiology and Immunology, Johns Hopkins Malaria Research Institute, Baltimore, MD USA
271 The Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD USA
272 rdf:type schema:Organization
273 grid-institutes:grid.255986.5 schema:alternateName Florida State University College of Medicine, Tallahassee, Florida, USA
274 schema:name Florida State University College of Medicine, Tallahassee, Florida, USA
275 The Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD USA
276 rdf:type schema:Organization
277 grid-institutes:grid.419681.3 schema:alternateName The Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD USA
278 schema:name The Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD USA
279 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...