Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSVijay Aswani, Fares Najar, Madhulatha Pantrangi, Bob Mau, William R. Schwan, Sanjay K. Shukla
ABSTRACTBACKGROUND: We describe the virulence factors of a methicillin-sensitive Staphylococcus aureus sequence type (ST) 45 strain, MCRF184, (spa type t917), that caused severe necrotizing fasciitis in a 72-year-old diabetic male. The genome of MCRF184 possesses three genomic islands: a relatively large type III νSaα with 42 open reading frames (ORFs) that includes superantigen- and lipoprotein-like genes, a truncated νSaβ that consists mostly of the enterotoxin gene cluster (egc), and a νSaγ island with 18 ORFs including α-toxin. Additionally, the genome has two phage-related regions: phage φSa3 with three genes of the immune evasion cluster (IEC), and an incomplete phage that is distinct from other S. aureus phages. Finally, the region between orfX and orfY harbors a putative efflux pump, acetyltransferase, regulators, and mobilization genes instead of genes of SCCmec. RESULTS: Virulence factors included phenol soluble modulins (PSMs) α1 through α4 and PSMs β1 and β2. Ten ORFs identified in MCRF184 had not been reported in previously sequenced S. aureus strains. CONCLUSION: The dire clinical outcome in the patient and the described virulence factors all suggest that MCRF184, a ST45 strain is a highly virulent strain of S. aureus. More... »
PAGES123
http://scigraph.springernature.com/pub.10.1186/s12864-018-5394-2
DOIhttp://dx.doi.org/10.1186/s12864-018-5394-2
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112022416
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30736742
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical Microbiology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University at Buffalo, State University of New York",
"id": "https://www.grid.ac/institutes/grid.273335.3",
"name": [
"Department of Internal Medicine & Pediatrics, University at Buffalo, Buffalo, New York, USA"
],
"type": "Organization"
},
"familyName": "Aswani",
"givenName": "Vijay",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Oklahoma",
"id": "https://www.grid.ac/institutes/grid.266900.b",
"name": [
"Department of Chemistry & Biochemistry, University of Oklahoma, Norman, OK, USA"
],
"type": "Organization"
},
"familyName": "Najar",
"givenName": "Fares",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Center for Human Genetics",
"id": "https://www.grid.ac/institutes/grid.492411.b",
"name": [
"Center for Human Genetics, 1000 North Oak Avenue # MLR, 54449, Marshfield, WI, USA"
],
"type": "Organization"
},
"familyName": "Pantrangi",
"givenName": "Madhulatha",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Wisconsin\u2013Madison",
"id": "https://www.grid.ac/institutes/grid.14003.36",
"name": [
"Wisconsin Institute for Discovery, University of Wisconsin, Madison, WI, USA"
],
"type": "Organization"
},
"familyName": "Mau",
"givenName": "Bob",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Wisconsin\u2013La Crosse",
"id": "https://www.grid.ac/institutes/grid.267462.3",
"name": [
"Department of Microbiology, University of Wisconsin \u2013La Crosse, La Crosse, WI, USA"
],
"type": "Organization"
},
"familyName": "Schwan",
"givenName": "William R.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Center for Human Genetics",
"id": "https://www.grid.ac/institutes/grid.492411.b",
"name": [
"Center for Human Genetics, 1000 North Oak Avenue # MLR, 54449, Marshfield, WI, USA"
],
"type": "Organization"
},
"familyName": "Shukla",
"givenName": "Sanjay K.",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1128/jb.01128-07",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001618624"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0154762",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002268780"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3390/toxins8110314",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003683589"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrmicro884",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006108697",
"https://doi.org/10.1038/nrmicro884"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrmicro884",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006108697",
"https://doi.org/10.1038/nrmicro884"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/gkr485",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007259041"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm1656",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008556143",
"https://doi.org/10.1038/nm1656"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/gkv401",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010031659"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0710217105",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011524503"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/jb.188.4.1310-1315.2006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012558410"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2174/1874285801307010059",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014671193"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrmicro2393",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014737326",
"https://doi.org/10.1038/nrmicro2393"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrmicro2393",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014737326",
"https://doi.org/10.1038/nrmicro2393"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.tim.2004.06.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014868889"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.ppat.1002744",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015853049"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(06)68231-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016115669"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/jb.00162-10",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017764660"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0065-2776(08)60534-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017820748"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/jb.01804-08",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019075669"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1472-6750-14-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019920195",
"https://doi.org/10.1186/1472-6750-14-8"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/gks419",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020019840"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev-micro-102215-095547",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020069514"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/bib/bbw019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020152272"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mmbr.00018-13",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020515005"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ismej.2016.163",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026128069",
"https://doi.org/10.1038/ismej.2016.163"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/gkw387",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028379982"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/genomea.00374-16",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029907689"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/jcm.01657-06",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030287646"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1086/432798",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032863046"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/genomea.00517-13",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036413237"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3390/toxins7030997",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038650528"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0402521101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038773719"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0147150",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039086401"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0147150",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039086401"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0147150",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039086401"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/jcm.03617-13",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042291241"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/mmi.12682",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044282295"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(02)08713-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044288096"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/1574-6976.12057",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044868865"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.ppat.1004984",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050972279"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ct500592m",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055425314"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1086/533591",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1058799172"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijmm.2017.04.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084932764"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/2159256x.2017.1368433",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091314330"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/jb.00476-17",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091848300"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/jb.00476-17",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091848300"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/gky427",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103861827"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41467-018-05490-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1106343628",
"https://doi.org/10.1038/s41467-018-05490-0"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "BACKGROUND: We describe the virulence factors of a methicillin-sensitive Staphylococcus aureus sequence type (ST) 45 strain, MCRF184, (spa type t917), that caused severe necrotizing fasciitis in a 72-year-old diabetic male. The genome of MCRF184 possesses three genomic islands: a relatively large type III \u03bdSa\u03b1 with 42 open reading frames (ORFs) that includes superantigen- and lipoprotein-like genes, a truncated \u03bdSa\u03b2 that consists mostly of the enterotoxin gene cluster (egc), and a \u03bdSa\u03b3 island with 18 ORFs including \u03b1-toxin. Additionally, the genome has two phage-related regions: phage \u03c6Sa3 with three genes of the immune evasion cluster (IEC), and an incomplete phage that is distinct from other S. aureus phages. Finally, the region between orfX and orfY harbors a putative efflux pump, acetyltransferase, regulators, and mobilization genes instead of genes of SCCmec.\nRESULTS: Virulence factors included phenol soluble modulins (PSMs) \u03b11 through \u03b14 and PSMs \u03b21 and \u03b22. Ten ORFs identified in MCRF184 had not been reported in previously sequenced S. aureus strains.\nCONCLUSION: The dire clinical outcome in the patient and the described virulence factors all suggest that MCRF184, a ST45 strain is a highly virulent strain of S. aureus.",
"genre": "research_article",
"id": "sg:pub.10.1186/s12864-018-5394-2",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1023790",
"issn": [
"1471-2164"
],
"name": "BMC Genomics",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "20"
}
],
"name": "Virulence factor landscape of a Staphylococcus aureus sequence type 45 strain, MCRF184",
"pagination": "123",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"6d7f20918a98910861a2af5b2c26ef9720a2404d25ae93acb39c1cdeffe6c6bd"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30736742"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"100965258"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s12864-018-5394-2"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1112022416"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s12864-018-5394-2",
"https://app.dimensions.ai/details/publication/pub.1112022416"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T09:08",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000338_0000000338/records_47960_00000002.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1186%2Fs12864-018-5394-2"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12864-018-5394-2'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12864-018-5394-2'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12864-018-5394-2'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12864-018-5394-2'
This table displays all metadata directly associated to this object as RDF triples.
244 TRIPLES
21 PREDICATES
72 URIs
21 LITERALS
9 BLANK NODES