Transcriptomic analysis and mutational status of IDH1 in paired primary-recurrent intrahepatic cholangiocarcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

C. Peraldo-Neia, P. Ostano, G. Cavalloni, Y. Pignochino, D. Sangiolo, L. De Cecco, E. Marchesi, D. Ribero, A. Scarpa, A. M. De Rose, A. Giuliani, F. Calise, C. Raggi, P. Invernizzi, M. Aglietta, G. Chiorino, F. Leone

ABSTRACT

BACKGROUND: Effective target therapies for intrahepatic cholangiocarcinoma (ICC) have not been identified so far. One of the reasons may be the genetic evolution from primary (PR) to recurrent (REC) tumors. We aim to identify peculiar characteristics and to select potential targets specific for recurrent tumors. Eighteen ICC paired PR and REC tumors were collected from 5 Italian Centers. Eleven pairs were analyzed for gene expression profiling and 16 for mutational status of IDH1. For one pair, deep mutational analysis by Next Generation Sequencing was also carried out. An independent cohort of patients was used for validation. RESULTS: Two class-paired comparison yielded 315 differentially expressed genes between REC and PR tumors. Up-regulated genes in RECs are involved in RNA/DNA processing, cell cycle, epithelial to mesenchymal transition (EMT), resistance to apoptosis, and cytoskeleton remodeling. Down-regulated genes participate to epithelial cell differentiation, proteolysis, apoptotic, immune response, and inflammatory processes. A 24 gene signature is able to discriminate RECs from PRs in an independent cohort; FANCG is statistically associated with survival in the chol-TCGA dataset. IDH1 was mutated in the RECs of five patients; 4 of them displayed the mutation only in RECs. Deep sequencing performed in one patient confirmed the IDH1 mutation in REC. CONCLUSIONS: RECs are enriched for genes involved in EMT, resistance to apoptosis, and cytoskeleton remodeling. Key players of these pathways might be considered druggable targets in RECs. IDH1 is mutated in 30% of RECs, becoming both a marker of progression and a target for therapy. More... »

PAGES

440

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12864-018-4829-0

DOI

http://dx.doi.org/10.1186/s12864-018-4829-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104398681

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29871612


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Fondazione Edo ed Elvo Tempia", 
          "id": "https://www.grid.ac/institutes/grid.452265.2", 
          "name": [
            "Medical Oncology Division, Candiolo Cancer Institute - FPO, IRCCS, Str. Prov. 142, km 3.95, 10060, Candiolo, Turin, Italy", 
            "Cancer Genomics Lab, Fondazione Edo ed Elvo Tempia Valenta, Biella, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peraldo-Neia", 
        "givenName": "C.", 
        "id": "sg:person.0762742413.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762742413.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fondazione Edo ed Elvo Tempia", 
          "id": "https://www.grid.ac/institutes/grid.452265.2", 
          "name": [
            "Cancer Genomics Lab, Fondazione Edo ed Elvo Tempia Valenta, Biella, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ostano", 
        "givenName": "P.", 
        "id": "sg:person.01361305475.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361305475.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Candiolo Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.419555.9", 
          "name": [
            "Medical Oncology Division, Candiolo Cancer Institute - FPO, IRCCS, Str. Prov. 142, km 3.95, 10060, Candiolo, Turin, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cavalloni", 
        "givenName": "G.", 
        "id": "sg:person.0646514013.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646514013.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Turin", 
          "id": "https://www.grid.ac/institutes/grid.7605.4", 
          "name": [
            "Department of Oncology, University of Turin, Torino, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pignochino", 
        "givenName": "Y.", 
        "id": "sg:person.01367541145.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367541145.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Turin", 
          "id": "https://www.grid.ac/institutes/grid.7605.4", 
          "name": [
            "Medical Oncology Division, Candiolo Cancer Institute - FPO, IRCCS, Str. Prov. 142, km 3.95, 10060, Candiolo, Turin, Italy", 
            "Department of Oncology, University of Turin, Torino, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sangiolo", 
        "givenName": "D.", 
        "id": "sg:person.01365220615.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365220615.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Functional Genomics and Bioinformatics, Department of Applied Research and Technology Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Cecco", 
        "givenName": "L.", 
        "id": "sg:person.015174075644.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015174075644.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Functional Genomics and Bioinformatics, Department of Applied Research and Technology Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marchesi", 
        "givenName": "E.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Candiolo Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.419555.9", 
          "name": [
            "Division of Hepatobilio-Pancreatic and Colorectal Surgery, Candiolo Cancer Institute - FPO, IRCCS, Str. Prov. 142, km 3.95, Candiolo, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ribero", 
        "givenName": "D.", 
        "id": "sg:person.01230125443.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230125443.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "ARC-Net Research Centre and Department of Diagnostics and Public Health \u2013 Section of Pathology, University and Hospital Trust of Verona, Verona, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scarpa", 
        "givenName": "A.", 
        "id": "sg:person.012622657362.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012622657362.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Agostino Gemelli University Polyclinic", 
          "id": "https://www.grid.ac/institutes/grid.411075.6", 
          "name": [
            "Hepatobiliary Surgery Unit, Gemelli Hospital, Catholic University of the Sacred Heart, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Rose", 
        "givenName": "A. M.", 
        "id": "sg:person.0622762573.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622762573.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Molise", 
          "id": "https://www.grid.ac/institutes/grid.10373.36", 
          "name": [
            "Department of Health\u2019s Sciences and Medicine \u201cV. Tiberio\u201d, University of Molise, Campobasso, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giuliani", 
        "givenName": "A.", 
        "id": "sg:person.013471530003.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013471530003.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Antonio Cardarelli", 
          "id": "https://www.grid.ac/institutes/grid.413172.2", 
          "name": [
            "Hepatobiliary and Liver Transplant Unit, Cardarelli Hospital, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Calise", 
        "givenName": "F.", 
        "id": "sg:person.01064454403.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064454403.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Florence", 
          "id": "https://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Center for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Rozzano, Italy", 
            "Department of Experimental and Clinical Medicine, University of Firenze, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raggi", 
        "givenName": "C.", 
        "id": "sg:person.01116467757.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116467757.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera San Gerardo", 
          "id": "https://www.grid.ac/institutes/grid.415025.7", 
          "name": [
            "Center for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Rozzano, Italy", 
            "UOC di Gastroenterologia, Azienda Ospedaliera San Gerardo, Monza, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Invernizzi", 
        "givenName": "P.", 
        "id": "sg:person.013553514320.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013553514320.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Turin", 
          "id": "https://www.grid.ac/institutes/grid.7605.4", 
          "name": [
            "Medical Oncology Division, Candiolo Cancer Institute - FPO, IRCCS, Str. Prov. 142, km 3.95, 10060, Candiolo, Turin, Italy", 
            "Department of Oncology, University of Turin, Torino, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aglietta", 
        "givenName": "M.", 
        "id": "sg:person.053143507.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053143507.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fondazione Edo ed Elvo Tempia", 
          "id": "https://www.grid.ac/institutes/grid.452265.2", 
          "name": [
            "Cancer Genomics Lab, Fondazione Edo ed Elvo Tempia Valenta, Biella, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chiorino", 
        "givenName": "G.", 
        "id": "sg:person.01227253023.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227253023.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Turin", 
          "id": "https://www.grid.ac/institutes/grid.7605.4", 
          "name": [
            "Medical Oncology Division, Candiolo Cancer Institute - FPO, IRCCS, Str. Prov. 142, km 3.95, 10060, Candiolo, Turin, Italy", 
            "Department of Oncology, University of Turin, Torino, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leone", 
        "givenName": "F.", 
        "id": "sg:person.0636227045.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636227045.64"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/cam4.501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001930861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.4539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004073465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007213822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007213822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2011-0386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008469500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.8775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009827264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-12-0095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011831914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djq262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013174504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-014-3828-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014604581", 
          "https://doi.org/10.1245/s10434-014-3828-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/biostatistics/kxj037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016217055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-10-0200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017014562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2013.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017782239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2011.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018944440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.juro.2011.06.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021275946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2014.45", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022580397", 
          "https://doi.org/10.1038/cdd.2014.45"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexmp.2016.07.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023627589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/hep.14.36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025638604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026622793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026622793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.1943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029018066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-016-5454-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030492412", 
          "https://doi.org/10.1245/s10434-016-5454-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-016-5454-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030492412", 
          "https://doi.org/10.1245/s10434-016-5454-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-5590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030818460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/bs.ctdb.2014.11.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031435167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcma.2015.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031881282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcma.2015.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031881282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scisignal.2004088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033807182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0b013e3283637292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034207087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0b013e3283637292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034207087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clinre.2016.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034418030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-319-24932-2_4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038009493", 
          "https://doi.org/10.1007/978-3-319-24932-2_4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature13441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039092450", 
          "https://doi.org/10.1038/nature13441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2016.02.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039282439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dld.2009.10.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039508590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-9-58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039680146", 
          "https://doi.org/10.1186/1471-2105-9-58"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3375", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040279504", 
          "https://doi.org/10.1038/ng.3375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6604129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041142222", 
          "https://doi.org/10.1038/sj.bjc.6604129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2015-0210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045288796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2014.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051515546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181e462e6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052260685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181e462e6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052260685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e3181e462e6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052260685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2012.08.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052838309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-15-1442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063281037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2202/1544-6115.1027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069289261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v21.i48.13418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071373296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v22.i10.3038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071373525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2015.2944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071513884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2015.2944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071513884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/15384101.2014.965054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072288176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074747899", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078783616", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Effective target therapies for intrahepatic cholangiocarcinoma (ICC) have not been identified so far. One of the reasons may be the genetic evolution from primary (PR) to recurrent (REC) tumors. We aim to identify peculiar characteristics and to select potential targets specific for recurrent tumors. Eighteen ICC paired PR and REC tumors were collected from 5 Italian Centers. Eleven pairs were analyzed for gene expression profiling and 16 for mutational status of IDH1. For one pair, deep mutational analysis by Next Generation Sequencing was also carried out. An independent cohort of patients was used for validation.\nRESULTS: Two class-paired comparison yielded 315 differentially expressed genes between REC and PR tumors. Up-regulated genes in RECs are involved in RNA/DNA processing, cell cycle, epithelial to mesenchymal transition\u00a0(EMT), resistance to apoptosis, and cytoskeleton remodeling. Down-regulated genes participate to epithelial cell differentiation, proteolysis, apoptotic, immune response, and inflammatory processes. A 24 gene signature is able to discriminate RECs from PRs in an independent cohort; FANCG is statistically associated with survival in the chol-TCGA dataset. IDH1 was mutated in the RECs of five patients; 4 of them displayed the mutation only in RECs. Deep sequencing performed in one patient confirmed the IDH1 mutation in REC.\nCONCLUSIONS: RECs are enriched for genes involved in EMT, resistance to apoptosis, and cytoskeleton remodeling. Key players of these pathways might be considered druggable targets in RECs. IDH1 is mutated in 30% of RECs, becoming both a marker of progression and a target for therapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12864-018-4829-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1023790", 
        "issn": [
          "1471-2164"
        ], 
        "name": "BMC Genomics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Transcriptomic analysis and mutational status of IDH1 in paired primary-recurrent intrahepatic cholangiocarcinoma", 
    "pagination": "440", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "25a7ed069378e5119e2820741e0b348396ad92eb701f8d316c38227609b51106"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29871612"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100965258"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12864-018-4829-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1104398681"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12864-018-4829-0", 
      "https://app.dimensions.ai/details/publication/pub.1104398681"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000570.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12864-018-4829-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12864-018-4829-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12864-018-4829-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12864-018-4829-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12864-018-4829-0'


 

This table displays all metadata directly associated to this object as RDF triples.

351 TRIPLES      21 PREDICATES      74 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12864-018-4829-0 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N77ed909b30794e4fb9922be08b44bc9b
4 schema:citation sg:pub.10.1007/978-3-319-24932-2_4
5 sg:pub.10.1038/cdd.2014.45
6 sg:pub.10.1038/nature13441
7 sg:pub.10.1038/ng.3375
8 sg:pub.10.1038/sj.bjc.6604129
9 sg:pub.10.1186/1471-2105-9-58
10 sg:pub.10.1245/s10434-014-3828-x
11 sg:pub.10.1245/s10434-016-5454-2
12 https://app.dimensions.ai/details/publication/pub.1074747899
13 https://app.dimensions.ai/details/publication/pub.1078783616
14 https://doi.org/10.1002/cam4.501
15 https://doi.org/10.1002/cncr.21421
16 https://doi.org/10.1002/path.1779
17 https://doi.org/10.1016/bs.ctdb.2014.11.021
18 https://doi.org/10.1016/j.canlet.2014.08.005
19 https://doi.org/10.1016/j.canlet.2016.02.041
20 https://doi.org/10.1016/j.ccr.2012.08.024
21 https://doi.org/10.1016/j.clinre.2016.04.001
22 https://doi.org/10.1016/j.dld.2009.10.009
23 https://doi.org/10.1016/j.jcma.2015.05.002
24 https://doi.org/10.1016/j.juro.2011.06.049
25 https://doi.org/10.1016/j.yexmp.2016.07.010
26 https://doi.org/10.1053/j.gastro.2011.12.005
27 https://doi.org/10.1053/j.gastro.2013.01.001
28 https://doi.org/10.1073/pnas.0506580102
29 https://doi.org/10.1093/biostatistics/kxj037
30 https://doi.org/10.1093/jnci/djq262
31 https://doi.org/10.1097/cad.0b013e3283637292
32 https://doi.org/10.1097/sla.0b013e3181e462e6
33 https://doi.org/10.1126/scisignal.2004088
34 https://doi.org/10.1158/0008-5472.can-07-5590
35 https://doi.org/10.1158/1541-7786.mcr-10-0200
36 https://doi.org/10.1158/2159-8290.cd-12-0095
37 https://doi.org/10.1158/2159-8290.cd-15-1442
38 https://doi.org/10.1634/theoncologist.2011-0386
39 https://doi.org/10.1634/theoncologist.2015-0210
40 https://doi.org/10.18632/oncotarget.1943
41 https://doi.org/10.18632/oncotarget.4539
42 https://doi.org/10.18632/oncotarget.8775
43 https://doi.org/10.2202/1544-6115.1027
44 https://doi.org/10.2217/hep.14.36
45 https://doi.org/10.3748/wjg.v21.i48.13418
46 https://doi.org/10.3748/wjg.v22.i10.3038
47 https://doi.org/10.3892/ijo.2015.2944
48 https://doi.org/10.4161/15384101.2014.965054
49 schema:datePublished 2018-12
50 schema:datePublishedReg 2018-12-01
51 schema:description BACKGROUND: Effective target therapies for intrahepatic cholangiocarcinoma (ICC) have not been identified so far. One of the reasons may be the genetic evolution from primary (PR) to recurrent (REC) tumors. We aim to identify peculiar characteristics and to select potential targets specific for recurrent tumors. Eighteen ICC paired PR and REC tumors were collected from 5 Italian Centers. Eleven pairs were analyzed for gene expression profiling and 16 for mutational status of IDH1. For one pair, deep mutational analysis by Next Generation Sequencing was also carried out. An independent cohort of patients was used for validation. RESULTS: Two class-paired comparison yielded 315 differentially expressed genes between REC and PR tumors. Up-regulated genes in RECs are involved in RNA/DNA processing, cell cycle, epithelial to mesenchymal transition (EMT), resistance to apoptosis, and cytoskeleton remodeling. Down-regulated genes participate to epithelial cell differentiation, proteolysis, apoptotic, immune response, and inflammatory processes. A 24 gene signature is able to discriminate RECs from PRs in an independent cohort; FANCG is statistically associated with survival in the chol-TCGA dataset. IDH1 was mutated in the RECs of five patients; 4 of them displayed the mutation only in RECs. Deep sequencing performed in one patient confirmed the IDH1 mutation in REC. CONCLUSIONS: RECs are enriched for genes involved in EMT, resistance to apoptosis, and cytoskeleton remodeling. Key players of these pathways might be considered druggable targets in RECs. IDH1 is mutated in 30% of RECs, becoming both a marker of progression and a target for therapy.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree true
55 schema:isPartOf N71ed498deb5b4d1da10ff07962e0e705
56 N9e2bad653b634523823b9c0d5f1c8272
57 sg:journal.1023790
58 schema:name Transcriptomic analysis and mutational status of IDH1 in paired primary-recurrent intrahepatic cholangiocarcinoma
59 schema:pagination 440
60 schema:productId N14904902df034cf68a0c64c2d3e8592e
61 N1abc9658be374e3b8c765386cfbb3994
62 N8b56741ce1874458b964922aaa15c7e2
63 N93398e2a3c65451b9ae0bc7021c56443
64 Nb74135df017946f08a391f34e2c4e39b
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104398681
66 https://doi.org/10.1186/s12864-018-4829-0
67 schema:sdDatePublished 2019-04-10T15:10
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher N349bbec4a982413f898d2169d1fb15de
70 schema:url https://link.springer.com/10.1186%2Fs12864-018-4829-0
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N14904902df034cf68a0c64c2d3e8592e schema:name nlm_unique_id
75 schema:value 100965258
76 rdf:type schema:PropertyValue
77 N1abc9658be374e3b8c765386cfbb3994 schema:name dimensions_id
78 schema:value pub.1104398681
79 rdf:type schema:PropertyValue
80 N20ecc6fce16f40c88c5c44738c5ca8b2 rdf:first sg:person.013471530003.25
81 rdf:rest N660e575de0e445ebbf996e07f867f8dd
82 N31f9e9ee6dcc44e68afbcbb4f2a18bc2 rdf:first sg:person.015174075644.23
83 rdf:rest Nea021fd90f5a436b9a1d5da15d5dc048
84 N349bbec4a982413f898d2169d1fb15de schema:name Springer Nature - SN SciGraph project
85 rdf:type schema:Organization
86 N47f23df4b3e34e5dbe9ae766783b93c0 rdf:first sg:person.0646514013.90
87 rdf:rest Ncaddb444dcd0497f8059c37c16de3af6
88 N4a3a3c69cc054c1998dabf39bc7bf1f0 rdf:first sg:person.01230125443.75
89 rdf:rest N941cf9c7908646be88876a25d8d1a021
90 N4aea59c98a2b49338cad58e9cc75a158 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
91 schema:familyName Marchesi
92 schema:givenName E.
93 rdf:type schema:Person
94 N4fbdb77cc20a452ea00b0695bd0b5455 rdf:first sg:person.01361305475.08
95 rdf:rest N47f23df4b3e34e5dbe9ae766783b93c0
96 N5f1beff03f574bd08b37c0255b41fa7e rdf:first sg:person.01365220615.60
97 rdf:rest N31f9e9ee6dcc44e68afbcbb4f2a18bc2
98 N660e575de0e445ebbf996e07f867f8dd rdf:first sg:person.01064454403.38
99 rdf:rest N8f89ce679abd4031a0e524cdcf1519e6
100 N71ed498deb5b4d1da10ff07962e0e705 schema:issueNumber 1
101 rdf:type schema:PublicationIssue
102 N72822720e831446fa01ad2680b29389a rdf:first sg:person.0622762573.93
103 rdf:rest N20ecc6fce16f40c88c5c44738c5ca8b2
104 N77ed909b30794e4fb9922be08b44bc9b rdf:first sg:person.0762742413.34
105 rdf:rest N4fbdb77cc20a452ea00b0695bd0b5455
106 N8b56741ce1874458b964922aaa15c7e2 schema:name readcube_id
107 schema:value 25a7ed069378e5119e2820741e0b348396ad92eb701f8d316c38227609b51106
108 rdf:type schema:PropertyValue
109 N8e04b9bd339040618912ee371e8fc3a8 rdf:first sg:person.013553514320.47
110 rdf:rest Nac4c3cb00a604820946c1bb616f9ff2e
111 N8f89ce679abd4031a0e524cdcf1519e6 rdf:first sg:person.01116467757.59
112 rdf:rest N8e04b9bd339040618912ee371e8fc3a8
113 N93398e2a3c65451b9ae0bc7021c56443 schema:name pubmed_id
114 schema:value 29871612
115 rdf:type schema:PropertyValue
116 N941cf9c7908646be88876a25d8d1a021 rdf:first sg:person.012622657362.12
117 rdf:rest N72822720e831446fa01ad2680b29389a
118 N98e271c106f942e5a3cfc67e6ed2c01b schema:name ARC-Net Research Centre and Department of Diagnostics and Public Health – Section of Pathology, University and Hospital Trust of Verona, Verona, Italy
119 rdf:type schema:Organization
120 N9e2bad653b634523823b9c0d5f1c8272 schema:volumeNumber 19
121 rdf:type schema:PublicationVolume
122 Nac4c3cb00a604820946c1bb616f9ff2e rdf:first sg:person.053143507.24
123 rdf:rest Nbea2af108c864b9f948816f95807682f
124 Nb74135df017946f08a391f34e2c4e39b schema:name doi
125 schema:value 10.1186/s12864-018-4829-0
126 rdf:type schema:PropertyValue
127 Nbea2af108c864b9f948816f95807682f rdf:first sg:person.01227253023.16
128 rdf:rest Ne67188bbaa524fc9a9d83478d545a204
129 Ncaddb444dcd0497f8059c37c16de3af6 rdf:first sg:person.01367541145.66
130 rdf:rest N5f1beff03f574bd08b37c0255b41fa7e
131 Ne67188bbaa524fc9a9d83478d545a204 rdf:first sg:person.0636227045.64
132 rdf:rest rdf:nil
133 Nea021fd90f5a436b9a1d5da15d5dc048 rdf:first N4aea59c98a2b49338cad58e9cc75a158
134 rdf:rest N4a3a3c69cc054c1998dabf39bc7bf1f0
135 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
136 schema:name Biological Sciences
137 rdf:type schema:DefinedTerm
138 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
139 schema:name Genetics
140 rdf:type schema:DefinedTerm
141 sg:journal.1023790 schema:issn 1471-2164
142 schema:name BMC Genomics
143 rdf:type schema:Periodical
144 sg:person.01064454403.38 schema:affiliation https://www.grid.ac/institutes/grid.413172.2
145 schema:familyName Calise
146 schema:givenName F.
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064454403.38
148 rdf:type schema:Person
149 sg:person.01116467757.59 schema:affiliation https://www.grid.ac/institutes/grid.8404.8
150 schema:familyName Raggi
151 schema:givenName C.
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116467757.59
153 rdf:type schema:Person
154 sg:person.01227253023.16 schema:affiliation https://www.grid.ac/institutes/grid.452265.2
155 schema:familyName Chiorino
156 schema:givenName G.
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227253023.16
158 rdf:type schema:Person
159 sg:person.01230125443.75 schema:affiliation https://www.grid.ac/institutes/grid.419555.9
160 schema:familyName Ribero
161 schema:givenName D.
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230125443.75
163 rdf:type schema:Person
164 sg:person.012622657362.12 schema:affiliation N98e271c106f942e5a3cfc67e6ed2c01b
165 schema:familyName Scarpa
166 schema:givenName A.
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012622657362.12
168 rdf:type schema:Person
169 sg:person.013471530003.25 schema:affiliation https://www.grid.ac/institutes/grid.10373.36
170 schema:familyName Giuliani
171 schema:givenName A.
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013471530003.25
173 rdf:type schema:Person
174 sg:person.013553514320.47 schema:affiliation https://www.grid.ac/institutes/grid.415025.7
175 schema:familyName Invernizzi
176 schema:givenName P.
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013553514320.47
178 rdf:type schema:Person
179 sg:person.01361305475.08 schema:affiliation https://www.grid.ac/institutes/grid.452265.2
180 schema:familyName Ostano
181 schema:givenName P.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361305475.08
183 rdf:type schema:Person
184 sg:person.01365220615.60 schema:affiliation https://www.grid.ac/institutes/grid.7605.4
185 schema:familyName Sangiolo
186 schema:givenName D.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365220615.60
188 rdf:type schema:Person
189 sg:person.01367541145.66 schema:affiliation https://www.grid.ac/institutes/grid.7605.4
190 schema:familyName Pignochino
191 schema:givenName Y.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367541145.66
193 rdf:type schema:Person
194 sg:person.015174075644.23 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
195 schema:familyName De Cecco
196 schema:givenName L.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015174075644.23
198 rdf:type schema:Person
199 sg:person.053143507.24 schema:affiliation https://www.grid.ac/institutes/grid.7605.4
200 schema:familyName Aglietta
201 schema:givenName M.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053143507.24
203 rdf:type schema:Person
204 sg:person.0622762573.93 schema:affiliation https://www.grid.ac/institutes/grid.411075.6
205 schema:familyName De Rose
206 schema:givenName A. M.
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622762573.93
208 rdf:type schema:Person
209 sg:person.0636227045.64 schema:affiliation https://www.grid.ac/institutes/grid.7605.4
210 schema:familyName Leone
211 schema:givenName F.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636227045.64
213 rdf:type schema:Person
214 sg:person.0646514013.90 schema:affiliation https://www.grid.ac/institutes/grid.419555.9
215 schema:familyName Cavalloni
216 schema:givenName G.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646514013.90
218 rdf:type schema:Person
219 sg:person.0762742413.34 schema:affiliation https://www.grid.ac/institutes/grid.452265.2
220 schema:familyName Peraldo-Neia
221 schema:givenName C.
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762742413.34
223 rdf:type schema:Person
224 sg:pub.10.1007/978-3-319-24932-2_4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038009493
225 https://doi.org/10.1007/978-3-319-24932-2_4
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/cdd.2014.45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022580397
228 https://doi.org/10.1038/cdd.2014.45
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/nature13441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039092450
231 https://doi.org/10.1038/nature13441
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/ng.3375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040279504
234 https://doi.org/10.1038/ng.3375
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/sj.bjc.6604129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041142222
237 https://doi.org/10.1038/sj.bjc.6604129
238 rdf:type schema:CreativeWork
239 sg:pub.10.1186/1471-2105-9-58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039680146
240 https://doi.org/10.1186/1471-2105-9-58
241 rdf:type schema:CreativeWork
242 sg:pub.10.1245/s10434-014-3828-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014604581
243 https://doi.org/10.1245/s10434-014-3828-x
244 rdf:type schema:CreativeWork
245 sg:pub.10.1245/s10434-016-5454-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030492412
246 https://doi.org/10.1245/s10434-016-5454-2
247 rdf:type schema:CreativeWork
248 https://app.dimensions.ai/details/publication/pub.1074747899 schema:CreativeWork
249 https://app.dimensions.ai/details/publication/pub.1078783616 schema:CreativeWork
250 https://doi.org/10.1002/cam4.501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001930861
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1002/cncr.21421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026622793
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1002/path.1779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007213822
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/bs.ctdb.2014.11.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031435167
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.canlet.2014.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051515546
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.canlet.2016.02.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039282439
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.ccr.2012.08.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052838309
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.clinre.2016.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034418030
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.dld.2009.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039508590
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.jcma.2015.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031881282
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.juro.2011.06.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021275946
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.yexmp.2016.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023627589
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1053/j.gastro.2011.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018944440
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1053/j.gastro.2013.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017782239
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1073/pnas.0506580102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705714
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1093/biostatistics/kxj037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016217055
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1093/jnci/djq262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013174504
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1097/cad.0b013e3283637292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034207087
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1097/sla.0b013e3181e462e6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052260685
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1126/scisignal.2004088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033807182
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1158/0008-5472.can-07-5590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030818460
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1158/1541-7786.mcr-10-0200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017014562
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1158/2159-8290.cd-12-0095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011831914
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1158/2159-8290.cd-15-1442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063281037
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1634/theoncologist.2011-0386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008469500
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1634/theoncologist.2015-0210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045288796
301 rdf:type schema:CreativeWork
302 https://doi.org/10.18632/oncotarget.1943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029018066
303 rdf:type schema:CreativeWork
304 https://doi.org/10.18632/oncotarget.4539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004073465
305 rdf:type schema:CreativeWork
306 https://doi.org/10.18632/oncotarget.8775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009827264
307 rdf:type schema:CreativeWork
308 https://doi.org/10.2202/1544-6115.1027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069289261
309 rdf:type schema:CreativeWork
310 https://doi.org/10.2217/hep.14.36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025638604
311 rdf:type schema:CreativeWork
312 https://doi.org/10.3748/wjg.v21.i48.13418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071373296
313 rdf:type schema:CreativeWork
314 https://doi.org/10.3748/wjg.v22.i10.3038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071373525
315 rdf:type schema:CreativeWork
316 https://doi.org/10.3892/ijo.2015.2944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071513884
317 rdf:type schema:CreativeWork
318 https://doi.org/10.4161/15384101.2014.965054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072288176
319 rdf:type schema:CreativeWork
320 https://www.grid.ac/institutes/grid.10373.36 schema:alternateName University of Molise
321 schema:name Department of Health’s Sciences and Medicine “V. Tiberio”, University of Molise, Campobasso, Italy
322 rdf:type schema:Organization
323 https://www.grid.ac/institutes/grid.411075.6 schema:alternateName Agostino Gemelli University Polyclinic
324 schema:name Hepatobiliary Surgery Unit, Gemelli Hospital, Catholic University of the Sacred Heart, Rome, Italy
325 rdf:type schema:Organization
326 https://www.grid.ac/institutes/grid.413172.2 schema:alternateName Ospedale Antonio Cardarelli
327 schema:name Hepatobiliary and Liver Transplant Unit, Cardarelli Hospital, Naples, Italy
328 rdf:type schema:Organization
329 https://www.grid.ac/institutes/grid.415025.7 schema:alternateName Azienda Ospedaliera San Gerardo
330 schema:name Center for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Rozzano, Italy
331 UOC di Gastroenterologia, Azienda Ospedaliera San Gerardo, Monza, Italy
332 rdf:type schema:Organization
333 https://www.grid.ac/institutes/grid.417893.0 schema:alternateName Istituto Nazionale dei Tumori
334 schema:name Functional Genomics and Bioinformatics, Department of Applied Research and Technology Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
335 rdf:type schema:Organization
336 https://www.grid.ac/institutes/grid.419555.9 schema:alternateName Candiolo Cancer Institute
337 schema:name Division of Hepatobilio-Pancreatic and Colorectal Surgery, Candiolo Cancer Institute - FPO, IRCCS, Str. Prov. 142, km 3.95, Candiolo, Italy
338 Medical Oncology Division, Candiolo Cancer Institute - FPO, IRCCS, Str. Prov. 142, km 3.95, 10060, Candiolo, Turin, Italy
339 rdf:type schema:Organization
340 https://www.grid.ac/institutes/grid.452265.2 schema:alternateName Fondazione Edo ed Elvo Tempia
341 schema:name Cancer Genomics Lab, Fondazione Edo ed Elvo Tempia Valenta, Biella, Italy
342 Medical Oncology Division, Candiolo Cancer Institute - FPO, IRCCS, Str. Prov. 142, km 3.95, 10060, Candiolo, Turin, Italy
343 rdf:type schema:Organization
344 https://www.grid.ac/institutes/grid.7605.4 schema:alternateName University of Turin
345 schema:name Department of Oncology, University of Turin, Torino, Italy
346 Medical Oncology Division, Candiolo Cancer Institute - FPO, IRCCS, Str. Prov. 142, km 3.95, 10060, Candiolo, Turin, Italy
347 rdf:type schema:Organization
348 https://www.grid.ac/institutes/grid.8404.8 schema:alternateName University of Florence
349 schema:name Center for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Rozzano, Italy
350 Department of Experimental and Clinical Medicine, University of Firenze, Florence, Italy
351 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...